Article
Obstetrics & Gynecology
E. Nilsson-Condori, K. Mattsson, A. Thurin-Kjellberg, J. L. Hedenbro, B. Friberg
Summary: Previous bariatric surgery does not significantly affect the cumulative live birth rate in IVF, despite a lower number of retrieved oocytes and frozen embryos in the surgery group, as well as a lower birth weight in children born to mothers with previous surgery.
HUMAN REPRODUCTION
(2022)
Article
Medicine, General & Internal
Marta Ciaffaglione, Marco Reschini, Martina Balli, Cristina Guarneri, Maria Carla Palermo, Monica Pinna, Valerio Pisaturo, Edgardo Somigliana, Alessio Paffoni, Paola Vigano
Summary: This study demonstrates that different post-thaw embryo culture timings do not negatively affect pregnancy outcomes. These findings are important in organizing the workflow in embryological laboratories.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Martina Balli, Anna Cecchele, Valerio Pisaturo, Sofia Makieva, Giorgia Carullo, Edgardo Somigliana, Alessio Paffoni, Paola Vigano'
Summary: This article reviews the advantages and limitations of conventional IVF and discusses fundamental questions related to the technique. It provides insights into the opportunities and best practices in human c-IVF in the field of reproductive medicine.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Salvatore Giovanni Vitale, Federico Ferrari, Michal Ciebiera, Magdalena Zgliczynska, Agnese Maria Chiara Rapisarda, Giada Maria Vecchio, Alessandra Pino, Giuseppe Angelico, Anna Knafel, Gaetano Riemma, Pasquale De Franciscis, Stefano Cianci
Summary: The human microbiome plays a crucial role in determining the health status of every human being. The microbiome of the genital tract affects infertility, with Lactobacillus-dominated flora playing a key role in determining fertility. The presence of pathogens also affects fertility, including cases of asymptomatic bacterial vaginosis. There is limited research on the tubal microbiome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Obstetrics & Gynecology
Akanksha Garg, Laura Burney Ellis, Ryan Laurence Love, Karen Grewal, Sarah Bowden, Phillip R. Bennett, Maria Kyrgiou
Summary: The vaginal microbiota has been found to affect a number of reproductive outcomes. Obesity, a global epidemic, has been shown to be a risk factor for adverse female health outcomes. A healthy vaginal microbiome is dominated by Lactobacillus crispatus, but obesity is associated with higher diversity and lower dominance of Lactobacillus. This review summarizes the evidence on the vaginal microbiome in obese women and its impact on reproductive outcomes, as well as explores the mechanisms by which obesity alters microbial composition and suggests potential therapeutic targets for the vaginal microbiota.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2023)
Article
Obstetrics & Gynecology
Stefania Antonia Noli, Stefania Ferrari, Elena Ricci, Marco Reschini, Sonia Cipriani, Chiara Dallagiovanna, Fabio Parazzini, Edgardo Somigliana
Summary: This study examined whether adherence to a Mediterranean diet before conception can affect the rate of poor response to ovarian stimulation in IVF cycles. The results showed that women with higher adherence to the Mediterranean diet had a lower risk of unexpected poor ovarian response.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Article
Obstetrics & Gynecology
Julia Kim, George Patounakis, Caroline Juneau, Scott Morin, Shelby Neal, Paul Bergh, Emre Seli, Richard Scott
Summary: Maternal obesity was found to have some impact on IVF outcomes, with increased risk of very low birth weight infants, but most embryology and pregnancy outcomes were equivalent to normal weight patients. Paternal obesity did not appear to affect IVF, pregnancy, or delivery outcomes.
FERTILITY AND STERILITY
(2021)
Review
Environmental Sciences
Mark P. Green, Alexandra J. Harvey, Bethany J. Finger, Gerard A. Tarulli
Summary: The study aims to review the effects of environmentally-relevant EDC concentrations on adult male and female fertility, with substantial evidence supporting a negative association between exposure to certain EDCs and male fertility. Moderate evidence exists for a negative association between specific EDCs and female fertility. There is a lack of data for both sexes for all major EDC classes, indicating the need for more research in this area to understand the impact on human fertility.
ENVIRONMENTAL RESEARCH
(2021)
Review
Endocrinology & Metabolism
Guannan Zhou, Yuanyuan Gu, Fangyue Zhou, Menglei Zhang, Ganrong Zhang, Ligang Wu, Keqin Hua, Jingxin Ding
Summary: Infertility is on the rise, and extracellular vesicles may play a crucial role in reproductive health, though the specific mechanism requires further investigation.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Li Ge, Yexing Li, Shengnan Guan, Linlin Cui, Zi-Jiang Chen
Summary: This study evaluated the effects of different ovarian stimulation protocols on IVF/ICSI outcomes in infertile women with adenomyosis. The results showed that in fresh ET cycles, the short protocol had significantly lower implantation rate and clinical pregnancy rate compared to ultra-long and long protocols. In FET cycles, the origin of embryos did not affect pregnancy outcomes.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
Piotr S. Gromski, Rajendra Sadashiv Patil, Shruti Mahesh Chougule, Deepali Atul Bhomkar, Padma Rekha Jirge, Scott M. Nelson
Summary: The study found that healthy Indian women have significantly lower levels of anti-Mullerian hormone (AMH) compared to European women, and this difference increases with age. Furthermore, different causes of infertility have varying effects on AMH levels in infertile Indian women compared to healthy controls.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Obstetrics & Gynecology
Dalila Invernici, Marco Reschini, Laura Benaglia, Edgardo Somigliana, Giulia Galati, Irene La Vecchia, Paola Vigano', Paolo Vercellini
Summary: This study found that endometriosis does not significantly affect the success of IVF, except for an increased risk of unexpected poor response.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Editorial Material
Obstetrics & Gynecology
Roy Homburg
Summary: The treatment options for unexplained infertility include expectant management, ovarian stimulation, intrauterine insemination (IUI) with or without ovarian stimulation, or IVF. When considering live births, a realistic choice between IUI with ovarian stimulation using low-dose gonadotrophins with strict cancellation criteria versus IVF is presented. Several studies have shown that three cycles of IUI can be as successful as one cycle of IVF. IUI is recommended as the first-line treatment for unexplained infertility due to its lower invasiveness, cost, patient comfort, and high compliance rate, especially for couples where the woman is under 38 years old.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Obstetrics & Gynecology
Mats Brannstrom, Pernilla Dahm-Kahler, Niclas Kvarnstrom, Anders Enskog, Jan I. Olofsson, Michael Olausson, Johan Molne, Randa Akouri, Stina Jarvholm, Lars Nilsson, Lennart Stigson, Henrik Hagberg, Hans Bokstrom
Summary: The first completed study of uterus transplantation (UTx) demonstrates that it is an effective treatment for infertility, resulting in the birth of healthy children and having only minor psychological and medical long-term effects on donors and recipients.
FERTILITY AND STERILITY
(2022)
Article
Obstetrics & Gynecology
Emanuele Garzia, Valentina Galiano, Jennifer Riparini, Patrizia Sulpizio
Summary: This case study describes a rare complication of unilateral massive hydrothorax after controlled ovarian stimulation for IVF in a patient lacking typical features and risk factors of OHSS. Treatment involved pleural drainage, hydration, albumin perfusion, and management of the intercurrent pregnancy, leading to improvement in clinical and hematological parameters. A high index of suspicion is necessary for prompt diagnosis and treatment in such cases.
REPRODUCTIVE SCIENCES
(2021)