Article
Neurosciences
Guiyuan Cai, Manfeng Wu, Qian Ding, Tuo Lin, Wanqi Li, Yinghua Jing, Hongying Chen, Huiting Cai, Tifei Yuan, Guangqing Xu, Yue Lan
Summary: The study found that the alpha2 power in the sensorimotor region is inversely correlated with corticospinal excitability. Additionally, the global efficiency of the brain network is correlated with corticospinal excitability, showing a positive correlation with global efficiency in the theta band and a negative correlation with global efficiency in the alpha2 band.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
C. Barbi, G. Vernillo, M. Emadi Andani, G. Giuriato, F. G. Laginestra, A. Cavicchia, G. Fiorini Aloisi, C. Martignon, A. Pedrinolla, F. Schena, M. Venturelli
Summary: Researchers evaluated the accuracy of neuronavigated TMS (nTMS) and a standardized function-guided procedure for maintaining TMS coil position during neuromuscular evaluations. The study found that the spatial accuracy of TMS coil position did not affect corticospinal excitability and inhibition in knee extensors. Variability in MEP and SP responses was attributed to spontaneous fluctuations in corticospinal excitability and inhibition, unaffected by the stability of the stimulation point.
NEUROSCIENCE LETTERS
(2023)
Article
Behavioral Sciences
Haruki Hoshi, Sho Kojima, Naofumi Otsuru, Hideaki Onishi
Summary: The study reveals that the timing of tRNS affects corticospinal excitability but does not have an impact on motor learning. Differences in corticospinal excitability were observed after motor training with tRNS applied at different timings, while there were no significant differences in motor function improvement between the conditions.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Arantzazu San Agustin, Guillermo Asin-Prieto, Juan C. Moreno, Antonio Oliviero, Jose L. Pons
Summary: Transcranial Magnetic Stimulation (TMS) can modulate cortico-spinal excitability and improve motor performance, as shown in a study using a customized video game. This finding highlights the potential of using TMS in neurorehabilitation strategies for complex movements.
Review
Neurosciences
Mikael Desmons, Michael Theberge, Catherine Mercier, Hugo Masse-Alarie
Summary: This systematic review focuses on the corticomotor control of low back muscles using transcranial magnetic stimulation (TMS) in healthy individuals. The findings suggest distinct corticomotor control mechanisms for low back muscles compared to hand muscles, including bilateral projections from each primary motor cortex and the presence of intracortical inhibitory and excitatory circuits in the primary motor cortex influencing contralateral corticospinal cells projecting to low back muscles. Understanding these mechanisms is important for improving the understanding of neuromuscular function and clinical management of conditions such as low back pain and stroke.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Massimo Bertoli, Angela Tataranni, Susanna Porziani, Patrizio Pasqualetti, Eugenia Gianni, Joy Grifoni, Teresa L'Abbate, Karolina Armonaite, Livio Conti, Andrea Cancelli, Carlo Cottone, Franco Marinozzi, Fabiano Bini, Federico Cecconi, Franca Tecchio
Summary: This study tested the effectiveness of a fatigue relief treatment in multiple sclerosis patients by modulating the cortical motor circuitry. The treatment led to positive effects on fatigue symptoms and altered the symmetry of the brain's hemispheres. This research provides new insights into the mechanisms of neuronal functional patterning.
Article
Neurosciences
Cecilia Neige, Florent Lebon, Catherine Mercier, Jeremie Gaveau, Charalambos Papaxanthis, Celia Ruffino
Summary: Pain interferes with the motor imagery process, preventing the enhancement of corticospinal excitability and use-dependent plasticity.
Article
Neurosciences
Fernanda de Figueiredo Torres, Bia Lima Ramalho, Marcelle Ribeiro Rodrigues, Ana Carolina Schmaedeke, Victor Hugo Moraes, Karen T. Reilly, Raquel de Paula Carvalho, Claudia D. Vargas
Summary: This study investigated the changes in hand-hand and face-hand sensorimotor integration in patients with traumatic brachial plexus injury (TBPI). The results showed that both hand-hand and face-hand sensorimotor integration were affected in TBPI patients.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Akihiko Asao, Kento Wada, Tomonori Nomura, Kenichi Shibuya
Summary: The combination of repetitive peripheral magnetic stimulation (rPMS) with motor imagery (MI) enhances corticospinal excitability, with over 10 minutes of intermittent rPMS combined with MI showing a greater effect than rPMS alone on corticospinal excitability.
NEUROSCIENCE LETTERS
(2022)
Article
Neurosciences
Akira Nakashima, Takefumi Moriuchi, Daiki Matsuda, Jirou Nakamura, Kengo Fujiwara, Yuta Ikio, Takashi Hasegawa, Wataru Mitunaga, Toshio Higashi
Summary: This study aimed to investigate the impact of fatigue caused by motor imagery training on performance improvement and corticospinal excitability. The results showed that motor imagery training resulted in central fatigue and affected performance improvement.
Article
Physiology
Gonzalo Marquez, David Colomer, Cristina Benavente, Luis Morenilla, Carlos Alix-Fages, Paulino Padial, Belen Feriche
Summary: The study tested the effects of acute exposure to high altitude on corticospinal excitability and intracortical inhibition, as well as the effects of training in hypoxia and normoxia. The results showed that training in hypoxia resulted in higher ratings of perceived exertion, muscle pain, and lactate concentration, but did not significantly influence corticospinal excitability and intracortical inhibition.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Medicine, General & Internal
Seung Yeon Jeon, Jung Ho Choi, Sun Seong Kang, Yong-Hwi An, Hyun Joon Shim
Summary: Personalized neuromodulation, where treatment modalities are chosen based on the patient's responses in a pilot trial, is an advantageous strategy for treating tinnitus. The study found that the improvement in Tinnitus Handicap Inventory (THI) score after 10 sessions of each neuromodulation was significantly greater in the personalized group compared to the randomized group.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Alexander D. Tang, William Bennett, Aidan D. Bindoff, Samuel Bolland, Jessica Collins, Ross C. Langley, Michael Garry, Jeffery J. Summers, Mark R. Hinder, Jennifer Rodger, Alison J. Canty
Summary: The study examined the effects of subthreshold rTMS on structural synaptic plasticity in the mouse motor cortex of young and aged mice. The results showed that subthreshold rTMS can alter the rate of dendritic spine losses and gains, and effectively drive structural synaptic plasticity in both young adult and aged mice.
Article
Neurosciences
Atsushi Sasaki, Naotsugu Kaneko, Yohei Masugi, Tatsuya Kato, Matija Milosevic, Kimitaka Nakazawa
Summary: This study aimed to investigate neural interactions between arm and trunk or arm and leg muscles during different arm muscle contractions. The results showed that trunk extensor corticospinal excitability depends on the task and the intensity of arm contraction, while this is not true for trunk flexor and leg muscles.
Article
Neurosciences
Tingting Zhang, Bingqi Guo, Zhentao Zuo, Xiaojing Long, Shimin Hu, Siran Li, Xin Su, Yuping Wang, Chunyan Liu
Summary: This study aimed to evaluate the modulatory effects of transcranial focus ultrasound stimulation (tFUS) on human motor cortex excitability and explore the mechanism of neurotransmitter-related intracortical circuitry and plasticity. The results showed that tFUS can significantly increase M1 excitability, decrease intracortical inhibition, and change the concentration of GABA and Glx in the brain. These findings provide new insights into how tFUS can modulate cortical excitability and plasticity.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Review
Neurosciences
George M. Opie, Wei-Yeh Liao, John G. Semmler
Summary: Research indicates that interactions between the cerebellum and primary motor cortex are crucial for effective motor function. A review of emerging literature on this topic offers valuable insights into the nature of these interactions.
Article
Physiology
Brodie J. Hand, George M. Opie, Simranjit K. Sidhu, John G. Semmler
Summary: The study found that endurance-trained cyclists had longer movement times, increased M1 plasticity, but no effect on visuomotor skill acquisition in a sequential visuomotor task.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Medicine, Research & Experimental
Ryoki Sasaki, John G. Semmler, George M. Opie
Summary: The study found that there was no relationship between the magnitude of C-SICI and TT-SICI, but there was a positive relationship between the slope of inhibition recorded with C-SICI and TT-SICI under a PA current; C-SICI measures were unrelated to TEP amplitude, while TT-SICI was predicted by the P30 generated with AP stimulation.
Article
Multidisciplinary Sciences
Wei-Yeh Liao, Ryoki Sasaki, John G. Semmler, George M. Opie
Summary: This study aimed to assess the impact of the cerebellum on the neuroplasticity of early and late I-wave circuits. The findings suggest that stimulation of the cerebellum has a disruptive effect on the excitatory response in the primary motor cortex, but the specific effect depends on the current direction.
Article
Medicine, Research & Experimental
Ryoki Sasaki, Brodie J. Hand, John G. Semmler, George M. Opie
Summary: This study aimed to investigate the effects of repetitive paired-pulse transcranial magnetic stimulation (iTMS) at different time intervals on the plasticity of specific I-wave circuits. The results showed that iTMS increased motorevoked potentials (MEPs) produced by transcranial magnetic stimulation (TMS) and had a facilitatory effect on short-interval intracortical facilitation (SICF).
Article
Neurosciences
Corey G. Wadsley, John Cirillo, Arne Nieuwenhuys, Winston D. Byblow
Summary: This study provides a freely available Selective Stopping Toolbox (SeleST) to investigate selective stopping using either anticipatory or stop-signal task variants. The results suggest that selective stopping can be successfully investigated with either anticipatory or stop-signal paradigms in SeleST. The anticipatory paradigm should be used when strict control of response times is desired, while the stop-signal paradigm should be used when it is desired to estimate stop-signal reaction time with the independent race model.
EXPERIMENTAL BRAIN RESEARCH
(2023)
Article
Neurosciences
Wei-Yeh Liao, George M. Opie, Ulf Ziemann, John G. Semmler
Summary: Previous research has shown that the connectivity between dorsal premotor cortex (PMd) and motor cortex (M1) weakens with age. However, the influence of PMd on specific indirect wave circuits within M1 and its effect on age are unclear. This study investigates the influence of PMd on early and late I-wave excitability in M1 of young and older adults.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Editorial Material
Geriatrics & Gerontology
Ann-Maree Vallence, Rachael D. Seidler, Mitchell Ryan Goldsworthy, John G. Semmler, George M. Opie
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Neurosciences
Corey G. Wadsley, John Cirillo, Arne Nieuwenhuys, Winston D. Byblow
Summary: This study aimed to determine whether nonselective response inhibition during selective stopping is the result of a global pause process or a nonselective cancel process. In a bimanual anticipatory response inhibition paradigm, participants showed delayed responses in the non-signaled hand during selective ignore and stop trials, indicating that stopping-interference cannot solely be attributed to attentional capture. Furthermore, a stimulus-nonselective increase in frontocentral beta-bursts occurred during stop and ignore trials. These findings suggest that nonselective response inhibition primarily arises from a nonselective pause process, but does not fully explain the stopping-interference effect.
Article
Neurosciences
Brodie J. Hand, Ashley Merkin, George M. Opie, Ulf Ziemann, John G. Semmler
Summary: The purpose of this study was to examine the effect of rppTMS on M1 excitability and visuomotor skill acquisition in young and older adults. The results showed that rppTMS can increase M1 excitability and improve visuomotor skill acquisition in both young and older adults.
Article
Neurosciences
Ryoki Sasaki, Wei-Yeh Liao, George M. Opie, John G. Semmler
Summary: Repetitive paired-pulse transcranial magnetic stimulation can enhance the plasticity of the primary motor cortex. The orientation of the TMS coil and muscle activation can affect the activity of I-waves, but their influence on M1 plasticity with iTMS is still unclear.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
R. Sasaki, B. J. Hand, W. Y. Liao, N. C. Rogasch, L. Fernandez, J. G. Semmler, G. M. Opie
Summary: This study investigated the utility of combining electroencephalography (EEG) with transcranial magnetic stimulation (TMS) to measure the response to cerebellar-brain inhibition (CBI). The results showed that both F8 and DC coils suppressed TMS-evoked EEG potentials (TEPs) in the motor cortex, and the TEP produced by CBI stimulation was related to the motor inhibitory response to CBI. These findings suggest that TMS-EEG can be used to measure the response to CBI.