Article
Oncology
Juliana Gomes Poli, Gabriela Paiva, Fernanda Freitas, Paulo Mora, Luis Guillermo Coca Velarde, Joffre Amim Junior, Jorge Rezende Filho, Kevin M. Elias, Neil S. Horowitz, Antonio Braga, Ross S. Berkowitz
Summary: This study compared the outcomes of low-risk GTN patients treated with 8-day MTX and different regimens of FA, finding no significant difference in primary remission rate but a higher number of chemotherapy cycles and longer time to remission in the 0.1 mg/kg FA group.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Oncology
Antonio Braga, Gabriela Paiva, Ehsan Ghorani, Fernanda Freitas, Luis Guillermo Coca Velarde, Baljeet Kaur, Nick Unsworth, Jingky Lozano-Kuehne, Ana Paula Vieira dos Santos Esteves, Jorge Rezende Filho, Joffre Amim Jr, Xianne Aguiar, Naveed Sarwar, Kevin M. Elias, Neil S. Horowitz, Ross S. Berkowitz, Michael J. Seckl
Summary: A multicentre retrospective cohort study identified predictive factors for resistance to single-agent therapy in patients with gestational trophoblastic neoplasia, informing clinicians on more effective treatment selection for patients with a FIGO score of 5 or 6.
Article
Oncology
Emelie Wallin, Isa Niemann, Louise Faaborg, Lars Fokdal, Ulrika Joneborg
Summary: The route of administration of methotrexate has different effects on low-risk gestational trophoblastic neoplasia treatment. Oral administration leads to a higher rate of drug resistance, but does not affect rates of complete remission, recurrence or overall survival.
Article
Obstetrics & Gynecology
Matthew C. Winter
Summary: The treatment of low-risk gestational trophoblastic neoplasia presents challenges, including the lack of a defined optimal treatment strategy for patients scoring WHO 5 and 6, as well as the toxicities associated with multi-agent chemotherapy. Further research is needed to evaluate dosing and long-term safety of immunotherapeutic agents.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2021)
Article
Oncology
A. Mohamud, C. Hogdall, T. Schnack
Summary: This study compared the prognostic performance of the FIGO 2009 and FIGO 2018 staging systems for cervical cancer in terms of risk stratification, survival, and treatment outcome. The results showed that the FIGO 2018 staging system had improved discriminatory ability for stage I and IV, and lymph node assessment was proven imperative for patients with specific clinical characteristics.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Obstetrics & Gynecology
P. Barnardt
Summary: Globally, HIV infection remains a serious issue, especially in sub-Saharan Africa. Women make up half of the HIV-infected population, and AIDS is still one of the major causes of death among women aged 15-49. Although there have been signs of declining mortality rates in some regions, treatment outcomes for HIV-positive patients still need improvement.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2021)
Article
Oncology
Qing Cong, Ling Lin, Biao Qi, Congjian Xu, Xiaoyan Zhang
Summary: The study developed an active targeted therapeutic system that efficiently delivered chemotherapy drug MTX to choriocarcinoma cells through HCG receptor mediation, significantly improving chemotherapy efficacy.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Oncology
Fang Jiang, Ming-yi Mao, Yang Xiang, Xin Lu, Chong-li Guan, Lan-zhou Jiao, Xi-Run Wan, Feng-Zhi Feng, Tong Ren, Jun-Jun Yang, Jun Zhao
Summary: This article describes a multicentre, randomized, prospective clinical trial aiming to compare the efficacy of two different single-agent chemotherapy regimens for low-risk gestational trophoblastic neoplasia patients. The primary objectives of the study are the complete remission rate by single-agent therapy and the overall complete remission rate. Secondary objectives include the duration and number of courses needed to achieve complete remission, incidence and severity of adverse effects, effects on menstrual conditions and ovarian function, and patient-reported quality of life.
Article
Radiology, Nuclear Medicine & Medical Imaging
Kari S. Wagner-Larsen, Njal Lura, Oyvind Salvesen, Mari Kylleso Halle, David Forsse, Jone Trovik, Noeska Smit, Camilla Krakstad, Ingfrid S. Haldorsen
Summary: The study evaluated the interobserver agreement and prognostic value of MRI-based 2018 FIGO staging parameters in cervical cancer patients. The results showed substantial agreement among radiologists for these parameters, and MRI improved the identification of patients with aggressive clinicopathological features and poor survival.
EUROPEAN RADIOLOGY
(2022)
Article
Oncology
Victoria L. Parker, Bryony F. Cushen, Annie Hills, Kaveetha Kandiah, Julia E. Palmer, Kamaljit Singh, Barry W. Hancock, John A. Tidy, Matthew C. Winter
Summary: Dose individualization based on body surface area or weight does not affect the efficacy and relapse rate of chemotherapy in low-risk gestational trophoblastic neoplasia. Therefore, fixed dosing remains the preferred standard treatment in the UK.
GYNECOLOGIC ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Jian Chen, Yang Sun, Li Chen, Lele Zang, Cuibo Lin, Yongwei Lu, Liang Lin, An Lin, Hu Dan, Yiyu Chen, Haixin He
Summary: Prognostic factors for neuroendocrine tumors of the cervix include advanced FIGO stage, large tumor, older age, and lymph node metastasis. TP/TC and EP regimens are frequently used with similar efficacy. Comprehensive multimodality treatment may enhance survival outcomes for patients with NETs.
Correction
Ophthalmology
N. Y. Ngan
Summary: A new sutureless technique is described for repositioning and scleral fixation of the capsular bag-IOL complex in the surgical treatment of subluxated lenses. The simultaneous use of a capsular tension ring (CTR) and iris retractors ensures good centration of the capsular bag-IOL complex.
JOURNAL OF CATARACT AND REFRACTIVE SURGERY
(2022)
Article
Medicine, Research & Experimental
Shaobin Wu, Mingjie Shao, Yi Zhang, Dazun Shi
Summary: Resistance to chemotherapy in cancer is often caused by aberrantly activated kinases. RSK2 was identified as a key player in promoting resistance to methotrexate in gestational trophoblastic neoplastic cells. RSK2 activation leads to increased SOX8 expression, which in turn reduces reactive oxygen species levels and contributes to methotrexate resistance. RSK2 inhibitors could be a promising therapeutic approach for treating methotrexate-resistant gestational trophoblastic neoplasia.
LABORATORY INVESTIGATION
(2021)
Review
Oncology
Fulvio Borella, Stefano Cosma, Domenico Ferraioli, Mario Preti, Niccolo Gallio, Giorgio Valabrega, Giulia Scotto, Alessandro Rolfo, Isabella Castellano, Paola Cassoni, Luca Bertero, Chiara Benedetto
Summary: This review provides an up-to-date summary of brain metastases from gestational trophoblastic neoplasia, including epidemiology, clinical presentation, innovations in therapeutic modalities, and outcomes. Multi-agent chemotherapy has shown good response rates, but there are significant health risks associated with brain involvement by GTNs. Immunotherapy has been proposed as a novel option for patients who develop resistance to treatment.
FRONTIERS IN ONCOLOGY
(2022)
Article
Obstetrics & Gynecology
Antonio Braga, Kevin M. Elias, Neil S. Horowitz, Ross S. Berkowitz
Summary: High-risk gestational trophoblastic neoplasia (GTN) patients should undergo multiagent chemotherapy, such as EMA/CO, with at least three consolidation courses of EMA-CO after remission. Chemoresistance may be present if hCG levels plateau or increase during treatment, and EMA-EP is commonly chosen for further treatment in such cases.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2021)
Article
Oncology
Nicolo Matteo Luca Battisti, Malcolm W. R. Reed, Esther Herbert, Jenna L. Morgan, Karen A. Collins, Sue E. Ward, Geoffrey R. Holmes, Michael Bradburn, Stephen J. Walters, Maria Burton, Kate Lifford, Adrian Edwards, Thompson G. Robinson, Charlene Martin, Tim Chater, Kirsty J. Pemberton, Anne Shrestha, Alan Brennan, Kwok L. Cheung, Annaliza Todd, Riccardo A. Audisio, Juliet Wright, Richard Simcock, Tracey Green, Deirdre Revell, Jacqui Gath, Kieran Horgan, Chris Holcombe, Matthew C. Winter, Jay Naik, Rishi Parmeshwar, Margot A. Gosney, Matthew Q. Hatton, Alastair M. Thompson, Lynda Wyld, Alistair Ring
Summary: Chemotherapy in older patients with early breast cancer has a significant negative impact on quality of life at 6 months, affecting various aspects such as global health score, physical, role, and social functioning. However, this impact diminishes by 18-24 months, highlighting the importance of informed decision-making for older patients considering chemotherapy.
EUROPEAN JOURNAL OF CANCER
(2021)
Article
Oncology
Alistair Ring, Nicolo Matteo Luca Battisti, Malcolm W. R. Reed, Esther Herbert, Jenna L. Morgan, Michael Bradburn, Stephen J. Walters, Karen A. Collins, Sue E. Ward, Geoffrey R. Holmes, Maria Burton, Kate Lifford, Adrian Edwards, Thompson G. Robinson, Charlene Martin, Tim Chater, Kirsty J. Pemberton, Alan Brennan, Kwok Leung Cheung, Annaliza Todd, Riccardo A. Audisio, Juliet Wright, Richard Simcock, Tracey Green, Deirdre Revell, Jacqui Gath, Kieran Horgan, Chris Holcombe, Matthew C. Winter, Jay Naik, Rishi Parmeshwar, Margot A. Gosney, Matthew Q. Hatton, Alastair M. Thompson, Lynda Wyld
Summary: Chemotherapy reduced the risk of metastatic recurrence in high-risk early breast cancer patients, with survival benefits seen only in those with ER-negative cancer. However, there were significant but transient negative impacts on quality of life for patients undergoing chemotherapy.
BRITISH JOURNAL OF CANCER
(2021)
Meeting Abstract
Oncology
J. Clark, S. Suyanto, L. Hennah, M. Winter, U. Joneborg, E. Wallin, A. Harry, N. Naban, B. Kaur, X. Aguiar, T. Tin, N. Sarwar, M. Gonzalez, M. Seckl
ANNALS OF ONCOLOGY
(2021)
Article
Oncology
Nicolo Matteo Luca Battisti, Matthew Q. Hatton, Malcolm W. R. Reed, Esther Herbert, Jenna L. Morgan, Michael Bradburn, Richard Simcock, Stephen J. Walters, Karen A. Collins, Sue E. Ward, Geoffrey R. Holmes, Maria Burton, Kate J. Lifford, Adrian Edwards, Thompson G. Robinson, Charlene Martin, Tim Chater, Kirsty J. Pemberton, Alan Brennan, Kwok Leung Cheung, Annaliza Todd, Riccardo A. Audisio, Juliet Wright, Tracy Green, Deirdre Revell, Jacqui Gath, Kieran Horgan, Chris Holcombe, Matthew C. Winter, Jay Naik, Rishi Parmeshwar, Margot A. Gosney, Alastair M. Thompson, Lynda Wyld, Alistair Ring
Summary: In older women with early breast cancer, the use of radiotherapy is influenced by age and recurrence risk, while geriatric parameters have limited impact on the type of surgery chosen. There is geographical variation in treatment patterns, with some fit older women with high-risk tumors not receiving radiotherapy and some older, low-risk patients receiving radiotherapy despite limited benefit. The impact on HRQoL is transient.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Medicine, General & Internal
Milana A. Bergamino, Elena Lopez-Knowles, Gabriele Morani, Holly Tovey, Lucy Kilburn, Eugene F. Schuster, Anastasia Alataki, Margaret Hills, Hui Xiao, Chris Holcombe, Anthony Skene, John F. Robertson, Ian E. Smith, Judith M. Bliss, Mitch Dowsett, Maggie C. U. Cheang
Summary: This study aimed to identify biomarkers for the response of ER+/HER2+ breast cancers to AI treatment. The results showed that HER2-E is a standardized biomarker associated with poor response to AI and worse prognosis in ER+/HER2+ breast cancers. HRD, TP53 mutational score, and immune-tumor tolerance are predictive biomarkers for poor response to AI. Additionally, new molecular subtypes identify non-HER2-E tumors that do not respond to AI and have an increased risk of relapse.
Article
Oncology
Matthew Winter, Rob Coleman, Jessica Kendall, Carlo Palmieri, Chris Twelves, Sacha Howell, Iain MacPherson, Caroline Wilson, Kash Purohit, Jacqui Gath, Christine Taylor, Richard Eastell, Geraldine Murden, Sarah R. Brown, Emma Rathbone, Janet Brown
Summary: This study evaluates the safety and efficacy of the combination of capecitabine and Ra-223 in MBC patients with bone metastases. The results show that the combination therapy is safe and feasible, but no significant clinical or biochemical efficacy signals were observed.
JOURNAL OF BONE ONCOLOGY
(2022)
Article
Oncology
N. C. Turner, C. Swift, B. Jenkins, L. Kilburn, M. Coakley, M. Beaney, L. Fox, K. Goddard, I. Garcia-Murillas, P. Proszek, P. Hall, C. Harper-Wynne, T. Hickish, S. Kernaghan, I. R. Macpherson, A. F. C. Okines, C. Palmieri, S. Perry, K. Randle, C. Snowdon, H. Stobart, A. M. Wardley, D. Wheatley, S. Waters, M. C. Winter, M. Hubank, S. D. Allen, J. M. Bliss
Summary: The c-TRAK TN study is the first prospective study to evaluate the clinical utility of ctDNA testing in guiding therapy in TNBC. It found that TNBC patients had a high rate of metastatic disease on ctDNA detection. These findings have important implications for future trial design, emphasizing the importance of starting ctDNA testing early and using more sensitive and/or frequent ctDNA testing regimes.
ANNALS OF ONCOLOGY
(2023)
Article
Oncology
Victoria L. Parker, Bryony F. Cushen, Annie Hills, Kaveetha Kandiah, Julia E. Palmer, Kamaljit Singh, Barry W. Hancock, John A. Tidy, Matthew C. Winter
Summary: Dose individualization based on body surface area or weight does not affect the efficacy and relapse rate of chemotherapy in low-risk gestational trophoblastic neoplasia. Therefore, fixed dosing remains the preferred standard treatment in the UK.
GYNECOLOGIC ONCOLOGY
(2023)
Article
Oncology
Victoria L. Parker, Matthew C. Winter, John A. Tidy, Barry W. Hancock, Julia E. Palmer, Naveed Sarwar, Baljeet Kaur, Katie McDonald, Xianne Aguiar, Kamaljit Singh, Nick Unsworth, Imran Jabbar, Allan A. Pacey, Robert F. Harrison, Michael J. Seckl
Summary: This study compares the performance of the International Federation of Gynaecology and Obstetrics (FIGO) scoring system with other models in assessing chemoresistance in gestational trophoblastic neoplasia (GTN) patients. The study found that the other models outperformed FIGO in terms of diagnostic accuracy and positive predictive value. However, most models had significant discordance in patient classification, leading to potential undertreatment or overtreatment.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Review
Oncology
B. Hapuarachi, J. A. Tidy, C. Romanowski, K. Singh, S. Gillett, J. Ireson, M. C. Winter
GYNECOLOGIC ONCOLOGY
(2023)
Meeting Abstract
Oncology
Alistair E. Ring, Laura Moretti, Angelica Afshari-Mehr, Andrew M. Wardley, Lucy Kilburn, Bora Gurel, Iain R. MacPherson, Richard D. Baird, Sue Martin, Alex Pearson, Rebecca Roylance, Matthew Winter, Kathryn Dunne, Ellen Copson, Tamas Hickish, Peter Stephens, Russell J. Burcombe, Katrina Randle, Judith Bliss, Nicholas C. Turner
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Meeting Abstract
Health Care Sciences & Services
Jane Ireson, Patricia Holch, Stephen Radley, Diana Greenfield, Matt Winter, John Tidy, Georgina Jones
QUALITY OF LIFE RESEARCH
(2022)
Meeting Abstract
Oncology
Matthew Winter, David Gonzalez de Castro, Jonathan Askham
Article
Surgery
L. Wyld, M. W. R. Reed, K. Collins, M. Burton, K. Lifford, A. Edwards, S. Ward, G. Holmes, J. Morgan, M. Bradburn, S. J. Walters, A. Ring, T. G. Robinson, C. Martin, T. Chater, K. Pemberton, A. Shrestha, A. Nettleship, C. Murray, M. Brown, P. Richards, K. L. Cheung, A. Todd, H. Harder, K. Brain, R. A. Audisio, J. Wright, R. Simcock, F. Armitage, M. Bursnall, T. Green, D. Revell, J. Gath, K. Horgan, C. Holcombe, M. Winter, J. Naik, R. Parmeshwar, M. Gosney, M. Hatton, A. M. Thompson
Summary: The study found that using decision support interventions in older women with breast cancer increases knowledge of treatment options, facilitates shared decision-making, and alters treatment choices.
BRITISH JOURNAL OF SURGERY
(2021)
Review
Pharmacology & Pharmacy
Mark P. Lythgoe, Jonathan Krell, Sarah Mahmoud, Emily C. Mills, Aishwarya Vasudevan, Philip Savage
Summary: An analysis of new anti-cancer drugs licensed in the UK from 2015 to 2019 showed a significant increase in the number of approved therapies, with kinase inhibitors and monoclonal antibodies being the most common. While these new drugs are providing longer treatment durations and clinical benefits, they are also bringing about economic challenges for healthcare providers due to rising costs.
DRUG DISCOVERY TODAY
(2021)