Article
Cardiac & Cardiovascular Systems
Ruoting Wang, Ivan Olier, Sandra Ortega-Martorell, Yingxin Liu, Zebing Ye, Gregory Y. H. Lip, Guowei Li
Summary: The impact of metabolic status and physical activity on the risk of atrial fibrillation in the obese population was investigated. The study found that metabolically healthy obesity was associated with a reduced risk of atrial fibrillation, while physical activity could modify the relationship between metabolic status and atrial fibrillation risk in metabolically unhealthy obesity participants.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Dongmei Wei, Vannina Gonzalez-Marrachelli, Jesus D. Melgarejo, Chia-Te Liao, Angie Hu, Stefan Janssens, Peter Verhamme, Lucas Van Aelst, Thomas Vanassche, Josep Redon, Maria Tellez-Plaza, Juan C. Martin-Escudero, Daniel Monleon, Zhen-Yu Zhang
Summary: A new definition of metabolically healthy obesity (MHO) has been proposed to stratify the mortality risk of obesity. This study aimed to evaluate the association between MHO and cardiovascular events and assess its metabolomic pattern.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Endocrinology & Metabolism
Shan Cai, Jiajia Dang, Panliang Zhong, Ning Ma, Yunfei Liu, Di Shi, Zhiyong Zou, Yanhui Dong, Jun Ma, Yi Song
Summary: This study analyzed the sex differences in the prevalence of obesity phenotypes and their risk factors among children and adolescents in China. The results showed higher prevalence of obesity phenotypes in boys and identified various risk factors such as parental smoking, birth weight, and lifestyle factors. The findings highlight the importance of considering sex differences in managing obesity phenotypes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Medicine, General & Internal
Cem Tanriover, Sidar Copur, Abduzhappar Gaipov, Batu Ozlusen, Rustu E. Akcan, Masanari Kuwabara, Mads Hornum, Daniel H. Van Raalte, Mehmet Kanbay
Summary: Obesity is a complex condition with different subtypes, one of which is metabolically healthy obesity (MHO). MHO has various definitions and its prevalence differs in different studies. Mechanisms underlying MHO include adipose tissue types and distribution, hormones, inflammation, diet, microbiota, and genetics. While MHO has relatively favorable metabolic characteristics compared to metabolically unhealthy obesity (MUO), it is still associated with important chronic diseases and has the potential to progress into an unhealthy phenotype. The major treatment options for MHO include dietary modifications, exercise, bariatric surgery, and specific medications.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Nutrition & Dietetics
Lisa Sanchez-Johnsen, Amanda Dykema-Engblade, Carlos E. Rosas, Leonilda Calderon, Alfred Rademaker, Magdalena Nava, Chandra Hassan
Summary: This study explored the preferences of Latinos regarding a healthy eating, physical activity, and body image intervention design, finding that most participants preferred interventions in Spanish or both Spanish and English, with bilingual and Hispanic/Latino intervention leaders considered important. Participants showed interest in attending interventions meeting twice per week for 1.5 to 2 hours, with activities involving Latin dance movements and music, as well as Latino sayings and folktales.
Article
Nutrition & Dietetics
Luigi Barrea, Giovanna Muscogiuri, Gabriella Pugliese, Giulia de Alteriis, Annamaria Colao, Silvia Savastano
Summary: This study found that compared to PCOS MHO patients, PCOS MUO patients have more severe metabolic parameters and higher inflammation levels, as well as lower adherence to the Mediterranean diet. Additionally, MUO patients also exhibit more severe hyperandrogenism and cardio-metabolic indices.
Article
Clinical Neurology
Hwanjin Park, Kounseok Lee
Summary: The study found that moderate waist circumference may reduce suicidal thoughts for metabolically healthy women above 40 years old. While severe abdominal obesity was associated with increased suicide risk, this association was not significant when emotional difficulties like depression were considered.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Medicine, General & Internal
Sidar Copur, Cem Tanriover, Furkan Yavuz, Katherine R. Tuttle, Mehmet Kanbay
Summary: Metabolically healthy obesity or overweight refers to being obese or overweight without any major metabolic disorder or cardiovascular diseases. However, it is recognized as an important risk factor for the development of cardiovascular diseases. Tirzepatide, a newly developed glucose-lowering agent, has shown potential benefits in reducing the risk of adverse cardiovascular outcomes in metabolically healthy obese or overweight patients.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Darlene L. S. Vilela, Pamela G. Fonseca, Sonia L. Pinto, Josefina Bressan
Summary: This study investigated the influence of dietary patterns on metabolically healthy obesity, finding that greater adherence to healthy eating patterns can prevent the transition to metabolically unhealthy obese phenotypes, improve metabolic health, and reduce the risk of cardiovascular disease and overall mortality. Unhealthy eating patterns, on the other hand, were associated with increased inflammation and risks of developing noncommunicable diseases.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Endocrinology & Metabolism
A. Viitasalo, K. Pahkala, T. Lehtimaki, J. S. A. Viikari, T. H. Tammelin, O. Raitakari, T. O. Kilpelainen
Summary: Adults with metabolically obese normal-weight (MONW) have lower BMI in childhood and young adulthood, but their BMI increases more than other adults after this age. They also experience a gradual decrease in physical activity levels since youth. These results emphasize the importance of a healthy lifestyle in preventing metabolic disorders, particularly in individuals who are slim in childhood.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Saioa Gomez-Zorita, Maite Queralt, Maria Angeles Vicente, Marcela Gonzalez, Maria P. Portillo
Summary: The relationship between obesity and metabolically healthy obese (MHO) as well as metabolically obese normal weight (MONW) individuals is complex and varied. Different classifications have been used in studies, making it difficult to define MHO and MONW. Main determinants of MHO include growth type, anatomical location, adipose tissue inflammation, while MONW is mainly influenced by genetic background and lifestyle factors.
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Nutrition & Dietetics
Patrice A. Hubert, Megan Mahoney, Tania B. Huedo-Medina, Tricia M. Leahey, Valerie B. Duffy
Summary: This study aimed to investigate physical activity liking in college women and found that body size perception and dietary behaviors impact physical activity liking. It also highlighted that women who enjoy but do not actively participate in physical activity tend to have higher levels of dietary restraint and lower diet quality.
Article
Endocrinology & Metabolism
Jing Fu, Qiu Wang, Lin Zhang, Jia Liu, Guang Wang
Summary: This study aimed to explore the relationship between serum bilirubin levels and metabolic alterations in different obesity phenotypes. The results showed that the metabolically healthy obesity (MHO) group had favorable metabolic profiles and higher bilirubin levels compared to the metabolically unhealthy obesity (MUHO) group. Bilirubin was negatively correlated with cholesterol, insulin resistance, and inflammation markers.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Nutrition & Dietetics
Matina Kouvari, Nathan M. D'Cunha, Thomas Tsiampalis, Manja Zec, Domenico Sergi, Nikolaj Travica, Wolfgang Marx, Andrew J. McKune, Demosthenes B. Panagiotakos, Nenad Naumovski
Summary: The aim of this study was to evaluate the association between metabolically healthy overweight/obesity (MHO) status and longitudinal cognitive function while considering the stability of the condition. The study found that maintaining a healthy metabolic status over time has a greater impact on cognitive function than body weight alone.
Article
Endocrinology & Metabolism
Ruziana Mona Wan Mohd Zin, Muhammad Yazid Jalaludin, Abqariyah Yahya, Ahmad Kamil Nur Zati Iwani, Fuziah Md Zain, Janet Yeow Hua Hong, Abdul Halim Mokhtar, Wan Nazaimoon Wan Mohamud
Summary: This study aimed to compare several parameters related to obesity between metabolically healthy obese (MHO) and metabolically unhealthy obese (MUO) children, and to examine the predictors associated with the MHO phenotype.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Yuan-Di Halvorsen, John Paul Lock, Juan P. Frias, Francisco Jose Tinahones, Dominik Dahl, Annie L. Conery, Mason W. Freeman
Summary: This study compared the effects of bexagliflozin tablets and glimepiride on the treatment of patients with type 2 diabetes. It was found that bexagliflozin tablets were noninferior to glimepiride in lowering HbA1c levels, and were superior in reducing body mass and systolic blood pressure. Additionally, bexagliflozin tablets were associated with fewer hypoglycemic events and had a favorable effect on estimated glomerular filtration rate (eGFR).
DIABETES OBESITY & METABOLISM
(2023)
Review
Nutrition & Dietetics
Hatim Boughanem, Pallavi Kompella, Francisco J. Tinahones, Manuel Macias-Gonzalez
Summary: Gene expression can be regulated by epigenomic modifications such as DNA methylation, histone modification, and chromosome remodeling. Vitamins, as natural bioactive compounds, have been found to modify epigenetic patterns and potentially impact the risk of cancer, including colorectal cancer (CRC). This review examines the relationship between vitamins and CRC risk through epidemiological and observational studies and discusses the potential of using vitamins as epigenetic modifiers for CRC treatment. Although more studies with better designs are needed, understanding the molecular mechanisms of vitamin-mediated epigenetic regulation can help identify effective therapeutic targets for CRC prevention and treatment.
Article
Endocrinology & Metabolism
Jazmin Castaneda, Mercedes Gil-Lespinard, Enrique Almanza-Aguilera, Fjorida Llaha, Jesus-Humberto Gomez, Nicola Bondonno, Anne Tjonneland, Kim Overvad, Verena Katzke, Matthias B. Schulze, Giovanna Masala, Claudia Agnoli, Maria Santucci de Magistris, Rosario Tumino, Carlotta Sacerdote, Guri Skeie, Magritt Brustad, Cristina Lasheras, Esther Molina-Montes, Maria-Dolores Chirlaque, Aurelio Barricarte, Emily Sonestedt, Marisa da Silva, Ingegerd Johansson, Johan Hultdin, Anne M. May, Nita G. Forouhi, Alicia K. Heath, Heinz Freisling, Elisabete Weiderpass, Augustin Scalbert, Raul Zamora-Ros
Summary: This study aimed to evaluate the associations between the intake of total polyphenols, polyphenol classes, and subclasses and body weight change over 5 years. The results showed an inverse association between total flavonoid intake and body weight change, and positive associations between total polyphenol and hydroxycinnamic acid intake and body weight gain. However, the positive association between hydroxycinnamic acid intake and body weight gain was only found in coffee consumers, not in coffee nonconsumers.
Article
Medicine, General & Internal
Ivan Jose Fuentes-Abolafio, Manuel Trinidad-Fernandez, Adrian Escriche-Escuder, Cristina Roldan-Jimenez, Jose Maria Arjona-Caballero, M. Rosa Bernal-Lopez, Michele Ricci, Ricardo Gomez-Huelgas, Luis Miguel Perez-Belmonte, Antonio Ignacio Cuesta-Vargas
Summary: This study aimed to assess gait and kinematic parameters in HFpEF patients during the 6MWT using inertial sensors, and discriminate patients based on their performance in the test. A cross-sectional study was conducted on HFpEF patients older than 70 years, and 6MWT was performed in a closed corridor. The results showed significant differences in gait and pure kinematic parameters between the two performance groups, and three parameters demonstrated good discriminant capacity.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Ramona Mihaela Ciubotaru, Mar Garcia-Aloy, Domenico Masuero, Pietro Franceschi, Luca Zulini, Marco Stefanini, Michael Oberhuber, Peter Robatscher, Giulia Chitarrini, Urska Vrhovsek
Summary: This study used UHPLC-MS/MS to investigate the impact of Erysiphe necator on the lipid profile of grapevine genotypes with different sources of resistance. The results showed that the lipidome alterations were most significant in the resistant genotypes, while the susceptible genotype had minimal changes. These findings contribute to a better understanding of the molecular mechanisms underlying grapevine resistance to pathogen infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Respiratory System
Nara Liessi, Valeria Tomati, Valeria Capurro, Nicoletta Loberto, Mar Garcia-Aloy, Pietro Franceschi, Massimo Aureli, Nicoletta Pedemonte, Andrea Armirotti
Summary: This article reports on how the triple drug combination ETI affects the synthesis pathway of sphingolipids in human bronchial epithelial cells. Treatment with ETI increases the levels of dihydrosphingolipids, possibly by modulating the activity of enzymes involved in their conversion. Interestingly, this effect is observed in both cystic fibrosis and non-cystic fibrosis subjects, suggesting it is an off-target effect of ETI.
JOURNAL OF CYSTIC FIBROSIS
(2023)
Article
Medicine, General & Internal
Rafael Gabriel, Nisa Boukichou-Abdelkader, Aleksandra Gilis-Januszewska, Konstantinos Makrilakis, Ricardo Gomez-Huelgas, Zdravko Kamenov, Bernhard Paulweber, Ilhan Satman, Predrag Djordjevic, Abdullah Alkandari, Asimina Mitrakou, Nebojsa Lalic, Jesus Egido, Sebastian Mas-Fontao, Jean Henri Calvet, Jose Carlos Pastor, Jaana Lindstrom, Marcus Lind, Tania Acosta, Luis Silva, Jaakko Tuomilehto
Summary: The objective of this study was to compare the impact of glucose-lowering drugs on peripheral nerve and kidney function in prediabetes. The results showed that the use of metformin alone, linagliptin alone, or the combination of both reduced the risk of small fiber peripheral neuropathy and slowed down the decrease in estimated glomerular filtration rate compared to the placebo. These findings suggest that treatment with metformin and linagliptin, either alone or in combination, can effectively protect prediabetes patients from developing peripheral nerve diseases and maintain kidney function.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Enrique Almanza-Aguilera, Estefania Davila-Cordova, Daniel Guinon-Fort, Marta Farras, Giovanna Masala, Maria Santucci de Magistris, Ivan Baldassari, Rosario Tumino, Lisa Padroni, Verena A. Katzke, Matthias B. Schulze, Augustin Scalbert, Raul Zamora-Ros
Summary: This study analyzed the correlations between the acute and habitual intake of dietary tyrosols and their main food sources with urinary excretions of tyrosol and hydroxytyrosol. The results showed that urinary excretions correlated more strongly with acute intake than habitual intake. They also found correlations between urinary excretions and other tyrosol precursors as well as major food sources. Based on these findings, urinary excretions could be proposed as biomarkers of total tyrosol intake, especially for acute intakes.
Article
Biology
Yentel Mateo-Otero, Francisco Madrid-Gambin, Marc Llavanera, Alex Gomez-Gomez, Noemi Haro, Oscar J. Pozo, Marc Yeste
Summary: Using pig as a model, this study investigated the relationship between metabolic activity of sperm and their quality, function, and fertility outcomes. High-quality sperm were associated with higher levels of glycolysis-derived metabolites, and the metabolic status of sperm greatly influenced oocyte fertilisation and embryo development. Overall, this study demonstrates that the basal metabolic activity of sperm influences their function, extending beyond fertilisation.
COMMUNICATIONS BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Alba Garcia-Baos, Antoni Pastor, Ines Gallego-Landin, Rafael de la Torre, Ferran Sanz, Olga Valverde
Summary: Patients with Fetal Alcohol Spectrum Disorder (FASD) exhibit long-lasting cognitive disabilities, including memory deficits, but the underlying neurobiological mechanisms are not clear. By studying alcohol-exposed mice, researchers found that prenatal and lactation alcohol exposure induces FASD-like memory impairments through the reduction of N-acylethanolamines (NAEs) and peroxisome proliferator-activated receptor gamma (PPAR-gamma) in the hippocampus during a childhood-like period. Pharmacological interventions targeting NAEs and PPAR-gamma were able to improve memory deficits, and overexpression of PPAR-gamma in hippocampal astrocytes mitigated memory impairments induced by alcohol exposure.
MOLECULAR PSYCHIATRY
(2023)
Article
Psychology, Clinical
Sangeetha Shyam, Carlos Gomez-Martinez, Indira Paz-Graniel, Jose J. Gaforio, Miguel Angel Martinez-Gonzalez, Dolores Corella, Montserrat Fito, J. Alfredo Martinez, Angel M. Alonso-Gomez, Julia Warnberg, Jesus Vioque, Dora Romaguera, Jose Lopez-Miranda, Ramon Estruch, Francisco J. Tinahones, Jose Manuel Santos-Lozano, J. Luis Serra-Majem, Aurora Bueno-Cavanillas, Josep A. Tur, Vicente Martin Sanchez, Xavier Pinto, Maria Ramos, Josep Vidal, Maria Mar Alcarria, Lidia Daimiel, Emilio Ros, Fernando Fernandez-Aranda, Stephanie K. Nishi, Oscar Garcia Regata, Estefania Toledo, Jose V. Sorli, Olga Castaner, Antonio Garcia-Rios, Rafael Valls-Enguix, Napoleon Perez-Farinos, M. Angeles Zulet, Elena Rayo-Gago, Rosa Casas, Mario Rivera-Izquierdo, Lucas Tojal-Sierra, Miguel Damas-Fuentes, Pilar Buil-Cosiales, Rebeca Fernandez-Carrion, Albert Goday, Patricia J. Pena-Orihuela, Laura Compan-Gabucio, Javier Diez-Espino, Susanna Tello, Ana Gonzalez-Pinto, Victor de la O, Miguel Delgado-Rodriguez, Nancy Babio, Jordi Salas-Salvado
Summary: COVID-19 is associated with long-term depression risk in older adults, especially in women. Long-term evaluations of the impact of COVID-19 on mental health and preventive public health initiatives are necessary for older adults.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Oncology
Enrique Almanza-Aguilera, Daniel Guinon-Fort, Aurora Perez-Cornago, Miriam Martinez-Huelamo, Cristina Andres-Lacueva, Anne Tjonneland, Anne Kirstine Eriksen, Verena Katzke, Rashmita Bajracharya, Matthias B. Schulze, Giovanna Masala, Andreina Oliverio, Rosario Tumino, Luca Manfredi, Cristina Lasheras, Marta Crous-Bou, Maria-Jose Sanchez, Pilar Amiano, Sandra M. Colorado-Yohar, Marcela Guevara, Emily Sonestedt, Anders Bjartell, Elin Thysell, Elisabete Weiderpass, Dagfinn Aune, Elom K. Aglago, Ruth C. Travis, Raul Zamora-Ros
Summary: In this large prospective cohort study, no association was found between (poly)phenol intake and the risk of prostate cancer among European men. This was observed for both overall intake and specific classes and subclasses of (poly)phenols.
Review
Biochemistry & Molecular Biology
Anna Boronat, Gabriele Serreli, Jose Rodriguez-Morato, Monica Deiana, Rafael de la Torre
Summary: Epidemiological studies suggest that consuming olive oil rich in phenolic bioactive compounds may lower the risk of neurodegenerative diseases and improve cognitive performance in the elderly. Preclinical evidence indicates that olive oil phenolic compounds can counteract oxidative stress and neuroinflammation, key processes in neurodegeneration. Clinical evidence suggests that high consumption of olive oil phenolic compounds is associated with better cognitive preservation, independent of dietary patterns. Further research is needed to understand the mechanisms and potential clinical applications.
Review
Medicine, Research & Experimental
Francisco Madrid-Gambin, David Fabregat-Safont, Alex Gomez-Gomez, Eulalia Olesti, Natasha L. Mason, Johannes G. Ramaekers, Oscar J. Pozo
Summary: Psychedelics are hallucinogen drugs that alter consciousness. There is renewed interest in using them for mental health disorders, but further research is needed to understand their biological effects, mechanism of action, and metabolism. Metabolic and metabolomics studies can help with this. Metabolic studies determine the drug's main metabolites, while metabolomics can shed light on the biological processes and therapeutic potential of psychedelics.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
