Article
Cell Biology
Jeong Seop Park, Doyoung Kim, Hyun Sook Hong
Summary: Classical aging-associated diseases include osteoporosis, diabetes, hypertension, and arthritis. This study investigates the effect of FGF2/HGF priming on the osteogenic potential of elderly adipose-derived stem cells (ADSC-E) and finds that FGF2/HGF priming can enhance the bone-forming capacity in ADSC-E.
Article
Oncology
Masahiro Mizuno, Behnoush Khaledian, Masao Maeda, Takanori Hayashi, Seiya Mizuno, Eiji Munetsuna, Takashi Watanabe, Seishi Kono, Seiji Okada, Motoshi Suzuki, Shintaro Takao, Hironobu Minami, Naoya Asai, Fumihiro Sugiyama, Satoru Takahashi, Yohei Shimono
Summary: The study found that adipsin secreted by adipocytes can enhance adipocytes themselves and increase their secretion of hepatocyte growth factor (HGF), thus enhancing the interaction between adipocytes and cancer cells. This mechanism provides a novel strategy for treating cancers associated with adipose tissues.
Article
Cell Biology
Zenan Zhang, Yutian Li, Tingting Zhang, Manyu Shi, Xin Song, Shulong Yang, Hengchen Liu, Mingzhao Zhang, Qingbo Cui, Zhaozhu Li
Summary: The acellular therapy consisting of conditioned medium (CM) of tendon stem cells (TSCs) induced with hepatocyte growth factor (HGF) was effective in promoting the healing of injured Achilles tendon in a rat model. The therapy enhanced the viability and migration of tendon fibroblasts, altered the expression of ECM proteins, promoted the organization of tendon fibers, suppressed inflammation, and improved the biomechanics of the injured Achilles tendon. This study suggests that HGF-induced TSC CM has therapeutic potential for tendinopathy treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Chong Fu, Yan Chen, Wei Xu, Yanping Zhang
Summary: Using genetic data, a Mendelian randomization analysis was conducted to explore the causal relationships between inflammatory cytokines and migraine. The results showed a positive association between hepatocyte growth factor (HGF) and migraine risk, while interleukin-2 (IL-2) was considered a downstream consequence of migraine.
SCIENTIFIC REPORTS
(2023)
Article
Cell Biology
Sami Gharbia, Simona-Rebeca Nazarie, Sorina Dinescu, Cornel Balta, Hildegard Herman, Victor Eduard Peteu, Mihaela Gherghiceanu, Anca Hermenean, Marieta Costache
Summary: This study investigates the antifibrotic effect of ADSC and HGF therapy on liver fibrosis in diabetic mice. In vitro experiments showed inhibition of hepatic stellate cell proliferation and decrease in fibrogenesis markers. In vivo experiments confirmed enhanced antifibrotic effects with coadministration of ADSCs and HGF, along with attenuation of inflammation, steatosis, and collagen deposits.
Article
Cell & Tissue Engineering
Ping Wang, Yan Cui, Jing Wang, Donghua Liu, Yue Tian, Kai Liu, Xue Wang, Lin Liu, Yu He, Yufeng Pei, Li Li, Liying Sun, Zhijun Zhu, Dehua Chang, Jidong Jia, Hong You
Summary: This study compared the therapeutic effects of mesenchymal stem cells (MSCs) and N-acetylcysteine (NAC) on acetaminophen (APAP)-induced liver failure and explored the underlying mechanism. The results showed that MSCs had comparable therapeutic effects to NAC, but had slightly different effects on hepatocyte necrosis and cell infiltration, and attenuated hepatocyte necrosis by secreting hepatocyte growth factor (HGF). These findings provide a theoretical basis for the clinical application of MSCs in treating APAP liver failure.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Cell & Tissue Engineering
Ning Li, Yichi Zhang, Narayan Nepal, Guoqing Li, Ningning Yang, Haoyuan Chen, Qiuchi Lin, Xuechun Ji, Sijia Zhang, Shizhu Jin
Summary: The study demonstrated that HGF-DPSCs can alleviate intestinal mucosa injuries by transdifferentiating into ISC-like cells, promoting ISC-like cell proliferation, suppressing inflammatory responses, and reducing oxidative stress damage, which offers new insights for the clinical treatment of UC.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Oncology
Kota Ishioka, Hiroyuki Yasuda, Junko Hamamoto, Hideki Terai, Katsura Emoto, Tae-Jung Kim, Shigemichi Hirose, Takashi Kamatani, Sachiyo Mimaki, Daisuke Arai, Keiko Ohgino, Tetsuo Tani, Keita Masuzawa, Tadashi Manabe, Taro Shinozaki, Akifumi Mitsuishi, Toshiki Ebisudani, Takahiro Fukushima, Mari Ozaki, Shinnosuke Ikemura, Ichiro Kawada, Katsuhiko Naoki, Morio Nakamura, Takashi Ohtsuka, Hisao Asamura, Katsuya Tsuchihara, Yuichiro Hayashi, Ahmed E. Hegab, Susumu S. Kobayashi, Takashi Kohno, Hideo Watanabe, David M. Ornitz, Tomoko Betsuyaku, Kenzo Soejima, Koichi Fukunaga
Summary: In this study, FGF9 was found to play a crucial role in the transdifferentiation of lung adenocarcinoma to small cell lung cancer. The upregulation of FGF9 was confirmed to induce neuroendocrine differentiation in established human lung adenocarcinoma cells, providing direct evidence for FGF9-mediated SCLC transdifferentiation and proposing the FGF9-FGFR axis as a therapeutic target for transdifferentiated SCLC.
Article
Cell & Tissue Engineering
Chijimatsu Ryota, Miwa Satoshi, Okamura Gensuke, Miyahara Junya, Tachibana Naohiro, Ishikura Hisatoshi, Higuchi Junya, Maenohara Yuji, Tsuji Shinsaku, Sameshima Shin, Takagi Kentaro, Nakazato Keiu, Kawaguchi Kohei, Yamagami Ryota, Inui Hiroshi, Taketomi Shuji, Sakae Tanaka, Taku Saito
Summary: This study investigated the chondrogenic potential of stem cells derived from adipose tissue and synovium, showing intrinsic differences in chondrogenic factors among cell types and species. The response to TGF beta 1 may play a crucial role in determining the fate of stem cells transplanted into cartilage defects.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Multidisciplinary Sciences
Shivanthy Pathmanathan, Zhong Yao, Paula Coelho, Robert Valla, Luka Drecun, Caroline Benz, Jamie Snider, Punit Saraon, Ingrid Grozavu, Max Kotlyar, Igor Jurisica, Morag Park, Igor Stagljar
Summary: In this study, the authors used the Mammalian Membrane Two-Hybrid (MaMTH) technique to generate an interactome map of the oncogene Met and its interactions with human SH2/PTB-domain-containing proteins. They discovered new interaction partners and further characterized the role of the protein BLNK in regulating the biology of Met in non-small cell lung cancer (NSCLC). Tumor phenotypical assays revealed that BLNK is involved in anchorage-independent growth and chemotaxis of NSCLC cell lines. This study provides valuable insights into the biology of Met and its interactions in cancer.
Article
Immunology
Yu Suematsu, Narihito Nagoshi, Munehisa Shinozaki, Yoshitaka Kase, Yusuke Saijo, Shogo Hashimoto, Takahiro Shibata, Keita Kajikawa, Yasuhiro Kamata, Masahiro Ozaki, Kaori Yasutake, Tomoko Shindo, Shinsuke Shibata, Morio Matsumoto, Masaya Nakamura, Hideyuki Okano
Summary: The study demonstrates that a dual therapeutic intervention utilizing HGF preconditioning and hiPSC-NS/PC transplantation enhances locomotor functional recovery post-SCI, highlighting a highly promising therapeutic strategy for acute to subacute SCI.
INFLAMMATION AND REGENERATION
(2023)
Article
Engineering, Biomedical
Shogo Hashimoto, Narihito Nagoshi, Munehisa Shinozaki, Katsuyuki Nakanishi, Yu Suematsu, Takahiro Shibata, Momotaro Kawai, Takahiro Kitagawa, Kentaro Ago, Yasuhiro Kamata, Kaori Yasutake, Ikuko Koya, Yoshinari Ando, Aki Minoda, Tomoko Shindo, Shinsuke Shibata, Morio Matsumoto, Masaya Nakamura, Hideyuki Okano
Summary: In this study, the therapeutic effect of environmental modulation on severe chronic spinal cord injury (SCI) was explored. The use of a clinically relevant hepatocyte growth factor (HGF)-releasing scaffold and human iPS cell-derived neural stem/progenitor cell (hNS/PCs) transplantation led to functional recovery. This study provides evidence for the feasibility of regenerative medicine strategies using clinically relevant materials in the treatment of severe chronic SCI.
Article
Multidisciplinary Sciences
Yu Chiuan Wu, Guan Xuan Wu, Kuan Wei Chen, Li-Yen Shiu, Satheesh Kumar, Guei-Sheung Liu, Shyh Ming Kuo
Summary: This study demonstrates the regenerative capacity of collagen fiber-based 3D ADSC/hepatocyte spheroids in response to TAA-induced liver injury, providing a promising alternative therapeutic strategy for liver cirrhosis.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Mingzhao Zhang, Hengchen Liu, Manyu Shi, Tingting Zhang, Wenjun Lu, Shulong Yang, Qingbo Cui, Zhaozhu Li
Summary: The study showed that hepatocyte growth factor (HGF)-expressing tendon stem cells (TSCs + HGF) have a significant promoting effect on tendon healing in rats, mainly by reducing inflammation and fibrosis. This provides a novel therapeutic strategy for tendon injuries.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Amanda Rose Khater, Tamara Abou-Antoun
Summary: Malignant nervous system cancers in children pose a significant challenge due to their aggressive nature and sometimes inoperable location in critical regions. The developmental processes of the nervous system during childhood further complicate treatment modalities. Pediatric oncologists are tasked with providing effective cures while navigating limited therapeutic options to minimize neurotoxicity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Engineering, Biomedical
Ryusuke Machino, Keitaro Matsumoto, Daisuke Taniguchi, Tomoshi Tsuchiya, Yosuke Takeoka, Yasuaki Taura, Masaaki Moriyama, Tomoyuki Tetsuo, Shosaburo Oyama, Katsunori Takagi, Takuro Miyazaki, Go Hatachi, Ryoichiro Doi, Koichiro Shimoyama, Naoto Matsuo, Naoya Yamasaki, Koichi Nakayama, Takeshi Nagayasu
ADVANCED HEALTHCARE MATERIALS
(2019)
Article
Surgery
Naoaki Rikihisa, Sadanori Akita, Keigo Osuga, Hidefumi Mimura, Shunsuke Yuzuriha, Satoru Sasaki
JOURNAL OF VASCULAR SURGERY-VENOUS AND LYMPHATIC DISORDERS
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hidefumi Mimura, Sadanori Akita, Akihiro Fujino, Masatoshi Jinnin, Mine Ozaki, Keigo Osuga, Hiroki Nakaoka, Eiichi Morii, Akira Kuramochi, Yoko Aoki, Yasunori Arai, Noriko Aramaki, Masanori Inoue, Yuki Iwashina, Tadashi Iwanaka, Shigeru Ueno, Akihiro Umezawa, Michio Ozeki, Junko Ochi, Yoshiaki Kinoshita, Masakazu Kurita, Shien Seike, Nobuyuki Takakura, Masataka Takahashi, Takao Tachibana, Kumiko Chuman, Shuji Nagata, Mitsunaga Narushima, Yasunari Niimi, Shunsuke Nosaka, Taiki Nozaki, Kazuki Hashimoto, Ayato Hayashi, Satoshi Hirakawa, Atsuko Fujikawa, Yumiko Hori, Kentaro Matsuoka, Hideki Mori, Yuki Yamamoto, Shunsuke Yuzuriha, Naoaki Rikihisa, Shoji Watanabe, Shinichi Watanabe, Tatsuo Kuroda, Shunsuke Sugawara, Kosuke Ishikawa, Satoru Sasaki
JAPANESE JOURNAL OF RADIOLOGY
(2020)
Article
Dermatology
Hidefumi Mimura, Sadanori Akita, Akihiro Fujino, Masatoshi Jinnin, Mine Ozaki, Keigo Osuga, Hiroki Nakaoka, Eiichi Morii, Akira Kuramochi, Yoko Aoki, Yasunori Arai, Noriko Aramaki, Masanori Inoue, Yuki Iwashina, Tadashi Iwanaka, Shigeru Ueno, Akihiro Umezawa, Michio Ozeki, Junko Ochi, Yoshiaki Kinoshita, Masakazu Kurita, Shien Seike, Nobuyuki Takakura, Masataka Takahashi, Takao Tachibana, Kumiko Chuman, Shuji Nagata, Mitsunaga Narushima, Yasunari Niimi, Shunsuke Nosaka, Taiki Nozaki, Kazuki Hashimoto, Ayato Hayashi, Satoshi Hirakawa, Atsuko Fujikawa, Yumiko Hori, Kentaro Matsuoka, Hideki Mori, Yuki Yamamoto, Shunsuke Yuzuriha, Naoaki Rikihisa, Shoji Watanabe, Shinichi Watanabe, Tatsuo Kuroda, Shunsuke Sugawara, Kosuke Ishikawa, Satoru Sasaki
JOURNAL OF DERMATOLOGY
(2020)
Article
Pediatrics
Hidefumi Mimura, Sadanori Akita, Akihiro Fujino, Masatoshi Jinnin, Mine Ozaki, Keigo Osuga, Hiroki Nakaoka, Eiichi Morii, Akira Kuramochi, Yoko Aoki, Yasunori Arai, Noriko Aramaki, Masanori Inoue, Yuki Iwashina, Tadashi Iwanaka, Shigeru Ueno, Akihiro Umezawa, Michio Ozeki, Junko Ochi, Yoshiaki Kinoshita, Masakazu Kurita, Shien Seike, Nobuyuki Takakura, Masataka Takahashi, Takao Tachibana, Kumiko Chuman, Shuji Nagata, Mitsunaga Narushima, Yasunari Niimi, Shunsuke Nosaka, Taiki Nozaki, Kazuki Hashimoto, Ayato Hayashi, Satoshi Hirakawa, Atsuko Fujikawa, Yumiko Hori, Kentaro Matsuoka, Hideki Mori, Yuki Yamamoto, Shunsuke Yuzuriha, Naoaki Rikihisa, Shoji Watanabe, Shinichi Watanabe, Tatsuo Kuroda, Shunsuke Sugawara, Kosuke Ishikawa, Satoru Sasaki
PEDIATRICS INTERNATIONAL
(2020)
Article
Oncology
Tomoshi Tsuchiya, Ryotaro Kamohara, Masashi Muraoka, Takeshi Nagayasu, Sho Saeki, Mitsuhiro Takenoyama, Makoto Suzuki, Kazuo Inada, Shoji Tokunaga, Tomayoshi Hayashi, Shogo Urabe, Takaomi Koga, Shinji Akamine, Kenji Sugio
Article
Oncology
Tomoshi Tsuchiya, Keitaro Matsumoto, Takuro Miyazaki, Ryoichiro Doi, Shoji Tokunaga, Hiroyuki Yamaguchi, Koichi Tomoshige, Hironosuke Watanabe, Takeshi Nagayasu, Kenji Sugio
Summary: This study aims to evaluate the effectiveness and safety of different chemotherapy regimens for stage II-IIIA non-small cell lung cancer, assessing treatment side effects along with quality of life, work productivity, and activity performance. The primary endpoint is 2-year relapse free survival, with secondary endpoints including overall survival, treatment completion rate, safety, work productivity, activity, and quality of adjusted life years. The study is designed to provide accurate information for future phase 3 randomized controlled trials.
Article
Biochemistry & Molecular Biology
Sadanori Akita, Keiji Suzuki, Hiroshi Yoshimoto, Akira Ohtsuru, Akiyoshi Hirano, Shunichi Yamashita
Summary: The study showed that ADSCs are resistant to ATV, while differentiating adipocytes are significantly induced to undergo apoptosis by ATV. Internal stress-mediated UPR induced in differentiating adipocytes in the presence of ATV leads to decreased adipogenic differentiation and increased autophagy, ultimately resulting in adipogenic apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Masaaki Moriyama, Keitaro Matsumoto, Daisuke Taniguchi, Ryusuke Machino, Tomoshi Tsuchiya, Koichi Nakayama, Takeshi Nagayasu
Summary: The study investigated the use of bio plugs for closure of bronchopleural fistulas, with results showing that bio plugs with mixed cells, including endothelial cells, contribute to bronchial closure. This study provides essential data on bronchial closure, although further experiments are needed to replicate clinical conditions.
INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Tomoshi Tsuchiya, Keitaro Matsumoto, Takuro Miyazaki, Ryoichiro Doi, Koichi Tomoshige, Hironosuke Watanabe, Soichiro Kiya, Takashi Miura, Hideki Ishimaru, Takeshi Nagayasu
Summary: The patient, a 53-year-old man, presented with a cough and dyspnea on exertion. An imaging study revealed a 3-cm tumor in the right upper lobe, which had invaded the hilar lymph nodes, superior vena cava, right main bronchus, and pulmonary artery. After being diagnosed with non-small cell lung cancer, the patient underwent preoperative induction radiochemotherapy and subsequently underwent surgery. A right upper double sleeve lobe lobectomy was performed, with reconstruction of the right main pulmonary artery. The patient experienced impaired blood flow in the right pulmonary artery post-surgery, but a metal vascular stent was successfully inserted to restore blood flow.
GENERAL THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Oncology
Koichi Tomoshige, William D. Stuart, Iris M. Fink-Baldauf, Masaoki Ito, Tomoshi Tsuchiya, Takeshi Nagayasu, Tomoki Yamatsuji, Morihito Okada, Takuya Fukazawa, Minzhe Guo, Yutaka Maeda
Summary: The transcription factor FOXA2 has different effects on lung tumorigenesis depending on the oncogenes present. It inhibits tumor development driven by EGFRL858R but promotes tumor growth driven by KRASG12D. Additionally, FOXA2 induces the expression of MUC5AC, leading to the development of invasive mucinous adenocarcinoma (IMA), a subtype of lung cancer.
Article
Biochemistry & Molecular Biology
Makoto Hisanaga, Tomoshi Tsuchiya, Hironosuke Watanabe, Koichiro Shimoyama, Mayumi Iwatake, Yukinori Tanoue, Keizaburo Maruyama, Hiroshi Yukawa, Kazuhide Sato, Yoshimi Kato, Keitaro Matsumoto, Takuro Miyazaki, Ryoichiro Doi, Koichi Tomoshige, Takeshi Nagayasu
Summary: Decellularized scaffolds are promising biomaterials for tissue and organ reconstruction. This study investigated the effect of isogeneic abdominal adipose-derived mesenchymal stem/stromal cells (ADMSCs) on xenogeneic biomaterial-induced immunoreactions.
Review
Emergency Medicine
Rei Ogawa, Sadanori Akita, Satoshi Akaishi, Noriko Aramaki-Hattori, Teruyuki Dohi, Toshihiko Hayashi, Kazuo Kishi, Taro Kono, Hajime Matsumura, Gan Muneuchi, Naoki Murao, Munetomo Nagao, Keisuke Okabe, Fumiaki Shimizu, Mamiko Tosa, Yasuyoshi Tosa, Satoko Yamawaki, Shinichi Ansai, Norihisa Inazu, Toshiko Kamo, Reiko Kazki, Shigehiko Kuribayashi
Article
Cardiac & Cardiovascular Systems
Tomoshi Tsuchiya, Keitaro Matsumoto, Takuro Miyazaki, Hiroyuki Yamaguchi, Takuya Yamazaki, Isao Sano, Junya Fukuoka, Yoichi Nakamura, Naoya Yamasaki, Takeshi Nagayasu
GENERAL THORACIC AND CARDIOVASCULAR SURGERY
(2019)
Meeting Abstract
Cell Biology
Sadanori Akita
WOUND REPAIR AND REGENERATION
(2019)
Editorial Material
Surgery
Meghal Shah, Tejas S. Sathe, Sukriti Bansal, Anai N. Kothari, Sophie Dream
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Zafer Turkyilmaz, Ramazan Karabulut, Kaan Sonmez
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Priyanka Jadhav, Gerald Gollin
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Kheira Hireche, Ludovic Canaud, Pierre Antoine Peyron, Linda Sakhri, Isabelle Serres, Sanaa Kamel, Youcef Lounes, Thomas Gandet, Pierre Alric
Summary: This study evaluated the elastic properties of commonly used vascular substitutes for pulmonary artery replacement and compared their compliance and stiffness indexes to human pulmonary artery. The results showed that allogenic arterial grafts appeared to be the most suitable vascular substitutes in terms of compliance and stiffness for PA replacement.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Margaret Siu, Aixa Perez Coulter, Heather M. Grant, Reginald Alouidor, Michael Tirabassi
Summary: There is no significant difference in adverse respiratory events between intubated, critically ill patients requiring operative intervention who are kept NPO for 6 hours or longer compared to those kept NPO for less than 6 hours. Patients commonly experience periods of fasting much longer than the recommended 6-hour period by the American Society of Anesthesiologists.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Whitney Elks, Allison G. McNickle, Matthew Kelecy, Kavita Batra, Shirley Wong, Shawn Wang, Lisa Angotti, Deborah A. Kuhls, Charles St Hill, Syed F. Saquib, Paul J. Chestovich, Douglas R. Fraser
Summary: This study aimed to compare the effects of early and late enteral feeding after PEG placement on achieving nutritional therapy goals and adverse outcomes. The results showed that patients with early initiation of feeds achieved a higher percentage of goals on day 0 without an increased rate of adverse events.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Manisha B. Bhatia, Cassandra M. Anderson, Abdiwahab N. Hussein, Brian Opondo, Nereah Aruwa, Otieno Okumu, Sarah G. Fisher, Tasha Sparks Joplin, JoAnna L. Hunter-Squires, Brian W. Gray, Peter W. Saula
Summary: This study aimed to understand postoperative pediatric nutrition practices in Kenya and the United States. The results showed that in the United States, patients initiated enteral nutrition earlier and had shorter hospital stays. However, in Kenya, patients initiated enteral nutrition earlier but had no significant difference in hospital stays.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David P. Stonko, Joseph Edwards, Hossam Abdou, Rebecca Treffalls, Patrick Walker, Jonathan J. Morrison
Summary: Raising mean arterial pressure (MAP) >90 mmHg with norepinephrine can increase gastroduodenal artery (GDA) flow and delay bowel ischemia.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David R. Mann, Kathryn E. Engelhardt, Barry C. Gibney, Macelyn E. Batten, Eric C. Klipsch, Rupak Mukherjee, Ian C. Bostock
Summary: Pathologic upstaging is associated with decreased overall survival in cT1b esophageal cancer. Esophagectomy has better survival outcomes compared to endoscopic local tumor excision. Neoadjuvant chemoradiation therapy does not improve overall survival in cT1b lesions.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ross Mudgway, Zachary Tran, Juan C. Quispe Espiritu, Woo Bin Bong, Hayden Schultz, Vamsi Vemireddy, Aarthy Kannappan, Marcos Michelotti, Kaushik Mukherjee, Jeffrey Quigley, Keith Scharf, Daniel Srikureja, Sharon S. Lum, Esther Wu
Summary: Comparison of medium-term outcomes between robotic-assisted cholecystectomy (RC) and laparoscopic cholecystectomy (LC) using validated quality of life (QoL) and pain assessments did not show significant differences.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ningjie Chen, Haitao Wang, Yang Shao, Jincun Yang, Guodong Song
Summary: This study aimed to compare the therapeutic effects of activated platelet-rich plasma (PRP) prepared from elderly individuals and young adults in treating pressure ulcers (PUs). The results showed that PRP from young adults had higher platelet concentrations and greater production of growth factors, leading to better wound healing.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Brendin R. Beaulieu-Jones, Margaret T. Berrigan, Kortney A. Robinson, Jayson S. Marwaha, Tara S. Kent, Gabriel A. Brat
Summary: Introduction: Prescription opioids, including those prescribed after surgery, have greatly contributed to the US opioid epidemic. Educating opioid prescribers is a crucial component of ensuring the safe use of opioids among surgical patients. This study implemented an annual education curriculum for new surgical prescribers, resulting in significant improvements in knowledge and comfort levels. However, there remains a persistent knowledge and comfort gap among these prescribers.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Sneha G. Bhat, Madhuri Nagaraj, Courtney Balentine, Timothy Hogan, Jennie Meier, Hillary Prince, Kareem Abdelfattah, Herbert Zeh, Benjamin Levi
Summary: This pilot study examined the effects of a structured mental fitness program on academic surgeons and found significant improvement in Positive Intelligence (PQ) scores, as well as increased connectedness and shared language among participants. However, there were no significant changes in sleep, well-being, or teaching evaluations.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Kristin E. Cox, Michael A. Turner, Siamak Amirfakhri, Thinzar M. Lavin, Mojgan Hosseini, Pradipta Ghosh, Marygorret Obonyo, Takashi Murakami, Robert M. Hoffman, Paul J. Yazaki, Michael Bouvet
Summary: This study demonstrates the potential of using humanized anti-carcinoembryonic antigen (CEA) antibodies conjugated with near-infrared dyes to specifically label gastric cancers in mouse models. Orthotopic models showed bright and specific labeling with more than ten times higher tumor-to-background ratios compared to the control. This tumor-specific fluorescent antibody has promising potential as a clinical tool for improving visualization of gastric cancer margins during surgical resection.
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Sarah Maki, Melissa Leon, Emily Glenn, Tiffany Tanner, Crystal Krause
Summary: This scoping review analyzed the literature on the use of broadband personality tests in the bariatric surgical population to optimize weight loss outcomes. The study found significant associations between personality scales and weight loss, but inconsistent reporting of outcome measures made it challenging to draw concrete conclusions. The American Society for Metabolic and Bariatric Surgery recommends standardization of outcome reporting to improve the reliability of predicting weight loss outcomes.
JOURNAL OF SURGICAL RESEARCH
(2024)