Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 140, Issue 2, Pages 598-601Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.7b12213
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- Duke University
- Duke Chemistry Department
- ACS Petroleum Research Fund [56575-DNI1]
- NIH [GM124286]
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We introduce a new strategy for synthesis of chiral amines: couplings of alpha-aminoalkyl nucleophiles generated by enantioselective migratory insertion of 2-azadienes to a Cu-H. In this report, we demonstrate its application in catalytic reductive coupling of 2-azadienes and ketones to furnish 1,2-amino tertiary alcohols with vicinal stereogenic centers.
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