Baseline immune profile by CyTOF can predict response to an investigational adjuvanted vaccine in elderly adults

Successful and Maladaptive T Cell Aging

(2017) Jörg J. Goronzy et al.   IMMUNITY

A phase 1a, first-in-human, randomized study of a respiratory syncytial virus F protein vaccine with and without a toll-like receptor-4 agonist and stable emulsion adjuvant

(2016) Judith Falloon et al.   VACCINE

Pre-vaccination inflammation and B-cell signalling predict age-related hyporesponse to hepatitis B vaccination

(2016) Slim Fourati et al.   Nature Communications

Reduced naïve CD8+T-cell priming efficacy in elderly adults

(2015) Olivia Briceño et al.   AGING CELL

Modelling estimates of the burden of Respiratory Syncytial virus infection in adults and the elderly in the United Kingdom

(2015) Douglas M. Fleming et al.   BMC INFECTIOUS DISEASES

Enhanced immunogenicity of a respiratory syncytial virus (RSV) F subunit vaccine formulated with the adjuvant GLA-SE in cynomolgus macaques

(2015) Kathryn Patton et al.   VACCINE

Superior antigen-specific CD4+T-cell response with AS03-adjuvantation of a trivalent influenza vaccine in a randomised trial of adults aged 65 and older

(2014) Robert B Couch et al.   BMC INFECTIOUS DISEASES

Systems Biology and immune aging

(2014) José-Enrique O’Connor et al.   IMMUNOLOGY LETTERS

Influenza symptoms and their impact on elderly adults: randomised trial of AS03-adjuvanted or non-adjuvanted inactivated trivalent seasonal influenza vaccines

(2014) Gerrit A. van Essen et al.   Influenza and Other Respiratory Viruses

Age-Related Decrease in TCR Repertoire Diversity Measured with Deep and Normalized Sequence Profiling

(2014) O. V. Britanova et al.   JOURNAL OF IMMUNOLOGY

Aging and Cytomegalovirus Infection Differentially and Jointly Affect Distinct Circulating T Cell Subsets in Humans

(2014) A. M. Wertheimer et al.   JOURNAL OF IMMUNOLOGY

Influence of pre-existing hemagglutination inhibition titers against historical influenza strains on antibody response to inactivated trivalent influenza vaccine in adults 50–80 years of age

(2014) Ted M Ross et al.   Human Vaccines & Immunotherapeutics

Normalization of mass cytometry data with bead standards

(2013) Rachel Finck et al.   CYTOMETRY PART A

Translational sciences approach to RSV vaccine development

(2013) Vanessa Kurzweil et al.   Expert Review of Vaccines

Understanding immunosenescence to improve responses to vaccines

(2013) Jörg J Goronzy et al.   NATURE IMMUNOLOGY

The Effect of Age on Thymic Function

(2013) Donald B. Palmer   Frontiers in Immunology

Adults 65 Years Old and Older Have Reduced Numbers of Functional Memory T Cells to Respiratory Syncytial Virus Fusion Protein

(2012) Anu Cherukuri et al.   Clinical and Vaccine Immunology

Preexisting influenza-specific CD4+ T cells correlate with disease protection against influenza challenge in humans

(2012) Tom M Wilkinson et al.   NATURE MEDICINE

Inactivated Influenza Vaccines

(2011) Valentina Parodi et al.   DRUGS & AGING

The effect of aging on human lymphocyte subsets: comparison of males and females

(2010) Jun Yan et al.   Immunity & Ageing

Age related changes in T cell mediated immune response and effector memory to Respiratory Syncytial Virus (RSV) in healthy subjects

(2010) Maria Grazia Cusi et al.   Immunity & Ageing

Randomized, Double‐Blind Controlled Phase 3 Trial Comparing the Immunogenicity of High‐Dose and Standard‐Dose Influenza Vaccine in Adults 65 Years of Age and Older

(2009) Ann R. Falsey et al.   JOURNAL OF INFECTIOUS DISEASES

Baseline Levels of Influenza-Specific CD4 Memory T-Cells Affect T-Cell Responses to Influenza Vaccines

(2008) Xiao-Song He et al.   PLoS One

Flow cytometer with mass spectrometer detection for massively multiplexed single-cell biomarker assay

(2008) Scott D. Tanner et al.   PURE AND APPLIED CHEMISTRY