Article
Clinical Neurology
Laura L. Laslett, Cynthia Honan, Jason A. Turner, Baye Dagnew, Julie A. Campbell, Tiffany K. Gill, Sarah Appleton, Leigh Blizzard, Bruce Taylor, Ingrid van der Mei
Summary: Poor sleep quality is common in people with multiple sclerosis (MS), and strongly associated with worse health-related quality of life. This association is independent of other MS symptoms and does not cluster with other common MS symptoms.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Otorhinolaryngology
Mario Chueire de Andrade Junior, Renato Stefanini, Juliana Maria Gazzola, Fernanda Louise Martinho Haddad, Fernando Freitas Gananca
Summary: The study aims to assess the impact of sleep quality on balance and quality of life in individuals with peripheral vestibulopathies, revealing a correlation between poor sleep quality and worse balance, increased risk of falls, and lower perceived quality of life.
BRAZILIAN JOURNAL OF OTORHINOLARYNGOLOGY
(2021)
Article
Multidisciplinary Sciences
Hiromitsu Negoro, Kazuya Setoh, Arinobu Fukunaga, Takahisa Kawaguchi, Satoshi Funada, Takayuki Yoshino, Koji Yoshimura, Bryan J. Mathis, Yasuharu Tabara, Fumihiko Matsuda, Osamu Ogawa, Takashi Kobayashi
Summary: The study found that there is a positive association between nocturia and poor sleep. Among good sleep participants, those with baseline nocturia were more likely to develop poor sleep. Among non-nocturia participants, baseline poor sleep was associated with the incidence of nocturia, particularly in women and those below the age of 50.
SCIENTIFIC REPORTS
(2023)
Review
Psychiatry
Julia Nowowiejska, Anna Baran, Iwona Flisiak
Summary: Psoriasis is a chronic autoimmune skin disease affecting about 2-4% of the global population, leading to decreased quality of life for patients. The relationship between sleep disorders and the psychosocial status of patients with psoriasis is bidirectional, causing a vicious cycle of abnormality triggering each other.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Clinical Neurology
Yi-Lu Li, Dan Qiu, Cheng Hu, Fei-Yun Ouyang, Jun He, Di-Fan Zang, Dan Luo, Shui-Yuan Xiao
Summary: This study examined the association between stressful life events and sleep quality in Chinese governmental employees, revealing that negative life events and specific events were significantly linked to poor sleep quality.
Article
Ophthalmology
Jing Li, Shi-yao Zhang, Zixin Fan, Ren Liu, Ling Jin, Lingyi Liang
Summary: The study found that allergic conjunctivitis has a negative impact on the sleep quality of children and their parents. Children with AC experience difficulties in sleep onset, increased sleep disturbances, and daytime sleepiness. Parents also have reduced sleep duration, increased sleep disturbances, and daytime sleepiness. The findings highlight the importance of assessing sleep quality in pediatric patients with allergic conjunctivitis.
Review
Oncology
A. Josephine Drijver, Quirien Oort, Rene Otten, Jaap C. Reijneveld, Martin Klein
Summary: Poor sleep is associated with neurocognitive impairment in cancer survivors, and improving sleep quality can decrease neurocognitive impairment.
JOURNAL OF CANCER SURVIVORSHIP
(2022)
Article
Clinical Neurology
Samantha Mombelli, Anne-Sophie Deshaies-Rugama, Helene Blais, Zoran Sekerovic, Cynthia Thompson, Alex Desautels, Jacques Montplaisir, Milan Nigam, Julie Carrier, Nadia Gosselin
Summary: This study aimed to investigate whether patients with unrefreshing naps and patients with refreshing naps are two subtypes of idiopathic hypersomnia (IH) based on their demographic/clinical characteristics and sleep architecture. The results showed that patients reporting unrefreshing naps had less fragmented sleep compared to those reporting refreshing naps, with fewer awakenings, a lower percentage of N1 sleep, fewer sleep stage transitions, and a higher percentage of REM sleep on the nighttime PSG. This suggests that patients with refreshing naps experience more disrupted sleep. Further research is needed to understand whether this difference indicates a weaker arousal drive.
Article
Psychology, Clinical
Stina Oftedal, Anna T. Rayward, Sasha Fenton, Mitch J. Duncan
Summary: The study found associations between poor sleep health, poor diet quality, physical inactivity, and poor self-rated health. Reporting multiple high-risk behaviors was more strongly correlated with poor self-rated health. Improving multiple high-risk behaviors together may be more effective in preventing decline in self-rated health than focusing on a single behavior.
Article
Public, Environmental & Occupational Health
Chao Sun, Xiaojun Wang, Xuetong Huang, Yongcong Shao, Anna Ling, Huanhuan Qi, Zhuolin Zhang
Summary: This study explored the relationship between sleep disorders and relapse inclination in substance users, as well as the potential mediating mechanisms and corresponding interventions. The results showed that sleep disorders had a positive effect on relapse inclination, and quality of life mediated this relationship. Additionally, a 12-week Health Qigong intervention aimed at treating sleep disorders improved sleep quality and overall quality of life, leading to a reduction in relapse tendency.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Gastroenterology & Hepatology
Emanuela Miceli, Natascia Brondino, Marco Vincenzo Lenti, Michele Di Stefano, Martina Staiani, Francesca Zugnoni, Martina Pisati, Costanza Caccia Dominioni, Gino Roberto Corazza, Pierluigi Politi, Antonio Di Sabatino
Summary: The study found that patients with AAG have significantly lower quality of life compared to healthy controls, but similar to patients with organic gastrointestinal disorders. Physical functioning is the main factor affecting quality of life, and vitamin B12 supplementation may improve patients' perception of body functioning.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Review
Multidisciplinary Sciences
Amir Hossein Khoshakhlagh, Saleh Al Sulaie, Saeid Yazdanirad, Robin Marc Orr, Hossein Dehdarirad, Alireza Milajerdi
Summary: Lack of sleep can impact the health and performance of firefighters. A systematic review and meta-analysis revealed that the global prevalence of sleep disorders among firefighters is 30.49%, and the prevalence of poor sleep quality is 51.43%. Various factors such as shift work, mental health, injuries and pain, and body mass index are associated with sleep health in firefighters.
Article
Clinical Neurology
Melissa Gilbertson, Cele Richardson, Peter Eastwood, Andrew Wilson, Peter Jacoby, Helen Leonard, Jenny Downs
Summary: This study found that sleep quality in children with intellectual disabilities is mainly influenced by comorbidities, rather than functional impairments. Factors such as recurrent pain, frequent seizures, coughing, constipation and prescription sleep medications are associated with abnormal sleep, with differences in predictors between diagnostic groups.
JOURNAL OF SLEEP RESEARCH
(2021)
Article
Pediatrics
Pramod Samota, Aaradhana Singh, Anju Aggarwal, Rajeev Malhotra
Summary: Sleep disorders are common in children with cerebral palsy and have a negative impact on quality of life. Routine screening and appropriate treatment are recommended.
INDIAN JOURNAL OF PEDIATRICS
(2023)
Review
Dermatology
Caroline Mann, Surajit Gorai, Petra Staubach-Renz, Mohamad Goldust
Summary: Sleep is a crucial physiological process that significantly impacts a person's well-being. There is bidirectional influence between sleep and skin disorders, and sleep disturbances can worsen dermatological conditions. This article reviews the association between sleep disorders, dermatological conditions, and certain drugs used in dermatology. It emphasizes the importance of addressing sleep disorders as part of the management of skin diseases.
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2023)
Review
Clinical Neurology
J. J. Poza, M. Pujol, J. J. Ortega-Albas, O. Romero
Summary: This review focuses on the role of melatonin in regulating the sleep-wake cycle and its potential use as a treatment for insomnia. Despite the theoretical appeal, there is limited scientific evidence supporting the benefits of this therapy, and the optimal dosage and formulations for melatonin administration have not been clearly defined.
Article
Respiratory System
Juan F. Masa, Ivan D. Benitez, Maria A. Sanchez-Quiroga, Francisco J. Gomez de Terreros, Jaime Corral, Auxiliadora Romero, Candela Caballero-Eraso, Estrella Ordax-Carbajo, Maria F. Troncoso, Monica Gonzalez, Soledad Lopez-Martin, Jose M. Marin, Sergi Marti, Trinidad Diaz-Cambriles, Eusebi Chiner, Carlos Egea, Javier Barca, Francisco J. Vazquez-Polo, Miguel A. Negrin, Maria Martel-Escobar, Ferran Barbe, Babak Mokhlesi
Summary: This study aimed to determine if CPAP and NIV have similar effectiveness in treating ambulatory patients with OHS and concomitant severe OSA, based on the severity of baseline hypercapnia. The results showed that long-term NIV therapy was similar to CPAP in improving awake hypercapnia, regardless of the severity of baseline hypercapnia. Therefore, the decision to prescribe CPAP or NIV cannot be solely based on the presenting level of PaCO2 in this patient population.
ARCHIVOS DE BRONCONEUMOLOGIA
(2022)
Article
Clinical Neurology
Sergi Marti, Alex Ferre, Gabriel Sampol, Mercedes Pallero, Odile Romero, Jaume Ferrer, Julia Sampol
Summary: In patients treated with noninvasive ventilation, sleep-related breathing changes impact patient-ventilator interactions, leading to reduced effectiveness. Leaks, asynchronies, and upper airway obstructive events are more frequent during nighttime sleep periods, with potential clinical implications.
JOURNAL OF CLINICAL SLEEP MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Jesus Castro-Marrero, Joan Carles Domingo, Begona Cordobilla, Roser Ferrer, Marina Giralt, Ramon Sanmartin-Sentanes, Jose Alegre-Martin
Summary: This study suggests that combined CoQ10 and selenium supplementation may have beneficial effects in ME/CFS patients, significantly improving overall fatigue severity and quality of life, and reducing oxidative stress levels in circulation.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Letter
Pediatrics
Maria J. Jurado, Julia Sampol, Manuel Quintana, Odile Romero, Roser Cambrodi, Alex Ferre, Gabriel Sampol
PEDIATRIC PULMONOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Trinitat Cambras, Maria Fernanda Zeron-Rugerio, Antoni Diez-Noguera, Maria Cleofe Zaragoza, Joan Carles Domingo, Ramon Sanmartin-Sentanes, Jose Alegre-Martin, Jesus Castro-Marrero
Summary: This study explored the association between autonomic dysfunction, circadian rhythms, and endothelial dysfunction in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) patients. The results showed that ME/CFS patients had higher blood pressure and heart rate values, as well as a larger amplitude of the activity rhythm. Circulating levels of endothelin-1 (ET-1) and vascular cell adhesion molecule-1 (VCAM-1) were also significantly higher in ME/CFS patients. These findings suggest that dysautonomia and vascular tone abnormalities may play a role in ME/CFS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Roser Ayats-Vidal, Montserrat Bosque-Garcia, Begona Cordobilla, Oscar De la Cruz, Miguel Garcia-Gonzalez, Jesus Castro-Marrero, Irene Lopez-Rico, Joan Carles Domingo
Summary: This study characterized the fatty acid profiles in the erythrocyte membrane of pediatric patients with cystic fibrosis (CF) receiving high-dose DHA supplementation. It found that DHA supplementation improved n-3 polyunsaturated fatty acids, particularly DHA and EPA, while decreasing n-6 PUFAs, mainly arachidonic acid. The long-term administration of DHA was safe and well tolerated, but essential fatty acid alterations could not be fully normalized with this treatment.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Nutrition & Dietetics
Marcos Lacasa, Jose Alegre-Martin, Ramon Sanmartin Sentanes, Luisa Varela-Sende, Joanna Jurek, Jesus Castro-Marrero
Summary: This research found that supplementation with yeast-derived beta-glucan may improve cognitive fatigue symptoms in ME/CFS patients, suggesting its potential use as a nutritional supplement or functional food to prevent or reduce cognitive dysfunction in these patients. Further research is needed to validate these findings and explore the immunometabolic pathomechanisms of beta-glucans in ME/CFS.
Article
Immunology
Franz Martin, Manuel Blanco-Suarez, Paola Zambrano, Oscar Caceres, Miriam Almirall, Jose Alegre-Martin, Beatriz Lobo, Ana Maria Gonzalez-Castro, Javier Santos, Joan Carles Domingo, Joanna Jurek, Jesus Castro-Marrero
Summary: This study found that biomarkers of intestinal barrier function and inflammation are associated with autonomic dysfunction in patients with fibromyalgia and myalgic encephalomyelitis/chronic fatigue syndrome. Anti-beta-lactoglobulin antibodies, zonulin-1, lipopolysaccharides, and soluble CD14 may be potential predictors of intestinal barrier dysfunction in these conditions.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Medicine, General & Internal
Juan Sahuquillo, Dulce Moncho, Alex Ferre, Diego Lopez-Bermeo, Aasma Sahuquillo-Muxi, Maria A. Poca
Summary: This review examines different classification approaches for Chiari malformations and proposes a simplified scheme to differentiate between various types of tonsillar herniations. It also explores the most appropriate terminology for acquired herniation of cerebellar tonsils and other secondary Chiari-like malformations. This paper contributes to the ongoing discussion by offering insights into the evolving understanding of Chiari malformations and proposing a simplified classification and terminology system for diagnosis and management.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
David Mantle, Lauren Millichap, Jesus Castro-Marrero, Iain P. Hargreaves, Alessandra Napolitano
Summary: Coenzyme Q10 (CoQ10) plays vital roles in all cells, including mitochondria and extra-mitochondrial functions. CoQ10 deficiency is associated with a wide range of disorders and can be classified into primary and secondary types. Oral supplementation of CoQ10 may be effective in treating patients, but early recognition is crucial to prevent irreversible tissue damage. This article reviews clinical studies on the identification of CoQ10 deficiencies and the outcomes of CoQ10 supplementation, resolving the discrepancies in previous review articles. Potential issues and unresolved matters regarding CoQ10 supplementation in primary CoQ10 deficiency are also discussed.
Article
Biochemistry & Molecular Biology
Sara Maurel, Lydia Gimenez-Llort, Jose Alegre-Martin, Jesus Castro-Marrero
Summary: This study identified four clusters of fibromyalgia patients based on their core clinical symptoms and neuropsychological comorbidities, providing insights into possible therapeutic targets. The results support the interaction between neurobiological, psychological, and social factors and emphasize the importance of assessing risk and protective factors in tailoring personalized interventions.
Article
Rheumatology
S. Maurel, N. Saez-Francas, N. Calvo, J. Alegre-Martin, J. Castro-Marrero
Summary: Objective Fibromyalgia (FM) is a prevalent and disabling condition characterized by chronic widespread pain. This study investigated the correlation between psychological variables (acceptance, negative affect, and mindfulness) and functional disability, physical impact, anxiety/depression symptoms, and emotional distress in individuals with FM. The results showed that negative affect was positively correlated with functional disability, anxiety/depression symptoms, and emotional distress, while acceptance and mindfulness were negatively correlated with these variables. Acceptance and mindfulness were found to mediate the relationship between negative affect and the dependent variables.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2022)