Article
Medicine, General & Internal
Long Xu, Xiaoxia Chen, Hong Huo, Yongye Liu, Xiaodan Yang, Dejian Gu, Mingming Yuan, Min Zhang, Rongrong Chen, Jiayin Wang, Zhendong Zheng
Summary: This case report highlights a NSCLC patient with dual ROS1 fusions SDC4-ROS1 and ROS1-GK, who showed partial response to crizotinib but developed a brain lesion possibly related to ROS1-GK rearrangement. Further large-scale investigations are needed to evaluate the efficacy of ROS1 inhibitors in patients with complex ROS1 fusions.
FRONTIERS IN MEDICINE
(2021)
Article
Multidisciplinary Sciences
Zhong Yao, Luka Drecun, Farzaneh Aboualizadeh, Sun Jin Kim, Zhijie Li, Heidi Wood, Emelissa J. Valcourt, Kathy Manguiat, Simon Plenderleith, Lily Yip, Xinliu Li, Zoe Zhong, Feng Yun Yue, Tatiana Closas, Jamie Snider, Jelena Tomic, Steven J. Drews, Michael A. Drebot, Allison McGeer, Mario Ostrowski, Samira Mubareka, James M. Rini, Shawn Owen, Igor Stagljar
Summary: A tri-part Nanoluciferase-based assay named SATiN is developed for detecting antibodies against SARS-CoV-2, showing similar sensitivity to ELISA and consistent results with various neutralizing antibody assays. This assay, performed directly in patient sera, offers rapid, quantitative, and cost-effective detection, suggesting potential applications in diagnostics and disease management.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Ning Li, Zhiqin Chen, Mei Huang, Ding Zhang, Mengna Hu, Feng Jiao, Ming Quan
Summary: This study used next-generation sequencing to identify ROS1 fusion partners in Chinese patients with solid tumors. The most common fusion partners found were CD74, EZR, SDC4, and TPM3, and 14 novel fusion partners were also discovered in 16 patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Diane Frankel, Isabelle Nanni, L'Houcine Ouafik, Clara Camilla, Eric Pellegrino, Nathalie Beaufils, Laurent Greillier, Herve Dutau, Philippe Astoul, Elise Kaspi, Patrice Roll
Summary: ALK and ROS1 rearrangement detection in advanced-stage non-small cell lung cancer can be performed using multiple techniques, including ICC, FISH, and NGS. Compared to NGS, ICC has lower sensitivity and specificity, while FISH has similar sensitivity and specificity. FISH can correct false-positive cases obtained by ICC. Although NGS has better detection capability for ALK and ROS1 rearrangements in cytological samples, it is still much more expensive than the sequential use of ICC and FISH.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Olalekan Olanrewaju Bakare, Marshall Keyster, Ashley Pretorius
Summary: Pneumonia is the main cause of death among children under five years old, with increasing mortality rates in the elderly. Research is ongoing to find new biomarkers for diagnosing the disease accurately. This study utilized AMPs as biomarkers to detect viral pneumonia pathogens and utilized computational technologies for analysis and identification.
SCIENTIFIC REPORTS
(2021)
Article
Engineering, Electrical & Electronic
Zijie Wang, Rongke Liu, Qirui Liu, Lincong Han, John S. Thompson
Summary: The proposed UAV-assisted anti-jamming positioning system overcomes the vulnerability of traditional positioning systems to jamming attacks through collaboration between multiple UAVs and ground reference stations. Numerical results demonstrate that the system is a promising alternative when facing disruptions caused by jamming.
IEEE TRANSACTIONS ON VEHICULAR TECHNOLOGY
(2021)
Article
Chemistry, Analytical
Everardo Gonzalez-Gonzalez, Ricardo Garcia-Ramirez, Gladys Guadalupe Diaz-Armas, Miguel Esparza, Carlos Aguilar-Avelar, Elda A. Flores-Contreras, Iram Pablo Rodriguez-Sanchez, Jesus Rolando Delgado-Balderas, Brenda Soto-Garcia, Diana Araiz-Hernandez, Marisol Abarca-Blanco, Jose R. Yee-de Leon, Liza P. Velarde-Calvillo, Alejandro Abarca-Blanco, Juan F. Yee-de Leon
Summary: The COVID-19 pandemic, with limited access to testing, has exacerbated the crisis, making reliable testing critical. Automated ELISA on-chip using microfluidic-based technologies is a promising alternative for detecting antibodies in COVID-19 patients and vaccinated individuals. Basic image analysis of photos taken with a smartphone can be a useful alternative in the absence of specialized equipment.
Review
Biochemistry & Molecular Biology
Olga Morozova
Summary: Nanosilver with various biological activities has multiple mechanisms of action towards proteins, DNA, and membranes, but can cause cell toxicity and instability. Protein shells can protect the silver nanoparticles core and be used for immunoassays and diagnostics, with limitations in specificity and sensitivity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Xuan Du, Zhenlin Yang, Guohui Xie, Changshi Wang, Laixing Zhang, Kaige Yan, Maojun Yang, Sisi Li, Jian-Kang Zhu, Jiamu Du
Summary: The plant-specific ROS1/DME enzyme family can directly remove 5-methyl-cytosine, resulting in efficient DNA demethylation. The cryo-electron microscopy structures of the Arabidopsis ROS1 catalytic fragment in complex with substrate DNA, mismatch DNA, and reaction intermediate were determined. The substrate 5-methyl-cytosine is flipped-out from the DNA duplex and recognized by the ROS1 base-binding pocket through hydrophobic and hydrogen-bonding interactions. The protonation states of the bases determine the substrate preference for 5-methyl-cytosine over T:G mismatch. The study provides insights into the substrate specificity and reaction mechanism of the ROS1/DME family of plant-specific DNA demethylases.
Article
Engineering, Chemical
Imad Abrao-Nemeir, Oumaima Zaki, Nathan Meyer, Mathilde Lepoitevin, Joan Torrent, Jean-Marc Janot, Sebastien Balme
Summary: In this study, two strategies based on single nanopore sensing and multipore membrane were combined to separate, detect, and identify antibodies. The ability to detect antibodies specifically in a single nanopore was demonstrated, and a multipore membrane was also designed to extract antibodies effectively.
JOURNAL OF MEMBRANE SCIENCE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lena M. Unterrainer, Simon Lindner, Lennert Eismann, Jozefina Casuscelli, Franz-Josef Gildehaus, Vinh Ngoc Bui, Nathalie L. Albert, Adrien Holzgreve, Leonie Beyer, Andrei Todica, Matthias Brendel, Clemens C. Cyran, Alexander Karl, Christian G. Stief, Stephan T. Ledderose, Marcus Unterrainer, Peter Bartenstein, Vera Wenter, Alexander Kretschmer
Summary: [Ga-68] Ga-FAPI-46 PET imaging shows distinctly elevated uptake in urothelial carcinoma (UC) lesions, suggesting its potential as a promising new biomarker for metastatic UC patients and improving the detection of metastatic sites.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Engineering, Environmental
Chih-Ping Lin, Yin Jeh Ngui, Yi-Pei Chan, Albert T. Yeung
Summary: The experimental investigation of using time-domain reflectometry (TDR) to detect fluid hydrocarbon leaks in underground pipelines and storage tanks proves the technical feasibility of this technique.
PROCESS SAFETY AND ENVIRONMENTAL PROTECTION
(2023)
Article
Biochemistry & Molecular Biology
Mohd Shahnawaz Khan, Nojood Altwaijry, Moneera Saud Al-Bagmi, Nouf Omar Alafaleq, Majed S. Alokail, Moyad Shahwan, Anas Shamsi
Summary: Proto-oncogene tyrosine-protein kinase ROS (ROS1) is a member of a receptor family that affects epithelial cell differentiation and is highly expressed in various tumors. This study identified two potential inhibitors of ROS1 through virtual screening of phytochemicals. The findings highlight the role of ROS1 in multiple physiological processes and suggest the potential use of phytochemicals for therapeutic development targeting ROS1-associated non-small cell lung cancer.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Medicine, General & Internal
Mio Adachi, Tsuyoshi Nakagawa, Tomoyuki Fujioka, Mio Mori, Kazunori Kubota, Goshi Oda, Takamaro Kikkawa
Summary: This study demonstrated the feasibility and safety of microwave radar-based breast imaging technology in detecting breast cancer. Compared to conventional mammography, microwave imaging showed higher accuracy in detecting breast cancer and delineating its location and size.
Article
Engineering, Electrical & Electronic
Xun Zhu, Sheng Li, Xinpeng Zhang, Haoliang Li, Alex C. Kot
Summary: This paper proposes a Contour Enhanced Mask R-CNN (CEM-RCNN) model for detecting face images with spoofing medium contours (SMCs), and experimental results demonstrate its significantly better performance than the state-of-the-art technology in cross-database scenarios.
IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS FOR VIDEO TECHNOLOGY
(2021)
