Article
Cardiac & Cardiovascular Systems
Maria del Carmen Vazquez Alvarez, Ryan Cantor, Devin Koehl, Deipanjan Nandi, Mariska S. Kemna, Simon Urschel, Shawn C. West, Kimberly Y. Lin, Heang M. Lim, Tina Allain-Rooney, Anne Dipchand
Summary: Retransplantation in pediatric patients is associated with worse outcomes and lower survival rates. However, recent studies have shown an improvement in graft survival in pediatric retransplants. It is important to carefully select suitable patients and avoid retransplantation in cases of early graft failure and the need for mechanical support.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Review
Respiratory System
A. Justin Rucker, Joseph R. Nellis, Jacob A. Klapper, Matthew G. Hartwig
Summary: Lung retransplantation is the only therapeutic option for patients with refractory allograft dysfunction, but its efficacy and ethics are still debated. Careful consideration should be given to patient selection, donor organ selection, surgical approaches, and future considerations to improve outcomes and address organ utilization.
JOURNAL OF THORACIC DISEASE
(2021)
Review
Medicine, General & Internal
Gbalekan Dawodu, Shubham Gulati, Helena Bugacov, Daniel Laskey, Brian Housman, Harish Seethamraju, Scott Scheinin
Summary: The efficacy of Lung Retransplantation (LRT) has been debated and retrospective analyses on thousands of cases provide insight into predictive patient criteria. However, the lack of a standardized approach remains apparent.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pediatrics
Romy Gander, Marino Asensio, Jose Andres Molino, Gloria Fatou Royo, Mercedes Lopez-Gonzalez, Victor Perez, Manuel Lopez, Gema Ariceta
Summary: This study retrospectively analyzed the outcomes of repeat pediatric kidney transplantation (RPKT) among pediatric kidney transplant recipients, focusing on surgical complications. The study found that patients undergoing RPKT face many challenges, but overall the incidence of surgical complications, particularly vascular complications, is low.
JOURNAL OF PEDIATRIC UROLOGY
(2022)
Article
Immunology
Francesco Tandoi, Licia Peruzzi, Pietro Lonardi, Davide Cussa, Silvia Catalano, Aldo Verri, Maurizio Merlo, Omidreza Sedigh, Simona Gerocarni Nappo, Claudia Melloni, Damiano Patrono, Bruno Gianoglio, Renato Romagnoli
Summary: This study reports on two pediatric patients who were unable to undergo kidney transplantation due to thrombosis or aberrant anatomy in the iliac-caval system. The patients were successfully managed by using splenic vessels as a source of arterial inflow or venous drainage during the transplantation.
Article
Cardiac & Cardiovascular Systems
Marco Schiavon, Stefania Camagni, Federico Venuta, Lorenzo Rosso, Massimo Boffini, Francesco Parisi, Alessandro Bertani, Federica Meloni, Piero Paladini, Eleonora Faccioli, Michele Colledan, Daniele Diso, Margherita Cattaneo, Fabrizio Scalini, Sara Alfieri, Domenica Giunta, Monica Morosini, Luca Luzzi, Giulia Lorenzoni, Andrea Dell'Amore, Federico Rea
Summary: This study analyzed the experience of pediatric lung transplantation in Italy and found that the outcomes were comparable to current literature. Attention should be paid to the Oto score and recipient body mass index, and adult donors and graft reductions can be safely used to expand the donor pool.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Immunology
Alyssa K. Mezochow, Peter L. Abt, Therese Bittermann
Summary: The study found that there is individual variability in immunosuppressive therapy decisions following liver retransplantation, with center factors also playing a role in treatment. Specific treatment regimens are influenced by the timing of the retransplant, initial liver disease cause, and the transplant center.
Article
Cardiac & Cardiovascular Systems
David R. Spielberg, Ernestina Melicoff, Jeffrey S. Heinle, Kathleen Hosek, George B. Mallory
Summary: Despite progress in clinical transplantation, a shortage of suitable donor organs remains a constraint. Lungs are the most likely organs to be deemed unsuitable for transplantation. Optimizing donor management can increase the availability of organs for transplantation.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Article
Medicine, General & Internal
Nina Pillokeit, Sascha Grzella, Panagiota Zgoura, Timm Westhoff, Richard Viebahn, Peter Schenker
Summary: Simultaneous pancreas-kidney retransplantation (Re-SPK) after previous SPK is a technical and immunological challenge with significantly increased mortality and complication rate, thus requiring strict patient selection criteria and careful preoperative diagnosis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Daisuke Nakajima, Satona Tanaka, Tadashi Ikeda, Shiro Baba, Hidefumi Hiramatsu, Takenori Suga, Akihiro Ohsumi, Hiroshi Date
Summary: This study evaluated the outcome of living-donor segmental lung transplantation in pediatric patients. The results showed that the procedure was technically difficult but feasible, with acceptable outcomes. The transplantation was successful in most cases, with only a few complications.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Multidisciplinary Sciences
Jinsoo Rhu, Jieun Kwon, Manuel Lim, Namkee Oh, Sunghyo An, Seung Wook Han, Sung Jun Jo, Sunghae Park, Gyu-Seong Choi, Jong Man Kim, Jae-Won Joh
Summary: This study analyzed the risk and factors associated with better outcome in liver retransplantation. The analysis included adult liver transplantations performed from 1996 to 2021. Comparisons were made between first transplantations and retransplantations, as well as between whole liver and partial liver grafts in retransplantation cases. Multivariable Cox analyses were conducted to identify risk factors for primary graft and overall patient survival. The results indicate that retransplantation is associated with poor graft and patient survival compared to the first transplantation, especially when the graft size is relatively small. Lowering the FK506 trough level during the first month can improve outcomes.
SCIENTIFIC REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Yuanjia Zhu, Yasuhiro Shudo, Bharathi Lingala, Michael Baiocchi, Philip E. Oyer, Y. Joseph Woo
Summary: This study evaluated the outcomes of heart retransplantation and found that the long-term survival rate after retransplantation was lower than after primary heart transplantation. Although the short-term outcomes were similar between the two groups, heart retransplantation should still be considered for select patients to optimize donor organ usage.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Horacio G. Carvajal, John P. Costello, Jacob R. Miller, Pirooz Eghtesady, Dilip S. Nath
Summary: This article reviews the current status of pediatric heart-lung transplantation, including indications, preoperative risk factors, outcomes, and its application in unique patient subsets, as well as the surgical techniques used.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Article
Surgery
Sophie Girerd, Kevin Duarte, Cecile Couchoud, Emmanuelle Laurain, Cecile Courivaud, Marc Bauwens, Michele Kessler, Luc Frimat, Nicolas Girerd
Summary: This study aimed to evaluate the impact of age at the time of returning to dialysis on the association between second kidney transplantation (2KT) and survival. The findings showed that 2KT was associated with better survival compared to remaining on dialysis after the first graft failure. However, this survival benefit decreased with increasing age.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Pediatrics
Daniele De Luca, Pierre Tissieres, Martin C. J. Kneyber, Marc Humbert, Olaf Mercier
Summary: Lung and heart & lung transplantations for neonates and infants are rarely performed in Europe, with main indications being congenital disorders. The main obstacle identified by physicians is the availability of donors, and there is interest in establishing a European network to address this issue and realize a transplantation program for neonates and infants.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Surgery
Anna E. Frick, Christiaan T. Gan, Robin Vos, Stefan Schwarz, Felix Kraft, Daria Kifjak, Arne P. Neyrinck, Dirk E. Van Raemdonck, Walter Klepetko, Peter Jaksch, Erik A. M. Verschuuren, Konrad Hoetzenecker
Summary: Acute respiratory distress syndrome (ARDS) is a rapidly progressive lung disease with high mortality, and the use of lung transplantation (LTx) for treating ARDS remains controversial. However, based on the findings from this study, LTx in carefully selected ARDS patients has shown promising survival rates, offering a potential life-saving option in the absence of alternative treatments.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Respiratory System
Martin L. Watzenboeck, Anna-Dorothea Gorki, Federica Quattrone, Riem Gawish, Stefan Schwarz, Christopher Lambers, Peter Jaksch, Karin Lakovits, Sophie Zahalka, Nina Rahimi, Philipp Starkl, Doerte Symmank, Tyler Artner, Celine Pattaroni, Nikolaus Fortelny, Kristaps Klavins, Florian Frommlet, Benjamin J. Marsland, Konrad Hoetzenecker, Stefanie Widder, Sylvia Knapp
Summary: Lung transplantation is the ultimate treatment option for patients with end-stage respiratory diseases, but the mortality rate is high due to chronic lung allograft dysfunction (CLAD). The mechanisms leading to CLAD are not well understood due to insufficient understanding of post-transplant adaptation processes. This study analyzed bronchoalveolar lavage samples from lung recipients and donors, and found that recipient-specific and environmental factors shape the long-term lung microbiome. Certain bacterial strains were found to be correlated with underlying lung diseases even after transplantation. Machine learning techniques accurately predicted future changes in lung function, with the microbial profiles showing high predictive power. The study highlights the importance of understanding lung adaptation processes and the role of microbiome in predicting allograft function.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Alberto Benazzo, Lukas Bajorek, Annika Morscher, Lore Schrutka, Eva Schaden, Walter Klepetko, Konrad Hoetzenecker
Summary: Early implementation of continuous renal replacement therapy for perioperative volume management does not impair long-term kidney function in idiopathic pulmonary arterial hypertension lung transplant recipients.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Surgery
Michael D. Parkes, Kieran Halloran, Alim Hirji, Shane Pon, Justin Weinkauf, Irina L. Timofte, Greg I. Snell, Glen P. Westall, Jan Havlin, Robert Lischke, Andrea Zajacova, Ramsey Hachem, Daniel Kreisel, Deborah Levine, Bartosz Kubisa, Maria Piotrowska, Stephen Juvet, Shaf Keshavjee, Peter Jaksch, Walter Klepetko, Philip F. Halloran
Summary: The study revealed that CLAD primarily reflects severe parenchymal injury-induced changes and dedifferentiation rather than inflammation. Fibrillar collagen genes were increased in CLAD, indicating matrix changes, and normal transcripts were decreased.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Surgery
Claus Neurohr, Nikolaus Kneidinger, Alessandro Ghiani, Victor Monforte, Christiane Knoop, Peter Jaksch, Jasvir Parmar, Piedad Ussetti, Amparo Sole, Joachim Mueller-Quernheim, Romain Kessler, Hubert Wirtz, Gerhard Boerner, Oliver Denk, Stefanie Prante Fernandes, Juergen Behr
Summary: The study investigated the effects of locally augmented immunosuppression with liposomal cyclosporine A for inhalation (L-CsA-i) for the prevention of bronchiolitis obliterans syndrome (BOS) in lung transplant recipients. Despite not meeting the primary endpoint in the overall study population, there was a potential treatment difference observed in single lung transplant recipients. The results suggest further investigation of L-CsA-i in lung transplant recipients is warranted.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Cardiac & Cardiovascular Systems
Ilhan Inci, Jonas Peter Ehrsam, Dirk Van Raemdonck, Laurens Joseph Ceulemans, Thorsten Krueger, Angela Koutsokera, Marco Schiavon, Eleonora Faccioli, Mario Nosotti, Lorenzo Rosso, Frank D'Ovidio, Miguel Leiva-Juarez, Clemens Aigner, Alexis Slama, Waleed Saleh, Khaled Manaa Alkattan, Pascal Alexandre Thomas, Geoffrey Brioude, Alberto Benazzo, Konrad Hoetzenecker
Summary: This study investigated the outcomes of recipients bridged to a first-time retransplantation (ReTx) by extracorporeal life support (ECLS). The results showed that the overall survival of the ECLS-ReTx group was significantly worse compared to the regular-ReTx and index-Tx groups. Risk factors such as recipient age, intertransplant interval, primary graft dysfunction as transplant indication, and type of ECLS were identified as significant factors affecting mortality in ECLS-ReTx recipients.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Respiratory System
Elias Seidl, Nicolaus Schwerk, Julia Carlens, Martin Wetzke, Nagehan Emiralioglu, Nural Kiper, Joanna Lange, Katarzyna Krenke, Zsolt Szepfalusi, Florian Stehling, Winfried Baden, Susanne Haemmerling, Silvija-Pera Jerkic, Marijke Proesmans, Nicola Ullmann, Frederik Buchvald, Katrin Knoflach, Matthias Kappler, Matthias Griese
Summary: The characteristics and impact of acute exacerbations (AEs) on children's interstitial lung disease (chILD) were comprehensively analyzed in this study. The results showed that AEs have a significant and deleterious effect on the clinical course and health-related quality of life in chILD.
Editorial Material
Cardiac & Cardiovascular Systems
Peter Jaksch, Konrad Hoetzenecker
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Stefan Schwarz, Nina Rahimi, Daria Kifjak, Florian Frommlet, Alberto Benazzo, Peter Jaksch, Walter Klepetko, Konrad Hoetzenecker
Summary: The use of organs from polytrauma donors for lung transplantation yields similar short- and long-term outcomes as transplantation from nontrauma donors. The radiologic signs of lung contusion at the time of offer have no impact on primary graft function and long-term survival.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Cell Biology
Sara Bozzini, Claudia Del Fante, Monica Morosini, Hatice Oya Berezhinskiy, Sophia Auner, Elena Cattaneo, Matteo Della Zoppa, Laura Pandolfi, Rosalia Cacciatore, Cesare Perotti, Konrad Hoetzenecker, Peter Jaksch, Alberto Benazzo, Federica Meloni
Summary: This study found that specific miRNAs, such as miR-155-5p and miR-23b-3p, were significantly regulated in the circulation of BOS patients treated with extracorporeal photopheresis. The upregulation of miR-155 may be correlated with immune system regulation, and SMAD4 may be a potential target for miR-155-5p.
Article
Immunology
Selma Tobudic, Alberto Benazzo, Maximilian Koblischke, Lisa Schneider, Stephan Blueml, Florian Winkler, Hannah Schmidt, Stefan Vorlen, Helmuth Haslacher, Thomas Perkmann, Heinz Burgmann, Peter Jaksch, Judith H. Aberle, Stefan Winkler
Summary: This prospective cohort study found that lung transplant recipients had reduced humoral and cellular immune responses compared to healthy controls after two doses of COVID-19 mRNA vaccination during a 6-month follow-up. A third dose of the vaccine may be beneficial.
Article
Oncology
Liliane Borik-Heil, Georg Endler, Walther Parson, Andreas Zuckermann, Lisa Schnaller, Keziban Uyanik-Uenal, Peter Jaksch, Georg Boehmig, Daniel Cejka, Katharina Staufer, Elisabeth Hielle-Wittmann, Susanne Rasoul-Rockenschaub, Peter Wolf, Raute Sunder-Plassmann, Alexandra Geusau
Summary: Due to life-long immunosuppression, organ transplant recipients are prone to skin cancer development. Cumulative UV burden, actinic keratosis, and certain MC1R genotypes increase the risk of skin cancer. Skin aging is only connected with a higher number of tumors, not with the development of skin cancer per se.
Editorial Material
Allergy
Zsolt Szepfalusi, Thomas Eiwegger
Article
Biochemistry & Molecular Biology
Lei Fang, Wei-Chih Chen, Peter Jaksch, Antonio Molino, Alessandro Saglia, Michael Roth, Christopher Lambers
Summary: Treprostinil was found to reduce mitochondrial damage and improve mitochondrial function in IPF cells, which may explain its therapeutic effects in IPF patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)