Article
Biochemistry & Molecular Biology
Nicole Schaefer, Susanne Graessel
Summary: Osteoarthritis affects over 500 million people worldwide, causing significant suffering and societal cost. Chronic, low-grade inflammation is central to its pathogenesis, with the complement system possibly playing a crucial role in its development. Despite potential side effects, targeting the complement system shows promising effects in alleviating inflammatory responses in joint tissues.
Review
Biochemistry & Molecular Biology
Giovanni Civieri, Laura Iop, Francesco Tona
Summary: This review summarizes the current evidence regarding the effects of AT1R-AAs and ETAR-AAs in cardiovascular pathologies, highlighting their roles in heart transplantation and mechanical circulatory support, preeclampsia, and acute coronary syndromes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Aurelie Philippe, Gunnar Kleinau, Jason Jannis Gruner, Sumin Wu, Daniel Postpieszala, David Speck, Harald Heidecke, Simon J. Dowell, Gabriela Riemekasten, Peter W. Hildebrand, Julian Kamhieh-Milz, Rusan Catar, Michal Szczepek, Duska Dragun, Patrick Scheerer
Summary: This study investigates the effects of AT(1)R-Abs on G-protein signaling and cell proliferation, as well as the involvement of extracellular receptor loops. The results show that AT(1)R-Abs activate G(q/11) signaling, leading to cell proliferation and inhibiting receptor internalization. Additionally, ligand-independent activation of G(i) signaling by AT(1)R has a negative effect on cell proliferation. The study also identifies the involvement of certain extracellular receptor loops in the interaction between AT(1)R and antibodies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Supaporn Kulthinee, Adis Tasanarong, Martha Franco, Luis Gabriel Navar
Summary: In angiotensin II (Ang II)-dependent hypertension, both angiotensin II type 1 receptors (AT1R) and purinergic P2X receptors (P2XR) are involved in maintaining renal vasoconstriction. The interaction between AT1R and P2XR activation is regulated by the release of adenosine triphosphate (ATP). P2XR exerts a dominant influence that can abrogate the actions of AT1R on renal afferent arterioles in Ang II-dependent hypertension. This finding has important clinical implications for the treatment of kidney function impairment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Reproductive Biology
Sri Vidya Dangudubiyyam, Jay S. Mishra, Ruolin Song, Sathish Kumar
Summary: Exposure to PFOS during rat pregnancy increases vascular resistance via increased angiotensin II-mediated vasoconstriction and decreased endothelium-dependent vasodilation.
BIOLOGY OF REPRODUCTION
(2022)
Article
Endocrinology & Metabolism
Amanda da Silva Chaves, Nathalia Santos Magalhaes, Daniella Bianchi Reis Insuela, Patricia Machado Rodrigues E Silva, Marco Aurelio Martins, Vinicius Frias Carvalho
Summary: This study investigates the role of the renin-angiotensin system (RAS) in the overproduction of corticosterone in diabetic mice. The results suggest that inhibition of angiotensin synthesis and AT(1) receptor activity can reduce corticosterone levels in diabetic mice. Furthermore, the protective effect of Olmesartan on corticosterone overproduction in diabetic mice depends on both AT(1) receptor blockade and AT(2) receptor activation.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Anesthesiology
Ayse B. Ozer, Murat Bicakcioglu, Seyma Baykan, Nilufer Bulut, Serkan Kalkan, Selcuk Demircan, Zeliha Korkmaz Disli, Deccane Duzenci, Mustafa S. Aydogan, Aytac Yucel, Neslihan Yucel, Yasemin Ersoy, Nermin Kibrislioglu Uysal, Zafer Dogan
Summary: In septic patients, levels of angiotensin II, AT-2, and AT-1/AT-2 can predict the likelihood of shock development and mortality.
MINERVA ANESTESIOLOGICA
(2022)
Article
Biotechnology & Applied Microbiology
Jie Xiong, Xingyi Kuang, Tingting Lu, Kunlin Yu, Xu Liu, Zhaoyuan Zhang, Weili Wang, Lu Zhao, Qin Fang, Depei Wu, Jishi Wang
Summary: The study demonstrates that levels of C3a and C5a are elevated in MM patients and their receptors are highly expressed on myeloma cells. These anaphylatoxins promote migration, invasion, and adhesion of MM cells through MEK/ERK pathway activation and Nrf2 nuclear translocation. Nrf2 downregulation could attenuate the migration of C3a and C5a-stimulated MM cells in vivo, suggesting potential therapeutic targets for MM treatment.
CANCER GENE THERAPY
(2021)
Review
Biochemistry & Molecular Biology
Lucile Yart, Edith Roset Bahmanyar, Marie Cohen, Begona Martinez de Tejada
Summary: Placental development and function are crucial for efficient maternal-fetal exchanges, pregnancy-specific hormone secretion, and immune modulation. Incorrect placental development can lead to serious pregnancy disorders, such as preeclampsia, endangering both the mother and the infant. The role of the uteroplacental renin-angiotensin system in placental development and function may have been underestimated.
Review
Physiology
Xiao Chun Li, Chih-Hong Wang, Ana Paula Oliveira Leite, Jia Long Zhuo
Summary: Hypertension is a major risk factor for cardiovascular diseases, stroke, and end-stage kidney failure. Approximately a quarter of the global adult population suffer from hypertension, with only 50% of patients responding to current antihypertensive drugs.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Respiratory System
Signe Vedel-Krogh, Katrine L. Rasmussen, Borge G. Nordestgaard, Sune F. Nielsen
Summary: This study found that high plasma complement C3 concentration is associated with an increased risk of asthma development and severity, particularly in individuals with allergic asthma. The findings support a causal role of the complement system in asthma severity.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Article
Peripheral Vascular Disease
Shinya Taguchi, Kengo Azushima, Takahiro Yamaji, Toru Suzuki, Eriko Abe, Shohei Tanaka, Keigo Hirota, Shunichiro Tsukamoto, Ryutaro Morita, Ryu Kobayashi, Sho Kinguchi, Akio Yamashita, Hiromichi Wakui, Kouichi Tamura
Summary: The combination of ATRAP deletion and Ang II stimulation accelerates the development of DKD in STZ-induced diabetic C57BL/6 mice that are resistant to kidney injury, which may be associated with intrarenal RAS overactivation.
HYPERTENSION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Maria Grazia Zizzo, Adele Cicio, Federica Corrao, Laura Lentini, Rosa Serio
Summary: This study investigates the contractile responses induced by Ang II in the jejunum of young and old rats, and evaluates possible functional differences associated with changes in receptor expression. The results show that Ang II modulates the spontaneous contractility of rat jejunum via postjunctional AT1 receptors and prejunctional AT2 receptors. Age-related changes in receptor expression are not reflected in the muscular contractile response to Ang II.
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Physiology
Julia Schrankl, Michaela Fuchs, Katharina Broeker, Christoph Daniel, Armin Kurtz, Charlotte Wagner
Summary: This study investigated the cell-specific localization of AT(1) receptor expression in rodent and human kidneys, revealing conserved AT(1) receptor mRNA expression sites in the (juxta)glomerular areas and tubulointerstitium across species, potentially serving as main target sites for ANG II in adult kidneys.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Theo Arthur Meister, Rodrigo Soria, Afzal Dogar, Franz H. Messerli, Ariane Paoloni-Giacobino, Ludwig Stenz, Urs Scherrer, Claudio Sartori, Emrush Rexhaj
Summary: Assisted Reproductive Technologies (ART) may increase arterial responsiveness to angiotensin II by epigenetically modifying the expression of its receptors, leading to arterial hypertension. This epigenetic effect causes an imbalance between vasoconstrictor and vasodilator receptors, contributing to the exaggerated vasoconstrictor response in ART mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)