Article
Biochemical Research Methods
Sonia Schoneich, Grant S. Ochoa, Celina M. Monzon, Robert E. Synovec
Summary: This study compared pacu fish raised in an integrated rice-fish farming system with those raised in tanks using F-ratio analysis, and discovered the impact of farming methods on the fish's metabolome. Despite challenges such as artifact peaks and redundant hits, improved analysis methods and artifact removal led to accurate results. The findings suggest that the integrated farming system may negatively affect the quality of pacu fish.
JOURNAL OF CHROMATOGRAPHY A
(2022)
Article
Chemistry, Analytical
Celina Monzon, Sonia Schoneich, Robert E. Synovec
Summary: The study used GC-GC-TOFMS and PCA to investigate the effects of farming pacu fish with rice fields on the metabolome of the fish. The majority of metabolites were found to be downregulated in the farmed fish, with some involved in important metabolic processes such as protein catabolism, nucleotide metabolism, and tissue repair.
MICROCHEMICAL JOURNAL
(2021)
Article
Environmental Sciences
Shiyuan Zhao, Haitao Zhong, Chunmei Geng, Hongjia Xue, Changshui Wang, Wenxue Sun, Ruili Dang, Wenxiu Han, Pei Jiang
Summary: In this study, gas chromatography-mass spectrometry was used to investigate the toxic mechanisms of ACR in the main target tissues of rats, revealing 14 metabolic pathways related to amino acid, fatty acid, purine, and energy metabolism. The study suggests that the toxic mechanism of ACR may involve oxidative stress, inflammation, amino acid metabolism, and energy disorders.
ENVIRONMENTAL POLLUTION
(2021)
Article
Medical Laboratory Technology
Yuyang Hou, Yuanping He, Jingjie Wang, Yanfen Zhou, Bo Ma, Xin Li, Liang Shi, Qi Zhang
Summary: By analyzing the metabolic profiles of four different types of asthenozoospermia, this study revealed abnormal changes in metabolites and metabolic pathways associated with the disease. The findings provide new clues and evidence for the etiology, diagnosis, and treatment of asthenozoospermia.
CLINICA CHIMICA ACTA
(2023)
Review
Food Science & Technology
Maria Perez-Jimenez, Emma Sherman, M. A. Pozo-Bayon, Farhana R. Pinu
Summary: Flavoromics is an alternative method to traditional targeted approaches, using non-targeted and data-driven techniques to establish relationships between the chemical composition of foods and their sensory properties. In wine research, untargeted volatile profiling through flavoromics can provide novel insights and assist in producing diverse wines and marketing them based on consumer preferences.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Chemistry, Medicinal
Yahao Gao, Di Jiang, Changshui Wang, Gang An, Li Zhu, Changmeng Cui
Summary: This study comprehensively evaluated the toxicity of sodium valproate (VPA) using metabolomics, and found that VPA-induced toxicity is closely related to 12 key pathways including oxidative stress, inflammation, amino acid metabolism, lipid metabolism, and energy disorder.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Multidisciplinary Sciences
Changmeng Cui, Li Zhu, Qian Wang, Ruijuan Liu, Dadi Xie, Yujin Guo, Dingyi Yu, Changshui Wang, Dan Chen, Pei Jiang
Summary: The study investigated the metabolic changes after vancomycin administration in mice, revealing that vancomycin affects the metabolism in various organs, providing new insights for identification of vancomycin-induced toxicity.
Review
Chemistry, Analytical
Nino B. L. Milani, Eric van Gilst, Bob W. J. Pirok, Peter J. Schoenmakers
Summary: Although comprehensive 2-D GC is a well-established and widely used analytical method, it is still a highly dynamic field due to numerous innovations. This review discusses recent developments in comprehensive 2-D GC technology, including exciting improvements in modulation methods, detection methods, retention modeling, and data analysis.
JOURNAL OF SEPARATION SCIENCE
(2023)
Article
Chemistry, Analytical
Grant S. Ochoa, Paige E. Sudol, Timothy J. Trinklein, Robert E. Synovec
Summary: Tile-based Fisher ratio (F-ratio) analysis is a versatile tool for supervised discovery experiments, but challenges may arise in analyte identification due to poor 2D resolution and low analyte abundance. To address this, the class comparison enabled mass spectrum purification (CCE-MSP) method is introduced, utilizing signal consistency between background interference compounds in F-ratio analysis to purify analyte mass spectra.
Article
Biochemical Research Methods
Andrea Hochegger, Sebastiano Panto, Nick Jones, Erich Leitner
Summary: In September 2022, the European Commission released a new regulation allowing the use of novel technologies to generate data for establishing regulatory processes on recycled plastic materials for food contact. This study compared different analytical approaches for screening commercially purchased post-consumer recycled polypropylene buckets. The results highlight the importance of detailed characterization and the advantages and disadvantages of using conventional gas chromatography and comprehensive two-dimensional gas chromatography with mass spectrometry.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Elba Garreta-Lara, Cristian Gomez-Canela, Bruno Campos, Carlos Barata, Roma Tauler, Silvia Lacorte
Summary: This study utilized a combination of target and untargeted analytical approaches to assess the metabolic changes of Daphnia magna exposed to the endocrine disruptor bisphenol A. The results indicated that bisphenol A had an impact on the metabolism of Daphnia magna and potential biomarkers of exposure were discovered.
MICROCHEMICAL JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Ivana Rubic, Richard Burchmore, Stefan Weidt, Clement Regnault, Josipa Kules, Renata Baric Rafaj, Tomislav Masek, Anita Horvatic, Martina Crnogaj, Peter David Eckersall, Predrag Novak, Vladimir Mrljak
Summary: This study aimed to explore and characterize the serum metabolome of dogs naturally infected with Babesia canis. By using different analytical platforms, 295 metabolites were detected and various metabolic pathways were found to be involved in canine babesiosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Kinjal Bhatt, Titziana Orlando, Marie-Alice Meuwis, Edouard Louis, Pierre-Hugues Stefanuto, Jean-Francois Focant
Summary: Colorectal cancer (CRC) is the third most commonly diagnosed cancer and the second leading cause of cancer-related deaths. Current diagnostic techniques are either invasive or lack sensitivity, highlighting the need for less invasive and more sensitive screening approaches. This study used advanced GC x GC-LR/HR-TOFMS technology to analyze serum samples from three different groups (adenocarcinoma, adenoma, and control). The findings revealed specific PUFA molecules inversely associated with CRC and identified metabolic changes in CRC. The study provides valuable insight into molecular-level changes associated with CRC and compares the efficiency of different analytical approaches for CRC screening.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Benjamin Trotter, Magdalena Wilde, Julian Brehm, Evdokia Dafni, Arlinda Aliu, Georg J. Arnold, Thomas Froehlich, Christian Laforsch
Summary: Research on the effects of microplastics on freshwater organisms, particularly Daphnia, has shown that chronic exposure to polystyrene microplastics can lead to decreased body length and offspring numbers in Daphnia magna. Proteomic analysis revealed changes in protein abundance, including alterations in enzymes and important physiological pathways. This study highlights the potential impact of long-term exposure to microplastics on the fitness of aquatic organisms.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Pharmacology & Pharmacy
Qing-Qing Yu, Heng Zhang, Shiyuan Zhao, Dadi Xie, Haibo Zhao, Weidong Chen, Min Pang, Baoqin Han, Pei Jiang
Summary: This study comprehensively analyzed the metabolite changes in a mouse model of irinotecan-induced intestinal mucositis, identifying 46 metabolites with significant changes in tissues and serum. The study highlighted key pathways related to these metabolites, offering insights into new biomarkers for diagnosis and treatment of intestinal mucositis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Claire Joannis-Cassan, Alfredo S. Rodriguez Castillo, Chloe Dezani, Cristian Gomez-Canela, Brice Reoyo-Prats, Carole Calas-Blanchard, Carlos Barata, Silvia Lacorte, Gael Plantard
Summary: This study proposes an innovative concept of integrating the photocatalytic oxidation process in a continuous recycling loop on a membrane bioreactor for the treatment of pharmaceutical compounds in wastewater, which can effectively improve the removal efficiency.
JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
(2021)
Article
Environmental Sciences
Gabino Bolivar-Subirats, Claudia Rivetti, Montserrat Cortina-Puig, Carlos Barata, Silvia Lacorte
Summary: The study evaluated the presence, seasonal variability, and impact of plastic additives in the Besos river basin in Catalonia, Spain. Only a few compounds were found to pose a small risk to the environment, mainly from WWTPs effluents and leaching from floating plastics.
Article
Engineering, Environmental
Maria Sapounidou, David J. Ebbrell, Mark A. Bonnell, Bruno Campos, James W. Firman, Steve Gutsell, Geoff Hodges, Jayne Roberts, Mark T. D. Cronin
Summary: This study developed a new classification scheme to group chemicals based on their toxicological mechanisms, with detailed categorization into three broad domains representing non-specific toxicity, reactive mechanisms, and specific mechanisms. The novelty of this approach lies in its reference to taxonomic diversity, transparency, quality of supporting evidence on molecular initiating events, and its ease of updating.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Environmental Sciences
Joan Dalmau-Soler, Ruben Ballesteros-Cano, Ma Rosa Boleda, Miquel Paraira, Nuria Ferrer, Silvia Lacorte
Summary: This study examined the presence of microplastics in the Llobregat river basin in Catalonia, Spain, and their removal efficiency in the drinking water treatment plant (DWTP). Sand filtration was identified as the key stage in microplastic removal, with ultrafiltration/reverse osmosis proving more effective for removal than ozonation/carbon filtration. Preliminary migration tests were also conducted to identify potential sources of microplastics in each treatment step.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Chemistry, Analytical
Elba Garreta-Lara, Cristian Gomez-Canela, Bruno Campos, Carlos Barata, Roma Tauler, Silvia Lacorte
Summary: This study utilized a combination of target and untargeted analytical approaches to assess the metabolic changes of Daphnia magna exposed to the endocrine disruptor bisphenol A. The results indicated that bisphenol A had an impact on the metabolism of Daphnia magna and potential biomarkers of exposure were discovered.
MICROCHEMICAL JOURNAL
(2021)
Article
Environmental Sciences
M. Gloria Pereira, Silvia Lacorte, Lee A. Walker, Richard F. Shore
Summary: The study found no significant differences in PFAS concentrations between different colonies of Northern gannets in the UK, but observed significant increases in PFSAs in the early stages followed by declines, and significant increases in PFCAs towards the end of the study. Most eggs contained residues of PFOS that exceeded suggested safe levels.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Biochemistry & Molecular Biology
Montserrat Sole, Silvia Lacorte, Dolors Vinyoles
Summary: Two endemic cyprinids were sampled from a small stream in the NW Mediterranean to analyze biomarkers in muscle and liver, revealing different biochemical responses to environmental stress. Catalan chub showed higher sensitivity to neurotoxic chemicals, while Mediterranean barbel displayed stronger antioxidant defenses.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2021)
Article
Environmental Sciences
Bruno Campos, Benjamin Pina, Carlos Barata
Summary: This study evaluated the transcriptomic responses in Daphnia magna exposed to feeding-inhibiting compounds and compared them with responses to food restriction. The results showed significant differences in molecular responses between chemical feeding inhibitors and food limitation. Chemical feeding inhibitors caused specific toxic effects instead of mimicking the physiological response to low energy intake.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2021)
Article
Medicine, Legal
Mark T. D. Cronin, Franklin J. Bauer, Mark Bonnell, Bruno Campos, David J. Ebbrell, James W. Firman, Steve Gutsell, Geoff Hodges, Grace Patlewicz, Maria Sapounidou, Nicoleta Spinu, Paul C. Thomas, Andrew P. Worth
Summary: Structure-activity relationships (SARs) are important in in silico toxicology, and this study proposes twelve criteria to assess the confidence associated with structural alerts. The criteria include purpose, chemistry, toxicology, mechanism, performance, and coverage. The evaluation scheme can be applied to various industrial and regulatory applications.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2022)
Article
Environmental Sciences
Maria Dulsat-Masvidal, Albert Bertolero, Rafael Mateo, Silvia Lacorte
Summary: The aim of this study is to evaluate the exposure of 91 emerging and legacy micropollutants in flamingo chicks, an emblematic species of the area. The results indicate a multi-exposure of flamingo's chicks from a very young age. This is the first study to describe flamingos chicks' exposure to multiple contaminants, highlighting the importance of biomonitoring for wildlife conservation and biodiversity preservation.
Article
Environmental Sciences
Pablo Zapata-Corella, Zi-He Ren, Yin-E Liu, Anna Rigol, Silvia Lacorte, Xiao-Jun Luo
Summary: This study evaluates the distribution, partitioning and environmental and human impact of organophosphate esters, legacy polychlorinated biphenyls, polybromodiphenyl ethers and organochlorine pesticides in the e-waste recycling area of Qingyuan county, China. The study finds that a plastic debris lump accumulated in a small pond is the main source of pollution, causing high concentrations of contaminants in water, sediments, soils and hen eggs in the surrounding area.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Claudia Rivetti, Jade Houghton, Danilo Basili, Geoff Hodges, Bruno Campos
Summary: Over the past two decades, there has been a strong trend towards integrating cell-based and computational approaches in safety assessments, leading to a shift in global regulatory paradigms towards reducing and replacing animal use in toxicity tests. The understanding of molecular targets and pathways conservation allows for extrapolation of effects across species and determination of the applicability of assays and biological effects. A novel pipeline, G2P-SCAN, has been developed to support cross-species extrapolation of biological processes by extracting and structuring data from various databases, such as gene orthologs, protein families, entities, and reactions. The use of G2P-SCAN enables the analysis of orthology and functional families to identify conservation and susceptibility at the pathway level. Five case studies are discussed to demonstrate the validity and potential use of this pipeline in supporting species extrapolation for research and safety decisions. Environ Toxicol Chem 2023;00:1-15. (c) 2023 UNILEVER GLOBAL IP LTD. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2023)
Review
Environmental Sciences
Giuseppina Zuri, Angeliki Karanasiou, Silvia Lacorte
Summary: This study provides an overview of the pathways of human exposure to microplastics (MP) through inhalation, ingestion, and dermal contact. It analyzes the concentrations of MP in outdoor and indoor air, dust, food and water, and highlights indoor air and drinking water as the main sources of MP. The study also reveals high MP concentrations in infants and newborns, emphasizing the need for further research on the presence and risk of MP in this vulnerable age population.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Environmental Sciences
A. Torres-Agullo, A. Karanasiou, S. Lacorte
Summary: During the COVID-19 pandemic, the pilot study evaluated the presence of microplastics (MP) accumulated in nasal cavities from wearing face masks. Different polymers, mainly within the 20-300 μm size, were detected in nasal lavages, indicating general exposure to airborne MP rather than association with face mask use. This study highlights the use of nasal lavages to assess human inhalation of MP and its potential sources and risks.
ENVIRONMENT INTERNATIONAL
(2023)
Review
Environmental Sciences
Giuseppina Zuri, Angeliki Karanasiou, Silvia Lacorte
Summary: This review provides an overview of the current human biomonitoring data available on microplastics (MPs), which are plastic particles ubiquitous in water, soil, and air. The review compiles 91 relevant studies and highlights that humans are exposed to MPs through ingestion and inhalation. The health risks associated with MPs exposure include inflammation, oxidative stress, and DNA damage, potentially leading to cardiovascular and respiratory diseases, as well as cancer.
ENVIRONMENTAL RESEARCH
(2023)
