Journal
JOURNAL OF STATISTICAL SOFTWARE
Volume 84, Issue 2, Pages 1-26Publisher
JOURNAL STATISTICAL SOFTWARE
DOI: 10.18637/jss.v084.i02
Keywords
effect size; proportional hazards model; R package; survival analysis; weighted estimation
Funding
- European Union [HEALTH F2-2009-241544]
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Cox's regression model for the analysis of survival data relies on the proportional hazards assumption. However, this assumption is often violated in practice and as a consequence the average relative risk may be under-or overestimated. Weighted estimation of Cox regression is a parsimonious alternative which supplies well interpretable average effects also in case of non-proportional hazards. We provide the R package coxphw implementing weighted Cox regression. By means of two biomedical examples appropriate analyses in the presence of non-proportional hazards are exemplified and advantages of weighted Cox regression are discussed. Moreover, using package coxphw, time-dependent effects can be conveniently estimated by including interactions of covariates with arbitrary functions of time.
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