Article
Environmental Sciences
Jessica P. R. Thorn, Julia A. Klein, Cara Steger, Kelly A. Hopping, Claudia Capitani, Catherine M. Tucker, Robin S. Reid, Robert A. Marchant
Summary: Research reveals diverse future trajectories of Mountain Social-Ecological Systems (MtSES), leading to the identification of four MtSES scenario archetypal configurations with similar key adaptation strategies, assumptions, risks, and uncertainties based on a systematic review of global participatory scenarios literature and archetype analysis.
GLOBAL ENVIRONMENTAL CHANGE-HUMAN AND POLICY DIMENSIONS
(2021)
Review
Oncology
Giulio Donati, Bruno Amati
Summary: The MYC transcription factor plays a crucial role in tumor progression and therapeutic responses. Overexpression of MYC can lead to therapy resistance and create specific vulnerabilities in cancer cells that can be targeted by novel anticancer drugs.
MOLECULAR ONCOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Christopher W. Wheldon
Summary: Gay, bisexual, and other men who have sex with men (GBM), as well as transgender women who have sex with men (TW), are at higher risk for anal cancer. However, the HPV vaccination rate among adult GBM/TW is low. Targeted HPV vaccination during PrEP treatment is a potential strategy to address this issue.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Article
Multidisciplinary Sciences
Yurika Ujiie, Yoshiyuki Ishitani, Yukiko Nagai, Yoshihiro Takaki, Takashi Toyofuku, Shun'ichi Ishii
Summary: In this study, the researchers identified genes involved in calcium ion transport/secretion and α-carbonic anhydrases that control calcification in foraminifera. These genes actively take up calcium ions to support mitochondrial ATP synthesis during calcification and transport excess intracellular calcium ions to prevent cell death. Unique α-carbonic anhydrase genes produce bicarbonate and protons from multiple CO2 sources. These control mechanisms have evolved independently since the Precambrian era, enabling foraminifera to develop large cells and calcify despite decreasing calcium ion concentrations and pH in seawater. These findings provide new insights into calcification mechanisms and their role in adapting to ocean acidification.
Editorial Material
Oncology
Eric Solary, Patricia Blanc, Michael Boutros, Charis Girvalaki, Franco Locatelli, Rene H. Medema, Peter Nagy, Josep Tabernero
Summary: UNCAN.eu is a European initiative aimed at advancing cancer research through the creation of a research data hub, leading to new developments in cancer care.
Article
Virology
Valentine M. Ferre, Alexandra M. Bitty-Anderson, Gilles Peytavin, Minh P. Le, Claver A. Dagnra, Romain Coppee, Fifonsi A. Gbeasor-Komlanvi, Diane Descamps, Charlotte Charpentier, Didier K. Ekouevi
Summary: This study aims to describe the ARV treatment coverage and virological response among key populations and evaluate the feasibility of an algorithm combining PK and VL to identify subjects at risk of ARV drug resistance. The results show that 50% of FSW and 66% of MSM are receiving ARV treatment, with 69% and 80% of them successfully treated, respectively. PK-VA might be an easier solution to identify patients needing ARV adaptation due to resistance in limited resources settings.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Biophysics
Divya Soundararajan, Lakshmi Narashimhan Ramana, Prakash Shankaran, Uma Maheswari Krishnan
Summary: Nanotechnology-based interventions have the potential to improve the therapeutic efficacy of antiretroviral drugs for HIV infections. The use of nanocarriers for drug delivery is gaining momentum, offering the possibility to overcome some of the disadvantages associated with conventional drugs.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Environmental Sciences
Matthew Dietrich, John T. Shukle, Mark P. S. Krekeler, Leah R. Wood, Gabriel M. Filippelli
Summary: Lead is a neurotoxicant that harms young children. This study developed a predictive model using household dust samples to determine the presence of lead. An interactive mobile app was also developed to increase awareness of lead risks and encourage lead screening.
Article
Biodiversity Conservation
Andres F. Suarez-Castro, Hawthorne L. Beyer, Caitlin D. Kuempel, Simon Linke, Pasquale Borrelli, Ove Hoegh-Guldberg
Summary: The study proposes a systematic approach to identify global forest restoration opportunities in order to reduce sediment runoff to coral reefs. Results show that coastal watersheds in Southeast Asian countries have significant sediment export impacts on coral reefs, and restoring forests could potentially decrease sediment input to 63,000 square kilometers of coral reefs.
GLOBAL CHANGE BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Nicholas P. Simpson, Portia Adade Williams, Katharine J. Mach, Lea Berrang-Ford, Robbert Biesbroek, Marjolijn Haasnoot, Alcade C. Segnon, Donovan Campbell, Justice Issah Musah-Surugu, Elphin Tom Joe, Abraham Marshall Nunbogu, Salma Sabour, Andreas L. S. Meyer, Talbot M. Andrews, Chandni Singh, A. R. Siders, Judy Lawrence, Maarten van Aalst, Christopher H. Trisos
Summary: This article provides a stocktake of the adaptation literature between 2013 and 2019, analyzing the effects of adaptation responses on risk under compound climate events. The study identifies different response types and their characteristics, as well as the vulnerabilities that hinder effective responses. The findings highlight the need for integrated climate risk assessment and management to enhance response urgency and protect the most vulnerable.
Article
Biochemical Research Methods
Camille N. Zenon-Melendez, Kelvin Carrasquillo Carrion, Yadira Cantres Rosario, Abiel Roche Lima, Loyda M. Melendez
Summary: This study investigated the deregulated proteins in neurons exposed to HIV-infected macrophage-conditioned media after inhibiting cathepsin B (CATB) or serum amyloid P component (SAPC) using tandem mass tag proteomics labeling. The results suggest that CATB, SAPC, and apoptosis-related proteins could be potential targets against HIV-induced neuronal degeneration.
JOURNAL OF PROTEOME RESEARCH
(2022)
Article
Immunology
Shibani S. Mukerji, Kalen J. Petersen, Kilian M. Pohl, Raha M. Dastgheyb, Howard S. Fox, Robert M. Bilder, Marie-Josee Brouillette, Alden L. Gross, Lori A. J. Scott-Sheldon, Robert H. Paul, Dana Gabuzda
Summary: Cognitive disorders are common in people with HIV despite antiretroviral therapy. Data-driven models are being used to identify biologically defined subtypes of these disorders. This article discusses the current state of using machine learning to understand cognitive phenotypes in people with HIV and their associated comorbidities, biological mechanisms, and risk factors.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Review
Nutrition & Dietetics
Olufemi K. Fabusoro, Luis A. Mejia
Summary: Undernutrition is a leading cause of death in infants and children, especially in HIV-prevalent poor-resource environments. The complexity of the relationship between HIV infection, nutrition, and the immune system requires further research and exploration to address the challenges.
ADVANCES IN NUTRITION
(2021)
Article
Immunology
Arthur Dujardin, Arnaud de La Blanchardiere, Julia Dina, Karl Stefic, Christophe Ravel, Julie Bonhomme, Renaud Verdon, Anna Lucie Fournier
Summary: This case report describes a severe visceral leishmaniasis in a patient with an acute primary HIV-1 infection, presenting with acute febrile psychotic disorder and hemophagocytic lymphohistiocytosis. The patient was successfully treated with intravenous liposomal amphotericin B, highlighting the complex interaction between HIV infection and visceral leishmaniasis in clinical presentation.
FRONTIERS IN IMMUNOLOGY
(2021)
Editorial Material
Biology
Eve H. Rogers
Summary: Cancer researchers explored unique mutational patterns of DNA mismatch repair machinery through genome editing and developed an algorithm to predict tumor responsiveness to immunotherapy.
COMMUNICATIONS BIOLOGY
(2021)
