Review
Biochemistry & Molecular Biology
Julian Bailes, Mikhail Soloviev
Summary: IGF-1, the principal mediator of GH, plays a crucial role in cell growth, differentiation, and apoptosis, with its bioavailability affected by IGFBPs. The varying expression levels of IGF-1 in clinical conditions and its misuse in sports have raised significant concerns.
Article
Veterinary Sciences
Diogo J. Cardilli, Kellen Sousa-Oliveira, Carolina Franchi-Joao, Faviana Azevedo-Voorwald, Marco A. Machado-Silva, Joao Ademir Oliveira, Maria Jesus Sanchez-Calabuig, Gilson H. Toniollo, Jose F. Perez-Gutierrez
Summary: IGF-1 plays an important role in the regulation of ovarian function, however, its specific function in the nuclear maturation of oocytes in the canine ovary remains unclear. Immunolocalization studies show the presence of IGF-1 throughout follicular growth stages in the ovary, but its role in oocyte nuclear maturation could not be demonstrated.
VETERINARY MEDICINE AND SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Aldona Kasprzak
Summary: Colorectal cancer is a common aggressive carcinoma with poor prognosis, often associated with metabolic syndrome and high blood sugar levels. The role of IGF-1 in glucose metabolism in colorectal carcinogenesis and its potential link to the Warburg effect require further investigation. Current therapeutic strategies targeting impaired glucose metabolism in CRC are being explored to improve treatment outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Armel H. H. Nwabo Kamdje, Paul F. Seke Etet, Maulilio J. Kipanyula, Lorella Vecchio, Richard Tagne Simo, Alfred K. Njamnshi, Kiven E. Lukong, Patrice N. Mimche
Summary: The tumor microenvironment plays a role in tumorigenesis and drug resistance through the overexpression of insulin-like growth factor 1 (IGF-1). Anti-IGF therapies have shown potential in inhibiting cancer and overcoming chemotherapy drug resistance in preclinical studies, but toxicity and resistance are challenges in clinical trials.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Fa Zhang, Emrah Altindis, C. Ronald Kahn, Richard D. DiMarchi, Vasily Gelfanov
Summary: The study identified viral insulin-like peptides with unique biological functions, including one that acts as a potent and full antagonist of the IGF-1R. The results revealed the importance of the internal structure of VILPs in regulating their biological activities and discovered a set of potentially medicinally important antagonists.
MOLECULAR METABOLISM
(2021)
Review
Biochemistry & Molecular Biology
Yuhan Zhu, Lin Chen, Binyu Song, Zhiwei Cui, Guo Chen, Zhou Yu, Baoqiang Song
Summary: The article describes the expression changes and fibrosis-promoting effects of insulin-like growth factor 2 (IGF-2) in different tissues during fibrosis process.
Article
Biochemical Research Methods
Mark S. Pratt, Martijn van Faassen, Noah Remmelts, Rainer Bischoff, Ido P. Kema
Summary: This study presents a simple and fast antibody-free LC-MS/MS method for the quantification of intact IGF-1 and IGF-2 in human plasma, allowing for reliable and simultaneous quantification without the need for enzymatic digestion. The method offers advantages of speed, accuracy, and potential wide application in clinical mass spectrometry laboratories.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Review
Endocrinology & Metabolism
Wentao Zhong, Xueqing Wang, Yufei Wang, Guoqian Sun, Jia Zhang, Zhuo Li
Summary: Obesity is a global epidemic and a risk factor for endocrine-related cancers. It affects insulin, IGF-1, sex hormones, IGFBPs, and adipokines, with IGF-1 playing a crucial role in obesity-related endocrine cancers. This review discusses the impact of obesity on prostate, breast, and pancreatic cancers, focusing on the mechanism of IGF-1 and its interaction with estrogen and adipokines. Additionally, the current status of IGF-1R inhibitors in clinical practice and their potential combination with other anticancer drugs are briefly introduced.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Immunology
Massimiliano Bissa, Veronica Galli, Luca Schifanella, Monica Vaccari, Mohammad Arif Rahman, Giacomo Gorini, Nicolo Binello, Sarkis Sarkis, Anna Gutowska, Isabela Silva de Castro, Melvin N. Doster, Ramona Moles, Guido Ferrari, Xiaoying Shen, Georgia D. Tomaras, David C. Montefiori, Kombo F. N'guessan, Dominic Paquin-Proulx, Pamela A. Kozlowski, David J. Venzon, Hyoyoung Choo-Wosoba, Matthew W. Breed, Joshua Kramer, Genoveffa Franchini
Summary: The efficacy of the DNA/ALVAC/gp120/alum vaccine in the absence of neutralizing antibodies is attributed to a delicate balance of pro-and anti-inflammatory immune responses, which effectively reduces the risk of SIVmac251 acquisition in macaques. This efficacy is associated with antibodies recognizing the V2 helical conformation, DC-10 tolerogenic dendritic cells promoting the clearance of apoptotic cells through efferocytosis, and downregulation of CCR5 on vaccine-induced gut homing CD4(+) cells. IGF-1, a potent RAS activator, was found to alter epitope recognition and affect ADCC and efferocytosis, but it also compensates for these negative effects by reducing CCR5 expression on CD4(+) gut-homing T-cells, resulting in equivalent vaccine efficacy (71% with IGF-1 and 69% without).
Review
Endocrinology & Metabolism
Mengyang Li
Summary: The GH/IGF system plays a role in growth regulation in the body. By studying the basal chordate amphioxus, it was discovered that most members of the GH/IGF system are present in amphioxus, providing strong evidence for the origin of this system in amphioxus.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Ecology
Zsofia Toth, Katharina Mahr, Gyula Oelveczki, Levente Ori, Adam Zoltan Lendvai
Summary: The study found that bearded reedlings showed variation in their IGF-1 reaction norms during food shortages, with heavier individuals more likely to decrease IGF-1 levels. This individual by environment interaction may have important implications for the evolution of IGF-1 related hormonal phenotypes in this species.
FRONTIERS IN ECOLOGY AND EVOLUTION
(2022)
Article
Integrative & Complementary Medicine
Zhihong Xie, Feng Yang
Summary: The meta-analysis found that lycopene intake did not significantly reduce serum IGF-1 levels, but showed a significant decrease under certain dose, intervention period, and age conditions, with potential health benefits in managing patients with cardiac disorders.
COMPLEMENTARY THERAPIES IN MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Archana Arjunan, Dhiraj Kumar Sah, Minna Woo, Juhyun Song
Summary: Neurodegenerative disorders are characterized by neuronal degeneration and glial dysfunction, leading to impairments in cognition, psychomotor function, and behavior. Metabolic syndrome has been linked to these disorders, and insulin growth factor-1 (IGF-1) deficiency has been associated with MetS-related pathologies. IGF-1 plays a crucial role in neurogenesis, plasticity, angiogenesis, and metabolic function in the brain, making it a potential therapeutic target for MetS-related neurodegenerative diseases. This review highlights the evidence for the potential therapeutic effects of IGF-1 and its involvement in molecular signaling defects in MetS-related neurodegeneration.
CELL AND BIOSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Huifen Liu, Qi Guo, Limin Zhang, Xue Tian, Xiao Ma, JianXin Zhang, Xuejun Li
Summary: The expression of IGF1 is increased during in vitro maturation of spotted steed oocytes, indicating its important role in fish reproduction. Treatment with recombinant IGF1 enhances the rate of oocyte maturation and influences the transcription of steroidogenesis-related genes. The expression profiles of receptors of Igf1, Fsh and Lh suggest a crosstalk response to IGF1-induced oocyte maturation. IGF1 also upregulates CyclinB and AKT protein expression.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Mariam Ahmed Galal, Samhar Samer Alouch, Buthainah Saad Alsultan, Huda Dahman, Nouf Abdullah Alyabis, Sarah Ammar Alammar, Ahmad Aljada
Summary: This comprehensive review thoroughly explores the intricate involvement of insulin receptor isoforms and insulin-like growth factor receptors in the insulin and insulin-like growth factor signaling pathway, emphasizing their crucial roles in cancer development and resistance to anti-cancer drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)