Article
Oncology
Tina J. Hieken, Daniel L. Price, Mara A. Piltin, Heidi J. Turner, Matthew S. Block
Summary: The study aimed to assess the impact of neoadjuvant systemic therapies (NST) on the technical aspects of operation for resectable stage III melanoma. Surgeon surveys were conducted to capture key impressions before and after NST, revealing that while many operations were considered more difficult than usual therapeutic lymphadenectomy, surgeries following NST were often perceived as easier compared to baseline impressions. This highlights the potential benefits of engaging surgical oncologists in structured assessments across clinical trials to analyze the effect of NSTs on lymphadenectomy.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Medicine, General & Internal
Helen M. Johnson, Heather Lin, Yu Shen, Emilia J. Diego, Savitri Krishnamurthy, Wei T. Yang, Benjamin D. Smith, Vicente Valero, Anthony Lucci, Susie X. Sun, Simona F. Shaitelman, Melissa P. Mitchell, Judy C. Boughey, Richard L. White, Gaiane M. Rauch, Henry M. Kuerer, Exceptional Responders Study Grp
Summary: This study evaluated longitudinal patient-reported outcomes among patients who chose to participate in a clinical trial for breast cancer treatment. The results showed that patients experienced improvements in decisional comfort and health-related quality of life over time, with minimal adverse effects of therapy.
Article
Oncology
Kelly E. Lloyd, Louise H. Hall, Lucy Ziegler, Samuel G. Smith
Summary: The study found that 39.5% of respondents reported medium breast cancer worry at baseline, and 21.2% reported high worry. Ethnic minority women and women educated below degree level were more likely to report high worry. However, no significant association was observed between worry and uptake rates.
BREAST CANCER RESEARCH AND TREATMENT
(2021)
Article
Medicine, General & Internal
Steven Habbous, Xiaochen Tai, Jaclyn M. Beca, Jessica Arias, Michael J. Raphael, Ambica Parmar, Andrea Crespo, Matthew C. Cheung, Andrea Eisen, Antoine Eskander, Simron Singh, Maureen Trudeau, Scott Gavura, Wei Fang Dai, Jonathan Irish, Monika Krzyzanowska, Lauren Lapointe-Shaw, Rohini Naipaul, Stuart Peacock, Lyndee Yeung, Leta Forbes, Kelvin K. W. Chan
Summary: This study compared the use and short-term outcomes of neoadjuvant-intent vs adjuvant systemic treatment (ST) in breast cancer patients during the COVID-19 era and the pre-COVID-19 era. It found that patients were more likely to receive neoadjuvant ST in the COVID-19 era, but there was limited evidence of substantial impact on short-term outcomes.
Article
Immunology
Linping Gu, Xue Wang, Yile Sun, Yunhua Xu, Xiaomin Niu, Ruiying Zhao, Yaxian Yao, Hong Jian, Yuchen Han, Jinwang Wei, Zhiwei Chen, Shun Lu
Summary: This study compared the efficacy of different neoadjuvant therapies in operable locally advanced non-small cell lung cancer. It found that neoadjuvant immunotherapy achieved better pathologic complete response and had a superior combined curative effect compared to neoadjuvant chemotherapy and neoadjuvant targeted therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Saba Baharvand, Mohammad Asghari-Jafarabadi, Roghaiyeh Nourizadeh, Niloufar Sattarzadeh Jahdi, Esmat Mehrabi, Maryam Vaezi
Summary: The decision aid can increase satisfaction with decisions among women with abnormal cervical cancer screening results, emphasizing the importance of using decision aid tools to guide patients.
Article
Oncology
Henry M. Kuerer, Benjamin D. Smith, Savitri Krishnamurthy, Wei T. Yang, Vicente Valero, Yu Shen, Heather Lin, Anthony Lucci, Judy C. Boughey, Richard L. White, Emilia J. Diego, Gaiane M. Rauch
Summary: This study aims to evaluate whether radiotherapy alone can replace breast surgery in early-stage triple-negative breast cancer or HER2-positive breast cancer patients who have achieved pathological complete response through image-guided vacuum-assisted core biopsy.
Article
Oncology
Crystal D. Chu, Caleigh E. Smith, Janelle Gorski, Mark Smolkin, Hui Zhao, Randy A. Jones, Patricia Hollen, Lynn T. Dengel
Summary: This study aimed to determine the feasibility and acceptability of using a patient decision aid (DA) for women with elevated breast cancer risk who are considering MRI screening. The study found that using the DA can guide shared decision-making and establish screening preferences. Further research is warranted.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Yoshihiro Sowa, Naoki Inafuku, Itaru Tsuge, Hiroki Yamanaka, Motoki Katsube, Michiharu Sakamoto, Ichiro Nakayama, Naoki Morimoto
Summary: A Japanese study found that using a decision aid can facilitate shared decision-making and reduce regret over the decision to undergo breast reconstruction surgery. The results showed that patients who used the decision aid had higher scores on the shared decision-making questionnaire and lower regret scores after the decision.
Article
Oncology
Tamara Cadet, Adlin Pinheiro, Maria Karamourtopoulos, Alicia R. Jacobson, Gianna M. Aliberti, Christine E. Kistler, Roger B. Davis, Mara A. Schonberg
Summary: The study found that a mammography decision aid was helpful for women aged 75 years and older regardless of their educational attainment. However, women with lower educational attainment may have difficulty understanding the DA and were less likely to reduce their screening intentions compared to those with a college degree.
Article
Gastroenterology & Hepatology
Grace Wang, Neda Karimi, Laura Willmann, Joseph Pipicella, Joseph Descallar, Katie O'Connor, Luiza Peculis, Yvette Leung, Susan Connor, Vivian Huang, Astrid-Jane Williams
Summary: This study assessed the impact of an online decision support tool called PIDA on patients with inflammatory bowel disease (IBD). The results showed that patients using PIDA had improved quality of reproductive decision-making and knowledge about IBD during pregnancy. PIDA was deemed highly useful and can empower women with IBD to make informed decisions regarding pregnancy.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Surgery
Hee Jeong Kim, Laura Dominici, Shoshana M. Rosenberg, Yue Zheng, Linda M. Pak, Philip D. Poorvu, Kathryn J. Ruddy, Rulla Tamimi, Lidia Schapira, Steven E. Come, Jeffrey Peppercorn, Virginia F. Borges, Ellen Warner, Hilde Vardeh, Laura C. Collins, Rachel Gaither, Tari A. King, Ann H. Partridge
Summary: Objective: This study aimed to investigate the eligibility for breast conserving surgery (BCS) pre- and post-neoadjuvant systemic therapy (NST), and trends in surgical treatment for young breast cancer patients. The results showed that the proportion of young women eligible for BCS increased after NST, but many patients still chose mastectomy. Surgical decisions were often driven by factors beyond disease extent and treatment response.
Article
Medicine, General & Internal
Abdullah R. Khazindar, Dalia Abdulmonem L. Hashem, Atlal Abusanad, Salwa Bakhsh, Alya Bin Mahfouz, Mohamed T. El-Diasty
Summary: This study evaluated the diagnostic accuracy of post-NAC MRI in detecting residual disease preoperatively and investigated the factors associated with pathological complete response (pCR). The results showed that MRI had a higher negative predictive value (NPV) for residual disease with the second pCR definition, but overall accuracy was not different. MRI accuracy in detecting residual disease after NAC is not adequate to replace pathological assessment.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Oncology
Ipshita Prakash, Samantha M. Thomas, Rachel A. Greenup, Jennifer K. Plichta, Laura H. Rosenberger, Terry Hyslop, Oluwadamilola M. Fayanju
Summary: The time to surgery (TTS) is a modifiable factor associated with survival after breast cancer diagnosis, affected by factors such as surgery extent, race/ethnicity, and insurance. Delay in TTS is associated with worse overall survival (OS) in upfront-surgery patients, but not in those receiving neoadjuvant systemic therapy (NST).
BREAST CANCER RESEARCH AND TREATMENT
(2021)
Article
Oncology
Bikash Panthi, Rania M. Mohamed, Beatriz E. Adrada, Medine Boge, Rosalind P. Candelaria, Huiqin Chen, Kelly K. Hunt, Lei Huo, Ken-Pin Hwang, Anil Korkut, Deanna L. Lane, Huong C. Le-Petross, Jessica W. T. Leung, Jennifer K. Litton, Sanaz Pashapoor, Frances Perez, Jong Bum Son, Jia Sun, Alastair Thompson, Debu Tripathy, Vicente Valero, Peng Wei, Jason White, Zhan Xu, Wei Yang, Zijian Zhou, Clinton Yam, Gaiane M. Rauch, Jingfei Ma
Summary: This study evaluated the performance of radiomic features from DCE-MRI in predicting early treatment response in TNBC patients undergoing NAST. The results showed that these radiomic features can differentiate pCR and non-pCR, and predictive models based on these features can improve the accuracy of early treatment response prediction in TNBC patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Neurosciences
Katrina Kenah, Julie Bernhardt, Neil J. Spratt, Christopher Oldmeadow, Heidi Janssen
Summary: This study aimed to explore boredom in stroke survivors during inpatient rehabilitation, examine the effect of activity promotion intervention on boredom, and investigate factors associated with boredom. A framework was developed and participants were divided into control and intervention groups. Results showed that depression and lower levels of socialization were related to high boredom levels.
NEUROPSYCHOLOGICAL REHABILITATION
(2023)
Article
Oncology
Nicci Bartley, Polly Havard, Phyllis Butow, Joanne Shaw
Summary: This study aimed to explore the perspectives of cancer stakeholders regarding COVID-19 vaccination. The findings revealed mostly positive attitudes towards the vaccine, but also highlighted concerns, hesitancy, and uncertainty. Policymakers need to provide clear tailored information to facilitate vaccine uptake.
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Elizabeth Hutchings, Belinda E. Butcher, Phyllis Butow, Frances M. Boyle
Summary: Australian breast cancer patients support the secondary use of de-identified administrative health data and clinical trial data, but express concerns regarding data security and privacy, emphasizing that reuse should be for improved societal health outcomes rather than profit. Many assumed that secondary analysis was already being conducted on de-identified administrative health data and clinical trial data.
ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Geriatrics & Gerontology
Mary Revelas, Anbupalam Thalamuthu, Anna Zettergren, Christopher Oldmeadow, Jenna Najar, Nazib M. Seidu, Nicola J. Armstrong, Carlos Riveros, John B. Kwok, Peter R. Schofield, Julian N. Trollor, Margda Waern, Margaret J. Wright, Henrik Zetterberg, David Ames, Kaj Belnnow, Henry Brodaty, Rodney J. Scott, Ingmar Skoog, John R. Attia, Perminder S. Sachdev, Karen A. Mather
Summary: This study found that individuals with a high polygenic risk for exceptional longevity have a lower prevalence of metabolic syndrome, suggesting that high-risk individuals have a healthy metabolic profile that promotes longevity.
Review
Biochemistry & Molecular Biology
Alison Luk Young, Aalya Imran, Michael J. Spoelma, Rachel Williams, Katherine M. Tucker, Jane Halliday, Laura E. Forrest, Claire E. Wakefield, Phyllis N. Butow
Summary: This review evaluated proband-mediated interventions in genetics clinics to increase genetic risk disclosure to at-risk relatives. The studies suggest that tailored genetic counseling can increase the proportion of informed relatives and relatives who contact the genetics clinic.
EUROPEAN JOURNAL OF HUMAN GENETICS
(2023)
Article
Oncology
Bogda Koczwara, Reegan Knowles, Lisa Beatty, Heather L. Shepherd, Joanne M. Shaw, Haryana M. Dhillon, Jonathan Karnon, Shahid Ullah, Phyllis Butow
Summary: This study evaluated the implementation of a web-based system for screening the symptoms and needs of cancer patients in an Australian hospital. The screening identified many unmet needs. However, the uptake of this intervention by nurses and patients was lower than expected.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Medicine, General & Internal
Danielle Wing Lam Ng, Richard Fielding, Catherine Tsang, Carmen Ng, Joyce Chan, Amy Or, Izy Wing Man Kong, Julia Wei Chun Tang, Wylie Wai Yee Li, Amy Tien Yee Chang, Chi Choo Foo, Ava Kwong, Simon Siu-Man Ng, Dacita Suen, Miranda Chan, Oi-Kwan Chun, Karen Kar Loen Chan, Phyllis N. Butow, Wendy Wing Tak Lam
Summary: The purpose of this study is to evaluate the effectiveness of the Chinese version of the ConquerFear-HK intervention in improving fear of cancer recurrence. A randomized controlled trial will be conducted with 174 eligible Chinese cancer survivors who will be assigned to either the ConquerFear-HK or BasicCancerCare intervention. Various measures will be used to assess the intervention's effects and psychological impacts.
Article
Health Care Sciences & Services
Phyllis Butow, Mona F. Faris, Joanne Shaw, Patrick Kelly, Sharon He, Marnie Harris, Jessica M. Cuddy, Lindy Masya, Liesbeth Geerligs, Brian Kelly, Afaf Girgis, Nicole Rankin, Philip Beale, Thomas Hack, Laura Kirsten, Haryana Dhillon, Peter Grimison, Rosalie Viney, Josephine L. Clayton, Timothy Schlub, Heather L. Shepherd
Summary: This study evaluated two implementation strategies (Core versus Enhanced) to facilitate the implementation of a clinical pathway for anxiety and depression management in cancer patients. The results showed that the implementation strategy did not have a significant effect on adherence to the clinical pathway, but anxiety/depression severity level did have a significant impact on adherence.
IMPLEMENTATION SCIENCE
(2023)
Review
Oncology
R. King, L. Stafford, P. Butow, S. Giunta, R. Laidsaar-Powell
Summary: This meta-review examines the qualitative evidence-base on breast cancer survivorship experiences and identifies the main themes and areas for further investigation.
JOURNAL OF CANCER SURVIVORSHIP
(2023)
Article
Health Care Sciences & Services
Mona M. N. Faris, Heather L. Shepherd, Phyllis N. Butow, Patrick Kelly, Sharon He, Nicole Rankin, Lindy Masya, ADAPT Program Grp, Joanne Shaw
Summary: This quantitative study examined the level of organisational readiness of cancer services preparing to implement a clinical pathway for the screening, assessment, and management of anxiety and depression in adult cancer patients. Factors such as the number of treatment modalities implemented and staff roles were found to impact organisational readiness. Higher organisational readiness scores were associated with more positive perceptions of the clinical pathway.
BMC HEALTH SERVICES RESEARCH
(2023)
Article
Oncology
Lesley Stafford, Michelle Sinclair, Phyllis Butow, Janemary Hughes, Allan Park, Leslie Gilham, Allison Rose, G. Bruce Mann
Summary: This study investigated the patient experience of de-escalation and its association with fear of cancer recurrence (FCR) in early breast cancer. The results show lower FCR in patients who omitted radiotherapy compared to those who received it. Qualitative analysis suggests that positive perceptions of tailored care, lower treatment burden, and trust in clinicians are protective against FCR.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Article
Oncology
Rebekah Laidsaar-Powell, Phyllis Butow, Bernadette Bea Brown, Kimberley Mander, Jane Young, Emily Stone, Venessa Chin, Emily Banks, Chloe Yi Shing Lim, Nicole M. Rankin
Summary: This study aimed to understand lung cancer survivors' physical/psychological challenges, experiences of immunotherapy and targeted therapy, and psychological adjustment. The findings showed that many survivors are adapting to issues as they arise and maintaining a sense of hope and optimism.
JOURNAL OF CANCER SURVIVORSHIP
(2023)
Meeting Abstract
Respiratory System
Rebekah Laidsaar-Powell, Phyllis Butow, Bea Brown, Kimberley Mander, Jane Young, Emily Stone, Venessa Chin, Emily Banks, Nicole Rankin
Meeting Abstract
Respiratory System
Rebekah Laidsaar-Powell, Phyllis Butow, Bea Brown, Kimberley Mander, Jane Young, Emily Stone, Venessa Chin, Emily Banks, Chloe Lim, Nicole Rankin
Article
Public, Environmental & Occupational Health
Ashleigh Guillaumier, Flora Tzelepis, Christine Paul, Megan Passey, Christopher Oldmeadow, Tonelle Handley, Kristen Mccarter, Laura Twyman, Amanda L. Baker, Kate Reakes, Phillipa Hastings, Billie Bonevski
Summary: This pilot study examined the feasibility of a smoking cessation intervention in rural areas of Australia and found that the intervention was feasible and acceptable. However, alternative methods for remote biochemical verification need further study.
HEALTH PROMOTION JOURNAL OF AUSTRALIA
(2023)