Article
Chemistry, Multidisciplinary
Terezia Vojtylova-Jurkovicova, Petra Vankatova, Magdalena Urbanska, Vera Hamplova, David Sykora, Alexej Bubnov
Summary: Effective control of optical purity through chiral separation of (S) and (R) enantiomers is crucial when designing new chiral organic materials. A method using chiral fluorinated liquid-crystalline materials with lateral substitution was developed and verified, with separations performed using chiral high-performance liquid chromatography.
Review
Biochemical Research Methods
Huifeng Liu, Zhihai Wu, Jia Chen, Jianhua Wang, Hongdeng Qiu
Summary: Chirality is a common phenomenon in nature and the separation of chiral drugs is crucial for their safe utilization. High-performance liquid chromatography (HPLC) is an effective tool for compound separation and analysis, with chromatographic packing playing a key role. Chiral pharmaceutical separation and analysis in HPLC rely on chiral stationary phases (CSPs), thus various CSPs are being developed to meet the needs of chiral drug separation and analysis.
JOURNAL OF CHROMATOGRAPHY A
(2023)
Article
Chemistry, Multidisciplinary
Anna Poryvai, Michal Smahel, Marie Svecova, Ahlam Nemati, Sasan Shadpour, Pavel Ulbrich, Timothy Ogolla, Jiao Liu, Vladimira Novotna, Miroslav Veverka, Jana Vejpravova, Torsten Hegmann, Michal Kohout
Summary: Combining cobalt ferrite nanocrystals with organic ligands featuring a robust photosensitive unit and a source of chirality, nanoparticles are developed to serve as a multifunctional and multiaddressable dopant to modify the properties of liquid crystalline matrices. These nanoparticles, when dispersed in achiral liquid crystals, form chiral supramolecular structures that can respond to UV-light illumination and possess strong magnetic response.
Article
Nanoscience & Nanotechnology
Qiong Zheng, Jiajia Huang, Yanting He, Huan Huang, Yin Ji, Yongfan Zhang, Zian Lin
Summary: A single-crystalline covalent organic framework (COF-300) packed column was developed for the successful separation of positional isomers in high-performance liquid chromatography (HPLC), demonstrating the great potential of single-crystalline COFs in separation science.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Analytical
Thomas Themelis, Jelle De Vos, Sebastiaan Eeltink
Summary: This article discusses the design aspects of microfluidic chips for spatial three-dimensional chromatography and establishes the corresponding kinetic performance limits using a Pareto-optimality approach. The advantages and disadvantages of integrating different separation mechanisms are discussed, and novel equations are proposed to determine the peak capacity and account for sample modulation. A microfluidic spatial prototype chip has been created with the potential to achieve a high peak capacity within a short analysis time.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Physical
Pragya Verma, Christoph Nancoz, Johann Bosson, Geraldine M. Labrador, Jerome Lacour, Eric Vauthey
Summary: By combining ultrafast time-resolved fluorescence and transient electronic absorption, we investigated the stereoselectivity in the static stage of photoinduced electron transfer (ET). Our results show that the quenching dynamics for different diastereomeric pairs are the same, regardless of solvent polarity.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Chemistry, Analytical
Rakesh Chandrakant Prabhu, Arthanareeswari Maruthapillai, Gopal Chandru Senadi
Summary: The article describes the development of a fast, selective, and precise analytical method using a statistically driven stage-wise AQbD approach with proven orthogonality. Challenging the method with orthogonality proved its robustness, in line with ICH guidelines for validation.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Ravi Bhushan
Summary: The study successfully separated and isolated enantiomers by using a de-novo approach of mixing chirally pure reagents or Cu(II)-L-amino acid complexes. More than 38 new chiral derivatizing reagents were synthesized in the laboratory, and a conceptual approach using both achiral phases in chromatography for enantioseparation was adopted. H-1 NMR and DFT based software were used to explain structures, determine configuration and separation mechanisms.
Article
Biochemical Research Methods
Kuan Li, Ling-Xiao Xiong, Ying Wang, You -Ping Zhang, Bang-Jin Wang, Sheng-Ming Xie, Jun -Hui Zhang, Li -Ming Yuan
Summary: In this study, a thiol-ene click reaction was used to construct a CSP for HPLC using a [4 + 8]-type chiral POC NC4-R as the chiral selector. The fabricated CSP exhibited good chiral resolution performance in both NP-HPLC and RP-HPLC, and showed excellent reproducibility and stability. This work demonstrated the high potential of chiral POCs for HPLC enantiomeric separation.
JOURNAL OF CHROMATOGRAPHY A
(2022)
Review
Engineering, Environmental
Qingsong Cheng, Hebing Pei, Qian Ma, Ruibin Guo, Nijuan Liu, Zunli Mo
Summary: This paper reviews the progress of chiral graphene materials for enantiomer separation, discussing their synthesis strategies, separation mechanism, and applications, as well as exploring related issues and future prospects.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Physical
Ang Li, Siru Ren, Chuanjiang Teng, Hongmei Liu, Qi Zhang
Summary: Deep eutectic solvents (DESs) have potential applications as additives/modifiers in chiral electrokinetic chromatography (EKC) and can moderately improve the enantioseparation performance. The improvement is mainly attributed to the contribution of hydrogen-bond acceptors (HBAs) rather than hydrogen-bond donors (HBDs). However, using chiral DESs does not show obvious advantages compared to achiral DESs, which is different from the performance of chiral ionic liquids (ILs) as additives in chiral EKC.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Chemistry, Analytical
Yuan Li, Xiaoning Jin, Yin Xiao, Xiaofei Ma, Yong Wang
Summary: Four allylimidazole cyclodextrin derivatives were synthesized and clicked onto silica surfaces to prepare chiral stationary phases. The chiral chromatographic performances were systematically evaluated and the results showed that the selective substitution of the hydroxyl groups significantly altered the enantioseparation ability. The role of secondary hydroxyl groups in the separation of chiral compounds was further investigated.
Review
Biochemical Research Methods
Hassan Y. Aboul-Enein, Valliappan Kannappan, Selvakumar Kanthiah
Summary: This review paper focuses on the recent development of monolithic chiral stationary phases (CSPs) in liquid chromatography (LC), with an emphasis on polysaccharide and cyclodextrin-based monolithic CSPs. It also discusses competing techniques and the application of monolithic chiral CSPs in LC and capillary electrochromatography.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
(2023)
Article
Engineering, Chemical
Yunhai Huang, Jingkang Wang, Na Wang, Xin Li, Xiongtao Ji, Jinyue Yang, Lina Zhou, Ting Wang, Xin Huang, Hongxun Hao
Summary: This study investigated the molecular mechanism of liquid-liquid phase separation (LLPS) before nucleation in the preparation of crystalline materials using citicoline sodium as a model compound. It was found that solute-solvent intermolecular interactions were enhanced and then weakened before and after LLPS, leading to the formation of dense liquid phase through self-assembly of solute molecules in binary mixed solvents. The proposed mechanism of LLPS was based on these results.
CHEMICAL ENGINEERING SCIENCE
(2022)
Article
Chemistry, Analytical
Marta Passamonti, Chiem de Roos, Peter J. Schoenmakers, Andrea F. G. Gargano
Summary: In this study, polymerization mixture was optimized to synthesize poly(acrylamide-co-N,N'-methylenebisacrylamide) monolithic stationary phases for HILIC of intact proteins. The monolithic structure exhibited a permeable and polar stationary phase suitable for HILIC. The monolith showed superior separation performance and lower ion interaction compared to silica-based particulate amide phase, enabling successful hyphenation with high-resolution mass spectrometry in HILIC of intact proteins.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Terezia Vojtylova-Jurkovicova, Petra Vankatova, Magdalena Urbanska, Vera Hamplova, David Sykora, Alexej Bubnov
Summary: Effective control of optical purity through chiral separation of (S) and (R) enantiomers is crucial when designing new chiral organic materials. A method using chiral fluorinated liquid-crystalline materials with lateral substitution was developed and verified, with separations performed using chiral high-performance liquid chromatography.
Article
Chemistry, Physical
Hsiu-Hui Chen, Martin Cigl, Chu-Ti Cheng, Krzysztof A. Bogdanowicz, Agnieszka Iwan, Natalia Podoliak, Petra Vankatova, Vera Hamplova, Karolina Dysz, Wojciech Przybyl, Pawel Nitschke, Ewa Schab-Balcerzak, Damian Pociecha, Alexej Bubnov
Summary: Three new discotic liquid crystalline compounds were used as smart dopants in organic solar cells to achieve one-dimensional charge transportation. The power conversion efficiency of the cells was found to be strongly influenced by the molecular conformation and specific amount of dopants in the active layer.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Chemistry, Multidisciplinary
Valeriia Muraveva, Vaclav Kozmik, Michal Kohout, Andrew Manko, Alexey Piryazev, Dimitri Ivanov, Sergey Abramchuk, Martin Cigl, Alexey Bobrovsky
Summary: This study investigates the broadening of the peak of selective light reflection in cholesteric liquid crystals during UV polymerisation, by creating a gradient of the cholesteric pitch. The results show the possibility of creating flexible and thin circular polarisers operating in a wide spectral range.
Article
Materials Science, Multidisciplinary
Alexey Yu. Bobrovsky, Sergey Svyakhovskiy, Ilya V. Roslyakov, Alexey A. Piryazev, Dimitri A. Ivanov, Valery P. Shibaev, Martin Cigl, Vera Hamplova, Alexej Bubnov
Summary: Photo-tunable photonic structures filled with photochromic azobenzene-containing compounds were prepared and their properties were studied. Irradiation with polarized blue light resulted in spectral changes associated with photo-orientation of azobenzene moieties. The observed photoinduced split was reversible and could be fully recovered by heating. The prepared composites have great potential in photonics applications.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Martin Cigl, Damian Pociecha, Rafal Jakubowski, Szymon Kapuscinski, Piotr Kaszynski
Summary: A new planar Blatter radical building block with 19 pi-delocalized electrons was developed for obtaining paramagnetic bent-core liquid crystals. The mesogens were studied in pure form and as binary mixtures using optical, thermal, powder XRD, and DFT methods. Comparisons with classical Blatter radical analogues revealed that planarization of the central angular element led to significantly higher stability of the mesophases and increased molecular organization, suitable for the formation of ordered banana and columnar mesophases with stronger pi-pi interactions. These results suggest the potential for accessing a new class of functional paramagnetic soft materials.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Natalia Podoliak, Vladimira Novotna, Vera Hamplova, Damian Pociecha, Martin Cigl
Summary: By optimizing the molecular structure and introducing chemical modifications, we have successfully enhanced the ferroelectric properties of liquid crystalline materials, extending the temperature range of ferroelectric phase and achieving higher spontaneous electric polarization at room temperature.
Article
Chemistry, Multidisciplinary
Alexey Bobrovsky, Valery Shibaev, Martin Cigl, Vera Hamplova, Alexej Bubnov
Summary: A multifunctional cholesteric liquid crystalline polymer-stabilised composite with photo- and electro-controllable photonic band gap was prepared, showing fast photo- and electro-optical switching.
Article
Crystallography
Andraz Resetic, Jerneja Milavec, Alexej Bubnov, Damian Pociecha, Vera Hamplova, Ewa Gorecka, Bostjan Zalar, Valentina Domenici
Summary: Side-chain liquid crystal elastomers (SC-LCEs) were designed using a new smectic crosslinker. Two types of monodomain films were prepared based on polysiloxane chains with different concentrations of crosslinker and mesogenic comonomers. Differential scanning calorimetry and polarized optical microscopy were used to investigate the mesomorphic behavior of the two SC-LCE systems, revealing different mesophases. The physical-chemical properties of SC-LCEs were studied using various techniques, and their thermo-elastic and thermo-mechanic behaviors were discussed for potential practical applications.
Article
Chemistry, Physical
Artem Boychuk, Valery Shibaev, Martin Cigl, Vera Hamplova, Vladimira Novotna, Alexey Bobrovsky
Summary: Stimuli responsive liquid crystalline polymers are synthesized and studied in this work. The hydrazone-containing copolyacrylate exhibited cholesteric liquid crystalline properties and the helix pitch length can be tuned under light irradiation. The selective light reflection peak shifted from 1650 nm to 500 nm under blue light irradiation, which is related to the Z-E isomerization of photochromic hydrazone-containing groups and is photochemically reversible. The photo-optical response was improved and faster after copolymer doping with low-molar-mass liquid crystal, and both E and Z isomers of hydrazone photochromic group are thermally stable, enabling a pure photoinduced switch without any dark relaxation.
Article
Chemistry, Multidisciplinary
Stanislav Campelj, Matic Pobreznik, Tomas Landovsky, Janez Kovac, Layla Martin-Samos, Vera Hamplova, Darja Lisjak
Summary: In this study, MNPs were successfully functionalized with CAT, GAL, CAF, and NDA at different pH values. The functionalized MNPs showed higher saturation magnetizations (M-s) compared to the starting material. XPS analyses confirmed the presence of Fe(III) ions on the surface, ruling out the formation of magnetite. DFT calculations demonstrated that the adsorption of catechols did not affect the M-s. The increase in the average size of the MNPs and the decrease in the fraction of the smallest MNPs explained the observed increase in M-s values.
Article
Materials Science, Multidisciplinary
Alexey Bobrovsky, Valery Shibaev, Boris Ostrovskii, Martin Cigl, Vera Hamplova, Alexej Bubnov
Summary: Fast progress in modern information technologies requires the creation of new optical devices and diffractive elements. In this study, a new approach for the design of photo- and electro-controllable diffraction gratings is proposed and implemented. The created gratings represent a promising class of advanced materials for applications in photonics and optoelectronics.
JOURNAL OF MATERIALS CHEMISTRY C
(2023)