Article
Medical Laboratory Technology
Pietro Iezzi, Fabrizio Cappellini, Jari Intra, Silvia Carnicelli, Lidia Fossati, Francesca Basta, Elisa Zucchetti, Gabriele Sala, Rossella Di Pierri, Laura Zullo, Adele Cappellani, Silvia Ippolito, Daniele Castelli, Annalisa Cavallero, Marco Casati
Summary: Urinary tract infection (UTI) is a common disease in both hospitalized and community subjects, but urine culture, the gold standard test, often yields negative results. This study evaluated the performance of the automated urinalysis system Atellica & REG; 1500 as a screening tool for ruling out UTI. Results showed that Atellica & REG; 1500 had satisfactory analytical performance in detecting bacteria but was not reliable for excluding UTI with urinalysis.
CLINICA CHIMICA ACTA
(2023)
Article
Infectious Diseases
Gregor John, Eric Mugnier, Etienne Pittet, Dominique Marianne Staehli, Olivier Clerc, Alain Foguena Kenfak, Andreas Konasch, Reto Lienhard, Daniel Genne
Summary: Urinary culture sensitivity decreases rapidly after administering empirical antibiotics, highlighting the impact of antibiotic treatment on urine culture results.
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Article
Microbiology
Amber M. M. Goedken, Kendra Y. Y. Foster, Erika J. J. Ernst
Summary: Females and males with recurrent urinary tract infections may receive prescription prophylaxis to reduce the infection frequency. Little is known about how prescription prophylaxis differs between patients meeting and exceeding the minimum threshold for recurrent urinary tract infections. This study aimed to estimate the association between infection frequency and receipt of prescription prophylaxis and describe the type of prescription prophylaxis initiated. The findings suggest that the odds of receiving prophylaxis were greater in patients with three or more infections compared to those with only two infections, and the type of prophylaxis used differed between the two groups.
Article
Medicine, General & Internal
Xuhui Li, Hua Fan, Hao Zi, Hankun Hu, Binghui Li, Jiao Huang, Pengcheng Luo, Xiantao Zeng
Summary: This study aimed to estimate the global and regional burden of bacterial antimicrobial resistance (AMR) in urinary tract infections (UTI) in 2019. The results showed that globally, there were approximately 64.89 thousand deaths attributed to and 0.26 million deaths associated with bacterial AMR in UTI. Escherichia coli and Klebsiella pneumoniae had the highest resistance rates, including resistance to fluoroquinolones, carbapenems, and third-generation cephalosporins. Tailored strategies, such as enhanced surveillance and rational use of antibiotics, should be developed for different regions based on their specific pathogen-antibiotic situations and resources.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Infectious Diseases
Eleonora Nicolai, Massimo Pieri, Enrico Gratton, Guido Motolese, Sergio Bernardini
Summary: The current methods for the diagnosis of UTIs and antimicrobial susceptibility testing take 2-3 days and lack rapid point-of-care AST, leading to antibiotic misuse and multi-drug-resistant organisms. A novel rapid phenotypic AST device can determine antibiotic susceptibility/resistance within 3 hours, which could help in early recognition of effective treatment options for individual patients.
Article
Infectious Diseases
Cristina Vercelli, Massimiliano Della Ricca, Mariachiara Re, Graziana Gambino, Giovanni Re
Summary: The study aims to design a specific working flow for a tailored antimicrobial treatment for canine and feline urinary tract infections, which achieved a very high success rate. Antimicrobial resistance phenomena in veterinary medicine is a significant issue that warrants further research and the implementation of antimicrobial stewardship programs.
Article
Public, Environmental & Occupational Health
Shen Xingrong, Feng Rui, Chai Jing, Cheng Jing, Isabel Oliver, Helen Lambert, Debin Wang
Summary: Antibiotics prescription was strongly associated with clinical diagnosis of respiratory tract infections (RTIs), but not with the presence of bacteria in patient samples. Some diagnoses may have been given by clinicians to justify the prescription of antibiotics. Additional measures, such as symptoms, should be used in conjunction with diagnosis to supervise or audit excessive use of antibiotics.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Infectious Diseases
Andreia Garces, Ricardo Lopes, Augusto Silva, Filipe Sampaio, Daniela Duque, Paula Brilhante-Simoes
Summary: This study investigated the current scenario of antimicrobial-resistant bacteria in companion animals with urinary tract infections in Portugal. The findings revealed a high level of bacterial resistance and a significant proportion of multidrug-resistant bacteria compared to northern European countries.
Article
Infectious Diseases
Felix Carrasco Calzada, John Jairo Aguilera-Correa, Juan Cuadros Gonzalez, Jaime Esteban Moreno, David Roca Biosca, Ramon Perez-Tanoira
Summary: A study conducted in Uganda isolated and tested the antimicrobial susceptibility of microorganisms causing urinary tract infections (UTI). The results showed a high prevalence of bacterial growth, with Enterococcus spp. and Escherichia coli being the most common uropathogens. The study suggests discontinuing the use of amoxicillin and ciprofloxacin as empirical treatments for UTIs in Uganda due to high resistance rates.
Article
Geriatrics & Gerontology
Jie Gu, Ping Song, Xiong Chen, Zhiming Yang, Xiaobo Zhang, Yao Bai
Summary: This study compared the bacterial spectrum and antibiotic susceptibility of uropathogens in older and younger patients with urinary stones. The results showed that the main pathogens in the older group with urinary tract infection were Escherichia coli and Klebsiella pneumoniae, while in the younger group, they were Escherichia coli and Enterococcus faecalis. In addition, the prevalence of Klebsiella pneumoniae and Enterococcus faecium was significantly higher in the older group. The proportion of males was higher in the older group. For antibiotic susceptibility, Escherichia coli and Klebsiella pneumoniae showed high sensitivity to piperacillin/tazobactam, imipenem, and amikacin, but high resistance to penicillin, tetracycline, and vancomycin. Enterococcus faecalis and Enterococcus faecium showed high sensitivity to gentamicin and vancomycin. Uropathogens isolated from younger patients were more susceptible to antimicrobials than those from older patients.
Article
Infectious Diseases
Adane Bitew, Nuhamen Zena, Abera Abdeta
Summary: This study aimed to determine the common etiology and prevalence of urinary tract infection in pediatric patients, analyze the antibiotic susceptibility profile of bacterial isolates, and identify associated risk factors. The results showed a high prevalence of urinary tract infection, with Enterobacteriaceae as the major causative agents. Length of hospital stay and catheterization were significantly associated with urinary tract infection. Both Gram-negative and Gram-positive bacteria exhibited high resistance to commonly used antibiotics.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Infectious Diseases
David Baunoch, Natalie Luke, Dakun Wang, Annah Vollstedt, Xinhua Zhao, Dicken S. C. Ko, Shuguang Huang, Patrick Cacdac, Larry T. Sirls
Summary: This study aimed to analyze the concordance between antibiotic resistance genes and antibiotic susceptibility results in urine samples from patients with urinary tract infections. The overall concordance rate between the presence of ABR genes and antimicrobial susceptibility was 60%, with variations across different antibiotics. However, certain antibiotics showed significantly lower concordance rates in polymicrobial infections.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Infectious Diseases
Xiaoqin Niu, Bolong Hou, Lunyun Yang, Wei Wang, Qinlong Yu, Minjie Mao, Weifeng Shen
Summary: This study assessed the frequency distribution and antibiotic resistance characteristics of bacterial pathogens causing urinary tract infections. The most common pathogens were Escherichia coli and Enterococcus faecium, and their resistance patterns differed. Antibiotics should be selected based on the sensitivity mode of the pathogenic bacteria.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Microbiology
Marcelina M. Jaworska, Paulina Pecyna, Katarzyna Jaskiewicz, Malgorzata Rydzanicz, Malgorzata Kaluzna, Krzysztof Pawlaczyk, Rafal Ploski, Dorota M. Nowak-Malczewska, Justyna A. Karolak, Marzena Gajecka
Summary: This study characterized and compared the bacterial composition of the urinary tract microbiome in patients undergoing dialysis and patients after kidney transplantation. The results showed differences in bacterial composition and identified potential diagnostic markers for the treatment of these patients.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Medicine, General & Internal
Jung Ki Jo, Dong Seob Kim, Younghun Sim, Soorack Ryu, Kyu Shik Kim
Summary: The study found that the severity of UTI is higher in patients with catheters, and the infecting strains vary depending on the presence of a catheter. Fosfomycin has a success rate of over 50% in treating UTIs, even in patients with catheters.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Ophthalmology
Stine Dahl Vest, Sarah E. Coupland, Bita Esmaeli, Paul T. Finger, Gerardo F. Graue, Hans E. Grossniklaus, Tine Gadegaard Hindso, Frederik Holm, Santosh G. Honavar, Jwu Jin Khong, Marina Knudsen Kirkegaard, Penelope A. McKelvie, Lauge Hjorth Mikkelsen, Kaustubh Mulay, Peter Kristian Rasmussen, Volkert Siersma, Lene Dissing Sjo, Matthew C. Sniegowski, Bradley A. Thuro, Geeta K. Vemuganti, Steffen Heegaard
Summary: The specific location of ocular adnexal lymphoma (OAL) and the AJCC TNM tumour stage are prognostic factors for mortality in different OAL subtypes. Eyelid lymphoma has the highest disease-specific mortality in all subtypes.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Infectious Diseases
Aline Cuenod, Martina Aerni, Claudia Bagutti, Banu Bayraktar, Efe Serkan Boz, Cynthia Beisert Carneiro, Carlo Casanova, Alix T. Coste, Peter Damborg, Dirk W. van Dam, Mehmet Demirci, Pavel Drevinek, Olivier Dubuis, Jose Fernandez, Gilbert Greub, Jaroslav Hrabak, Gulen Hurkal Yigitler, Jakub Hurych, Thoger Gorm Jensen, Geraldine Jost, Greetje A. Kampinga, Sonja Kittl, Christine Lammens, Claudia Lang, Reto Lienhard, Julie Logan, Carola Maffioli, Ivana Marekovic, Matthias Marschal, Jacob Moran-Gilad, Oliver Nolte, Michael Oberle, Michael Pedersen, Valentin Pfluger, Sigrid Pranghofer, Julia Reichl, Rob J. Rentenaar, Arnaud Riat, Belen Rodriguez-Sanchez, Camille Schilt, Ann-Kathrin Schlotterbeck, Jacques Schrenzel, Shani Troib, Elise Willems, Mandy Wootton, Dominik Ziegler, Adrian Egli
Summary: The study assessed the mass spectral quality (MSQ) of MALDI-TOF MS and identified simple workflow adaptations to improve it. The intervention of providing feedback and instructions on acquiring MALDI-TOF mass spectra showed improvements in MSQs.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Obstetrics & Gynecology
Ruth Kirk Ertmann, Dagny Ros Nicolaisdottir, Jakob Kragstrup, Gritt Overbeck, Margit Kriegbaum, Volkert Siersma
Summary: There seems to be little association between common pregnancy symptoms in the first trimester and the risk of future pregnancy and birth complications, although some symptoms such as pain and bleeding may cause concern.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Medicine, Research & Experimental
Gritt Overbeck, Jakob Kragstrup, Mette Gortz, Ida Scheel Rasmussen, Anette Hauskov Graungaard, Volkert Siersma, Sarah de Voss, Ruth Kirk Ertmann, Sinead Shahrzad, Clara Lundmark Appel, Philip Wilson
Summary: This article introduces a complex intervention aimed at improving maternal mentalisation skills and promoting a healthy mother-infant relationship in early parenthood. The study is a cluster-randomised controlled trial conducted in general practices in Denmark. The main outcomes measure child socio-emotional and language development at 30 months using parentally reported questionnaires.
Article
Medicine, General & Internal
Oliver Van Hecke, Lars Bjerrum, Ivan Gentile, Rogier Hopstaken, Hasse Melbye, Andreas Plate, Jan Y. Verbakel, Carl Llor, Annamaria Staiano
Summary: The threat of increasing antimicrobial resistance necessitates swift action to improve the rational use of antibiotics and increase stewardship to protect this key resource in healthcare. This paper discusses the role of CRP point-of-care testing in improving antibiotic stewardship in primary care for the diagnosis and treatment of adult patients with lower respiratory tract infections. It recommends promoting CRP POCT to identify adults who may benefit from antibiotics, and suggests enhanced communication and delayed prescribing as complementary strategies to reduce inappropriate antibiotic use.
FRONTIERS IN MEDICINE
(2023)
Correction
Infectious Diseases
Maria L. V. Jensen, Volkert Siersma, Lillian M. Soes, Dagny Nicolaisdottir, Lars Bjerrum, Barbara J. Holzknecht
Article
Rehabilitation
Bolette Skjodt Rafn, Jan Hartvigsen, Volkert Siersma, John Sahl Andersen
Summary: This study investigated the prevalence of multimorbidity among low back pain (LBP) patients in chiropractic practice and examined whether multimorbidity affects pain intensity, self-rated health, physical and mental health. The results showed that patients with multimorbidity have poorer general health and recovery from LBP compared to those without chronic disease. Clinical follow-up is recommended for patients with multimorbidity.
CHIROPRACTIC & MANUAL THERAPIES
(2023)
Article
Psychology, Developmental
Mads Schwartz, Ida Scheel Rasmussen, Philip Wilson, Gritt Overbeck, Volkert Siersma
Summary: This study evaluated the Danish version of the prenatal parental reflective functioning questionnaire (P-PRFQ). It found that better parental reflective functioning leads to better outcomes for the child. The regression analysis showed unexpected associations between the P-PRFQ score and predictive variables, raising questions about its use as a screening tool for assessing prenatal reflective functioning.
INFANT MENTAL HEALTH JOURNAL
(2023)
Article
Health Care Sciences & Services
Laura Trolle Saust, Volkert Dirk Siersma, Lars Bjerrum, Malene Plejdrup Hansen
Summary: A set of quality indicators for the diagnosis and antibiotic treatment of adult patients with suspected urinary tract infections in general practice was developed. Consensus was reached through expert discussion, resulting in 24 quality indicators that can strengthen the focus on managing patients with potential urinary tract infections in general practice.
Article
Sport Sciences
Anne-Sofie Agergaard, Jonathan D. Comins, Volkert Siersma, Nikolaj M. Malmgaard-Clausen, Christian Couppe, Mikkel H. Hjortshoej, Jens L. Olesen, S. Peter Magnusson
Summary: The current study aimed to assess the psychometric properties of the Victorian Institute of Sports Assessment-patellar tendinopathy (VISA-P) questionnaire. The results showed that the VISA-P did not fit a unidimensional model, yielded at best a 3-factor model, and exhibited differential item functioning (DIF) across healthy subjects versus people with patellar tendinopathy. Therefore, a new PROM for patellar tendinopathy should be developed and appropriately validated.
TRANSLATIONAL SPORTS MEDICINE
(2023)
Article
Obstetrics & Gynecology
Ruth K. Ertmann, Dagny R. Nicolaisdottir, Volkert Siersma, Gritt Overbeck, Sarah Stroyer de Voss, Frederikke Agerbo Modin, Melissa C. Lutterodt
Summary: This study aimed to investigate the relative importance of various physiological and psychosocial factors during the first trimester of pregnancy on the occurrence of pain symptoms later in pregnancy. The results showed that experiencing pain during the first trimester was the most important predictor for pain later in pregnancy.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Oncology
Emma Grundtvig Gram, Tulia Filipa Roberto Manso, Bruno Heleno, Volkert Siersma, Jessica A. Rogvi, John Brandt Brodersen
Summary: The study compared the psychosocial consequences of early-stage breast cancer (DCIS) and invasive breast cancer (IBC), and found that they may have different long-term effects. It suggests renaming DCIS to exclude cancer nomenclature.
Article
Clinical Neurology
Sofie Olsgaard Bergien, Volkert Dirk Siersma, Maria Kristiansen, Lasse Skovgaard
Summary: This study examines how social relations and engagement in leisure activities predict wellbeing among older adults with MS in Denmark. The findings show that emotional and instrumental social support are associated with better wellbeing, while strained social relations are associated with lower levels of wellbeing. Engagement in leisure activities is also found to be a predictor of wellbeing.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Infectious Diseases
Signe Teglbraender-Bjergkvist, Volkert Siersma, Anne Holm
Summary: This study aimed to assess differences in severity and bothersomeness of urinary tract infection (UTI) symptoms between pre- and postmenopausal women. The study found that premenopausal women had higher scores for symptom severity and bothersomeness compared to postmenopausal women.