Journal
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
Volume 38, Issue 1, Pages 44-50Publisher
WILEY-BLACKWELL
DOI: 10.1002/hed.23836
Keywords
veterans; oropharyngeal cancer; racial disparities
Categories
Funding
- Department of Veterans Affairs VISN 16 Pilot Project Grant
- National Cancer Institute [R01CA163103]
- Center for Innovations in Quality, Effectiveness, and Safety [CIN 13-413]
- Pathology and Histology Core at Baylor College of Medicine
- NIH [NCI P30-CA125123]
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Background. Racial disparities in oropharyngeal squamous cell carcinoma (SCC) have been demonstrated and attributed to differences in human papillomavirus (HPV) status. The purpose of this study was to examine racial disparities in oropharyngeal SCC among veterans. Methods. Retrospective review of patients with oropharyngeal SCC at a tertiary-care Veterans Affairs (VA) hospital. Adjusted Cox proportional hazards models were conducted to examine the effect of race on oropharyngeal SCC outcomes. Results. Of 158 patients, 126 (79.7%) were white and 32 (20.3%) were African American. No difference in p16 tumor expression was noted between the groups. Five-year disease-free survival (DFS) was 42.6% and 55.1% for African Americans and whites, respectively (p = .372). Five-year overall survival (OS) for African Americans and whites was 54.6% and 51.8%, respectively (p = .768). On multivariate analysis, there was no significant difference in risk of recurrence or death by race. Conclusion. Racial disparities are largely ameliorated in patients with oropharyngeal SCC treated within the VA, there were no racial differences in p16 tumor expression, and outcomes remain poor. (C) 2015 Wiley Periodicals, Inc.
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