Article
Cardiac & Cardiovascular Systems
Andrew W. Gardner, Polly S. Montgomery, Ming Wang, Menglu Liang
Summary: This randomized controlled trial compared the long-term effects of different exercise programs on symptomatic participants with peripheral artery disease. The study found that a long-term home exercise program (HEP) and transitioning from short-term supervised exercise therapy (SET) to HEP (SET/HEP) were both effective in improving peak walking time and exercise time-to-minimum calf muscle oxygen saturation. These improvements were also correlated with each other.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Rehabilitation
Marilia Almeida Correia, Gustavo Oliveira Silva, Paulo Longano, Ivani Credidio Trombetta, Fernanda Consolim-Colombo, Pedro Puech-Leao, Nelson Wolosker, Gabriel Grizzo Cucato, Raphael Mendes Ritti-Dias
Summary: The study analyzed the impact of diabetes on lifestyle, physical fitness, and cardiovascular health of PAD patients, finding that diabetic PAD patients exhibit more sedentary behavior, less physical activity, shorter walking distance, and impaired cardiac autonomic modulation compared to non-diabetic PAD patients.
ANNALS OF PHYSICAL AND REHABILITATION MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Poghni A. Peri-Okonny, Sarthak Patel, John A. Spertus, Elizabeth A. Jackson, Ali O. Malik, Jeremy Provance, Carlos Mena-Hurtado, Mehdi H. Shishehbor, Vittal Hijjaji, Kensey L. Gosch, Kim G. Smolderen
Summary: The study found no association between invasive treatment and physical activity levels in patients with claudication, despite the greater improvement in health status in the invasive treatment group. Increased physical activity was associated with better health status gains, suggesting that improving physical activity levels could potentially improve outcomes in peripheral artery disease (PAD).
AMERICAN JOURNAL OF CARDIOLOGY
(2021)
Article
Surgery
Madeline D. Cetlin, Tamar Polonsky, Karen Ho, Dongxue Zhang, Lu Tian, Lihui Zhao, Philip Greenland, Diane Treat-Jacobson, Melina R. Kibbe, Michael H. Criqui, Jack M. Guralnik, Mary M. McDermott
Summary: This study identified barriers to participation in supervised exercise therapy covered by CMS for lower extremity PAD. The majority of participants had never been prescribed or recommended supervised exercise therapy by their physicians, and most were unwilling or unable to pay the required copay for CMS-covered sessions. Many individuals also cited travel to medical centers as a significant obstacle to participation. These findings highlight the significant barriers faced by PAD patients in accessing and participating in supervised exercise therapy.
JOURNAL OF VASCULAR SURGERY
(2023)
Article
Biochemistry & Molecular Biology
Zhe Li, Erin K. Englund, Michael C. Langham, Jinchao Feng, Kebin Jia, Thomas F. Floyd, Arjun G. Yodh, Wesley B. Baker
Summary: The study investigated the effects of exercise training on muscle oxygen metabolism in PAD patients, showing that exercise training can improve muscle oxygen metabolism and blood flow, thereby reducing walking-induced muscle pain symptoms.
Article
Surgery
Kruti Patel, Tamar S. Polonsky, Melina R. Kibbe, Jack M. Guralnik, Lu Tian, Luigi Ferrucci, Michael H. Criqui, Robert Sufit, Christiaan Leeuwenburgh, Dongxue Zhang, Lihui Zhao, Mary M. McDermott
Summary: Among individuals with PAD, there is significant variation in walking improvement after SET, with shorter baseline 6-minute walk distance associated with greater improvement. However, age, sex, disease severity, and other clinical characteristics do not affect responsiveness to exercise therapy.
JOURNAL OF VASCULAR SURGERY
(2021)
Article
Medicine, General & Internal
Nicola Lamberti, Lorenzo Caruso, Giovanni Piva, Luca Traina, Valentina Ficarra, Paolo Zamboni, Vincenzo Gasbarro, Fabio Manfredini
Summary: Patients' self-reported claudication distance often exceeds the objectively assessed values, and a formula with an adjustment factor for diabetes was developed to reduce this overestimation by 92%. This study highlights the importance of reliable estimation of walking ability in patients with peripheral artery disease for appropriate treatment choices.
Article
Medicine, Research & Experimental
Alexandra Gratl, Dominik Pesta, Leonhard Gruber, Fiona Speichinger, Ben Raude, Safwan Omran, Andreas Greiner, Jan Paul Frese
Summary: This study found that revascularization procedures have significant effects on mitochondrial function and content in ischemic muscles, with no significant changes in non-ischemic muscles. This indicates that revascularization can promote mitochondrial recovery in affected muscle regions.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Adam A. Behroozian, Joshua A. Beckman
Summary: Peripheral Artery Disease (PAD) is a manifestation of atherosclerosis that can lead to reduced perfusion of the limb and metabolic dysregulation. The classification of asymptomatic PAD is relatively new, and there is a lack of clinical research on therapies for this population, presenting an opportunity for further exploration. Widespread screening for asymptomatic PAD could potentially reduce morbidity and mortality associated with PAD.
PROGRESS IN CARDIOVASCULAR DISEASES
(2021)
Article
Health Care Sciences & Services
Anna Crepaldi, Lorenzo Caruso, Giovanni Piva, Luca Traina, Vincenzo Gasbarro, Roberto Manfredini, Nicola Lamberti, Natascia Rinaldo, Fabio Manfredini, Pablo Jesus Lopez-Soto
Summary: This study aimed to detect foot perfusion changes in PAD patients after a home-based exercise program using infrared thermography. The results showed that after 20 weeks of exercise, foot temperature in both limbs significantly increased, with no significant difference between genders. Additionally, the ankle brachial index and performance also significantly improved over time.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Vinai C. Bhagirath, David Nash, Darryl Wan, Sonia S. Anand
Summary: Peripheral artery disease (PAD) is associated with high risks of cardiovascular and limb events and death. Preventive therapies, such as antithrombotic therapy, lipid lowering, blood pressure control, diabetes management, smoking cessation, and exercise programs, have been shown to improve symptoms and reduce complications. However, these therapies are underutilised in PAD patients due to barriers including lack of knowledge and access to secondary prevention programs.
CANADIAN JOURNAL OF CARDIOLOGY
(2022)
Article
Neurosciences
Ryan L. Mizner, Ashley A. Mays, Ryan J. Mays
Summary: Adding carbon fiber ankle foot orthoses (AFO) to a community-based walking program for patients with peripheral artery disease (PAD) improves patient mobility and delays claudication onset during walking. The AFO alters ankle walking mechanics and reduces ankle motion and joint power, while maintaining walking speed.
Review
Peripheral Vascular Disease
Ulf G. Bronas, Judith G. Regensteiner
Summary: This article provides a historical review of exercise training for peripheral artery disease (PAD). Supervised exercise training (SET) has been proven to be highly effective in improving walking ability for patients with claudication due to PAD. The findings of these studies led to a national coverage determination for SET by the CMS in 2017. Future research directions include optimal delivery strategies for SET and further elucidation of the mechanisms of improvement in walking ability resulting from SET.
Article
Cardiac & Cardiovascular Systems
Olivier Stivalet, Anita Paisant, Dihia Belabbas, Alexis Le Faucheur, Philippe Landreau, Estelle Le Pabic, Loukman Omarjee, Guillaume Mahe
Summary: The combination of post-exercise ABI with Exercise-TcPO2 criteria shows better sensitivity in diagnosing arterial stenoses compared to using AHA post-exercise criteria alone or Exercise-TcPO2 criteria alone.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Mary M. McDermott, Lu Tian, Michael H. Criqui, Luigi Ferrucci, Philip Greenland, Jack M. Guralnik, Melina R. Kibbe, Lingyu Li, Robert Sufit, Lihui Zhao, Tamar S. Polonsky
Summary: The study showed that exercise significantly improved the 6-minute walk distance in people with peripheral artery disease, but many participants randomized to exercise reported no change or decline in walking ability. These findings suggest a significant discrepancy in objectively measured walking improvement relative to perceived walking improvement in people with peripheral artery disease.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)