Article
Oncology
Erica Schleicher, Edward McAuley, Kerry S. Courneya, Phillip Anton, Diane K. Ehlers, Siobhan M. Phillips, Robert A. Oster, Dorothy Pekmezi, Laura Q. Rogers
Summary: This study investigated moderators of response to a physical activity behavior change intervention for breast cancer survivors. The results showed that breast cancer survivors who received chemotherapy, were within 2 years of diagnosis, and were single were less likely to achieve moderate-to-vigorous physical activity of 150+ weekly minutes. Further research is needed to determine additional support and resources that may benefit these subgroups of breast cancer survivors.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Psychology, Multidisciplinary
Andela Dosic, Danijela Zivkovic, Zoran Milanovic, Mladen ivkovic, Ljiljana Bjelakovic, Marija Bratic, Sasa Pantelic
Summary: The study aims to investigate the relationship between physical activity level, BMI, and quality of life. Results indicate that high- and moderate-intensity physical activity benefit physical health, with moderate PA showing higher significance levels. Additionally, elderly women with higher BMI values achieve better results in the environmental domain of quality of life.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Multidisciplinary Sciences
Glen E. Duncan, Ally Avery, Jennifer L. M. Thorson, Eric E. Nilsson, Daniel Beck, Michael K. Skinner
Summary: An epigenome-wide association study on monozygotic twins revealed that physical activity can promote systemic epigenetic alterations and impact metabolic risk factors. The study analyzed differences in body mass index, physical activity levels, and neighborhood walkability between twin pairs and identified DNA methylation alterations associated with reduced metabolic parameters. The study also identified genes related to vigorous physical activity, metabolic risk factors, and sex.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Michael J. Leach, Georgina Barber, Stephanie Monacella, Philip Jamieson, Thi Trinh, Ngan Vo, Ulla Schmidt, Anny Byrne, Eli Ristevski
Summary: The purpose of this study was to investigate the relationship between physical activity (PA), obesity, and quality of life (QoL) among rural Australian cancer survivors. The study found that sufficient PA was associated with better QoL and more energy, while obesity was associated with worse QoL and more pain. The interaction between PA and obesity on QoL was not significant.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Oncology
Shana J. Kim, Jan Lubinski, Tomasz Huzarski, Pal Moller, Susan Armel, Beth Y. Karlan, Leigha Senter, Andrea Eisen, William D. Foulkes, Christian F. Singer, Nadine Tung, Louise Bordeleau, Susan L. Neuhausen, Olufunmilayo Olopade, Charis Eng, Jeffrey N. Weitzel, Robert Fruscio, Steven A. Narod, Joanne Kotsopoulos
Summary: Weight gain of more than 20 kg since age 18 is associated with an increased risk of ovarian cancer in BRCA1 or BRCA2 mutation carriers, while a current BMI of 26.5 kg/m(2) or greater is linked to an elevated risk of ovarian cancer in BRCA1 mutation carriers. There were no significant associations between height or BMI at age 18 and risk of ovarian cancer.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2021)
Article
Oncology
Ashley E. Stenzel, Lauren Thomaier, Patricia I. Jewett, Allison C. Dona, Katherine Brown, Rachael Gotlieb, Anne Blaes, Deanna Teoh, Rachel I. Vogel
Summary: This study examined the association between meeting the American Cancer Society's physical activity recommendations and psychosocial outcomes in gynecologic cancer survivors. The results showed that gynecologic cancer survivors who received chemotherapy had a stronger association between physical activity and depression, anxiety, and quality of life. No significant associations were found for those who received radiation therapy or minimally invasive surgery.
GYNECOLOGIC ONCOLOGY
(2022)
Review
Oncology
Sylvia L. Crowder, Acadia W. Buro, Marilyn Stern
Summary: This study summarized the effectiveness of physical activity interventions on physical functioning, body composition, and quality of life in pediatric, adolescent, and young adult cancer survivors. Results showed mixed improvements in physical activity behaviors, with future research needed to explore interventions specifically for young adult cancer survivors. Personalized physical activity components and behavior change techniques should be emphasized to maximize physical health and quality of life improvements.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Nutrition & Dietetics
Sousana K. K. Papadopoulou, Maria Mantzorou, Gavriela Voulgaridou, Eleni Pavlidou, Konstantinos Vadikolias, Georgios Antasouras, Theofanis Vorvolakos, Evmorfia Psara, Georgios K. K. Vasios, Aspasia Serdari, Efthymios Poulios, Constantinos Giaginis
Summary: This study explores the associations between nutritional status and health-related quality of life, physical activity, and sleep quality in older exclusively Caucasian adults from Greec. The results show that a better nutritional status is significantly and independently associated with higher physical activity levels, better quality of life, and better sleep quality. Further intervention studies are needed to clarify the associations and test the feasibility of improving the nutritional status, physical activity levels, and sleep quality of the elderly.
Article
Green & Sustainable Science & Technology
N. Z. M. Saat, Siti Aishah Hanawi, Nor M. F. Farah, Hazilah Mohd Amin, Hazlenah Hanafiah, Thavamalar Selvaraj
Summary: The study found that physical activity levels in young university students are associated with sleep quality, waist circumference, and blood pressure. Some students engage in moderate to vigorous physical exercise, but the average sleep quality is low. Waist circumference has significant relationships with body mass index, blood pressure, and there is a need to encourage regular and sustainable participation in physical activity among this population.
Article
Oncology
Xiaomeng Zhang, Evropi Theodoratou, Xue Li, Susan M. Farrington, Philip J. Law, Peter Broderick, Marion Walker, Yann C. Klimentidis, Jessica M. B. Rees, Richard S. Houlston, Ian P. M. Tomlinson, Stephen Burgess, Harry Campbell, Malcolm G. Dunlop, Maria Timofeeva
Summary: Genetically represented measures of moderate-to-vigorous physical activity and acceleration vector magnitude physical activity are associated with decreased colorectal cancer risk, with effects distinct from those mediated through genetic measures of obesity, indicating the positive impact of promoting physical activity on colorectal cancer prevention.
BRITISH JOURNAL OF CANCER
(2021)
Article
Oncology
K. E. Dibble, K. M. Bellizzi, P. Taxel, L. S. Pescatello, E. J. Siembida, E. D. Schifano, S. Guarneri, S. Tannenbaum
Summary: The study examined the impact of physical activity on health-related quality of life in postmenopausal women with breast cancer. The results showed that a proportion of women in the sample met physical activity recommendations, but there were no significant relationships between physical activity and health-related quality of life.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Oncology
Mary C. Hidde, Kate Lyden, Kim Henry, Heather J. Leach
Summary: This study examined the effects of reallocating time between physical activity, sedentary time, and sleep on quality of life in cancer survivors. The findings suggest that changes in 30 minutes of these activities may not impact quality of life among survivors achieving adequate levels of physical activity and sleep. Future research should aim to recruit a larger, more representative sample and explore the role of bouted activity time.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Environmental Sciences
Brenda Gamboa-Loira, Mariano E. Cebrian, Lizbeth Lopez-Carrillo
Summary: This study confirmed the relationship between body mass index (BMI) and inorganic arsenic (iAs) metabolism parameters, as well as provided new evidence on the association between physical activity and iAs metabolism. These associations were independent of the effect of BMI.
ENVIRONMENTAL RESEARCH
(2021)
Article
Oncology
Chiara Papini, Ameera A. Fayad, Mingjuan Wang, Fiona S. M. Schulte, I-Chan Huang, Yu-Ping Chang, Rebecca M. Howell, Deokumar Srivastava, Wendy M. Leisenring, Gregory T. Armstrong, Todd M. Gibson, Leslie L. Robison, Kevin C. Oeffinger, Kevin R. Krull, Tara M. Brinkman
Summary: Young adult survivors of childhood cancer have an increased risk of loneliness, which can lead to physical and mental health issues in the future.
Article
Psychology, Multidisciplinary
Linda Cole, Julie Easley, Leslie Grightmire, Ellil Mathiyan Lakshmanan, Sharon J. Matthias, Karen McBoyle, Emily Piercell, Amelia Purdy, Nancy Schneider, Richard J. Wassersug, Rosemary Martino, Margaret I. Fitch
Summary: The perspectives of cancer survivors offer valuable insights into the experiences of being diagnosed and treated for cancer, highlighting the importance of communication and support in providing person-centered cancer care.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Oncology
Lisanne Verhoef, Maaike C. G. Bleeker, Nicole Polman, Renske D. M. Steenbergen, Chris J. L. M. Meijer, Willem J. G. Melchers, Ruud L. Bekkers, Anco C. Molijn, Wim G. Quint, Folkert J. van Kemenade, Johannes Berkhof, Danielle A. M. Heideman
Summary: This study validated individual host-cell DNA methylation classifiers and the bi-marker panel ASCL1/LHX8 for the detection of CIN3+ in high-risk HPV-positive women invited for routine screening, showing promising clinical utility.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Medicine, General & Internal
Caroline L. P. Muntinga, Peggy J. de Vos van Steenwijk, Ruud L. M. Bekkers, Edith M. G. van Esch
Summary: This review outlines the changes in the immune microenvironment in cervical high-grade squamous intraepithelial lesions (cHSILs) and discusses the impact of spontaneous regression, persistence, and immunotherapy on this immune microenvironment.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Mieke L. G. Ten Eikelder, Floor Hinten, Anke Smits, Maaike A. Van der Aa, Ruud L. M. Bekkers, Joanna IntHout, Hans H. B. Wenzel, Petra L. M. Zusterzeel
Summary: The introduction of the revised FIGO 2018 staging system for cervical cancer has improved the accuracy of predicting survival outcomes for early stage patients. In addition to stage, factors such as LVSI and invasion depth should be considered in treatment decisions. The FIGO 2018 staging system accurately reflects prognosis and allows for better prognostic differentiation.
Article
Endocrinology & Metabolism
Renata Germano Borges de Oliveira Nascimento Freitas, Ana Carolina Junqueira Vasques, Francieli Barreiro Ribeiro, Isabela Solar, Alfredo Shigueo Hanada, Marina Gomes Barbosa, Angelica Marques Martins Valente, Bianca de Almeida Pititto, Ilana Eshriqui, Tito Livio da Cunha Lopes, Bruno Geloneze, Sandra Roberta Gouvea Ferreira
Summary: The intrauterine environment and gestational weight gain could influence offspring's body composition, including lean mass, adiposity, and fat distribution. Maternal preconception BMI was associated with offspring's lean mass, adiposity, and overall fat mass, while gestational weight gain was associated with offspring's body mass index and fat distribution.
ARCHIVES OF ENDOCRINOLOGY METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Anderson Franca da Silva, Josivan Regis Farias, Danielle Cristine Gomes Franco, Andrea Araruna Galiza, Elizangela Pestana Motta, Aluisio da Silva Oliveira, Cleydlenne Costa Vasconcelos, Maria do Socorro de Sousa Cartagenes, Claudia Quintino da Rocha, Mayara Cristina Pinto da Silva, Alberto Jorge Oliveira Lopes, Flavia Raquel Fernandes do Nascimento, Cristina Andrade Monteiro, Rosane Nassar Meireles Guerra
Summary: This study investigated the antifungal activity of ononin using in silico and in vitro assays as well as an alternative in vivo model. The results suggested that ononin has anti-Candida albicans activity and could be a potential candidate for new therapeutic alternatives.
Article
Chemistry, Medicinal
Alberto Jorge Oliveira Lopes, Gustavo Pereira Calado, Yuri Nascimento Froes, Sandra Alves de Araujo, Lucas Martins Franca, Antonio Marcus de Andrade Paes, Sebastiao Vieira de Morais, Claudia Quintino da Rocha, Cleydlenne Costa Vasconcelos
Summary: This study computationally evaluated 55 plant compounds for their potential in inhibiting the interaction between SARS-CoV-2 Spro and human ACE-2. The results indicated that certain plant compounds showed strong electronic interaction with the targets, but their ability to inhibit the interaction between Spro and ACE-2 was limited. Therefore, these plant metabolites still need to be considered in the research of therapeutic agents for COVID-19 treatment.
Article
Orthopedics
M. Graca Pereira, Susana Pedras, Andre Louro, Alberto Lopes, Margarida Vilaca
Summary: This study aimed to assess the impact of stress reduction interventions on chronic diabetic foot ulcers and psychological wellbeing according to the perceptions of patients and their family caregivers. The interventions included progressive muscle relaxation and hypnosis sessions. The results showed that both patients and caregivers reported positive effects of the interventions on DFU healing and emotional wellbeing.
JOURNAL OF FOOT AND ANKLE RESEARCH
(2023)
Article
Oncology
Lara C. C. Burg, Roy F. P. M. Kruitwagen, Annemarie de Jong, Johan Bulten, Tijmen J. J. Bonestroo, Arjan A. A. Kraayenbrink, Dorry Boll, Sandrina Lambrechts, Huberdina P. M. Smedts, Annechien Bouman, Mirjam J. A. Engelen, Jenneke C. Kasius, Ruud L. M. Bekkers, Petra L. M. Zusterzeel
Summary: This study aims to investigate the incidence of sentinel lymph node (SLN) metastases and the contribution of SLN mapping in the management of presumed low- and intermediate-risk endometrial cancer (EC). A total of 152 patients were enrolled, with overall and bilateral SLN detection rates of 91% and 61%, respectively. The final results showed that SLN metastases were present in 11.2% of patients, and 5.9% of patients had adjuvant radiotherapy based on SLN metastases. The study emphasizes the importance of SLN mapping in presumed early-stage, grade 1 and 2 EC.
Article
Oncology
Anke Smits, Khadra Galaal, Steve Winnan, Alberto Lopes, Ruud L. M. Bekkers
Summary: This study investigated the impact of an individualized exercise program on the quality of life and other health outcomes in endometrial cancer patients. The results demonstrated that the individualized one-to-one exercise intervention is feasible in terms of recruitment, adherence, and safety, and it significantly improved the patients' quality of life, weight, and physical fitness.
Article
Infectious Diseases
Elizangela Pestana Motta, Josivan Regis Farias, Arthur Andre Castro da Costa, Anderson Franca da Silva, Alberto Jorge Oliveira Lopes, Maria do Socorro Sousa Cartagenes, Roberto Nicolete, Afonso Gomes Abreu, Elizabeth Soares Fernandes, Flavia Raquel Fernandes Nascimento, Claudia Quintino da Rocha, Cristina Andrade Monteiro, Rosane Nassar Meireles Guerra
Summary: This study evaluated the anti-Candida activity of the hydroalcoholic extract from the leaves of Vismia guianensis and found that it inhibited the virulence factors of the fungi. The main compound responsible for this activity was identified as vismione D.
Article
Oncology
Lisanne Verhoef, Maaike C. G. Bleeker, Nicole Polman, Renske D. M. Steenbergen, Renee M. F. Ebisch, Willem J. G. Melchers, Ruud L. M. Bekkers, Anco C. Molijn, Wim G. Quint, Folkert van Kemenade, Chris J. L. M. Meijer, Johannes Berkhof, Danielle A. M. Heideman
Summary: This study evaluated the use of DNA methylation analysis as a triage method for high-risk HPV-positive self-collected cervicovaginal samples in cervical cancer screening. The methylation markers ASCL1 and LHX8 showed a sensitivity of 73.3% and specificity of 61.1% for detecting CIN3+. Compared to clinician-collected samples, self-collected samples had a relative sensitivity of 0.95 and relative specificity of 0.82. Therefore, the ASCL1/LHX8 methylation marker panel is a feasible triage method for HPV-positive women participating in routine self-sampling.
BRITISH JOURNAL OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
Yuri Nascimento Froes, Joao Guilherme Nantes Araujo, Joyce Resende dos Santos Goncalves, Milena de Jesus Marinho Garcia de Oliveira, Gustavo Oliveira Everton, Victor Elias Mouchrek Filho, Maria Raimunda Chagas Silva, Luis Douglas Miranda Silva, Lucilene Amorim Silva, Lidio Goncalves Lima Neto, Renata Mondego de Oliveira, Mylena Andrea Oliveira Torres, Luis Claudio Nascimento da Silva, Alberto Jorge Oliveira Lopes, Amanda Silva dos Santos Alianca, Claudia Quintino da Rocha, Joicy Cortez de Sa Sousa
Summary: This study evaluated the antileishmanial activity of V. brasiliana leaves using in vitro and in silico approaches. The results showed that V. brasiliana had inhibitory activity against Leishmania and low cytotoxicity. Therefore, V. brasiliana and its metabolites may serve as potential lead compounds for leishmaniasis treatment.
Article
Multidisciplinary Sciences
Sharell Bas, Jasmijn Sijben, Erik W. M. A. Bischoff, Ruud L. M. G. Bekkers, Inge M. C. M. de Kok, Willem J. G. Melchers, Albert Siebers, Danielle van der Waal, Mireille J. M. Broeders
Summary: This qualitative study aimed to gain insights into the acceptability of risk-based triage in cervical cancer screening among women aged 30-60 years. The study identified several factors that influence the acceptability of risk-stratified triage, such as the adequacy of the screening program, personal information, emotional impact, communication, and autonomy.
Review
Oncology
Lara C. Burg, Shenna Verheijen, Ruud L. M. Bekkers, Joanna IntHout, Robert W. Holloway, Salih Taskin, Sarah E. Ferguson, Yu Xue, Antonino Ditto, Glauco Baiocchi, Andrea Papadia, Giorgio Bogani, Alessandro Buda, Roy F. P. M. Kruitwagen, Petra L. M. Zusterzeel
Summary: The use of indocyanine green in SLN mapping shows a high detection rate and negative predictive value in low- and intermediate-risk endometrial cancers, providing important clinical guidance for choosing appropriate treatment options.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2022)
