Article
Engineering, Environmental
Xinlong Pang, Haoran Zhao, Yuanxiong Cao, Jiaqi Wang, Zhiwei Hu, Wilhelm T. S. Huck, Shaohua Ma
Summary: Researchers have developed a membrane reactor that utilizes polymer photosensitizers to generate singlet oxygen (O-1(2)) for organic reactions. The reactor significantly accelerates oxidation reactions and polymerization reactions, showing potential for green industrial use.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Food Science & Technology
Zhanchen Dong, Tianming Qiu, Jingyuan Zhang, Shanshan Sha, Xiuyan Han, Jian Kang, Xiaoxia Shi, Xiance Sun, Liping Jiang, Guang Yang, Xiaofeng Yao, Yufang Ma
Summary: The study revealed the association and mechanism of action of SPNS1 in the interplay between autophagy and LMP induced by PFOS, emphasizing the importance of SPNS1-tyrosinated alpha-tubulin interaction. Stable overexpression of SPNS1 can accelerate lysosomal acidification, thereby worsening PFOS-induced LMP.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Oncology
Xin Zhang, Yulian Guo, Hao Li, Lizhang Han
Summary: FIN56, a novel ferroptosis inducer, showed promising anti-tumor effects on glioblastoma cells by inducing ferroptosis and lysosomal membrane permeabilization in a ferroptosis and transfactor EB dependent manner. Animal study confirmed the inhibitory effect of FIN56 on glioma growth in vivo.
Article
Biochemistry & Molecular Biology
Debasna Pritimanjari Panigrahi, Srimanta Patra, Bishnu Prasad Behera, Pradyota Kumar Behera, Shankargouda Patil, Birija Sankar Patro, Laxmidhar Rout, Itisam Sarangi, Sujit Kumar Bhutia
Summary: Stress-induced mitochondrial hyperfusion (SIMH) has a protective effect on cell survival, but in the absence of mitochondrial fission, SIMH can induce apoptosis related to oxidative stress. This study found that MTP18, a protein promoting mitochondrial fission, is increased in oral cancer. A novel inhibitor of MTP18 called S28 was identified, which induces SIMH and triggers apoptosis. S28 inhibits MTP18-mediated mitochondrial fission and induces autophagy, resulting in the loss of mitochondrial membrane potential and the generation of mitochondrial superoxide to induce apoptosis. Combining S28 with FDA-approved anticancer drugs enhances apoptotic activity and decreases cell viability.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Kenichiro Omoto, Shohei Tashiro, Mitsuhiko Shionoya
Summary: The study investigated the photochemical oxygenation reactions of a host-guest complex in solution and in the solid state, showing remarkable phase dependence in reactivity and functions. The result revealed that in solution, the anthracene moieties of the ligand were fully oxygenated to form a macrocycle, while in the solid state, a site-selectively oxygenated inclusion complex was formed with controlled oxygenated sites.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Biochemistry & Molecular Biology
Vitalij Novickij, Aukse Zinkeviciene, Eivina Radzeviciute, Julita Kulbacka, Nina Rembialkowska, Jurij Novickij, Irute Girkontaite
Summary: Electroporation is a phenomenon where the cell membrane becomes temporarily or irreversibly permeable after treatment with pulsed electric fields. In this study, different pulse sequences were used to trigger cell permeabilization, and the differences in response were evaluated using a fluorescent probe and D-luciferin oxidation method. The results showed that extracellular calcium concentration affects the bioluminescence of cells after electroporation, and the changes in bioluminescence can be used as a marker of cell membrane permeability.
BIOELECTROCHEMISTRY
(2022)
Article
Cell Biology
Shumei Ma, Xinxin Fu, Lin Liu, Yi Liu, Hao Feng, Heya Jiang, Xiaomei Liu, Rui Liu, Zhenzhen Liang, Mengke Li, Zhujun Tian, Boqi Hu, Yongheng Bai, Bing Liang, Xiaodong Liu
Summary: The study revealed that in breast cancer MDA-MB-231 cells, radiation-induced cell death is iron-dependent and exhibits characteristics of autophagy. The accumulation of iron increases oxidative stress, leading to enhanced autophagy and cell death.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Shiquan Lin, Leo N. Y. Cao, Zhen Tang, Zhong Lin Wang
Summary: This study proposes a method for quantifying the amount of charge carried by water microdroplets produced by ultrasonic atomization, and reveals the size-dependent charge transfer between microdroplets. Furthermore, a theoretical model for microdroplets charging is proposed, providing evidence for the contact electrification-induced spontaneous generation of H2O2 in water microdroplets.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Infectious Diseases
Samuel Cashman-Kadri, Patrick Lague, Ismail Fliss, Lucie Beaulieu
Summary: This study investigated the structure-activity relationships and mode of action of synthesized GAPDH-related antimicrobial peptides. It was found that increasing the net positive charge and hydrophobicity improved the antimicrobial and antifungal activities of the peptides. The peptides were shown to cause membrane permeabilization and target intracellular components, indicating a mixed mode of action.
Article
Ecology
Rachel Stirrup, Michaela A. Mausz, Eleonora Silvano, Andrew Murphy, Richard Guillonneau, Mussa Quareshy, Branko Rihtman, Maria Aguilo Ferretjans, Ruo He, Jonathan D. Todd, Feng Chen, David J. Scanlan, Yin Chen
Summary: Lipids play a crucial role in maintaining cell integrity and homeostasis. The cosmopolitan marine roseobacter clade (MRC) and SAR11 clade bacteria produce a variety of amino acid-containing lipids. The study reveals that these lipids are present in both the inner and outer membranes of MRC bacteria. The inability to produce these lipids impacts membrane proteome, nutrient transport, competitiveness, and phage attachment.
Review
Pharmacology & Pharmacy
Yiyuan Kang, Jia Liu, Yanping Jiang, Suhan Yin, Zhendong Huang, Yanli Zhang, Junrong Wu, Lili Chen, Longquan Shao
Summary: The interactions between inorganic-based nanomaterials (NMs) and biological membranes are crucial for developing NM-based therapeutics and addressing nanotoxicology issues. Biological membranes act as platforms mediating NM-immune system contacts, and the challenges and potential applications in these areas are discussed in the overview. Understanding these concepts will enhance the design of therapeutic NM for drug delivery systems by leveraging NMs-membrane interactions and functions.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Cell Biology
Mateus Milani, Philippe Pihan, Claudio Hetz
Summary: Calcium is a crucial messenger in regulating cellular processes and interorganelle communication. Lysosomal function is dependent on calcium, and ion channels on the lysosomal membrane regulate lysosomal properties such as pH. Lysosome-dependent cell death (LDCD) is a specific type of cell death involving lysosomes that plays important roles in tissue homeostasis, development, and pathology. This article focuses on recent advances in understanding the role of calcium signaling in LDCD.
Article
Multidisciplinary Sciences
Changhyeok Choi, Geun Ho Gu, Juhwan Noh, Hyun S. Park, Yousung Jung
Summary: The study investigates the potential-dependent competition between electrochemical NRR and HER, revealing that the crossover of H coverage and N-2 coverage leads to the premature decrease of NRR activity. The larger charge transfer in H+ adsorption poses a fundamental challenge to practical electrochemical NRR, and several strategies are suggested to overcome this challenge.
NATURE COMMUNICATIONS
(2021)
Review
Microbiology
Luis Ferraz, Michael Sauer, Maria Joao Sousa, Paola Branduardi
Summary: Microbial-based biotechnological processes are moving towards sustainability by utilizing renewable feedstocks, but their viability and competitiveness are often hindered by harsh conditions. The impact of these conditions on the plasma membrane of microbial cell factories is crucial for designing strategies to enhance their fitness and productivity under industrial processes.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Chemistry, Physical
Karina Araus, Eileen Santos, Ricardo Couto, Feral Temelli
Summary: Polymeric reverse osmosis membranes have been used for separating lipid mixtures with supercritical carbon dioxide, with the solute-solvent-membrane interactions and operating conditions impacting the separation process. Wetting behavior was studied by determining contact angles of oleic acid and triolein in both air and SC-CO2, showing that SC-CO2 enhances the wetting behavior of oleic acid due to its higher solubility and lower interfacial tension compared to triolein. This suggests potential for using SG membrane processing coupled with SC-CO2 to separate oleic acid from complex lipid mixtures.
JOURNAL OF SUPERCRITICAL FLUIDS
(2022)
Review
Biochemistry & Molecular Biology
Laura G. Rezende, Thiago T. Tasso, Pedro H. S. Candido, Mauricio S. Baptista
Summary: This article reviews the experimental tools used to study lipid oxidation products, and raises key concepts to rationalize a comprehensive model for the initiation and progression steps of photoinduced lipid oxidation.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Marwa Naguib, Nicolas Feldman, Paulina Zarodkiewicz, Holly Shropshire, Christina Biamis, Omar M. El-Halfawy, Julia McCain, Clement Dezanet, Jean-Luc Decout, Yin Chen, Gonzalo Cosa, Miguel A. Valvano
Summary: This study identified a novel peroxidation detoxification system composed of BcnA, LcoA, and PsrA, which protects the bacterial cell envelope from lipid peroxyl radicals.
Article
Biochemistry & Molecular Biology
Lucas M. O. S. Martins, Xuhui Wang, Gustavo T. M. Silva, Helena C. Junqueira, Barbara Fornaciari, Lohanna F. Lopes, Cassio P. Silva, Peng Zhou, Victor F. Cavalcante, Mauricio S. Baptista, Frank H. Quina
Summary: Hydroxypyranoflavylium (HPF) cations are synthetic analogs with excellent photophysical properties and can serve as sensitizers for photodynamic therapy (PDT). The study found that HPF cations have phototoxic effects on human cervical adenocarcinoma cells at lower concentrations, and even small structural differences can lead to significant variations in phototoxicity. Therefore, HPF cations are potential PDT sensitizers that deserve further evaluation.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lohanna de Faria Lopes, Jana Jandova, Rebecca Justiniano, Jessica Perer, Mauricio S. Baptista, Georg T. Wondrak
Summary: Cellular oxidative stress plays a significant role in solar ultraviolet radiation-induced skin photoaging and photocarcinogenesis. Methylglyoxal (MG), a metabolic byproduct, has been found to act as a UVA-photosensitizer, causing photooxidative stress and caspase-dependent cell death in human keratinocytes. Additionally, MG induces gene expression changes related to proteotoxic and oxidative stress response. Further investigation into the role of MG photosensitizer activity in human skin photodamage is crucial.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Aya Sakaya, Isabel O. L. Bacellar, Jose Luis Fonseca, Andres M. Durantini, Julia McCain, Laiyi Xu, Mariana Vignoni, Andres H. Thomas, Mauricio S. Baptista, Gonzalo Cosa
Summary: A sensitive fluorogenic probe is developed to quantify the arrival of singlet oxygen (1O2) on lipid membranes, allowing for the study of membrane dynamics. The probe shows remarkable intensity enhancement upon 1O2 trapping and enables the visualization of membrane expansion dynamics.
Review
Biochemistry & Molecular Biology
Mauricio S. Baptista, Jean Cadet, Alexander Greer, Andres H. Thomas
Summary: The interaction of light with natural matter can lead to either detrimental or beneficial photosensitized reactions in living organisms. These reactions can degrade biomolecules or be used in photomedicine for disease treatment. Different processes of photosensitization reactions, both oxygen-dependent and oxygen-independent, are discussed in this review, along with various approaches and techniques for investigation. The aim is to provide a general description of techniques and good practices, illustrated by key biomarkers measurement in DNA, and target students and beginners.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2023)
Article
Oncology
Isabele Fattori Moretti, Antonio Marcondes Lerario, Paula Rodrigues Sola, Janaina Macedo-da-Silva, Mauricio da Silva Baptista, Giuseppe Palmisano, Sueli Mieko Oba-Shinjo, Suely Kazue Nagahashi Marie
Summary: This study analyzed the effects of MET combined with TMZ treatment in two GBM cell lines, U87MG and A172, stimulated with LPS. MET treatment led to mitochondrial respiration blunting and oxidative stress in both cell lines, with U87MG cells exhibiting increased apoptosis after MET + LPS + TMZ treatment and A172 cells showing cell cycle arrest after MET + TMZ treatment. The observed differential response was associated with the metabolic status of the cells. This study highlights the potential of MET as a treatment option for GPM-GBM cases with an activated TLR4 pathway and suggests the use of combination therapies, such as an IL8 inhibitor for cases with upregulated CXCL8 and an antioxidant inhibitor for MTC-GBM cases.
Article
Biochemistry & Molecular Biology
Adriano B. Chaves-Filho, Albert S. Peixoto, Erique Castro, Tiago E. Oliveira, Luiz A. Perandini, Rafael J. Moreira, Railmara P. Da Silva, Beatriz P. Da Silva, Eduardo H. Moretti, Alexandre A. Steiner, Sayuri Miyamoto, Marcos Y. Yoshinaga, William T. Festuccia
Summary: The deletion of peroxisome proliferator-activated receptor gamma (PPAR gamma) in adipocytes leads to severe lipoatrophy and metabolic disorders. This study found that this condition results in the depletion of essential fatty acids and increased lipid metabolism in the liver, leading to liver enlargement and fatty liver. The activation of both fatty acid oxidation and de novo lipogenesis in the liver creates a futile metabolic cycle and contributes to the depletion of specific fatty acids.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2023)
Article
Chemistry, Multidisciplinary
Rodrigo Ken Kawassaki, Mariana Romano, Mayara Klimuk Uchiyama, Roberta Mansini Cardoso, Mauriicio S. Baptista, Sandra H. P. Farsky, Khallil Taverna Chaim, Robson Raphael Guimaraes, Koiti Araki
Summary: A novel ultrasmall paramagnetic nanoparticle (UPN), decorated with iron oxide on 3 nm titanium dioxide nanoparticles, has been developed as a potential alternative blood-pool contrast agent to gadoteric acid (GA) for MR angiography. It exhibits comparable relaxometric parameters to GA and has strong and prolonged contrast enhancement before renal excretion.
Article
Multidisciplinary Sciences
Rini Ravindran, Isabel O. L. Bacellar, Xavier Castellanos-Girouard, Haytham M. M. Wahba, Zhenghao Zhang, James G. G. Omichinski, Lydia Kisley, Stephen W. W. Michnick
Summary: Peroxisomes are responsible for the ss-oxidation of fatty acids and amino acids. Dysfunction of peroxisomes can lead to both rare and prevalent diseases. The import machinery of peroxisomal proteins, which shows similarities with chloroplasts, transports folded and large protein complexes into peroxisomes. Pex13 undergoes liquid-liquid phase separation with Pex5-cargo and plays a role in the transient protein transport channels.
Article
Biochemistry & Molecular Biology
Maria C. Oliveira, Rodrigo M. Cordeiro, Annemie Bogaerts
Summary: Intercellular communication mediated by connexins is crucial for cell growth, differentiation, and homeostasis. This study investigates the influence of lipid oxidation on the properties of Cx26 hemichannels. The results demonstrate that oxidized lipids affect the compactness and permeability of Cx26 hemichannels, potentially contributing to intracellular accumulation of reactive species and oxidative stress. Understanding this process can enhance the effectiveness of oxidative stress-based cancer treatments.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)
Review
Chemistry, Multidisciplinary
Erick L. Bastos, Frank H. Quina, Mauricio S. Baptista
Summary: Endogenous photosensitizers play a crucial role in light-induced transformations in biological systems. This comprehensive review focuses on their mode of action and its implications in various fields, such as photomedicine, photoredox catalysis, and the development of sun care products. The analysis reveals the potential causes of the increase in skin cancer cases and highlights the limitations of current sun protection approaches.
Article
Biochemistry & Molecular Biology
Davronjon Abduvokhidov, Maksudbek Yusupov, Aamir Shahzad, Pankaj Attri, Masaharu Shiratani, Maria C. Oliveira, Jamoliddin Razzokov
Summary: The potential of cold atmospheric plasma (CAP) in biomedical applications lies in its ability to generate reactive oxygen and nitrogen species (RONS). This study used molecular dynamics simulations to investigate the permeation capabilities of RONS across modified cell membranes, revealing that less hydrophilic species have a higher penetration ability through nitro-oxidized membranes. This research enhances our understanding of RONS translocation abilities in plasma biomedical applications and highlights the importance of further analyzing their role in intracellular signaling pathways.