Article
Pharmacology & Pharmacy
Elmar Damasceno Junior, Raquel de Melo Barbosa, Rita de Cassia Dantas da Silva, Felipe dos Santos Costa, Djalma Ribeiro da Silva, Cesar Viseras, Luana Perioli, Nedja Suely Fernandes
Summary: This study describes the development of a pH-responsive system using montmorillonite as a nanocarrier for rifampicin. The drug incorporation process was evaluated under different operational variables. The optimized conditions allowed an incorporated drug dose equivalent to 98.60 +/- 1.21 mg/g. Characterization techniques were used to understand the interaction mechanism between the compounds. In vitro release studies showed that approximately 70% of the drug was released after sixteen hours in simulated intestinal fluid, indicating the efficacy of the pH-dependent system obtained. The study highlights the viability of using montmorillonite as a carrier to develop a stable anti-TB/clay hybrid system.
Article
Biochemistry & Molecular Biology
Parinaz Jabbari, Gholam Reza Mahdavinia, Parisa Fathi Rezaei, Bagher Kazemi Heragh, Parisa Labib, Hessam Jafari, Shahrzad Javanshir
Summary: A nanocomposite carrier with double-responsive features was developed by integrating magnetic montmorillonite into a chitosan matrix and crosslinking it with citric acid. The carrier showed high sustained release and antibacterial activity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Polymer Science
Nour M. AlSawaftah, Nahid S. Awad, William G. Pitt, Ghaleb A. Husseini
Summary: Stimuli-responsive nanoparticles have shown promising potential in overcoming the limitations of conventional chemotherapy. pH-sensitive nanoparticles, in particular, have proven to be highly efficient in delivering drugs to tumors compared to conventional nanoparticles. This review summarizes the different strategies used to develop pH-sensitive nanoparticles for cancer therapy.
Article
Multidisciplinary Sciences
Shilpy Bhullar, Navdeep Goyal, Shikha Gupta
Summary: In this study, two types of nanoparticles were used for the pH-responsive release study of the drug Imatinib. The results showed that both nanoparticles can control the pH-sensitive delivery of the drug and do not result in the formation of ROS under human physiological conditions. This has important implications for the development of targeted drug delivery systems.
SCIENTIFIC REPORTS
(2022)
Review
Plant Sciences
Soojin Oh, Gareth Cave, Chungui Lu
Summary: Developing a resilient food supply is crucial in delivering necessary nutrients to consumers and addressing micronutrient deficiencies that can lead to severe health issues. Therefore, focus should be on enhancing minerals and nutrients in food through various methods to improve the sustainability of the food system.
FRONTIERS IN PLANT SCIENCE
(2021)
Review
Polymer Science
Rachel Yie Hang Tan, Choy Sin Lee, Mallikarjuna Rao Pichika, Sit Foon Cheng, Ki Yan Lam
Summary: This review summarizes the applications of pH-responsive polyurethane in the biomedical and drug delivery fields in recent years, including controlled drug delivery systems for oral administration, intravaginal administration, and targeted drug delivery systems for chemotherapy treatment. Additionally, it discusses other applications such as surface biomaterials, sensors, and optical imaging probes.
Article
Chemistry, Analytical
Nail Altunay, Adil Elik, Didem Aydin
Summary: A novel analytical method, SS MA LPME, based on supramolecular nanosized solvent, was developed for pre-concentration and separation of trace Vit-B-12 in infant formula, food supplement, and dairy products. Under optimized conditions, the method showed high recovery rates and precision for the determination of Vit-B-12.
MICROCHEMICAL JOURNAL
(2021)
Article
Polymer Science
Hsi-Chin Wu, Wei-Ting Kuo
Summary: The study developed a smart tumor-targeting co-delivery system capable of simultaneously delivering chemotherapy drugs and siRNA, with dual responsiveness and high cellular uptake efficiency. This system shows potential for application in functional co-delivery and tumor therapy.
Article
Chemistry, Physical
Chaolei Hu, Yimeng Sun, Gil van Wissen, Yitong Peng, Andrij Pich
Summary: In this study, visible light- and temperature-responsive poly(N-vinylcaprolactam) microgels decorated by donor-acceptor Stenhouse adducts (DASAs) were synthesized for the first time using a robust and straightforward post-modification synthesis route. The microgels exhibited homogeneous distributions and temperature responsiveness in aqueous solutions. The photoswitching behaviors of the microgels in different solvents were systematically investigated, and their size in aqueous solutions could be modulated by visible light irradiation. Moreover, the microgels showed potential application in the photostimulated delivery of hydrophobic drugs.
CHEMISTRY OF MATERIALS
(2022)
Article
Engineering, Chemical
Dan-Na Hu, Xiao-Jie Ju, Xing-Qun Pu, Rui Xie, Wei Wang, Zhuang Liu, Liang-Yin Chu
Summary: The copolymer Alg-g-PNA shows temperature and glucose responsiveness, with the ability to transition between sol and gel states for insulin delivery based on environmental conditions. Additionally, the hydrogels demonstrate good biocompatibility and reversible sol-gel transitions in response to changes in blood glucose levels, making them a promising option for self-regulating insulin delivery in diabetes therapy.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2021)
Article
Polymer Science
Zahn Stanvliet, Yiyi Deng, Dietmar Appelhans, Silvia Moreno, Susanne Boye, Jens Gaitzsch, Albena Lederer
Summary: This study investigates the temperature sensitivity of polymeric nanoparticles based on tertiary amine methacrylate block copolymers. The research shows that these nanoparticles can undergo a reversible morphological transformation in response to changes in pH and temperature. The findings also demonstrate the ability to lock their intermediate self-assembly structures through cross-linking and validate the morphology transition using analytical tools, which opens up new possibilities for responsive nanocarriers.
Article
Nutrition & Dietetics
Katarzyna Stos, Agnieszka Wozniak, Ewa Rychlik, Izabela Ziolkowska, Aneta Glowala, Maciej Oltarzewski
Summary: In Poland, a minority of adults use food supplements, mainly consisting of vitamin supplements. More men use mineral supplements, while more women use vitamin and mineral supplements. Food supplements serve as a significant source of vitamins and minerals in these populations and their intake should be monitored.
FRONTIERS IN NUTRITION
(2021)
Article
Polymer Science
Yiluo Hu, Yohan Kim, Inki Hong, Moosung Kim, Seunho Jung
Summary: Agarose/succinoglycan hydrogels exhibit significantly improved flexibility, stability, and swelling pattern compared to agarose gels alone, and they also demonstrate pH-responsive drug delivery of ciprofloxacin. The non-toxicity of these hydrogels makes them potential natural biomaterials for biomedical applications.
Article
Chemistry, Physical
Feng-Qin Luo, Guojun Chen, Wei Xu, Daojia Zhou, Jia-Xian Li, Yong-Cong Huang, Run Lin, Zhen Gu, Jin-Zhi Du
Summary: The study presents a novel glucose-responsive insulin delivery system using pH-sensitive insulin-loaded nanoparticles and glucose oxidase-catalase-loaded pH-insensitive nanoparticles. This system effectively regulates blood glucose levels within normal ranges for a prolonged period and reduces inflammation risks towards normal skin.
Article
Biochemistry & Molecular Biology
Javad Yekrang, Nasim Gholam Shahbazi, Fatemeh Rostami, Mahmoud Ramyar
Summary: In this study, a vitamin B-12-loaded polyvinyl alcohol (PVA)/chitosan (Cs) nanofiber patch (NFP) was prepared and cross-linked by glutaraldehyde (GA). The physicochemical properties of the nanofiber patches were evaluated, including morphological studies, FTIR analysis, hydrophilicity test, mechanical tests, and in-vitro evaluations. In-vivo studies were also conducted to measure vitamin B-12 levels in the bloodstream and assess tissue damage in animal models. The results showed that cross-linking of NFP led to a lower, slower, and more continuous release of the vitamin, with slight changes in biodegradability and improved mechanical properties. Furthermore, the NFP demonstrated cytocompatibility and no tissue damage, making it a potential candidate for transdermal drug delivery.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Applied
Mozhgan Akbari Alavijeh, Mehdi Nasiri Sarvi, Zahra Ramazani Afarani
Article
Chemistry, Analytical
Mozhgan Akbari Alavijeh, Michael Schindler, Mark G. G. Wirth, Odeta Qafoku, Libor Kovarik, Daniel E. E. Perea
Summary: This study investigates the sequestration and transformation of silver (Ag) and arsenic (As) ions in soil organic matter (OM) at the nanoscale using advanced microscopy techniques. The results show that both Ag and As are predominantly sequestered by OM through various mechanisms, such as co-precipitation and adsorption on Fe-(hydr)oxides. The study also reveals the formation of different types of nanoparticles and their transformation processes.
ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS
(2023)
Article
Multidisciplinary Sciences
Mozhgan Akbari Alavijeh, Mehdi Nasiri Sarvi, Zahra Ramazani Afarani
Article
Engineering, Chemical
Xu Yang, Jieshi Xiao, Jian Huang, Kaixiang Peng
Summary: This study introduces an online convolutional adversarial autoencoder (AAE) model to learn representative industrial process information. By extracting features that reflect diverse information and follow a Gaussian distribution, the model improves the accuracy of fault detection and removes redundant information through a feature selection strategy.
JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS
(2024)
Article
Engineering, Chemical
Shao-Yang Wu, Meng-Tsun Lai, Chung-Hui Hsu, Kevin C. W. Wu, Yesong Gu
Summary: This study investigated the effectiveness of using Fe-based MOF or MIL-100(Fe) in conjunction with a PEDOT-modified Pt electrode for detecting the synthetic azo dye tartrazine. By modifying the electrode with two different methods, favorable lower reductive potentials, competitive sensitivities, and good repeatability and stability were achieved in all MIL-100(Fe)/PEDOT/Pt electrodes.
JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS
(2024)
