Journal
JOURNAL OF PROTEOMICS
Volume 173, Issue -, Pages 1-11Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jprot.2017.11.017
Keywords
Label-free quantitative proteomic analysis; Citrus-limon nanovesicles; Acetyl-CoA carboxylase; Colorectal cancer
Categories
Funding
- Associazione Italiana per la Ricerca sul Cancro (AIRC) [18783]
- AIRC-FIRC (Associazione Italiana Ricerca sul Cancro and Fondazione Italiana Ricerca sul Cancro) fellowship
- Italian Ministry of University and Research (PON) [DOT1320875]
- Doctoral Course of Experimental Oncology and Surgery
- Cycle XXXII
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We have previously isolated exosome-like nanoparticles from Citrus-limon juice, able to inhibit in vitro and in vivo tumor cell growth. In order to deeply understand the mechanism underlying nanovesicle effects, we performed a proteomic profile of treated colorectal cancer cells. Among the proteins differentially expressed after nanovesicle treatment, we found a significant downregulation of the Acetyl-CoA Carboxylase 1 (ACACA) and we demonstrated that silencing ACACA in cancer cells leads to a reduction of cell growth. Our study proved that the antitumor effects of Citrus-limon nanovesicles is partly mediated by lipid metabolism inhibition, in particular via ACACA downregulation. Significance: This study represents the attempt to achieve, by a proteomic approach, a better understanding of the role of lemon nanovesicles in affecting colorectal cancer cell growth.
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