Article
Nanoscience & Nanotechnology
Zhiyao Liao, Liwei Fu, Pinxue Li, Jiang Wu, Xun Yuan, Chao Ning, Zhengang Ding, Xiang Sui, Shuyun Liu, Quanyi Guo
Summary: A bioactive multifunctional scaffold was developed using Mg2+ and aptamer Apt19S to promote articular cartilage regeneration and early inflammatory regulation, offering a promising strategy for AC defect treatment.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Biochemistry & Molecular Biology
Zhengjie Zhou, Jingtong Zheng, Xiaoting Meng, Fang Wang
Summary: There is increasing evidence that chondrocytes within articular cartilage are affected by endogenous force-related electrical potentials. Furthermore, electrical stimulation (ES) promotes the proliferation of chondrocytes and the synthesis of extracellular matrix (ECM) molecules, which accelerate the healing of cartilage defects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Engineering, Biomedical
Wenying Wei, Honglian Dai
Summary: Osteochondral defect regeneration remains a challenging issue in the musculoskeletal system, with traditional clinical treatments showing limited efficacy. However, the development of tissue engineering has provided more promising results in regenerating damaged osteochondral tissues.
BIOACTIVE MATERIALS
(2021)
Review
Chemistry, Physical
Farah Daou, Andrea Cochis, Massimiliano Leigheb, Lia Rimondini
Summary: Functional ability is essential for healthy aging, but articular cartilage degeneration is a common degenerative condition that leads to adverse impacts on quality of life, as well as being a key factor in osteoarthritis. Tissue engineering offers a promising therapeutic strategy for articular cartilage repair, but there is significant heterogeneity in the biomaterials, biofabrication, and assessments used in research studies. This literature review provides an overview of recent advances in cell-based and cell-free tissue engineering for articular cartilage repair, and focuses on the assessments performed in various in vitro, ex vivo, preclinical animal models, and clinical studies, in order to summarize the latest findings and clinical translation in the context of degenerated articular cartilage and osteoarthritis.
Article
Engineering, Biomedical
Yinghan Hu, Chengqi Lyu, Lin Teng, Anqian Wu, Zeyu Zhu, YuShi He, Jiayu Lu
Summary: Proteoglycans (PGs) are important components of cartilage extracellular matrix (ECM) and their loss leads to irreversible degeneration of cartilage tissue, eventually developing into osteoarthritis (OA). This study proposes a new PGs analogue, glycopolypeptide hydrogels, which show good biocompatibility, controlled enzyme-triggered degradation, and beneficial effects on chondrocytes. In vitro and in vivo experiments demonstrate that the hydrogels promote ECM deposition, up-regulate cartilage-specific gene expression, and have the potential for cartilage regeneration. The Gel-3 group, with a pore size of 122 +/- 12 μm, shows particularly promising results.
MATERIALS TODAY BIO
(2023)
Review
Engineering, Multidisciplinary
Liangbin Zhou, Peng Guo, Matteo D'Este, Wenxue Tong, Jiankun Xu, Hao Yao, Martin J. Stoddart, Gerjo J. V. M. van Osch, Kevin Ki-Wai Ho, Zhen Li, Ling Qin
Summary: Articular cartilage (AC) is a flexible connective tissue located on the bone surface in the joints. AC defects are common in physically active individuals. Functionalized hydrogels have emerged as promising substitutes for damaged cartilage in AC repair due to their favorable properties. This article introduces the composition, structure, and function of AC and its defects, and reviews the design and fabrication of functionalized hydrogels for AC repair.
Review
Biotechnology & Applied Microbiology
Qian Zhang, Yixin Hu, Xuan Long, Lingling Hu, Yu Wu, Ji Wu, Xiaobing Shi, Runqi Xie, Yu Bi, Fangyuan Yu, Pinxue Li, Yu Yang
Summary: Cartilage regeneration relies on cellular-ECM interactions. Traditional tissue engineering methods have not been able to replicate the physiological structure of natural cartilage, but recent advances in ECM-based scaffolds show promise in improving cartilage regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Maciej Baranowski, Monika Wasyleczko, Anna Kosowska, Andrzej Plichta, Sebastian Kowalczyk, Andrzej Chwojnowski, Wojciech Bielecki, Jaroslaw Czubak
Summary: The study demonstrates that different membranes implanted in rabbit articular cartilage defects support the regeneration process and degrade at an appropriate rate, aiding in cartilage regeneration.
Article
Engineering, Multidisciplinary
Xue Yang, Shuai Li, Ya Ren, Lei Qiang, Yihao Liu, Jinwu Wang, Kerong Dai
Summary: Three-dimensional printed hydrogel is a promising approach in cartilage tissue engineering due to its similarity to the extracellular matrix and its ability to fabricate 3D cell culture scaffolds. Various hydrogels, both natural and synthetic, have been tested for 3D printing in vitro articular cartilage tissues. The advancement in materials and printing techniques allows for the fabrication of delicate cartilage structures on multiple scales. Stimuli-responsive hydrogels and their application prospects in tissue engineering are also discussed in this review. The development of novel composite hydrogels that meet the requirements of native articular cartilage is crucial for further advancement in the field.
COMPOSITES PART B-ENGINEERING
(2022)
Review
Medicine, Research & Experimental
Weichang Xu, Jing Zhu, Jiawei Hu, Lin Xiao
Summary: Tissue engineering holds great promise in cartilage injury repair and replacement. However, issues such as immunogenicity, stability, and mechanical strength have remained unsolved in articular cartilage tissue engineering. The lack of replicating the chondrocyte biomechanical microenvironment (BME) has been a notable factor. Recent studies have highlighted the crucial role of BME in chondrocyte phenotype and cartilage functions, leading to more precise research in engineering the chondrocyte BME for articular cartilage tissue engineering. This review discusses the effects of the chondrocyte BME and explores the strategies for engineering it in articular cartilage tissue engineering, with a focus on simulating key characteristics and providing dynamic mechanical stimulation.
Article
Multidisciplinary Sciences
Heng Li, Jinming Li, Shengbo Yu, Chengwei Wu, Wei Zhang
Summary: The articular cartilage in the knee joint can be anatomically divided into different regions, with distinct mechanical properties observed among these regions. Histological analysis and the use of constitutive models help to explain the differences in cartilage properties, with the Fung and Ogden models found to be suitable for representing the effects of strain rate on stiffening.
SCIENTIFIC REPORTS
(2021)
Review
Engineering, Biomedical
Dorsa Dehghan-Baniani, Babak Mehrjou, Paul K. Chu, Wayne Yuk Wai Lee, Hongkai Wu
Summary: Articular cartilage (AC) has limited healing capacity due to its avascular and acellular nature. Cartilage tissue engineering faces challenges in remodeling the complex cartilage composition and architecture. Understanding intrinsic AC properties and cell response to stimuli is crucial for producing functional cartilaginous constructs. Biopolymers have shown promise in creating polymeric scaffolds that mimic zonal AC layers using physical, mechanical, and biological/chemical signals. This review discusses the properties, challenges, and potential ways to overcome them.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Mohammad B. Aljaber, Fiona Verisqa, Zalike Keskin-Erdogan, Kapil D. Patel, David Y. S. Chau, Jonathan C. Knowles
Summary: Approximately half of an adult human's body weight is made up of muscles. The source and bloom number of gelatin have been found to have an impact on the mechanical properties and biological activities of GelMA hydrogels.
Article
Polymer Science
Rachel Cordeiro, Rui D. D. Alvites, Ana C. C. Sousa, Bruna Lopes, Patricia Sousa, Ana C. C. Mauricio, Nuno Alves, Carla Moura
Summary: Osteoarthritis is a prevalent disease causing cartilage loss, and tissue engineering with different cellulose incorporated poly(epsilon-caprolactone) (PCL) scaffolds shows promise for its repair. The study manufactured and characterized PCL scaffolds with various percentages of commercial cellulose (microcrystalline and methyl cellulose) or cellulose from agro-industrial residues (corncob). The results indicate that cellulose incorporation promotes cellular adhesion/proliferation, and methyl cellulose scaffolds demonstrate compressive properties closer to native cartilaginous tissue.
Article
Engineering, Biomedical
Guillermo Bauza-Mayol, Marcos Quintela, Ava Brozovich, Michael Hopson, Shazad Shaikh, Fernando Cabrera, Aaron Shi, Federica Banche Niclot, Francesca Paradiso, Emma Combellak, Tom Jovic, Paul Rees, Ennio Tasciotti, Lewis W. Francis, Patrick Mcculloch, Francesca Taraballi
Summary: The use of biomimetic scaffolds in cartilage tissue engineering shows promising results in enhancing cartilaginous tissue formation and suppressing host cartilage degeneration. This approach may provide a clinical solution for cartilage tissue repair by modulating the immune environment to favor regenerative processes and suppress cartilage degeneration.
ADVANCED HEALTHCARE MATERIALS
(2022)