Article
Oncology
Parbatraj Regmi, Aliza Paudyal, Pranita Paudyal, Hai-Jie Hu, Fei Liu, Wen-Jie Ma, Yan-Wen Jin, Fu-Yu Li
Summary: Tumor budding is identified as a significant predictor of poor survival for biliary tract cancer (BTC), associated with poor histologic differentiation, lymphovascular invasion, and other factors. It has the potential to serve as a prognostic marker for BTC, pending the development of a standardized international consensus.
Article
Biochemistry & Molecular Biology
Luis O. Gonzalez, Noemi Eiro, Maria Fraile, Rosario Sanchez, Alejandro Andicoechea, Silvia Fernandez-Francos, Jose Schneider, Francisco J. Vizoso
Summary: High-grade tumor budding is associated with a more aggressive tumor phenotype, and when combined with MMP/TIMP expression by stromal cells at the invasive front of the tumor, it helps identify patients with poor prognosis. The optimal cut-off for predicting both relapse-free and overall survival was found to be a tumor budding count >= 4. The study also showed that high-grade tumor budding was linked to MMP/TIMP expression by cancer-associated fibroblasts.
Article
Oncology
Chan Su Park, Min Je Sung, So Jeong Kim, Jung Hyun Jo, Hee Seung Lee, Moon Jae Chung, Seungmin Bang, Seung Woo Park, Si Young Song, Jeong Youp Park
Summary: This study aimed to explore the prognostic factors of pembrolizumab in patients with advanced biliary tract cancer (BTC) and provide treatment guidelines for patients who are refractory to gemcitabine-based chemotherapy. The results showed that high albumin levels and lymphocyte-to-monocyte ratio (LMR), as well as low alkaline phosphatase (ALP) levels and total bilirubin (TB), were significantly associated with better overall survival in patients treated with pembrolizumab.
Article
Medicine, General & Internal
Sung Yong Han, Sung Hee Park, Hyun Suk Ko, Aelee Jang, Hyung Il Seo, So Jeong Lee, Gwang Ha Kim, Dong Uk Kim
Summary: The study evaluated the diagnostic efficacy and prognostic value of vimentin-positive circulating tumor cells (V-CTCs) in patients with biliary tract cancer (BTC). Results showed significant differences in V-CTC count and ratio between BTC and benign biliary disease (BBD), and combining these parameters improved accuracy. V-CTC count > 50/mL blood was a significant factor affecting survival, suggesting its potential as a biomarker for early diagnosis and prognosis prediction in BTC patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Troels D. Christensen, Christina Jensen, Ole Larsen, Bonna Leerhoy, Carsten P. Hansen, Kasper Madsen, Dan Hogdall, Morten A. Karsdal, Inna M. Chen, Dorte Nielsen, Julia S. Johansen, Nicholas Willumsen
Summary: Collagen remodeling is increased in patients with biliary tract cancer (BTC) and is associated with survival. The pro-peptides of collagen (PRO-C3 and PRO-C6) could be used as novel biomarkers for these patients.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Simone Conci, Tommaso Campagnaro, Elisa Danese, Ezio Lombardo, Giulia Isa, Alessandro Vitali, Ivan Marchitelli, Fabio Bagante, Corrado Pedrazzani, Mario De Bellis, Andrea Ciangherotti, Alfredo Guglielmi, Giuseppe Lippi, Andrea Ruzzenente
Summary: This study evaluated the prognostic performance of different inflammatory and immune-nutritional markers in patients undergoing surgery for biliary tract cancer (BTC). The results showed that LMR is an independent prognostic factor for long-term survival, while PNI is associated with higher risk of postoperative mortality.
Article
Oncology
Lejia Sun, Yuxi Wei, Yang Chen, Wenmo Hu, Xin Ji, Haifeng Xu, Shunda Du, Haitao Zhao, Xin Lu, Xinting Sang, Shouxian Zhong, Huayu Yang, Yilei Mao
Summary: This study aimed to evaluate the prognostic value of platelet-related indices in predicting overall survival in patients with biliary tract cancer (BTC) and to establish a new prognostic model. The results showed that MPV and PDW/PCT had high prognostic accuracy, and the new staging system based on these indices demonstrated better discriminative power compared with the traditional TNM staging system.
CANCER RESEARCH AND TREATMENT
(2021)
Article
Medicine, Research & Experimental
Lejia Sun, Ai Guan, Yukai Jin, Meixi Liu, Yao Xiao, Haifeng Xu, Shunda Du, Haitao Zhao, Xin Lu, Xinting Sang, Shouxian Zhong, Huayu Yang, Yilei Mao
Summary: The study compared and evaluated the clinical value of red blood cell-related parameters in predicting prognosis of biliary tract cancer patients. The combination parameter including HALP was identified as a superior predictor and an independent factor for overall survival prediction. The developed nomogram based on HALP, tumor-node-metastasis staging, and operative outcome showed promising results in predicting overall survival.
ADVANCES IN THERAPY
(2021)
Article
Oncology
Hyung-Don Kim, Jwa Hoon Kim, Yeon-Mi Ryu, Danbee Kim, Sunmin Lee, Jaehoon Shin, Seung-Mo Hong, Ki-Hun Kim, Dong-Hwan Jung, Gi Won Song, Dae Wook Hwang, Jae Hoon Lee, Ki Byung Song, Baek-Yeol Ryoo, Jae Ho Jeong, Kyu-pyo Kim, Sang-Yeob Kim, Changhoon Yoo
Summary: The density of T cell subsets, including CD8(+) T cells and different types of CD4(+) T cells, is higher in the tumor margin compared to the stroma and tumor core in biliary tract cancer patients treated with gemcitabine plus cisplatin. A high density of FoxP3(-) CD4(+) helper T cells in the tumor margin may be associated with better clinical outcomes.
CANCER RESEARCH AND TREATMENT
(2021)
Article
Oncology
Hirotoshi Takayama, Shogo Kobayashi, Kunihito Gotoh, Kazuki Sasaki, Yoshifumi Iwagami, Daisaku Yamada, Yoshito Tomimaru, Hirofumi Akita, Tadafumi Asaoka, Takehiro Noda, Hiroshi Wada, Hidenori Takahashi, Masahiro Tanemura, Yuichiro Doki, Hidetoshi Eguchi
Summary: In biliary tract cancer, the expression of SPARC at the invasion front is higher and associated with poor prognosis. CTGF can activate SPARC expression in the tumor stroma, promoting tumor progression. After NAC-RT, the expression of SPARC at the invasion front significantly decreases and can serve as a predictor of prognosis.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Sun-ju Byeon, Mee Soo Chang, Hwa Jin Cho, Jeong Hwan Park, Ki Hwan Kim, Jin Hyun Park, In Sil Choi, Won Kim, Dong-Seok Han, Hye Seong Ahn, Seung Chul Heo
Summary: The expression of PD-L1 and leptin in biliary tract cancers is associated with prognosis, which may depend on tumor protein expression and anatomical site.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Cell Biology
Sabina Sanegre, Nuria Eritja, Carlos de Andrea, Juan Diaz-Martin, Angel Diaz-Lagares, Maria Amalia Jacome, Carmen Salguero-Aranda, David Garcia Ros, Ben Davidson, Rafel Lopez, Ignacio Melero, Samuel Navarro, Santiago Ramon Y Cajal, Enrique de Alava, Xavier Matias-Guiu, Rosa Noguera
Summary: The invasive tumor front is crucial for malignant cell progression and metastasis, with interactions between tumor cells and host cells determining the fate of the tumor. While similarities were found between uterine adenocarcinomas and leiomyosarcomas at the invasive front, differences were also observed in immune cell populations, gene expression, and methylation signatures. Further research on the molecular and architectural characterization of invasive front in uterine malignancies could provide additional prognostic information.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Medicine, General & Internal
Salma Naheed, Chloe Holden, Lulu Tanno, Linda Pattini, Neil W. Pearce, Bryan Green, Eleanor Jaynes, Judith Cave, Christian H. Ottensmeier, Giuseppe Pelosi
Summary: The objective of this study was to evaluate the prognostic biomarker Ki-67 in lung NENs. Through a systematic review and meta-analysis, the results showed that a high Ki-67 labeling index is associated with poor clinical outcomes in pulmonary NENs.
Article
Oncology
Masashi Utsumi, Koji Kitada, Naoyuki Tokunaga, Yusuke Yoshida, Toru Narusaka, Ryosuke Hamano, Hideaki Miyasou, Yousuke Tsunemitsu, Shinya Otsuka, Masaru Inagaki
Summary: The study confirmed that high JmGPS is an independent prognostic predictor for BTC patients after surgical resection, and it is superior to other prognostic scores.
ANTICANCER RESEARCH
(2021)
Article
Oncology
Zaishang Li, Xueying Li, Ying Liu, Jiequn Fang, Xueqi Zhang, Kefeng Xiao
Summary: The study found that, in surgically treated invasive upper tract urothelial carcinoma (UTUC) patients, stage IV patients can be stratified into different risk groups based on metastasis or grade, thereby increasing the level of prognostic detail and individualizing survival prediction.
Article
Gastroenterology & Hepatology
Yusuke Nakayama, Motokazu Sugimoto, Tatsushi Kobayashi, Naoto Gotohda, Shinichiro Takahashi, Masahiko Kusumoto, Masaru Konishi
Article
Chemistry, Multidisciplinary
John D. Martin, Myrofora Panagi, Chenyu Wang, Thahomina T. Khan, Margaret R. Martin, Chrysovalantis Voutouri, Kazuko Toh, Panagiotis Papageorgis, Fotios Mpekris, Christiana Polydorou, Genichiro Ishii, Shinichiro Takahashi, Naoto Gotohda, Toshiyuki Suzuki, Matthew E. Wilhelm, Vinicio Alejandro Melo, Sabina Quader, Jumpei Norimatsu, Ryan M. Lanning, Motohiro Kojima, Matthew David Stuber, Triantafyllos Stylianopoulos, Kazunori Kataoka, Horacio Cabral
Article
Gastroenterology & Hepatology
Motokazu Sugimoto, Michael L. Kendrick, Michael B. Farnell, Shogo Nomura, Naoki Takahashi, Tatsushi Kobayashi, Shin Kobayashi, Shinichiro Takahashi, Masaru Konishi, Naoto Gotohda
Article
Oncology
Yasuhiro Shimizu, Shoichi Mizuno, Norihiro Fujinami, Toshihiro Suzuki, Keigo Saito, Masaru Konishi, Shinichiro Takahashi, Naoto Gotohda, Toshifumi Tada, Hidenori Toyoda, Takashi Kumada, Masahiro Miura, Kouzou Suto, Taiki Yamaji, Takahisa Matsuda, Itaru Endo, Tetsuya Nakatsura
Article
Medicine, Research & Experimental
Motohiro Kojima, Chisako Yamauchi, Shunsuke Oyamada, Takashi Hojo, Satoru Iwase, Atsushi Naito, Kazuhiko Yamano, Shinichiro Takahashi, Atsushi Ochiai
LYMPHATIC RESEARCH AND BIOLOGY
(2020)
Article
Multidisciplinary Sciences
Satoshi Okubo, Motohiro Kojima, Yoko Matsuda, Masayoshi Hioki, Yasuhiro Shimizu, Hirochika Toyama, Soichiro Morinaga, Naoto Gotohda, Katsuhiko Uesaka, Genichiro Ishii, Mari Mino-Kenudson, Shinichiro Takahashi
SCIENTIFIC REPORTS
(2019)
Article
Gastroenterology & Hepatology
Daigoro Takahashi, Motohiro Kojima, Ryo Morisue, Motokazu Sugimoto, Shin Kobayashi, Shinichiro Takahashi, Masaru Konishi, Naoto Gotohda, Masafumi Ikeda, Atsushi Ochiai
Editorial Material
Oncology
Shin Kobayashi, Shinichiro Takahashi, Takayuki Yoshino, Hiroya Taniguchi
ANNALS OF SURGICAL ONCOLOGY
(2020)
Article
Oncology
Shin Kobayashi, Shinichiro Takahashi, Naoki Takahashi, Toshiki Masuishi, Hirokazu Shoji, Eiji Shinozaki, Tatsuro Yamaguchi, Motohiro Kojima, Naoto Gotohda, Shogo Nomura, Takayuki Yoshino, Hiroya Taniguchi
ANNALS OF SURGICAL ONCOLOGY
(2020)
Article
Surgery
Shinichiro Takahashi, Izumi Ohno, Masafumi Ikeda, Masaru Konishi, Tatsushi Kobayashi, Tetsuo Akimoto, Motohiro Kojima, Soichiro Morinaga, Hirochika Toyama, Yasuhiro Shimizu, Atsushi Miyamoto, Moriaki Tomikawa, Norihisa Takakura, Wataru Takayama, Satoshi Hirano, Takehito Otsubo, Masato Nagino, Wataru Kimura, Keishi Sugimachi, Katsuhiko Uesaka
Summary: This study evaluated the effectiveness of neoadjuvant chemoradiotherapy (CRT) with S-1 in patients with locally advanced pancreatic cancer (BRPC). The results showed that S-1 and concurrent radiotherapy can effectively increase the R0 resection rate and improve survival in BRPC patients.
Article
Multidisciplinary Sciences
Yoko Matsuda, Satoshi Ohkubo, Yuko Nakano-Narusawa, Yuki Fukumura, Kenichi Hirabayashi, Hiroshi Yamaguchi, Yatsuka Sahara, Aya Kawanishi, Shinichiro Takahashi, Tomio Arai, Motohiro Kojima, Mari Mino-Kenudson
SCIENTIFIC REPORTS
(2020)
Article
Oncology
Sho Yasuta, Tatsushi Kobayashi, Hidetoshi Aizawa, Shinichiro Takahashi, Masafumi Ikeda, Masaru Konishi, Motohiro Kojima, Hirofumi Kuno, Katsuhiko Uesaka, Soichiro Morinaga, Atsushi Miyamoto, Hirochika Toyama, Norihisa Takakura, Keishi Sugimachi, Wataru Takayama
Article
Gastroenterology & Hepatology
Masashi Kudo, Tatsushi Kobayashi, Naoto Gotohda, Masaru Konishi, Shinichiro Takahashi, Shin Kobayashi, Motokazu Sugimoto, Satoshi Okubo, John Martin, Horacio Cabral, Genichiro Ishii, Motohiro Kojima
Article
Gastroenterology & Hepatology
Motokazu Sugimoto, Tatsushi Kobayashi, Shin Kobayashi, Shinichiro Takahashi, Masaru Konishi, Shuichi Mitsunaga, Masafumi Ikeda, Naoto Gotohda
Article
Immunology
Kumiko Umemoto, Yosuke Togashi, Yasuhito Arai, Hiromi Nakamura, Shinichiro Takahashi, Tokiyoshi Tanegashima, Mikiya Kato, Tsubasa Nishikawa, Daisuke Sugiyama, Motohiro Kojima, Naoto Gotohda, Takeshi Kuwata, Masafumi Ikeda, Tatsuhiro Shibata, Hiroyoshi Nishikawa
INTERNATIONAL IMMUNOLOGY
(2020)
