Effect of ultraviolet photofunctionalization of dental titanium implants on osseointegration

The aim of the current study was to evaluate the effect of ultraviolet (UV) photofunctionalization of dental titanium implants with exposure to the oral cavity on osseointegration in an animal model. Forty-eight titanium implants (CamlogA (R) ConelogA (R) 4.3 mmx9.0 mm) were placed epicrestally into the edentulous jaws of three minipigs and implant stability was assessed by measuring the implant stability quotient (ISQ). Prior to implantation half of the implants were photofunctionalized with intense UV-light. After three months, the implants were exposed and ISQ was measured again. After six months of implant exposure, the minipigs were sacrificed and the harvested specimens were analyzed using histomorphometric, light, and fluorescence microscopy. Forty-two of 48 implants osseointegrated. The overall mean bone-implant contact area (BIC) was (64 +/- 22)%. No significant differences were found in BIC or ISQ value (multivariate analysis of variance (MANOVA), P > 0.05) between implants with and without exposure to UV photofunctionalization. No significant effects were observed on osseointegration of dental titanium implants nine months after exposure of UV photofunctionalization.