Journal
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
Volume 34, Issue 10, Pages 539-546Publisher
WILEY
DOI: 10.1016/j.kjms.2018.05.002
Keywords
ADSC; CTACK/CCL27; Diabetes mellitus; Wound
Categories
Funding
- Ministry of Science and Technology, Taiwan [MOST 103-2628-B-037-002-MY3]
- Kaohsiung Municipal Ta-Tung Hospital [kmtth105-011]
- Kaohsiung Medical University Hospital [kmuh98-8G42]
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Diabetic wound care is a major health care concern. The major cause of non-healing of wounds in patients with diabetes mellitus (DM) patients mainly involves poor glycemic control, which hinders the migration of progenitor cells including mesenchymal stem cells to the wound site. In this study, we introduced adipose-derived stromal cells (ADSCs) into wound sites and demonstrated that the local transplantation of ADSCs accelerated DM-related wound healing. Furthermore, the migration ability of ADSCs, which diminishes in a high-glucose environment, was partially restored by the exogenous replenishment of the cutaneous T-cell attracting chemokine (CTACK/CCL27). Our findings suggest that CTACK is a potential novel therapeutic target in DM-related wound healing. Copyright (C) 2018, Kaohsiung Medical University. Published by Elsevier Taiwan LLC.
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