Review
Surgery
Laurence Verstraeten, Ina Jochmans
Summary: This article discusses the use of organ perfusion technology as a tool for assessing organ viability before transplantation, highlighting current issues, potential developments, and the pros and cons of various perfusion methods.
TRANSPLANT INTERNATIONAL
(2022)
Review
Biochemistry & Molecular Biology
Rebecca Panconesi, Mauricio Flores Carvalho, Matteo Mueller, David Meierhofer, Philipp Dutkowski, Paolo Muiesan, Andrea Schlegel
Summary: Assessment and prediction of liver function is crucial due to the increase of donor risk and majority of marginal organs. Traditional tests require prolonged diagnostic time and are difficult to assess, while dynamic organ preservation strategies offer an opportunity to evaluate organs before implantation through analysis of recirculating perfusates, bile, and perfused liver tissue.
Article
Multidisciplinary Sciences
Yuhei Higashi, Jun Homma, Hidekazu Sekine, Hiroki Yago, Eiji Kobayashi, Tatsuya Shimizu
Summary: This study proposes a method of improving the circulatory distribution of organs during perfusion by applying intermittent air pressure from outside. Experimental results demonstrate that this method can improve the circulatory distribution of organs, reduce tissue damage, and maintain the ability to filter perfusate.
SCIENTIFIC REPORTS
(2022)
Article
Surgery
Michal Grat, Marcin Morawski, Andriy Zhylko, Pawel Rykowski, Maciej Krasnodebski, Anya Wyporski, Jan Borkowski, Zbigniew Lewandowski, Konrad Kobryn, Rafal Stankiewicz, Jan Stypulkowski, Waclaw Holowko, Waldemar Patkowski, Magdalena Mielczarek-Puta, Marta Struga, Benedykt Szczepankiewicz, Barbara Gornicka, Marek Krawczyk
Summary: This study suggests that routine use of end-ischemic hypothermic oxygenated machine perfusion (HOPE) in liver transplantations from donors after brain death (DBD) is not justified, as the clinical benefits are limited to high-risk donors.
Article
Medicine, General & Internal
Sophie Romann, Tristan Wagner, Shadi Katou, Stefan Reuter, Thomas Vogel, Felix Becker, Haluk Morgul, Philipp Houben, Philip Wahl, Andreas Pascher, Sonia Radunz
Summary: The aim of this study was to evaluate hyperspectral imaging (HSI) as a rapid and non-ionizing technique for assessing organ quality and predicting delayed graft function (DGF) in kidney transplantation. The study found that HSI is a reliable method for assessing renal microperfusion and can be used after organ preservation through static cold storage (SCS) and hypothermic machine perfusion (HMP). Additionally, HSI can predict the development of DGF.
Article
Surgery
Ann Etohan Ogbemudia, Gabriella Hakim, Fungai Dengu, Faysal El-Gilani, Richard Dumbill, John Mulvey, Karen Sayal, Thomas Prudhomme, Benoit Mesnard, Kaithlyn Rozenberg, Letizia Lo Faro, Timothy James, Joshua Oliver, Edward Sharples, Shruti Mittal, Paul Johnson, Peter J. Friend, Rutger Ploeg, James Hunter, Julien Branchereau
Summary: The study compared static cold storage (SCS) with hypothermic machine perfusion with oxygenation (HMPO2) in pancreas preservation, showing that HMPO2 had better outcomes during normothermic reperfusion assessments.
TRANSPLANT INTERNATIONAL
(2021)
Article
Engineering, Biomedical
Damiano Patrono, Davide Cussa, Federica Rigo, Renato Romagnoli
Summary: This survey reveals significant heterogeneity in indications, techniques, and timing of machine perfusion (MP) in liver transplantation among experts, highlighting the importance of identifying optimal scenarios for each technique. Additionally, viability assessment is emphasized as a fundamental need for transplant professionals when considering the use of MP.
Review
Immunology
Jiale Li, Qinbao Peng, Ronghua Yang, Kunsheng Li, Peng Zhu, Yufeng Zhu, Pengyu Zhou, Gabor Szabo, Shaoyi Zheng
Summary: This review discusses the use of machine perfusion and mesenchymal stem cells to improve the quality and outcomes of marginal organs in transplantation. By continuously perfusing the organs to mimic physiological conditions, evaluating pre-transplant organ function, and treating the organs with pharmacological, gene, and stem cell therapy, the quality and adaptability of the organs can be enhanced. Promising preclinical results indicate the potential clinical translation of this innovative strategy to improve the quality of marginal grafts.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Maria Irene Bellini, Francesco Tortorici, Maria Ida Amabile, Vito D'Andrea
Summary: Kidney transplantation is the preferred treatment for end-stage renal disease, with static cold storage being the standard preservation method. However, dynamic techniques like machine perfusion have shown potential to improve graft function and quality assessment, particularly in kidneys from extended criteria donors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Tom Darius, Jay Nath, Michel Mourad
Summary: The use of high-risk renal grafts for transplantation requires optimization of pretransplant preservation and assessment strategies to improve clinical outcomes and decrease organ discard rate. Oxygenation during hypothermic machine preservation is proposed as a resuscitative measure, providing a critical overview of the fundamentals and suggesting different strategies for clinical implementation.
Article
Medicine, General & Internal
Alessandro Parente, Mauricio Flores Carvalho, Rebecca Panconesi, Yuri L. Boteon, Riccardo De Carlis, Philipp Dutkowski, Paolo Muiesan, Daniele Dondossola, Andrea Schlegel
Summary: This study investigates the current trends and obstacles to the implementation of dynamic perfusion concepts in liver transplantation on an international scale. A web-based survey was conducted among experts from 70 centers in 34 countries. The results show that while dynamic preservation techniques are increasingly used in clinical practice, financial, knowledge, and personnel challenges remain.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Ngee-Soon Lau, Mark Ly, Claude Dennis, Andrew Jacques, Marti Cabanes-Creus, Shamus Toomath, Joanna Huang, Nicole Mestrovic, Paul Yousif, Sumon Chanda, Chuanmin Wang, Leszek Lisowski, Ken Liu, James G. Kench, Geoffrey McCaughan, Michael Crawford, Carlo Pulitano
Summary: Long-term machine perfusion of human livers outside the body is an emerging field with tremendous potential for the assessment, recovery, and modification of organs prior to transplantation. Here, the authors report the long-term ex situ perfusion of human livers and demonstrate the ability to split and perfuse these organs using a standardised protocol.
NATURE COMMUNICATIONS
(2023)
Article
Engineering, Biomedical
Daniel J. Portillo, Jose Gonzalez, Carorina Villarreal, Sophia J. Salazar, Anjelyka Fasci, Brandt Wearden, Jessica Oseghale, Anis Khalil, Thomas Perillo, Leslie Muenchow, Robert De Lorenzo, R. Lyle Hood
Summary: This study presents a novel, portable, and nonelectronic device that is capable of delivering oxygenated machine perfusion to different organs. Through an innovative pneumatic circuit system and silicone tube design, the device achieved perfusion parameters consistent with previous kidney preservation studies.
ANNALS OF BIOMEDICAL ENGINEERING
(2022)
Article
Cardiac & Cardiovascular Systems
Louise E. See, Gianluigi Li Bassi, Karin Wildi, Margaret R. Passmore, Mahe Bouquet, Kei Sato, Silver Heinsar, Carmen Ainola, Nicole Bartnikowski, Emily S. Wilson, Kieran Hyslop, Kris Skeggs, Nchafatso G. Obonyo, Tristan Shuker, Lucy Bradbury, Chiara Palmieri, Sanne Engkilde-Pedersen, Charles McDonald, Sebastiano M. Colombo, Matthew A. Wells, Janice D. Reid, Hollier O'Neill, Samantha Livingstone, Gabriella Abbate, Andrew Haymet, Jae-Seung Jung, Noriko Sato, Lynnette James, Ting He, Nicole White, Meredith A. Redd, Jonathan E. Millar, Maximillian Malfertheiner, Peter Molenaar, David Platts, Jonathan Chan, Jacky Y. Suen, David C. McGiffin, John F. Fraser
Summary: There is a shortage of donor hearts for transplantation, but using hypothermic machine perfusion (HMP) can safely extend the ischemic time of donor hearts and improve transplantation outcomes.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Article
Medicine, General & Internal
Margot Fodor, Julia Hofmann, Lukas Lanser, Giorgi Otarashvili, Marlene Puehringer, Theresa Hautz, Robert Sucher, Stefan Schneeberger
Summary: Organ transplantation survival rates have been improving due to advancements in the field, allowing for more patients with higher risk profiles to be added to waiting lists. Strategies to tackle organ shortage include the use of hypothermic and normothermic machine perfusion, as well as the implementation of hyperspectral imaging for assessing organ quality. Combining organ machine perfusion with hyperspectral imaging is seen as a prospective feasibility concept for the future of organ transplantation.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Linda Feldbruegge, Alan C. Moss, Eric U. Yee, Eva Csizmadia, Shuji Mitsuhashi, Maria Serena Longhi, Bynvant Sandhu, Holger Stephan, Yan Wu, Adam S. Cheifetz, Christa E. Mueller, Jean Sevigny, Simon C. Robson, Z. Gordon Jiang
JOURNAL OF CROHNS & COLITIS
(2017)
Editorial Material
Medicine, Research & Experimental
Wayne J. Hawthorne, Arielle Cimeno, Mohamed Ezzelarab, Bynvant Sandhu, Christopher Burlak
XENOTRANSPLANTATION
(2017)
Article
Surgery
M. Willicombe, B. Sandhu, P. Brookes, W. Gedroyc, N. Hakim, M. Hamady, P. Hill, A. G. McLean, S. Moser, V. Papalois, P. Tait, M. Wilcock, D. Taube
AMERICAN JOURNAL OF TRANSPLANTATION
(2014)
Article
Oncology
R. Marudanayagam, B. Sandhu, M. T. P. R. Perera, S. R. Bramhall, D. Mayer, J. A. C. Buckels, D. F. Mirza
Article
Gastroenterology & Hepatology
Ravi Marudanayagam, Vivekanandan Shanmugam, Bynvant Sandhu, Bridget K. Gunson, Darius F. Mirza, David Mayer, John Buckels, Simon R. Bramhall
Article
Gastroenterology & Hepatology
Ravi Marudanayagam, Bynvant Sandhu, M. Thamara P. R. Perera, Phillipe Taniere, Chris Coldham, Simon Bramhall, David Mayer, John Buckels, Darius Mirza
Editorial Material
Surgery
Ravi Marudanayagam, Bynvant Sandhu, Mike Hallissey
ANNALS OF THE ROYAL COLLEGE OF SURGEONS OF ENGLAND
(2009)
Editorial Material
Surgery
Meghal Shah, Tejas S. Sathe, Sukriti Bansal, Anai N. Kothari, Sophie Dream
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Zafer Turkyilmaz, Ramazan Karabulut, Kaan Sonmez
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Priyanka Jadhav, Gerald Gollin
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Kheira Hireche, Ludovic Canaud, Pierre Antoine Peyron, Linda Sakhri, Isabelle Serres, Sanaa Kamel, Youcef Lounes, Thomas Gandet, Pierre Alric
Summary: This study evaluated the elastic properties of commonly used vascular substitutes for pulmonary artery replacement and compared their compliance and stiffness indexes to human pulmonary artery. The results showed that allogenic arterial grafts appeared to be the most suitable vascular substitutes in terms of compliance and stiffness for PA replacement.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Margaret Siu, Aixa Perez Coulter, Heather M. Grant, Reginald Alouidor, Michael Tirabassi
Summary: There is no significant difference in adverse respiratory events between intubated, critically ill patients requiring operative intervention who are kept NPO for 6 hours or longer compared to those kept NPO for less than 6 hours. Patients commonly experience periods of fasting much longer than the recommended 6-hour period by the American Society of Anesthesiologists.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Whitney Elks, Allison G. McNickle, Matthew Kelecy, Kavita Batra, Shirley Wong, Shawn Wang, Lisa Angotti, Deborah A. Kuhls, Charles St Hill, Syed F. Saquib, Paul J. Chestovich, Douglas R. Fraser
Summary: This study aimed to compare the effects of early and late enteral feeding after PEG placement on achieving nutritional therapy goals and adverse outcomes. The results showed that patients with early initiation of feeds achieved a higher percentage of goals on day 0 without an increased rate of adverse events.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Manisha B. Bhatia, Cassandra M. Anderson, Abdiwahab N. Hussein, Brian Opondo, Nereah Aruwa, Otieno Okumu, Sarah G. Fisher, Tasha Sparks Joplin, JoAnna L. Hunter-Squires, Brian W. Gray, Peter W. Saula
Summary: This study aimed to understand postoperative pediatric nutrition practices in Kenya and the United States. The results showed that in the United States, patients initiated enteral nutrition earlier and had shorter hospital stays. However, in Kenya, patients initiated enteral nutrition earlier but had no significant difference in hospital stays.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David P. Stonko, Joseph Edwards, Hossam Abdou, Rebecca Treffalls, Patrick Walker, Jonathan J. Morrison
Summary: Raising mean arterial pressure (MAP) >90 mmHg with norepinephrine can increase gastroduodenal artery (GDA) flow and delay bowel ischemia.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David R. Mann, Kathryn E. Engelhardt, Barry C. Gibney, Macelyn E. Batten, Eric C. Klipsch, Rupak Mukherjee, Ian C. Bostock
Summary: Pathologic upstaging is associated with decreased overall survival in cT1b esophageal cancer. Esophagectomy has better survival outcomes compared to endoscopic local tumor excision. Neoadjuvant chemoradiation therapy does not improve overall survival in cT1b lesions.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ross Mudgway, Zachary Tran, Juan C. Quispe Espiritu, Woo Bin Bong, Hayden Schultz, Vamsi Vemireddy, Aarthy Kannappan, Marcos Michelotti, Kaushik Mukherjee, Jeffrey Quigley, Keith Scharf, Daniel Srikureja, Sharon S. Lum, Esther Wu
Summary: Comparison of medium-term outcomes between robotic-assisted cholecystectomy (RC) and laparoscopic cholecystectomy (LC) using validated quality of life (QoL) and pain assessments did not show significant differences.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ningjie Chen, Haitao Wang, Yang Shao, Jincun Yang, Guodong Song
Summary: This study aimed to compare the therapeutic effects of activated platelet-rich plasma (PRP) prepared from elderly individuals and young adults in treating pressure ulcers (PUs). The results showed that PRP from young adults had higher platelet concentrations and greater production of growth factors, leading to better wound healing.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Brendin R. Beaulieu-Jones, Margaret T. Berrigan, Kortney A. Robinson, Jayson S. Marwaha, Tara S. Kent, Gabriel A. Brat
Summary: Introduction: Prescription opioids, including those prescribed after surgery, have greatly contributed to the US opioid epidemic. Educating opioid prescribers is a crucial component of ensuring the safe use of opioids among surgical patients. This study implemented an annual education curriculum for new surgical prescribers, resulting in significant improvements in knowledge and comfort levels. However, there remains a persistent knowledge and comfort gap among these prescribers.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Sneha G. Bhat, Madhuri Nagaraj, Courtney Balentine, Timothy Hogan, Jennie Meier, Hillary Prince, Kareem Abdelfattah, Herbert Zeh, Benjamin Levi
Summary: This pilot study examined the effects of a structured mental fitness program on academic surgeons and found significant improvement in Positive Intelligence (PQ) scores, as well as increased connectedness and shared language among participants. However, there were no significant changes in sleep, well-being, or teaching evaluations.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Kristin E. Cox, Michael A. Turner, Siamak Amirfakhri, Thinzar M. Lavin, Mojgan Hosseini, Pradipta Ghosh, Marygorret Obonyo, Takashi Murakami, Robert M. Hoffman, Paul J. Yazaki, Michael Bouvet
Summary: This study demonstrates the potential of using humanized anti-carcinoembryonic antigen (CEA) antibodies conjugated with near-infrared dyes to specifically label gastric cancers in mouse models. Orthotopic models showed bright and specific labeling with more than ten times higher tumor-to-background ratios compared to the control. This tumor-specific fluorescent antibody has promising potential as a clinical tool for improving visualization of gastric cancer margins during surgical resection.
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Sarah Maki, Melissa Leon, Emily Glenn, Tiffany Tanner, Crystal Krause
Summary: This scoping review analyzed the literature on the use of broadband personality tests in the bariatric surgical population to optimize weight loss outcomes. The study found significant associations between personality scales and weight loss, but inconsistent reporting of outcome measures made it challenging to draw concrete conclusions. The American Society for Metabolic and Bariatric Surgery recommends standardization of outcome reporting to improve the reliability of predicting weight loss outcomes.
JOURNAL OF SURGICAL RESEARCH
(2024)