Article
Cardiac & Cardiovascular Systems
Chao Wu, Xiaojin Gao, Ling Li, Quanmin Jing, Weimin Li, Haiyan Xu, Wenbo Zhang, Sidong Li, Yanyan Zhao, Yang Wang, Wei Li, Yongjian Wu, Fenghuan Hu, Chen Jin, Shubin Qiao, Jingang Yang, Yuejin Yang
Summary: This study evaluated the role of ST-segment resolution (STR) and Thrombolysis in Myocardial Infarction (TIMI) flow in reperfusion evaluation after primary percutaneous coronary intervention (PPCI) for ST-segment-elevation myocardial infarction. The results showed that STR =50% and complete STR were significantly associated with lower 2-year mortality compared to STR <50%. Additionally, the combination of STR and TIMI flow provided incremental prognostic information beyond either measure alone.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Gladys N. Janssens, Jorrit S. Lemkes, Nina W. van der Hoeven, Maarten A. H. van Leeuwen, Henk Everaars, Peter M. van de Ven, Stijn L. Brinckman, Jorik R. Timmer, Martijn Meuwissen, Joost C. M. Meijers, Arno P. van der Weerdt, Tim J. F. ten Cate, Jan J. Piek, Clemens von Birgelen, Roberto Diletti, Javier Escaned, Albert C. van Rossum, Robin Nijveldt, Niels van Royen
Summary: Transient STEMI patients present with a different profile of cardiovascular risk factors, angiographic characteristics, and myocardial injury compared to persistent STEMI patients, showing less thrombus burden and myocardial damage. The more effective fibrinolysis in transient STEMI patients may provide insights for future treatment strategies for STEMI.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Alexander Jobs, Jasper Boeddinghaus, Johannes Tobias Neumann, Alina Gossling, Nils A. Soerensen, Raphael Twerenbold, Thomas Nestelberger, Pedro Lopez-Ayala, Maria Rubini Gimenez, Oscar Miro, Luca Koechlin, Natacha Buergin, Hans-Josef Feistritzer, Jean-Philippe Collet, Deepak L. Bhatt, Christopher B. Granger, Stefan Blankenberg, Steffen Desch, Christian Mueller, Dirk Westermann, Holger Thiele
Summary: This study evaluated the diagnostic performance of different GRACE risk scores compared to the ESC 0/1 h-algorithm using hs-cTn. It found that there were significant differences in risk classification and sensitivity between the different GRACE risk scores. The ESC 0/1 h-algorithm had the highest sensitivity for detecting myocardial infarction. Combining GRACE risk scoring with hs-cTn testing increased detection but also increased the risk of false positive results.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Article
Environmental Sciences
Jyun-Bin Huang, Kuo-Chen Huang, Ting-Min Hsieh, Chih-Min Tsai, Hao-Yi Hsiao, Chi-Yung Cheng, Fu-Jen Cheng
Summary: The aim of this study was to estimate the impact of air pollutants on the outcomes of STEMI. The study found that an increase in NO2 during the warm season was associated with an elevated risk of in-hospital mortality in patients with STEMI, while an increase in PM10 during the cold season was associated with an increased risk of in-hospital mortality. Therefore, exposure to NO2 (during the warm season) and PM10 (during the cold season) may contribute to a higher risk of poor prognosis in patients with STEMI.
Article
Medical Laboratory Technology
Marcus Hjort, Kai M. Eggers, Lars Lindhagen, Tomasz Baron, David Erlinge, Tomas Jernberg, Gyorgy Marko-Varga, Melinda Rezeli, Jonas Spaak, Bertil Lindahl
Summary: The study identified biomarkers that could differentiate between STEMI and NSTEMI patients, indicating greater myocardial dysfunction and inflammation in STEMI. However, these biomarkers showed similar prognostic value in both types of myocardial infarction, suggesting that treatment strategies based on biomarker concentrations may not need to differ between STEMI and NSTEMI patients.
CLINICAL BIOCHEMISTRY
(2021)
Article
Medicine, General & Internal
You Zhang, Shan Wang, Datun Qi, Xianpei Wang, Muwei Li, Zhongyu Zhu, Qianqian Cheng, Dayi Hu, Chuanyu Gao
Summary: This study assessed the changes in care processes and outcomes for ST elevation myocardial infarction (STEMI) patients in Henan province, central China, from 2011 to 2018. The results showed an increase in the use of guideline-recommended treatments and a decrease in in-hospital mortality. However, gaps still exist between clinical practice and guideline recommendations.
CHINESE MEDICAL JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Shih-Sheng Chang, Chiung-Ray Lu, Ke-Wei Chen, Zhe-Wei Kuo, Shao-Hua Yu, Shih-Yi Lin, Hong-Mo Shi, Hei-Tung Yip, Chia-Hung Kao
Summary: This study investigated the prognostic differences between elderly patients with ST-elevation myocardial infarction (STEMI) and non-ST-elevation myocardial infarction (NSTEMI) by analyzing data from the Longitudinal Health Insurance Database in Taiwan. The results showed that there was no difference in cardiovascular and all-cause mortality between STEMI and NSTEMI in patients who received revascularization. However, in patients who did not receive revascularization, NSTEMI was associated with a higher risk of all-cause death. Moreover, there was no difference in major bleeding between STEMI and NSTEMI patients aged ≥65 years old.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Yong Hoon Kim, Ae-Young Her, Seung-Woon Rha, Cheol Ung Choi, Byoung Geol Choi, Ji Bak Kim, Soohyung Park, Dong Oh Kang, Ji Young Park, Sang-Ho Park, Myung Ho Jeong
Summary: Using a new-generation drug-eluting stent, the study compared the 2-year clinical outcomes of patients with diabetes mellitus (DM) and non-DM concomitant with a non-ST-segment elevation myocardial infarction (NSTEMI) and an ST-segment elevation myocardial infarction (STEMI) who underwent percutaneous coronary intervention. The results showed higher non-CD rates in patients with DM and higher CD rates in patients without DM in the NSTEMI group.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Yong Hoon Kim, Ae-Young Her, Myung Ho Jeong, Byeong-Keuk Kim, Sung-Jin Hong, Seung-Jun Lee, Chul-Min Ahn, Jung-Sun Kim, Young-Guk Ko, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang
Summary: The study compared the 2-year major clinical outcomes between STEMI and NSTEMI patients who are current smokers treated with PCI, and found no significant difference in outcomes. Further research is needed to confirm these results.
Article
Medicine, General & Internal
Carl Semaan, Arthur Charbonnier, Jeremy Pasco, Walid Darwiche, Christophe Saint Etienne, Xavier Bailleul, Thierry Bourguignon, Laurent Fauchier, Denis Angoulvant, Fabrice Ivanes, Thibaud Genet
Summary: The study evaluated the performance of the ENCOURAGE score in predicting mortality in STEMI patients with refractory cardiogenic shock, showing that the ENCOURAGE score outperformed other risk scores in predicting mortality. It may assist decision-making teams in better selecting patients suitable for VA-ECMO therapy.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Amir Sharon, Eias Massalha, Boris Fishman, Paul Fefer, Israel M. Barbash, Amit Segev, Shlomi Matetzky, Victor Guetta, Ehud Grossman, Elad Maor
Summary: Among NSTEMI patients, an early invasive strategy is associated with a significant 30% lower mortality compared with a delayed strategy. However, this association is modified by CKD, and the survival benefit of an early invasive strategy is not observed in patients with eGFR <45 mL/min/1.73 m(2).
JACC-CARDIOVASCULAR INTERVENTIONS
(2022)
Article
Medicine, General & Internal
Marcin Kozuch, Maciej Poludniewski, Emil Julian Dabrowski, Ewa Tarasiuk, Slawomir Dobrzycki
Summary: This study aimed to assess the relationship between GDF-15 concentration on admission and the occurrence of the no-reflow phenomenon. The results showed a negative correlation between GDF-15 concentration and TIMI flow after PCI. Multivariate logistic regression analysis identified higher age, GDF-15 concentration > 1503 pg/mL, lower systolic blood pressure, and higher troponin I concentration on admission as risk factors for no-reflow.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Mohamed Abo-Aly, Elica Shokri, Lakshman Chelvarajan, Wadea M. Tarhuni, Himi Tripathi, Ahmed Abdel-Latif
Summary: Circulating monocytes have different subsets and play different roles in cardiovascular physiology and disease progression. This study found that CD14+CD16++ monocytes and their subsets expressing CCR2, CD42, and CD11b may be important predictors of clinical outcomes in patients with ST-elevation myocardial infarction (STEMI). Further studies are needed to confirm these findings.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Marie V. Hjortbak, Kevin K. W. Olesen, Jacob M. Seefeldt, Thomas R. Lassen, Rebekka V. Jensen, Alexander Perkins, Matthew Dodd, Tim Clayton, Derek Yellon, Derek J. Hausenloy, Hans Erik Botker
Summary: The study explored the translational cardioprotective potential of P2Y(12) inhibitors in acute myocardial ischemia/reperfusion injury, showing that ticagrelor may have better effects in reducing infarct size.
BASIC RESEARCH IN CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Juan Carlos C. Montoy, Yu-Chu Shen, Ralph G. Brindis, Harlan M. Krumholz, Renee Y. Hsia
Summary: The study found that regionalization programs for ST-segment-elevation myocardial infarction did not have a statistically significant impact on the treatment and outcomes of patients with NSTEMIs. Over the study period, there were slight increases in early angiography rates and decreases in mortality rates, but these changes were not directly related to regionalization policies.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
