HCN4 pacemaker channels attenuate the parasympathetic response and stabilize the spontaneous firing of the sinoatrial node

G protein-gatedIKAChchannels as therapeutic targets for treatment of sick sinus syndrome and heart block

(2016) Pietro Mesirca et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The end effector of circadian heart rate variation: the sinoatrial node pacemaker cell

(2015) Yael Yaniv et al.   BMB Reports

Age-associated expression of HCN channel isoforms in rat sinoatrial node

(2015) Xin Huang et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Zinc-Induced Effects on Osteoclastogenesis Involves Activation of Hyperpolarization-Activated Cyclic Nucleotide Modulated Channels via Changes in Membrane Potential

(2015) Takuya Notomi et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Ectopic automaticity induced in ventricular myocytes by transgenic overexpression of HCN2

(2015) Kensuke Oshita et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Principles and standards for reporting animal experiments inThe Journal of PhysiologyandExperimental Physiology

(2015) David Grundy   JOURNAL OF PHYSIOLOGY-LONDON

Functional role of voltage gated Ca2+ channels in heart automaticity

(2015) Pietro Mesirca et al.   Frontiers in Physiology

The Symptom Complex of Familial Sinus Node Dysfunction and Myocardial Noncompaction Is Associated With Mutations in the HCN4 Channel

(2014) Patrick A. Schweizer et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Exercise training reduces resting heart rate via downregulation of the funny channel HCN4

(2014) Alicia D’Souza et al.   Nature Communications

Cardiac arrhythmia induced by genetic silencing of ‘funny’ (f) channels is rescued by GIRK4 inactivation

(2014) Pietro Mesirca et al.   Nature Communications

Sick Sinus Syndrome in HCN1-Deficient Mice

(2013) Stefanie Fenske et al.   CIRCULATION

Upregulation of the Hyperpolarization-Activated Current Increases Pacemaker Activity of the Sinoatrial Node and Heart Rate During Pregnancy in Mice

(2013) Nabil El Khoury et al.   CIRCULATION

Hyperpolarisation-activated cyclic nucleotide-gated channels regulate the spontaneous firing rate of olfactory receptor neurons and affect glomerular formation in mice

(2013) Noriyuki Nakashima et al.   JOURNAL OF PHYSIOLOGY-LONDON

Essential Role of the m2R-RGS6-IKACh Pathway in Controlling Intrinsic Heart Rate Variability

(2013) Ekaterina Posokhova et al.   PLoS One

Ion channel-kinase TRPM7 is required for maintaining cardiac automaticity

(2013) R. Sah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adrenergic Regulation of HCN4 Channel Requires Protein Association with β2-Adrenergic Receptor

(2012) Derek Greene et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Funny Current and Cardiac Rhythm: Insights from HCN Knockout and Transgenic Mouse Models

(2012) Annalisa Bucchi et al.   Frontiers in Physiology

HCN channels in the heart: lessons from mouse mutants

(2011) S Herrmann et al.   BRITISH JOURNAL OF PHARMACOLOGY

New Molecular Mechanisms for Cardiovascular Disease: Transcriptional Pathways and Novel Therapeutic Targets in Heart Failure

(2011) Koichiro Kuwahara et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Deep bradycardia and heart block caused by inducible cardiac-specific knockout of the pacemaker channel gene Hcn4

(2011) M. Baruscotti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Coupled SYSTEM of Intracellular Ca 2+ Clocks and Surface Membrane Voltage Clocks Controls the Timekeeping Mechanism of the Heart’s Pacemaker

(2010) Edward G. Lakatta et al.   CIRCULATION RESEARCH

The Role of the Funny Current in Pacemaker Activity

(2010) Dario DiFrancesco   CIRCULATION RESEARCH

cAMP Sensitivity of HCN Pacemaker Channels Determines Basal Heart Rate But Is Not Critical for Autonomic Rate Control

(2010) Patrick A. Schweizer et al.   Circulation-Arrhythmia and Electrophysiology

Phosphorylation and modulation of hyperpolarization-activated HCN4 channels by protein kinase A in the mouse sinoatrial node

(2010) Zhandi Liao et al.   JOURNAL OF GENERAL PHYSIOLOGY

What keeps us ticking: a funny current, a calcium clock, or both?

(2009) Edward G. Lakatta et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Hyperpolarization-Activated Cation Channels: From Genes to Function

(2009) Martin Biel et al.   PHYSIOLOGICAL REVIEWS

Control of heart rate by cAMP sensitivity of HCN channels

(2009) J. Alig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cardiac pacemaker function of HCN4 channels in mice is confined to embryonic development and requires cyclic AMP

(2008) Dagmar Harzheim et al.   EMBO JOURNAL

Tamoxifen-inducible gene deletion in the cardiac conduction system

(2008) Evelyn Hoesl et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Genesis and Regulation of the Heart Automaticity

(2008) Matteo E. Mangoni et al.   PHYSIOLOGICAL REVIEWS