Article
Radiology, Nuclear Medicine & Medical Imaging
Go Kamimura, Kazuhiro Ueda, Soichi Suzuki, Koki Maeda, Hiroto Hakamada, Masami Sato
Summary: Intraoperative CT is reliable for confirming the success of sublobar resection for indistinct lung cancer lesions by confirming complete resection and estimating surgical margin length. The intraoperative CT-based tumor diameter and margin length closely correlate with measurements on formalin-fixed specimens.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Article
Oncology
Wei Zhou, Pang Wang, Xinyu Ti, Yutian Yin, Shigao Huang, Zhi Yang, Jie Li, Guangjin Chai, Bo Lyu, Zhaohui Li, Yan Zhou, Feng Xiao, Lin Xu, Mei Shi, Lina Zhao
Summary: This study compared the efficacy and toxicities of sequential chemotherapy and hypofractionated radiotherapy vs concurrent twice-daily schedule for limited-stage small-cell lung cancer (LS-SCLC) using propensity score-matched analysis (PSM). The results showed that the sequential hypofractionated schedule was associated with comparable survival and less toxicity, and it could be used as an alternative to concurrent twice-daily regimens.
Article
Oncology
Neal S. McCall, James R. Janopaul-Naylor, H. Scott McGinnis, Aparna H. Kesarwala, Sibo Tian, William A. Stokes, Joseph W. Shelton, Conor E. Steuer, Jennifer W. Carlisle, Ticiana A. Leal, Suresh S. Ramalingam, Jeffrey D. Bradley, Kristin A. Higgins
Summary: This study aimed to evaluate the efficacy and tolerability of durvalumab in Black and non-Black patients after concurrent chemoradiation. The results showed no significant differences in overall survival, progression-free survival, and ≥3 grade pneumonitis-free survival between Black and non-Black patients.
Article
Oncology
Marleen E. Logtenberg, Ben Tomlow, Elisabeth A. Kastelijn, Franz M. N. H. Schramel
Summary: A large retrospective cohort study conducted in the Netherlands compared the effects of concurrent and sequential chemoradiotherapy in elderly patients with stage III NSCLC. The study found that elderly patients benefited more from concurrent chemoradiotherapy and did not experience more toxicity compared to their younger counterparts.
CLINICAL LUNG CANCER
(2022)
Article
Respiratory System
Melissa J. J. Voorn, Loes P. A. Aerts, Gerbern P. Bootsma, Jacques B. Bezuidenhout, Vivian E. M. Van Kampen-van den Boogaart, Bart C. Bongers, Dirk K. de Ruysscher, Maryska L. G. Janssen-Heijnen
Summary: This study aimed to evaluate the associations between pretreatment physical status parameters and tolerance of concurrent chemoradiation (cCHRT) and survival among patients with stage III non-small cell lung cancer (NSCLC). The study found that poor WHO performance status and BMI<18.5 kg/m(2) were independently associated with tolerance of cCHRT in patients with stage III NSCLC receiving cCHRT. Additionally, physical status parameters and intolerance of cCHRT were independently associated with poorer survival.
Article
Surgery
Kentaro Shinohara, Tomoki Ebata, Yoshie Shimoyama, Takashi Mizuno, Yukihiro Yokoyama, Junpei Yamaguchi, Shunsuke Onoe, Nobuyuki Watanabe, Masato Nagino
Summary: The study investigated the status of radial margin (RM) in resected perihilar cholangiocarcinoma (PHCC) and found that positive RM was the most common cause of R1 resection, with a positivity rate of 61.2%. The survival of patients with positive RM was poorer than that of R0 patients and similar to patients with positive ductal margin (DM). Meticulous handling of resected specimens is crucial for accurately evaluating RM status along with DM status.
Article
Oncology
Shi Tang, Xiaofeng Cong, Dan Zheng, Chen Chen, Zengguang Liu, Jie Gao, Huimin Zhang, Youhao Zhang, Ziling Liu
Summary: Concurrent use of sintilimab with sequential chemoradiotherapy showed better objective response rate (ORR) and progression-free survival (PFS) than sequential chemoradiotherapy alone in Chinese patients with unresectable stage III non-small-cell lung cancer (NSCLC), with manageable safety profiles.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Jianghao Ren, Mingyang Zhu, Yuanyuan Xu, Ruijun Liu, Ting Ren, Zhiyi Guo, Jiangbin Ren, Kan Wang, Qiang Tan
Summary: The study found that the margin status after sleeve lobectomies is not a risk factor for prognosis, but patients with more lymph nodes resection should pay attention to the margin status.
Article
Oncology
Xiwen Zhou, Jianting Du, Guobing Xu, Chun Chen, Bin Zheng, Jiahe Chen
Summary: This study aims to evaluate the cost-effectiveness of osimertinib postoperative adjuvant therapy in China. A Markov model was constructed using data from the ADAURA trial. The results showed that compared to placebo, patients in the osimertinib group had a higher quality-adjusted life year (QALY) gain and a higher cost-effectiveness ratio.
Article
Surgery
Zhiyuan Yu, Xudong Zhao, Jingwang Gao, Sixin Zhou, Peiyu Li, Na Liu
Summary: This study aimed to explore the correlations between demographic, surgical, and pathological characteristics with local recurrence-free survival (LRFS) for surgical resected retroperitoneal liposarcoma (RPLS). It was found that elevated preoperative neutrophil/lymphocyte ratio (NLR), ≥ 2nd time surgical frequency, extended operation time, irregular tumor shape, no well-differentiated histological subtype, and tumor necrosis could be used as predictors of LRFS for surgical resected RPLS. A nomogram was constructed based on these predictors to predict the LRFS for surgical resected RPLS at 1, 3, and 5 years.
WORLD JOURNAL OF SURGERY
(2023)
Article
Oncology
Chih-Yen Tu, Hung-Jen Chen, Te-Chun Hsia, Hsin-Yuan Fang, Chia-Chin Li, Chun-Ru Chien
Summary: This study compared the outcomes of patients with locally advanced non-small cell lung cancer receiving adjuvant concurrent chemoradiotherapy (aCCRT) and adjuvant chemotherapy (aCT). The results showed that the addition of radiotherapy did not provide a significant overall survival benefit for patients with microscopic residual disease after radical surgery.
ANTICANCER RESEARCH
(2022)
Article
Otorhinolaryngology
Hao Li, Marlena McGill, Natascha Putri, Avery Yuan, Richard J. Wong, Snehal G. Patel, Ian Ganly
Summary: The impact of parapharyngeal extension on margin status, local recurrence-free probability, and disease-specific survival in the resection of parotid carcinomas was evaluated. Results showed that parapharyngeal extension did not worsen oncologic outcomes, including margin positivity, local recurrence, and disease-specific survival.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Oncology
M. Altan, F. Soto, T. Xu, N. Wilson, M. C. Franco-Vega, C. A. Simbaqueba Clavijo, V. R. Shannon, S. A. Faiz, S. Gandhi, S. H. Lin, P. Lopez, L. Zhong, F. Akhmedzhanov, M. C. B. Godoy, G. S. Shroff, J. Wu, F. Khawaja, S. T. Kim, A. Naing, J. V. Heymach, C. Daniel-Macdougall, Z. Liao, A. Sheshadri
Summary: This study aimed to identify the risk factors for pneumonitis in patients with locally advanced non-small cell lung cancer undergoing combined chemoradiation and immune checkpoint inhibition therapy and investigate its impact on survival. The study found that risk factors for pneumonitis include the mean radiation dose to the lung and pre-treatment interstitial lung disease, and higher-grade pneumonitis is associated with increased all-cause mortality.
Article
Medicine, Research & Experimental
Yun Zhang, Jing Wang, Zhuang Yu, Hong Ge, Lin-Wei Zhang, Ling-Xin Feng
Summary: A study on 271 patients with advanced non-small cell lung cancer showed that combination therapy of icotinib and chemotherapy had better survival outcomes compared to the standard two-line therapy. This combination therapy resulted in significantly higher progression-free survival (PFS), overall survival (OS), and objective response rate, indicating its potential as a more effective treatment strategy for these patients.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2021)
Article
Oncology
Shubin Guan, Weiguang Long, Yang Liu, Bin Cai, Juan Luo
Summary: This study compared the prognosis of concurrent chemo-radiotherapy (CCRT) versus sequential chemo-radiotherapy (SCRT) induction followed by surgical resection in patients with advanced thymic epithelial tumors (TETs). The study found no significant differences in induction response rate and surgical complete resection rate between CCRT and SCRT groups, but CCRT had significantly higher adverse events in the hematologic system.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Shane Mesko, He Wang, Samuel Tung, Congjun Wang, Dario Pasalic, Bhavana V. Chapman, Amy C. Moreno, Jay P. Reddy, Adam S. Garden, David I. Rosenthal, G. Brandon Gunn, Steven J. Frank, Clifton D. Fuller, William Morrison, Jack Phan
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2020)
Article
Oncology
Moran Amit, Chuan Liu, Frederico O. Gleber-Netto, Sameer Kini, Samantha Tam, Avi Benov, Mohamed Aashiq, Adel K. El-Naggar, Amy C. Moreno, David I. Rosenthal, Bonnie S. Glisson, Renata Ferrarotto, Michael K. Wong, Michael R. Migden, Erez N. Baruch, Guojun Li, Anshu Khanna, Ryan P. Goepfert, Priyadharsini Nagarajan, Randal S. Weber, Jeffrey N. Myers, Neil D. Gross
Summary: The study included 1258 patients with cutaneous head and neck squamous cell carcinoma and showed that the number of metastatic lymph nodes and the presence of extranodal extension are independent prognostic factors for disease-specific survival. Incorporating these factors into staging systems can improve the performance of the American Joint Committee on Cancer lymph node classification.
Article
Radiology, Nuclear Medicine & Medical Imaging
Christopher Wilke, Vinita Takiar, He Wang, Amy C. Moreno, Shih-Ming Samuel Tung, Sean R. Quinlan-Davidson, Adam S. Garden, David I. Rosenthal, Clifton D. Fuller, Gary B. Gunn, Jay P. Reddy, William H. Morrison, Congjun Wang, George Zhao, Katherine A. Hutcheson, Jack Phan
Summary: This study compared three commonly used intensity modulated radiation therapy approaches for laryngeal sparing in patients with oropharyngeal cancer treated to the bilateral neck. The results indicated that modern whole-field techniques can effectively spare the larynx in patients with advanced oropharyngeal cancers.
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS
(2021)
Article
Oncology
Amy Moreno, Abhishek A. Solanki, Tianlin Xu, Ruitao Lin, Jatinder Palta, Emily Daugherty, David Hong, Julian Hong, Sophia C. Kamran, Evangelia Katsoulakis, Kristy Brock, Mary Feng, Clifton Fuller, Charles Mayo
Summary: Prostate cancer is a common cancer and a major cause of cancer-related deaths in men in the United States. Accurate diagnosis, management, and surveillance are important for improving survival and quality of life. The study aimed to develop a consensus on key data elements for prostate cancer care. Through the Delphi method, experts identified a standardized list of treatment-related toxicities, ranked symptom questionnaires, and defined disease control metrics. These findings have facilitated the development of an operational ontology for prostate cancer care.
Article
Oncology
Sweet Ping Ng, Carlos E. Cardenas, Houda Bahig, Baher Elgohari, Jihong Wang, Jason M. Johnson, Amy C. Moreno, Shalin J. Shah, Adam S. Garden, Jack Phan, G. Brandon Gunn, Steven J. Frank, Yao Ding, Lumine Na, Ying Yuan, Diana Urbauer, Abdallah S. R. Mohamed, David Rosenthal, William H. Morrison, Michael P. MacManus, Clifton D. Fuller
Summary: The PREDICT-HN study assessed the kinetics of imaging MR biomarkers during head and neck radiotherapy. It found that primary tumors and nodal disease exhibit different treatment responses based on the changes in tumor volume and ADC values.
Article
Oncology
Stephen R. Grant, Tyler D. Williamson, Sonja Stieb, Shalin J. Shah, C. David Fuller, David I. Rosenthal, Steven J. Frank, Adam S. Garden, William H. Morrison, Jack Phan, Amy C. Moreno, Jay P. Reddy, Richard C. Cardoso, Amy Y. Liu, Richard Y. Wu, G. Brandon Gunn
ADVANCES IN RADIATION ONCOLOGY
(2020)
Meeting Abstract
Oncology
Alan Sosa, Catherine Wang, Theresa Nguyen, Jay Reddy, Amy Moreno, Adam Garden, David Rosenthal, Steven Frank, Clifton Fuller, Shalin Shah, William Morrison, Brandon Gunn, Shirley Su, Jack Phan
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2020)
Meeting Abstract
Oncology
H. Wang, L. E. Court, R. Mumme, C. I. H. M. Nguyen, S. Beddar, X. A. Wang, C. Wang, S. Tung, M. K. Martel, A. C. Moreno, J. Reddy, A. S. Garden, D. I. Rosenthal, J. Phan
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2020)
Meeting Abstract
Oncology
S. P. Ng, C. E. Cardenas, H. Bahig, B. Elgohari, J. Wang, J. M. Johnson, A. C. Moreno, S. J. Shah, A. S. Garden, J. Phan, G. B. Gunn, S. J. Frank, Y. Ding, L. Na, Y. Yuan, D. Urbauer, D. I. Rosenthal, W. H. Morrison, M. P. MacManus, C. D. Fuller
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2020)
Meeting Abstract
Oncology
J. K. Bronk, A. Augustyn, A. S. Mohamed, R. Wang, S. J. Frank, C. D. Fuller, A. S. Garden, A. C. Moreno, W. H. Morrison, J. Phan, J. Reddy, D. I. Rosenthal, M. Zafereo, R. Ferrarotto, M. E. Cabanillas, G. B. Gunn
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2020)
Meeting Abstract
Oncology
N. Ausat, D. I. Rosenthal, G. B. Gunn, R. Ye, A. S. Garden, W. H. Morrison, C. D. Fuller, J. Phan, J. P. Reddy, A. C. Moreno, H. Bahig, E. M. Sturgis, B. S. Glisson, S. J. Frank
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2020)
Meeting Abstract
Oncology
A. N. Hanania, G. B. Gunn, D. I. Rosenthal, A. S. Garden, C. D. Fuller, J. Phan, J. P. Reddy, A. C. Moreno, N. Ausat, J. N. Myers, R. Ferrarotto, S. J. Frank
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2020)
Meeting Abstract
Oncology
J. Phan, A. Bagley, G. Adam, S. J. Frank, G. B. Gunn, D. I. Rosenthal, J. Reddy, C. D. Fuller, W. H. Morrison, S. J. Shah, A. C. Moreno, R. Ferrarotto, E. M. Sturgis, N. D. Gross
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2020)
Article
Oncology
Amy C. Moreno, Jillian R. Gunther, Sarah Milgrom, C. David Fuller, Tyler Williamson, Amy Liu, Richard Wu, X. Ronald Zhu, Bouthaina S. Dabaja, Chelsea C. Pinnix
ADVANCES IN RADIATION ONCOLOGY
(2020)
Article
Oncology
Amy C. Moreno, Yan Heather Lin, Isabelle Bedrosian, Yu Shen, Gildy V. Babiera, Simona F. Shaitelman