Article
Neurosciences
Chun-Yang Li, Hai-Feng Jiang, Li Li, Xiao-Jing Lai, Qian-Rong Liu, Shang-Bin Yu, Cheng-La Yi, Xiao-Qian Chen
Summary: The discovery of neuroglobin (Ngb) has revolutionized our understanding of brain oxygen metabolism. Ngb is found to co-localize and co-migrate with mitochondria, and upon hypoxia, Ngb migrates towards the cell membrane to facilitate neuronal oxygenation. This novel mechanism provides new insights into the understanding and treatment of neurological diseases and diseases that cause hypoxia in the brain.
NEUROSCIENCE BULLETIN
(2023)
Article
Biochemistry & Molecular Biology
Yujiao Lu, Jing Wang, Fulei Tang, Uday P. Pratap, Gangadhara R. Sareddy, Krishnan M. Dhandapani, Ana Capuano, Zoe Arvanitakis, Ratna K. Vadlamudi, Darrell W. Brann
Summary: Hemoglobin plays an important role in regulating neuronal oxygenation and neuroprotection. The levels of neuronal hemoglobin decrease with age in mice, leading to increased hypoxia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Liam M. Koehn, Kevin Nguyen, Xiaodi Chen, Andre Santoso, Richard Tucker, Yow-Pin Lim, Barbara S. Stonestreet
Summary: Targeting hypoxia-ischemia (HI)-related brain injury can effectively alleviate behavioral deficits and brain infarct volume in newborns, with no significant differences found in the efficacy of hIAIPs at different doses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Kazuki Hatayama, Sydney Riddick, Fares Awa, Xiaodi Chen, Daniela Virgintino, Barbara S. Stonestreet
Summary: Exposure to hypoxic-ischemic insults in newborns can lead to severe neurological sequelae. This study investigated the changes in the neurovascular unit (NVU) after hypoxic-ischemic injury in neonatal rats. The findings showed increased vascular density, neurovascular remodeling, and changes in pericyte coverage and claudin-5 expression in different brain regions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Berenice Le Dieu-Lugon, Nicolas Dupre, Celine Derambure, Francois Janin, Bruno J. Gonzalez, Stephane Marret, Arnaud Arabo, Philippe Leroux
Summary: MgSO4 is widely used in preventing neurological disabilities in preterm infants, mainly by suppressing synaptogenesis and axonal development to reduce inflammation and innate immune responses. Additionally, MgSO4 affects neural development by inhibiting RNA polymerase II transcription and regulating mitochondrial function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Helene Roumes, Ursule Dumont, Stephane Sanchez, Leslie Mazuel, Jordy Blanc, Gerard Raffard, Jean-Francois Chateil, Luc Pellerin, Anne-Karine Bouzier-Sore
Summary: Lactate has shown neuroprotective effects in a neonatal hypoxia-ischemia model, reducing brain lesion volume rapidly and efficiently. Lactate metabolism plays a key role in this protection, and lactate administration holds promise as an effective therapy for neonatal HI insult.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Immunology
Vanessa C. Bobbo, Daiane F. Engel, Carlos Poblete Jara, Natalia F. Mendes, Roberta Haddad-Tovolli, Thais P. Prado, Davi Sidarta-Oliveira, Joseane Morari, Licio A. Velloso, Eliana P. Araujo
Summary: IL6 in the hypothalamus induces neurogenesis-related gene expression in both wild-type and IL6 knockout mice, potentially offering a approach to prevent or attenuate obesity.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Engineering, Biomedical
Changho Chun, Alec S. T. Smith, Hyejin Kim, Dana S. Kamenz, Jung Hyun Lee, Jong Bum Lee, David L. Mack, Mark Bothwell, Claire D. Clelland, Deok-Ho Kim
Summary: This study investigated the impact of astrocyte-derived extracellular vesicles (EVs) on human neurons cultured in vitro, demonstrating that these EVs can enhance the electrophysiological function and anti-apoptotic behavior of neurons. The cargo proteins found in the EVs include various neuroprotective proteins and proteins that positively regulate neuronal excitability and synaptic development, suggesting the potential for EV-based therapeutics in treating neuropathies.
Editorial Material
Biochemistry & Molecular Biology
Andrey Y. Abramov
Summary: The brain is the organ that coordinates the entire body, and neurons and glia have evolved to be highly specialized and regulated by diverse receptors and neurotransmitters. Unique features such as the brain-blood barrier, high-energy demand, and electrical activity make neurons and astrocytes diverse components that vary across brain regions. This Special Issue includes 19 review articles that cover various aspects of neuroscience, including neurodevelopment, physiology, memory formation, and the mechanisms underlying neurodegenerative diseases.
Article
Plant Sciences
Rong Ma, Danni Lu, Qian Xie, Jianmei Yuan, Mihong Ren, Yong Li, Jiajun Wang, Jinxiu Li, Zhuo Xu, Jian Wang
Summary: Borneolum and L-Borneolum have neuroprotective effects by promoting neurogenesis and blood circulation in the striatal and subventricular zones during recovery from cerebral ischaemia. Their mechanisms may be related to the regulation of the Wnt3a and Notch-1 pathways.
Review
Neurosciences
Jianhui Liu, Xuanran Feng, Yi Wang, Xiaohuan Xia, Jialin C. Zheng
Summary: Astrocytes, the most abundant glial cells in the brain, have been found to be GABAceptive and play a role in regulating neurotransmission and brain function by capturing and releasing GABA.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Ranjithmenon Muraleedharan, Biplab Dasgupta
Summary: AMPK is an integrative metabolic sensor that maintains cellular energy balance and plays a crucial role in coordinating intertissue metabolic signaling. Studies suggest a link between AMPK dysregulation and neurodegenerative diseases, although the exact mechanisms involved remain unclear. AMPK activation may have dual effects on neurons, potentially being neuroprotective or pro-apoptotic depending on specific conditions.
Article
Pharmacology & Pharmacy
Danqing Xin, Tingting Li, Xili Chu, Hongfei Ke, Dexiang Liu, Zhen Wang
Summary: This study demonstrates the key role of OPN in EVs-mediated neuroinflammation following hypoxia-ischemia (HI) in neonatal mice. By preventing NE-kappa B-mediated OPN expression, MSCs-EVs suppressed neuroinflammation, synaptic damage, and microglial phagocytosis after HI injury.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Physiology
Tyler C. Hillman, Ryan Idnani, Christopher G. Wilson
Summary: Understanding hypoxia/hyperoxia exposure requires precise control of gas concentrations. Current commercial chambers are expensive and limited in functionality. We developed a low-cost and customizable chamber controlled by open-source software, allowing for reproducible data acquisition and analysis for different exposure protocols.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Beom-Seok Kang, Bo-Young Choi, A-Ra Kho, Song-Hee Lee, Dae-Ki Hong, Min-Kyu Park, Si-Hyun Lee, Chang-Juhn Lee, Hyeun-Wook Yang, Seo-Young Woo, Se-Wan Park, Dong-Yeon Kim, Jae-Bong Park, Won-Suk Chung, Sang-Won Suh
Summary: Ischemic stroke is caused by insufficient blood flow to the brain. Astrocytes play a crucial role in supplying lactate to neurons through the astrocyte-neuron lactate shuttle (ANLS). The deletion of the pyruvate kinase M2 (PKM2) gene in astrocytes reduces lactate supply and exacerbates neuronal death. Lactate administration can prevent neuronal damage following ischemic stroke by maintaining energy metabolism in neurons through the ANLS.
Article
Neurosciences
E. Rocha-Ferreira, E. Phillips, E. Francesch-Domenech, L. Thei, D. M. Peebles, G. Raivich, M. Hristova
Review
Neurosciences
Eridan Rocha-Ferreira, Mariya Hristova
Article
Multidisciplinary Sciences
Eridan Rocha-Ferreira, Amy Vincent, Sarah Bright, Donald M. Peebles, Mariya Hristova
Article
Clinical Neurology
Nicola J. Robertson, Stuart Faulkner, Bobbi Fleiss, Alan Bainbridge, Csilla Andorka, David Price, Elizabeth Powell, Lucy Lecky-Thompson, Laura Thei, Manigandan Chandrasekaran, Mariya Hristova, Ernest B. Cady, Pierre Gressens, Xavier Golay, Gennadij Raivich
Article
Cell Biology
Xavier Fontana, Mariya Hristova, Clive Da Costa, Smriti Patodia, Laura Thei, Milan Makwana, Bradley Spencer-Dene, Morwena Latouche, Rhona Mirsky, Kristjan R. Jessen, Ruediger Klein, Gennadij Raivich, Axel Behrens
JOURNAL OF CELL BIOLOGY
(2012)