Review
Biochemistry & Molecular Biology
Dai Koguchi, Kazumasa Matsumoto, Izuru Shiba, Takahiro Harano, Satoshi Okuda, Kohei Mori, Shuhei Hirano, Kazuki Kitajima, Masaomi Ikeda, Masatsugu Iwamura
Summary: Early detection of bladder cancer is crucial, but current screening methods have limited diagnostic accuracy. Liquid biopsy, including CTCs, ucfDNA, and umiRNA, has shown promise as a complementary diagnostic tool. However, more research is needed to validate its clinical application.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Xiangyang Tian, Jianlan Chang, Ningning Zhang, Shouxin Wu, Huimin Liu, Junyan Yu
Summary: This study revealed that miR-429 regulated the proliferation and apoptosis of colorectal cancer cells via HMGB3, suggesting a specific tumor suppressive function of the miR-429/HMGB3 signaling pathway in CRC.
Article
Oncology
Lijiang Gu, Yuhang Chen, Xing Li, Yibo Mei, Jinlai Zhou, Jianbin Ma, Mengzhao Zhang, Tao Hou, Dalin He, Jin Zeng
Summary: This study analyzed the role of RNA-binding proteins (RBPs) in bladder cancer (BC) and identified six RBPs that may serve as predictors of BC. By analyzing clinical information and RNA sequencing data, RBPs associated with patient survival were identified. The study also found that the expression of four RBPs was significantly upregulated in BC tissues and cell lines. A prognostic model based on these six RBPs was developed and functionally validated.
Article
Immunology
Fabio Pagliarulo, Phil F. Cheng, Laurin Brugger, Nick van Dijk, Michiel van den Heijden, Mitchell P. Levesque, Karina Silina, Maries van den Broek
Summary: Lymphoid neogenesis in muscle invasive bladder cancer (MIBC) leads to the formation of tertiary lymphoid structures (TLS) in the tumor microenvironment (TME), which have positive prognostic and predictive associations. This study found that high TLS density, when combined with tumor mutational burden, serves as a novel independent prognostic biomarker in MIBC. Tumors with high TLS density showed increased gene signatures and infiltration of activated lymphocytes, particularly B-cell and CD8(+) T-cell co-infiltration. The study also identified TLS maturation subtypes, although TLS composition appeared to be influenced by the TME rather than the maturation status.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Guohua Cheng, Yarong Li, Zhaoyu Liu, Xiang Song
Summary: Overexpression of miR-429 can enhance the sensitivity of CRC cells to nintedanib by inhibiting the JNK signaling pathway through targeting DUSP4, which may help prevent drug resistance of CRC cells to nintedanib.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Medicine, Research & Experimental
Katerina-Marina Pilala, Maria-Alexandra Papadimitriou, Konstantina Panoutsopoulou, Petros Barbarigos, Panagiotis Levis, Georgios Kotronopoulos, Konstantinos Stravodimos, Andreas Scorilas, Margaritis Avgeris
Summary: Bladder cancer (BlCa) is characterized by heterogeneous molecular landscape and lacks personalized treatment. In this study, we investigated the epigenetic regulation of the miR-143/145 cluster in BlCa. We found that the methylation of MIR145 core promoter was associated with disease progression and poor survival in BlCa patients. Combining MIR145 core promoter methylation with established disease markers improved risk stratification and prediction of treatment outcome. Our findings highlight the importance of personalized risk stratification and management in BlCa.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Genetics & Heredity
Antonio D. Pagano, Bruna F. F. Barreto, William B. B. Domingues, Tony L. R. Silveira, Leandro S. S. Nunes, Eduardo B. B. Blodorn, Eduardo N. N. Dellagostin, Mariana H. H. Remiao, Ricardo B. B. Robaldo, Vinicius F. F. Campos
Summary: Silverside fish, which inhabit the coastal waters of southern South America, have the ability to tolerate a wide range of salinity variations. A study found that a microRNA called miR-429 plays a crucial role in osmoregulation, making it a potential biomarker for silverside aquaculture.
FRONTIERS IN GENETICS
(2022)
Article
Cell Biology
Ziming Jiang, Yiming Zhang, Yu Zhang, Zhankui Jia, Zhengguo Zhang, Jinjian Yang
Summary: The study revealed that exosomes released by bladder cancer cells can promote the immunosuppressive polarization of macrophages, facilitating tumor growth. This process is mediated by down-regulation of PTEN and activation of AKT/STAT3/6 signaling. Inhibiting the generation or secretion of exosomes can suppress the immunosuppressive transformation of macrophages, thereby inhibiting tumor growth.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Oncology
Mackenzie L. Davenport, John B. Echols, Austin D. Silva, Joshua C. Anderson, Philip Owens, Clayton Yates, Qing Wei, Shuko Harada, Douglas R. Hurst, Mick D. Edmonds
Summary: miR-31 demonstrates oncogenic properties in specific subtypes of lung cancer, highlighting its potential as a therapeutic target in these subtypes.
Article
Biochemistry & Molecular Biology
Jen-Tai Lin, Kuo-Wang Tsai
Summary: The study showed that certain miRNAs in urine could potentially serve as noninvasive biomarkers for diagnosing bladder cancer, with implications for early detection and patient survival. Further validation in larger cohorts is necessary to confirm the clinical utility of urinary miRNAs in bladder cancer diagnosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Hao Lin, Xiaojun Shi, Haoran Li, Jialiang Hui, Ruiyu Liu, Zihao Chen, Yuwen Lu, Wanlong Tan
Summary: The study identified miR-93-5p and miR-516a-5p in urinary exosomes as potential biomarkers for bladder cancer detection, showing promising diagnostic value in BC patients. Further validation demonstrated that the expression level of miR-93-5p was associated with the progression of bladder cancer.
Article
Oncology
Naomi Kiyota, Makoto Tahara, Bruce Robinson, Martin Schlumberger, Steven Sherman, Sophie Leboulleux, Eun Kyung Lee, Takuya Suzuki, Min Ren, Kazuma Fushimi, Lori J. Wirth
Summary: Tumor response and tumor burden have a significant impact on overall survival (OS) in patients with RAI-R DTC treated with lenvatinib. Lenvatinib responders have longer OS compared to nonresponders, and patients with lower tumor burden receiving lenvatinib have longer OS compared to those with higher tumor burden. Therefore, baseline tumor burden may serve as a prognostic factor for OS in RAI-R DTC patients treated with lenvatinib.
Article
Biochemistry & Molecular Biology
Aleksandra Majewska, Klaudia Brodaczewska, Aleksandra Filipiak-Duliban, Arkadiusz Kajdasz, Claudine Kieda
Summary: MicroRNAs are important regulators of gene expression and play a role in various pathological states, including cancer. This study focuses on the miRNA pattern in renal cancer and its association with hypoxia and PTEN dysregulation. The findings show that hypoxia induces changes in miRNA expression, and the loss of PTEN affects the response to hypoxia. It is important to consider the specificity of the tumor microenvironment and key suppressor mutations when identifying miRNA patterns in cancer.
Article
Oncology
Piyatida Molika, Rassanee Bissanum, Komwit Surachat, Kovit Pattanapanyasat, Jitti Hanprasertpong, Wilaiwan Chotigeat, Raphatphorn Navakanitworakul
Summary: Cervical cancer is a common type of cancer in women and a leading cause of cancer-related deaths. This study found that the expression profiles of lncRNAs in extracellular vesicles change during the development of cervical cancer, and these lncRNAs are associated with important pathways involved in cell proliferation, inflammation, and cancer progression. Some of the highly expressed lncRNAs are also associated with poor overall survival of cervical cancer patients.
Article
Cell Biology
Songjie Shen, Yu Song, Bin Zhao, Yali Xu, Xinyu Ren, Yidong Zhou, Qiang Sun
Summary: The study identified miR-7641 as a key miRNA in cancer-derived exosomes promoting tumor progression and metastasis via intercellular communication. Exosomal miR-7641 may serve as a non-invasive diagnostic biomarker and potential therapeutic target in breast cancer treatment.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Integrative & Complementary Medicine
Ren-Jun Hsu, Yao-Chin Hsu, Shu-Pin Chen, Chia-Lynn Fu, Jyh-Cherng Yu, Fung-Wei Chang, Ying-Hsin Chen, Jui-Ming Liu, Jar-Yi Ho, Cheng-Ping Yu
BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2015)
Article
Oncology
Yi-Ta Tsai, Mei-Jen Chuang, Shou-Hung Tang, Sheng-Tang Wu, Yu-Chi Chen, Guang-Huan Sun, Pei-Wen Hsiao, Shih-Ming Huang, Hwei-Jen Lee, Cheng-Ping Yu, Jar-Yi Ho, Hui-Kuan Lin, Ming-Rong Chen, Chung-Chih Lin, Sun-Yran Chang, Victor C. Lin, Dah-Shyong Yu, Tai-Lung Cha
Article
Biochemistry & Molecular Biology
Tong-Hong Wang, Chau-Ting Yeh, Jar-Yi Ho, Kwai-Fong Ng, Tse-Ching Chen
MOLECULAR CARCINOGENESIS
(2016)
Article
Multidisciplinary Sciences
Jar-Yi Ho, Fung-Wei Chang, Fong Shung Huang, Jui-Ming Liu, Yueh-Ping Liu, Shu-Pin Chen, Yung-Liang Liu, Kuan-Chen Cheng, Cheng-Ping Yu, Ren-Jun Hsu
Article
Oncology
Jar-Yi Ho, Ren-Jun Hsu, Chih-Hsi Wu, Guo-Shiou Liao, Hong-Wei Gao, Tong-Hong Wang, Cheng-Ping Yu
Article
Oncology
Jar-Yi Ho, Ren-Jun Hsu, Jui-Ming Liu, Szu-Chi Chen, Guo-Shiou Liao, Hong-Wei Gao, Cheng-Ping Yu
Article
Oncology
Chia-Lun Wu, Jar-Yi Ho, Sheng-Chieh Chou, Dah-Shyong Yu
Article
Cell Biology
Chin-Chuan Chen, Chi-Yuan Chen, Shir-Hwa Ueng, Chuen Hsueh, Chau-Ting Yeh, Jar-Yi Ho, Li-Fang Chou, Tong-Hong Wang
CELL DEATH & DISEASE
(2018)
Article
Oncology
Chun-Jung Cho, Ching-Wei Yang, Chia-Lun Wu, Jar-Yi Ho, Cheng-Ping Yu, Sheng-Tang Wu, Dah-Shyong Yu
Article
Cell Biology
Cheng-Shuo Huang, Jar-Yi Ho, Jung-Hwa Chiang, Cheng-Ping Yu, Dah-Shyong Yu
Article
Medicine, Research & Experimental
Chun-Jung Cho, Cheng-Ping Yu, Chia-Lun Wu, Jar-Yi Ho, Ching-Wei Yang, Dah-Shyong Yu
Summary: The study demonstrated that capsaicin has the strongest synergistic cytotoxic effect with gemcitabine on T24-GCB cells, while quercetin, curcumin, and resveratrol have additive effects. Different phytochemicals have varying mechanisms when combined with gemcitabine for the treatment of bladder cancer.
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Oncology
Tai-Han Lin, Hong-Wei Gao, Guo-Shiou Liao, Jyh-Cherng Yu, Ming-Shen Dai, Jar-Yi Ho, Cheng-Ping Yu
Summary: Breast cancer is the most commonly diagnosed cancer and the leading cause of cancer death of women worldwide. This retrospective study aimed to propose better prognostic cut-off levels for ER and PgR, and found that patients with PgR expression <= 50% or an Allred score <= 5 exhibited a poor prognosis, needing more attention during follow-up.
Article
Oncology
Ying-Si Wu, Jar-Yi Ho, Cheng-Ping Yu, Chun-Jung Cho, Chia-Lun Wu, Cheng-Shuo Huang, Hong-Wei Gao, Dah-Shyong Yu
Summary: The study demonstrated that TGF-beta/Smad-induced EMT contributes to GCB resistance in bladder cancer by reducing GCB influx, and elucidated the novel mechanisms of ellagic acid-mediated inhibition of TGF-beta/Smad-induced EMT to overcome GCB resistance. The findings suggest further investigation of ellagic acid as an effective therapeutic adjuvant agent for overcoming GCB resistance in bladder cancer.
Article
Oncology
Cheng-Shuo Huang, Chen-Hua Tsai, Cheng-Ping Yu, Ying-Si Wu, Ming-Fong Yee, Jar-Yi Ho, Dah-Shyong Yu
Summary: This study demonstrates that LINC02470 plays a crucial role in promoting TGF-beta-induced EMT through the miR-143-3p/SMAD3 axis, thus aggravating bladder cancer progression. The findings suggest that LINC02470 could be a potential prognostic marker for bladder cancer.