Article
Clinical Neurology
Merel van Andel, Natasja M. van Schoor, Nicole C. Korten, Annemieke C. Heijboer, Madeleine L. Drent
Summary: The study revealed significant associations between ghrelin and depressive symptoms in older adults, particularly in younger age groups and those with lower waist-hip ratios. In men, leptin was associated with depressive symptoms, while there was no significant association for high-molecular-weight adiponectin.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Multidisciplinary Sciences
Camilla O. D. Araujo, Renan M. Montenegro, Amanda P. Pedroso, Virginia O. Fernandes, Ana Paula D. R. Montenegro, Annelise B. de Carvalho, Lila M. Oyama, Carla S. C. Maia, Eliane B. Ribeiro
Summary: This study found that patients with congenital generalized lipodystrophy (CGL) have appetite disturbances compared to eutrophic individuals, with lower fasting acylated ghrelin levels and no physiological drop after meal intake. These disturbances seem to play a role in hunger attenuation and satiety, but not in acute satiation.
Article
Environmental Sciences
Aina Jansen, Jan O. Aaseth, Jan L. Lyche, Jens P. Berg, Mette H. B. Muller, Stian Lydersen, Per G. Farup
Summary: Bariatric surgery leads to the release of persistent organic pollutants (POPs), which may cause endocrine disruption. This study aimed to explore the associations between POPs and adiponectin, leptin, and ghrelin in subjects undergoing bariatric surgery. The results showed significant increases in adiponectin and all POPs levels after surgery, as well as a decrease in leptin. The main finding was the highly significant associations between adiponectin and all POPs.
Article
Nutrition & Dietetics
Lorena Desdentado, Jaime Navarrete, Maria Folgado-Alufre, Ana de Blas, Jessica Navarro-Siurana, Francisco Ponce, Guadalupe Molinari, Andrea Jimeno-Martinez, Azahara I. Ruperez, Gloria Bueno-Lozano, Aida Cuenca-Royo, Emili Corbella, Zaida Aguera, Rosa M. Banos, Julio Alvarez-Pitti
Summary: This study found that higher levels of ghrelin concentration were associated with lower scores in restrained eating. No other relationships were found between obesity-related biomarkers and eating behaviors.
Article
Nutrition & Dietetics
Sara Becerril, Amaia Rodriguez, Victoria Catalan, Beatriz Ramirez, Amaia Mentxaka, Gabriela Neira, Javier Gomez-Ambrosi, Gema Fruhbeck
Summary: Biological sex and aging play a role in obesity development and type 2 diabetes, affecting the secretion of leptin and adiponectin. The Adpn/Lep ratio is proposed as a reliable biomarker for adipose tissue dysfunction. The study found that female mice were more metabolically protected from obesity and its comorbidities than males, with an increased Adpn/Lep ratio in aged females negatively correlated with body weight gain and insulin resistance.
Article
Endocrinology & Metabolism
Jessie Nallely Zurita-Cruz, Miguel Angel Villasis-Keever, Leticia Manuel-Apolinar, Leticia Damasio-Santana, Eulalia Garrido-Magana, Aleida de Jesus Rivera-Hernandez
Summary: In girls with central precocious puberty (CPP) undergoing GnRH analogs treatment, leptin levels and higher leptin/adiponectin ratio (LAR) are associated with greater weight gain. This association is particularly evident in girls with BMI < 94th percentile.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Chemistry, Medicinal
Rajeev Shrestha, Pallavi Gurung, Junmo Lim, Til Bahadur Thapa Magar, Cheong-Wun Kim, Hak Yong Lee, Yong-Wan Kim
Summary: This study evaluated the efficacy of Ce6-based PDT for anti-obesity activities in HFD-induced obesity mouse models. Both low and high doses of Ce6 with high irradiation dose showed better anti-obesity effects, decreasing body weight and lipid accumulation. Ce6-PDT also affected lipid metabolism biomarkers in the mice. These findings suggest Ce6-PDT as a potential alternative therapy for obesity and obesity-related diseases.
Article
Nutrition & Dietetics
Alessandro Micarelli, Alessandra Vezzoli, Sandro Malacrida, Beatrice Micarelli, Ilaria Misici, Valentina Carbini, Ilaria Iennaco, Sara Caputo, Simona Mrakic-Sposta, Marco Alessandrini
Summary: This study aimed to evaluate the differences in gustatory sensitivity, nutritional habits, circulating levels of modulators, anthropometric measures, and metabolic assays between overweight and obesity participants and lean subjects. The results showed significant reductions in taste scores and changes in biochemical factors and nutritional habits as obesity progressed.
Article
Multidisciplinary Sciences
Xixi Chen, Kaiwen Wang, Tao Lu, Jiajia Wang, Ting Zhou, Juan Tian, Bin Zhou, Li Long, Qiao Zhou
Summary: This study investigated the relationship between serum adiponectin level and disease activity in treatment-naive Han Chinese RA patients, finding a negative correlation with DAS28(ESR) and the Sharp score. These results suggest that adiponectin may be useful for assessing disease activity and radiographic progression of RA.
SCIENTIFIC REPORTS
(2022)
Review
Cardiac & Cardiovascular Systems
Shangang Zhao, Christine M. Kusminski, Philipp E. Scherer
Summary: The discovery of leptin and adiponectin established adipose tissue as an important endocrine organ in cardiovascular health. Normal levels of adiponectin and leptin are crucial for proper cardiovascular function, while both excess and insufficient levels may contribute to cardiovascular disorders. High levels of both adiponectin and leptin are a paradoxical factor in the pathogenesis of cardiovascular diseases.
CIRCULATION RESEARCH
(2021)
Article
Endocrinology & Metabolism
Jacqueline Soto-Sanchez, Israel Martinez-Navarro, Gilberto Mandujano-Lazaro, Maria Judith Rios-Lugo, Hector Hernandez-Mendoza
Summary: In this study, the correlation between copper status and serum adipokine levels in normal-weight, overweight, and obese adult women was investigated. The results showed that leptin and resistin levels were elevated, while adiponectin and ghrelin values were decreased in overweight and obese women. Furthermore, there was a positive association between BMI and copper levels in obese women, and a negative association between copper and resistin in normal-weight subjects.
HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Adela-Viviana Sitar-Taut, Angela Cozma, Adriana Fodor, Sorina-Cezara Coste, Olga Hilda Orasan, Vasile Negrean, Dana Pop, Dan-Andrei Sitar-Taut
Summary: The study aimed to assess the relationship between adipokines such as leptin and ghrelin and their ratio with obesity and diabetes. Results showed that obese patients had higher leptin values and leptin/ghrelin ratios, with significant differences found in analyses stratified by obesity and gender. Obesity and diabetes were associated with changes in the levels of adipokines, even in overweight subjects, indicating a basis for early intervention in diabetic and obese patients.
Article
Chemistry, Multidisciplinary
Monthana Weerawatanakorn, Sang He, Chun-Han Chang, Yen-Chun Koh, Meei-Ju Yang, Min-Hsiung Pan
Summary: Obesity and overweight pose a growing risk for various health conditions, and diet, especially tea consumption, has been identified as a potential intervention. This study aimed to investigate the effects of GABA oolong tea extracts (OTEs) on high-fat diet (HFD)-induced obesity using male C57BL/6 J mice. The results showed that GABA OTEs reduced leptin expression, protected against fatty liver disease, and promoted thermogenesis and lipid metabolism, therefore preventing obesity development.
Article
Pediatrics
Ulrika K. Andersson-Hall, Aldina Pivodic, Hanna K. de Mare, J. Pernilla Svedin, E. Carina Mallard, Kerstin G. Albertsson-Wikland, Agneta B. Holmang
Summary: In normal-weight women, maternal leptin and sOB-R levels during pregnancy are associated with infant fat mass accumulation, while in women with obesity, maternal fat mass before pregnancy has a greater impact on infant fat mass. Understanding these relationships is important for addressing the intergenerational programming of obesity.
PEDIATRIC RESEARCH
(2021)
Article
Nutrition & Dietetics
Rachel Ginieis, Sashie Abeywickrema, Indrawati Oey, Mei Peng
Summary: This study investigates the effects of ghrelin and leptin on olfactory processing. The results show a positive correlation between ghrelin levels and supra-threshold sensitivity and odor intensity, while leptin levels are not significantly linked to any olfactory measures. These findings suggest that ghrelin may play an important role in olfactory perception.
FRONTIERS IN NUTRITION
(2022)
Article
Sport Sciences
Susana Povoas, Antonio Ascensao, Jose Magalhaes, Pedro Silva, Havard Wiig, Truls Raastad, Carlo Castagna, Helena Andersson
Summary: This study found that performing four consecutive football matches separated by 48-72 hours during a FIFA tournament did not significantly alter plasma stress markers, physical load, and technical performance in elite female football players. Players from low-rank teams played more time than high-rank players, and differences in technical performance actions were mainly explained by match time. Uric acid levels increased across matches, with a larger increase in high-rank players, while CRP levels also increased across matches. Only high-rank players showed a significant time effect for uric acid.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2022)
Article
Medicine, General & Internal
Jelena Stevanovic-Silva, Jorge Beleza, Pedro Coxito, Rui Carlos Costa, Antonio Ascensao, Jose Magalhaes
Summary: Regular physical exercise during pregnancy has the potential to counteract the intergenerational transmission of metabolic burden and offer a more stable in utero environment to the foetus, thus rescuing offspring vulnerability to metabolic disturbances. The beneficial consequences of maternal physical exercise on offspring metabolism underscore the importance of physical exercise during pregnancy as an indispensable strategy in improving offspring health.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Environmental Sciences
Jessica B. Bonet, Casimiro Javierre, Joao Tiago Guimaraes, Sandra Martins, David Rizo-Roca, Jorge Beleza, Gines Viscor, Teresa Pages, Jose Magalhaes, Joan R. Torrella
Summary: Both MICT and HIIT have similar moderate effects on hematological and biochemical markers in middle-aged female recreational runners before the half-marathon race, but HIIT leads to better adaptation to the competition possibly due to repeated exposure to higher oxygen consumption and eccentric loading exercise.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Jorge Beleza, Jelena Stevanovic-Silva, Pedro Coxito, Hugo Rocha, Paulo Santos, Antonio Ascensao, Joan Ramon Torrella, Jose Magalhaes
Summary: Mothers' strategies to improve the intrauterine environment can positively impact their offspring's performance and muscle biomarkers. Gestational exercise can modulate the effects of a high-fat, high-sucrose diet on male offspring, leading to increased workload performance and alterations in mitochondrial density and functional markers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Emanuel Passos, Cidalia Pereira, Ines O. Goncalves, Ana Faria, Antonio Ascensao, Rosario Monteiro, Jose Magalhaes, Maria J. Martins
Summary: Obesity is a predictive factor for the development of nonalcoholic steatohepatitis (NASH). This study analyzed the effects of physical activity and endurance training on hepatic endoplasmic reticulum (ER) stress and oxidative stress in an animal model of high-fat diet (HFD)-induced NASH. The results suggest that physical exercise can counteract NASH-related ER stress through modulation of the hepatic IRE1 alpha-X-box binding protein 1 pathway.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Jelena Stevanovic-Silva, Jorge Beleza, Pedro Coxito, Hugo Rocha, Tiago Bordeira Gaspar, Fatima Gartner, Rossana Correia, Rui Fernandes, Paulo J. Oliveira, Antonio Ascensao, Jose Magalhaes
Summary: This study found that gestational exercise can modulate the effects of maternal high-fat high-sucrose diet-induced gestational diabetes mellitus on hepatic metabolism and mitochondrial outcomes in female offspring. Gestational exercise can prevent early weight gain in female offspring of mothers with gestational diabetes mellitus and reduce hepatic lipid accumulation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Sport Sciences
Ana M. Lopes, Manoel Rios, Jorge Beleza, Diogo D. Carvalho, Sofia Monteiro, Tiago Montanha, Sandra Martins, Joao T. Guimaraes, Ricardo J. Fernandes, Jose Magalhaes, Vitor H. Teixeira, Antonio Ascensao
Summary: A study on 10 middle-distance runners concluded that the addition of protein to a pre-exercise carbohydrate beverage does not significantly affect running performance and metabolic biomarkers.
JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS
(2023)
Review
Sport Sciences
Jose Afonso, Jesus Olivares-Jabalera, Ricardo J. Fernandes, Filipe Manuel Clemente, Silvia Rocha-Rodrigues, Joao Gustavo Claudino, Rodrigo Ramirez-Campillo, Cristina Valente, Renato Andrade, Joao Espregueira-Mendes
Summary: The effectiveness of different conservative interventions for acute hamstring injuries in athletes is unclear. This study compared the effects of various conservative interventions on the time to return to sport or full training and reinjury rates. The results showed that no single intervention or combination of interventions demonstrated superior outcomes in terms of faster recovery time or reduced risk of reinjury.
Article
Environmental Sciences
Jelena Stevanovic-Silva, Jorge Beleza, Pedro Coxito, Paulo J. Oliveira, Antonio Ascensao, Jose Magalhaes
Summary: Maternal high-caloric nutrition and gestational diabetes mellitus (GDM) increase the risk of liver metabolic alterations in mothers and offspring. Exercise is recommended in GDM treatment. This study showed that gestational exercise protected mothers from diet-induced GDM metabolic consequences and ameliorated liver mitochondrial alterations in offspring.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Article
Sport Sciences
Ivone Carneiro, Peter Krustrup, Carlo Castagna, Magni Mohr, Jose Magalhaes, Rita Pereira, Rute Santos, Sandra Martins, Joao Tiago Guimaraes, Eduardo Coelho, Susana Povoas
Summary: This study aimed to examine the dose-response of a recreational team handball exercise-based programme on cardiometabolic health and physical fitness in inactive middle-aged-to-elderly males without TH experience. The results showed that performing three 60-minute team handball exercise sessions per week can improve aerobic performance in middle-aged-to-elderly men, and it is more effective than training with a lower weekly frequency.
EUROPEAN JOURNAL OF SPORT SCIENCE
(2023)
Article
Sport Sciences
Rita Pereira, Peter Krustrup, Carlo Castagna, Eduardo Coelho, Eva Wulff Helge, Niklas Rye Jorgensen, Carolina Vila-Cha, Sandra Martins, Joao Tiago Guimaraes, Jose Magalhaes, Susana Povoas
Summary: A multicomponent exercise training protocol (recreational team handball training) has long-term positive effects on global health status in inactive postmenopausal women. After 36 weeks of training, participants in the exercise group showed improvements in cardiovascular, bone, metabolic health, body composition, and physical fitness markers.
EUROPEAN JOURNAL OF SPORT SCIENCE
(2023)
Review
Nutrition & Dietetics
Karenia Lorenzo, Garoa Santocildes, Joan Ramon Torrella, Jose Magalhaes, Teresa Pages, Gines Viscor, Josep Lluis Torres, Sara Ramos-Romero
Summary: This paper reviews the bioactivities of proteins, fiber, and polysaccharides in Chlorella, as well as their role in exercise-related nutrition. It highlights the beneficial effects of Chlorella on performance, physical stamina, and fatigue reduction. It also emphasizes the importance of Chlorella as a dietary source of essential nutrients for athletes and recreational exercisers.
Article
Nutrition & Dietetics
Diana Sousa, Mariana Rocha, Andreia Amaro, Marcos Divino Ferreira-Junior, Keilah Valeria Naves Cavalcante, Tamaeh Monteiro-Alfredo, Catia Barra, Daniela Rosendo-Silva, Lucas Paulo Jacinto Saavedra, Jose Magalhaes, Armando Caseiro, Paulo Cezar de Freitas Mathias, Susana P. Pereira, Paulo J. Oliveira, Rodrigo Mello Gomes, Paulo Matafome
Summary: Obesogenic environments during the perinatal period can reprogram offspring energy balance mechanisms and increase the risk of metabolic diseases in adulthood. Different obesogenic models have varying effects on metabolic parameters and energy storage pathways in offspring.
Review
Biology
Oscar F. Araneda, Cristian Rosales-Antequera, Felipe Contreras-Briceno, Marcelo Tuesta, Rafael Rossi-Serrano, Jose Magalhaes, Gines Viscor
Summary: Damage to the spinal cord affects the voluntary control of skeletal muscles and the autonomic nervous system, which in turn affects the cardiorespiratory system. Physical exercise may be a potential therapeutic strategy to improve lung functionality and control systemic and pulmonary inflammation. Specific respiratory muscular training or combined with general exercise protocols may positively contribute to the function of the respiratory system.
Article
Sport Sciences
Michal Boraczynski, Jose Magalhaes, Jacek J. Nowakowski, James J. Laskin
Summary: This study investigated the effects of 8-week heavy-resistance or plyometric training on neuromuscular functional performance in professional soccer players. The results showed that both training methods significantly improved speed, strength, and jumping ability. The heavy-resistance training performed better in terms of relative strength and muscle peak torque. Additionally, a significant proportion of participants showed knee muscular strength imbalance.