A review on gradient hydrogel/fiber scaffolds for osteochondral regeneration

Differentiation of mesenchymal stem cells for cartilage tissue engineering: Individual and synergetic effects of three-dimensional environment and mechanical loading

(2016) J.A. Panadero et al.   Acta Biomaterialia

Multilayered polycaprolactone/gelatin fiber-hydrogel composite for tendon tissue engineering

(2016) Guang Yang et al.   Acta Biomaterialia

Influencing chondrogenic differentiation of human mesenchymal stromal cells in scaffolds displaying a structural gradient in pore size

(2016) Andrea Di Luca et al.   Acta Biomaterialia

Highly efficient intracellular transduction in three-dimensional gradients for programming cell fate

(2016) Hoda M. Eltaher et al.   Acta Biomaterialia

Multi-layered collagen-based scaffolds for osteochondral defect repair in rabbits

(2016) Tanya J. Levingstone et al.   Acta Biomaterialia

Surface modification of electrospun fibres for biomedical applications: A focus on radical polymerization methods

(2016) Lina Duque Sánchez et al.   BIOMATERIALS

Cell-free multi-layered collagen-based scaffolds demonstrate layer specific regeneration of functional osteochondral tissue in caprine joints

(2016) Tanya J. Levingstone et al.   BIOMATERIALS

3D bioprinting for engineering complex tissues

(2016) Christian Mandrycky et al.   BIOTECHNOLOGY ADVANCES

Formation of three-dimensionality in polyaniline-based nanofibers: A highly conductive permeable scaffold for stem cells residence

(2016) Sajedeh Khorshidi et al.   International Journal of Polymeric Materials and Polymeric Biomaterials

Integration of PCL and PLA in a monolithic porous scaffold for interface tissue engineering

(2016) Roberto Scaffaro et al.   Journal of the Mechanical Behavior of Biomedical Materials

Repair of large osteochondritis dissecans lesions using a novel multilayered tissue engineered construct in an equine athlete

(2016) J. David Stack et al.   Journal of Tissue Engineering and Regenerative Medicine

Microfluidic Directed Synthesis of Alginate Nanogels with Tunable Pore Size for Efficient Protein Delivery

(2016) Salime Bazban-Shotorbani et al.   LANGMUIR

Fabrication of poly(L-lactic acid) tissue engineering scaffolds with precisely controlled gradient structure

(2016) Taotao Nie et al.   MATERIALS LETTERS

Composite scaffolds for osteochondral repair obtained by combination of additive manufacturing, leaching processes and hMSC-CM functionalization

(2016) Andrés Díaz Lantada et al.   Materials Science & Engineering C-Materials for Biological Applications

Wet-laid soy fiber reinforced hydrogel scaffold: Fabrication, mechano-morphological and cell studies

(2016) Andrew T. Wood et al.   Materials Science & Engineering C-Materials for Biological Applications

Structural hydrogels

(2016) Shuanhong Ma et al.   POLYMER

Integrated three-dimensional fiber/hydrogel biphasic scaffolds for periodontal bone tissue engineering

(2016) Dario Puppi et al.   POLYMER INTERNATIONAL

Formation of three-dimensionality in polyaniline-based nanofibers: A highly conductive permeable scaffold for stem cells residence

(2016) Sajedeh Khorshidi et al.   International Journal of Polymeric Materials and Polymeric Biomaterials

Three-Dimensional Nanofiber Hybrid Scaffold Directs and Enhances Axonal Regeneration after Spinal Cord Injury

(2016) Ulla Milbreta et al.   ACS Biomaterials-Science & Engineering

3D-Bioprinting of Polylactic Acid (PLA) Nanofiber–Alginate Hydrogel Bioink Containing Human Adipose-Derived Stem Cells

(2016) Lokesh Karthik Narayanan et al.   ACS Biomaterials-Science & Engineering

Electrospun Polyurethane and Hydrogel Composite Scaffolds as Biomechanical Mimics for Aortic Valve Tissue Engineering

(2016) Daniel S. Puperi et al.   ACS Biomaterials-Science & Engineering

Polymerization of Hydrogel Network on Microfiber Surface: Synthesis of Hybrid Water-Absorbing Matrices for Biomedical Applications

(2016) Jin-Yang Wang et al.   ACS Biomaterials-Science & Engineering

Three-Dimensional Nanofiber Hybrid Scaffold Directs and Enhances Axonal Regeneration after Spinal Cord Injury

(2016) Ulla Milbreta et al.   ACS Biomaterials Science & Engineering

3D-Bioprinting of Polylactic Acid (PLA) Nanofiber–Alginate Hydrogel Bioink Containing Human Adipose-Derived Stem Cells

(2016) Lokesh Karthik Narayanan et al.   ACS Biomaterials Science & Engineering

Electrospun Polyurethane and Hydrogel Composite Scaffolds as Biomechanical Mimics for Aortic Valve Tissue Engineering

(2016) Daniel S. Puperi et al.   ACS Biomaterials Science & Engineering

Polymerization of Hydrogel Network on Microfiber Surface: Synthesis of Hybrid Water-Absorbing Matrices for Biomedical Applications

(2016) Jin-Yang Wang et al.   ACS Biomaterials Science & Engineering

Gradients in pore size enhance the osteogenic differentiation of human mesenchymal stromal cells in three-dimensional scaffolds

(2016) Andrea Di Luca et al.   Scientific Reports

Bilayered silk/silk-nanoCaP scaffolds for osteochondral tissue engineering: In vitro and in vivo assessment of biological performance

(2015) Le-Ping Yan et al.   Acta Biomaterialia

Therapeutic-designed electrospun bone scaffolds: Mesoporous bioactive nanocarriers in hollow fiber composites to sequentially deliver dual growth factors

(2015) Min Sil Kang et al.   Acta Biomaterialia

Dynamic stiffening of poly(ethylene glycol)-based hydrogels to direct valvular interstitial cell phenotype in a three-dimensional environment

(2015) Kelly M. Mabry et al.   BIOMATERIALS

Radially oriented collagen scaffold with SDF-1 promotes osteochondral repair by facilitating cell homing

(2015) Pengfei Chen et al.   BIOMATERIALS

A multi-layered vascular scaffold with symmetrical structure by bi-directional gradient electrospinning

(2015) Tong Wu et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Surgical treatment of early knee osteoarthritis with a cell-free osteochondral scaffold: results at 24 months of follow-up

(2015) Alessandro Di Martino et al.   INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED

Biocompatibility of biomimetic multilayered alginate–chitosan/β-TCP scaffold for osteochondral tissue

(2015) Derya Algul et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Composites of electrospun-fibers and hydrogels: A potential solution to current challenges in biological and biomedical field

(2015) Shuxin Xu et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS

Generation and characterization of osteochondral grafts with human nasal chondrocytes

(2015) Marina Barandun et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Enhanced bone healing using collagen-hydroxyapatite scaffold implantation in the treatment of a large multiloculated mandibular aneurysmal bone cyst in a thoroughbred filly

(2015) Florent David et al.   Journal of Tissue Engineering and Regenerative Medicine

A review of key challenges of electrospun scaffolds for tissue-engineering applications

(2015) Sajedeh Khorshidi et al.   Journal of Tissue Engineering and Regenerative Medicine

Preparation of polymeric foams with a pore size gradient via Thermally Induced Phase Separation (TIPS)

(2015) G.A. Mannella et al.   MATERIALS LETTERS

The effect of interface microstructure on interfacial shear strength for osteochondral scaffolds based on biomimetic design and 3D printing

(2015) Weijie Zhang et al.   Materials Science & Engineering C-Materials for Biological Applications

Reinforcement of hydrogels using three-dimensionally printed microfibres

(2015) Jetze Visser et al.   Nature Communications

Current Concepts and Challenges in Osteochondral Tissue Engineering and Regenerative Medicine

(2015) Le-Ping Yan et al.   ACS Biomaterials-Science & Engineering

Current Concepts and Challenges in Osteochondral Tissue Engineering and Regenerative Medicine

(2015) Le-Ping Yan et al.   ACS Biomaterials Science & Engineering

Three-Dimensional Printing Fiber Reinforced Hydrogel Composites

(2014) Shannon E. Bakarich et al.   ACS Applied Materials & Interfaces

An anti-inflammatory cell-free collagen/resveratrol scaffold for repairing osteochondral defects in rabbits

(2014) Wei Wang et al.   Acta Biomaterialia

A biomimetic multi-layered collagen-based scaffold for osteochondral repair

(2014) Tanya J. Levingstone et al.   Acta Biomaterialia

Perspectives in Multiphasic Osteochondral Tissue Engineering

(2014) June E. Jeon et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Decellularized tissue and cell-derived extracellular matrices as scaffolds for orthopaedic tissue engineering

(2014) Christina W. Cheng et al.   BIOTECHNOLOGY ADVANCES

Three-dimensional osteogenic and chondrogenic systems to model osteochondral physiology and degenerative joint diseases

(2014) Peter G Alexander et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Tibial plateau lesions. Surface reconstruction with a biomimetic osteochondral scaffold: Results at 2 years of follow-up

(2014) Elizaveta Kon et al.   INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED

Fiber-reinforced hydrogel scaffolds for heart valve tissue engineering

(2014) Maryam Eslami et al.   JOURNAL OF BIOMATERIALS APPLICATIONS

Current strategies in multiphasic scaffold design for osteochondral tissue engineering: A review

(2014) Azizeh-Mitra Yousefi et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Evaluation of oriented electrospun fibers for periosteal flap regeneration in biomimetic triphasic osteochondral implant

(2014) Xudong Liu et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS

A review of hydrogel use in fracture healing and bone regeneration

(2014) David M. R. Gibbs et al.   Journal of Tissue Engineering and Regenerative Medicine

Electrospinning of nanofibrous scaffolds with continuous structure and material gradients

(2014) Jiankang He et al.   MATERIALS LETTERS

Enhanced chondrogenesis of human nasal septum derived progenitors on nanofibrous scaffolds

(2014) Abbas Shafiee et al.   Materials Science & Engineering C-Materials for Biological Applications

Effective method for multi-scale gradient porous scaffold design and fabrication

(2014) Nan Yang et al.   Materials Science & Engineering C-Materials for Biological Applications

Origin and function of cartilage stem/progenitor cells in osteoarthritis

(2014) Yangzi Jiang et al.   Nature Reviews Rheumatology

Fabrication of composition-graded collagen/chitosan–polylactide scaffolds with gradient architecture and properties

(2014) Dengke Yin et al.   REACTIVE & FUNCTIONAL POLYMERS

Nanofibrous hydrogel composites as mechanically robust tissue engineering scaffolds

(2014) Annabel L. Butcher et al.   TRENDS IN BIOTECHNOLOGY

Hydrogels for tissue engineering and regenerative medicine

(2014) John A. Hunt et al.   Journal of Materials Chemistry B

Bi-layer collagen/microporous electrospun nanofiber scaffold improves the osteochondral regeneration

(2013) Shufang Zhang et al.   Acta Biomaterialia

Gradient fiber electrospinning of layered scaffolds using controlled transitions in fiber diameter

(2013) Casey P. Grey et al.   BIOMATERIALS

The promotion of osteochondral repair by combined intra-articular injection of parathyroid hormone-related protein and implantation of a bi-layer collagen-silk scaffold

(2013) Wei Zhang et al.   BIOMATERIALS

Preparation of collagen porous scaffolds with a gradient pore size structure using ice particulates

(2013) Qin Zhang et al.   MATERIALS LETTERS

Novel HA-PVA/NOCC bilayered scaffold for osteochondral tissue-engineering applications – Fabrication, characterization, in vitro and in vivo biocompatibility study

(2013) Nurul Syuhada Ibrahim et al.   MATERIALS LETTERS

Repair of large osteochondral defects in a beagle model with a novel type I collagen/glycosaminoglycan-porous titanium biphasic scaffold

(2013) Xin Duan et al.   Materials Science & Engineering C-Materials for Biological Applications

Biomimetics of the extracellular matrix: an integrated three-dimensional fiber-hydrogel composite for cartilage tissue engineering

(2013) Jeannine Coburn et al.   Smart Structures and Systems

Microporous calcium phosphate ceramics as tissue engineering scaffolds for the repair of osteochondral defects: Biomechanical results

(2012) H.O. Mayr et al.   Acta Biomaterialia

Osteochondral tissue engineering: Current strategies and challenges

(2012) Syam P. Nukavarapu et al.   BIOTECHNOLOGY ADVANCES

Osteochondral tissue engineering: scaffolds, stem cells and applications

(2012) Patcharakamon Nooeaid et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Biphasic scaffolds for repair of deep osteochondral defects in a sheep model

(2012) Iris Schleicher et al.   JOURNAL OF SURGICAL RESEARCH

Flexible Generation of Gradient Electrospinning Nanofibers Using a Microfluidic Assisted Approach

(2012) Xu Zhang et al.   LANGMUIR

Graded biomimetic osteochondral scaffold prepared via CO2 foaming and micronized NaCl leaching

(2012) A. Salerno et al.   MATERIALS LETTERS

Bone scaffolds with homogeneous and discrete gradient mechanical properties

(2012) C. Jelen et al.   Materials Science & Engineering C-Materials for Biological Applications

State of the art composites comprising electrospun fibres coupled with hydrogels: a review

(2012) Lucy A. Bosworth et al.   Nanomedicine-Nanotechnology Biology and Medicine

Gradient biomaterials for soft-to-hard interface tissue engineering

(2011) Azadeh Seidi et al.   Acta Biomaterialia

A Three-Layered Osteochondral Plug: Structural, Mechanical, and in vitro Biocompatibility Analysis

(2011) Halil Murat Aydin   ADVANCED ENGINEERING MATERIALS

Mechanical properties and in vivo behavior of a biodegradable synthetic polymer microfiber–extracellular matrix hydrogel biohybrid scaffold

(2011) Yi Hong et al.   BIOMATERIALS

The Role of Growth Factors in Cartilage Repair

(2011) Lisa A. Fortier et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

Design properties of hydrogel tissue-engineering scaffolds

(2011) Junmin Zhu et al.   Expert Review of Medical Devices

Enhanced chondrocyte proliferation and mesenchymal stromal cells chondrogenesis in coculture pellets mediate improved cartilage formation

(2011) Chitrangada Acharya et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Evaluation of early-stage osteochondral defect repair using a biphasic scaffold based on a collagen–glycosaminoglycan biopolymer in a caprine model

(2011) Alan M.J. Getgood et al.   KNEE

Bioactive Stratified Polymer Ceramic-Hydrogel Scaffold for Integrative Osteochondral Repair

(2010) Jie Jiang et al.   ANNALS OF BIOMEDICAL ENGINEERING

Biomimetic gradient hydrogels for tissue engineering

(2010) Shilpa Sant et al.   CANADIAN JOURNAL OF CHEMICAL ENGINEERING

A novel MSC-seeded triphasic construct for the repair of osteochondral defects

(2010) B. Marquass et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Growth factor delivery-based tissue engineering: general approaches and a review of recent developments

(2010) K. Lee et al.   Journal of the Royal Society Interface

“Aligned-to-random” nanofiber scaffolds for mimicking the structure of the tendon-to-bone insertion site

(2010) Jingwei Xie et al.   Nanoscale

Hydrogel/electrospun fiber composites influence neural stem/progenitor cell fate

(2010) Anne Hsieh et al.   Soft Matter

Chondrogenesis and Mineralization During In Vitro Culture of Human Mesenchymal Stem Cells on Three-Dimensional Woven Scaffolds

(2010) Christoffer K. Abrahamsson et al.   TISSUE ENGINEERING PART A

Material properties and osteogenic differentiation of marrow stromal cells on fiber-reinforced laminated hydrogel nanocomposites

(2009) Weijie Xu et al.   Acta Biomaterialia

Multiscale three-dimensional scaffolds for soft tissue engineering via multimodal electrospinning

(2009) Sherif Soliman et al.   Acta Biomaterialia

Engineering human cell-based, functionally integrated osteochondral grafts by biological bonding of engineered cartilage tissues to bony scaffolds

(2009) Celeste Scotti et al.   BIOMATERIALS

Cartilage and Bone Extracellular Matrix

(2009) Chiara Gentili/snm et al.   CURRENT PHARMACEUTICAL DESIGN

Extracellular Signal-Regulated Kinase 1 (ERK1) and ERK2 Play Essential Roles in Osteoblast Differentiation and in Supporting Osteoclastogenesis

(2009) T. Matsushita et al.   MOLECULAR AND CELLULAR BIOLOGY

Photodegradable Hydrogels for Dynamic Tuning of Physical and Chemical Properties

(2009) April M. Kloxin et al.   SCIENCE

Stem cell- and scaffold-based tissue engineering approaches to osteochondral regenerative medicine

(2009) Sarah Sundelacruz et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Spatially controlled hydrogel mechanics to modulate stem cell interactions

(2009) Ross A. Marklein et al.   Soft Matter

Matrix Metalloprotease Inhibitors Suppress Initiation and Progression of Chondrogenic Differentiation of Mesenchymal Stromal Cells In Vitro

(2009) Helge Bertram et al.   STEM CELLS AND DEVELOPMENT

The Evaluation of a Biphasic Osteochondral Implant Coupled with an Electrospun Membrane in a Large Animal Model

(2009) Saey Tuan Barnabas Ho et al.   TISSUE ENGINEERING PART A

Bilayered chitosan-based scaffolds for osteochondral tissue engineering: Influence of hydroxyapatite on in vitro cytotoxicity and dynamic bioactivity studies in a specific double-chamber bioreactor

(2008) Patrícia B. Malafaya et al.   Acta Biomaterialia

Orthopedic Interface Tissue Engineering for the Biological Fixation of Soft Tissue Grafts

(2008) Kristen L. Moffat et al.   CLINICS IN SPORTS MEDICINE

Growth factor gradients via microsphere delivery in biopolymer scaffolds for osteochondral tissue engineering

(2008) Xiaoqin Wang et al.   JOURNAL OF CONTROLLED RELEASE

Engineering graded tissue interfaces

(2008) J. E. Phillips et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microenvironments Engineered by Inkjet Bioprinting Spatially Direct Adult Stem Cells Toward Muscle- and Bone-Like Subpopulations

(2007) Julie A. Phillippi et al.   STEM CELLS