Article
Gastroenterology & Hepatology
Guy Boeckxstaens, Stefanie Elsen, Ann Belmans, Vito Annese, Albert J. Bredenoord, Olivier R. Busch, Mario Costantini, Uberto Fumagalli, Andre J. P. M. Smout, Jan Tack, Tim Vanuytsel, Giovanni Zaninotto, Renato Salvador
Summary: The 10-year follow-up of the European Achalasia Trial comparing endoscopic pneumodilation (PD) with laparoscopic Heller myotomy (LHM) showed that both treatments are equally effective in treating achalasia, with limited risk of developing gastro-oesophageal reflux.
Article
Gastroenterology & Hepatology
Caroline M. G. Saleh, Pietro Familiari, Barbara A. J. Bastiaansen, Paul Fockens, Jan Tack, Guy Boeckxstaens, Raf Bisschops, Aaltje Lei, Marlies P. Schijven, Jan Guido Costamagna, Albert J. Bredenoord
Summary: This study compares the efficacy of POEM and PD for patients with persistent or recurrent symptoms after LHM. The results show that POEM has a higher success rate than PD, with a higher incidence of reflux esophagitis in the POEM group.
Article
Surgery
Jocelyn de Heer, Madhav Desai, Guy Boeckxstaens, Giovanni Zaninotto, Karl-Hermann Fuchs, Prateek Sharma, Guido Schachschal, Oliver Mann, Thomas Roesch, Yuki Werner
Summary: The study found that the advent of peroral endoscopic myotomy (POEM) shed some light on the treatment of achalasia, however, existing meta-analyses comparing pneumatic dilatation (PD) and laparoscopic Heller myotomy (LHM) have unreliable conclusions. Future research should focus on conducting more randomized studies based on uniform criteria, while avoiding excessive meta-analyses.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Gastroenterology & Hepatology
Zhao -Chao Zhang, Jia-Qi Xu, Xin-Yang Liu, Hai-Ting Pan, Shi-Yao Chen, Yun-Shi Zhong, Yi-Qun Zhang, Wei-Feng Chen, Li -Li Ma, Jian-Wei Hu, Ming-Yan Cai, Wen-Zheng Qin, Quan-Lin Li, Ping-Hong Zhou
Summary: Salvage POEM is a promising treatment option for achalasia patients who have experienced myotomy failure, especially after a previous POEM failure, as it has a high rate of treatment success and clinical relief.
GASTROINTESTINAL ENDOSCOPY
(2023)
Article
Gastroenterology & Hepatology
Pamela Milito, Stefano Siboni, Andrea Lovece, Erika Andreatta, Emanuele Asti, Luigi Bonavina
Summary: Revisional therapy for esophageal achalasia after failed Heller myotomy is feasible, safe, and effective in specialized and multidisciplinary centers. Following revisional therapy, patients experienced a significant improvement in symptoms with a low overall complication rate.
JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Article
Gastroenterology & Hepatology
Joseph R. Triggs, Amanda J. Krause, Dustin A. Carlson, Erica N. Donnan, Ryan A. J. Campagna, Anand S. Jain, Peter J. Kahrilas, Eric S. Hungness, John E. Pandolfino
Summary: BOM is a common adverse event after myotomy for achalasia, associated with post-treatment symptom severity, achalasia type, and treatment modality. Pretreatment type III achalasia, LHM as opposed to POEM, and an increased post-treatment integrated relaxation pressure are risk factors for BOM development.
GASTROINTESTINAL ENDOSCOPY
(2021)
Review
Surgery
Rebecca C. Dirks, Geoffrey P. Kohn, Bethany Slater, Jake Whiteside, Noe A. Rodriguez, Salvatore Docimo, Aurora Pryor, Dimitrios Stefanidis
Summary: POEM has similar outcomes to HM and greater efficacy than PD. Reflux remains a critical outcome with unknown long-term clinical significance due to insufficient data and inconsistent reporting.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Surgery
Megan Blaustein, Rachel Sillcox, Andrew S. Wright, Roger Tatum, Robert Yates, Mary Kate Bryant, Brant K. Oelschlager
Summary: This study aims to characterize gastroesophageal reflux disease (GERD) following laparoscopic Heller myotomy with Toupet fundoplication (LHM+T) in treated achalasia patients. The incidence of postoperative GERD burden is relatively low, but accurate diagnosis and differentiation from poor esophageal clearance in treated patients are important. Symptom correlation to abnormal pH study is unreliable, necessitating objective postoperative testing and manual review of abnormal pH studies.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Christopher Zimmermann, Nate Torell, Anne Lidor, Luke Funk, Amber Shada
Summary: Patients undergoing PD or POEM for recurrent dysphagia after myotomy have similar rates of dysphagia resolution and reflux symptoms.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Review
Gastroenterology & Hepatology
Edoardo Vespa, Gaia Pellegatta, Viveksandeep T. Chandrasekar, Marco Spadaccini, Harsh Patel, Roberta Maselli, Piera A. Galtieri, Elisa Carlani, Prateek Sharma, Cesare Hassan, Alessandro Repici
Summary: Long-term clinical efficacy of POEM persisted in 87% of patients with achalasia. Post-POEM symptomatic reflux remained stable over time. The risk for Barrett's esophagus and peptic strictures appeared minimal.
Article
Surgery
Maryam Soheilipour, Delaram Zirachi, Amirmohammad Bavandipour, Peyman Adibi
Summary: This study compared the effects of endoscopic balloon dilation (EBD) and laparoscopic Heller myotomy (LHM) on the asymptomatic period, symptom improvement, and treatment failure in patients with achalasia. The results showed that LHM had better outcomes in terms of symptom improvement, treatment failure, and the duration of the asymptomatic period after the procedure.
INDIAN JOURNAL OF SURGERY
(2023)
Article
Surgery
Hong Jin, Bin Wang, Zhong-qing Zheng, Li-li Zhang, Qiu-yu Chen, Chun Shan Zhao, Bang-mao Wang, Wei Zhao
Summary: The study found that POEM therapy can effectively relieve symptoms in achalasia patients, even those who had previously undergone pneumatic dilation. There may be differences in fibrosis levels and complications between patients who underwent POEM after pneumatic dilation and those who did not. Longer follow-up studies with larger cohorts are needed to evaluate the long-term outcomes and complications of POEM.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Cardiac & Cardiovascular Systems
Maria Doubova, Stephen Gowing, Hassan Robaidi, Sebastien Gilbert, Donna E. Maziak, Farid M. Shamji, R. Sudhir Sundaresan, Patrick James Villeneuve, Andrew J. E. Seely
Summary: The study results demonstrate the durability of LHMDor in the management of achalasia, offering consistent symptomatic relief and significant improvement in quality of life over the decade after surgery. Despite some increase in GERD symptoms and antireflux medication use in some patients in the years following surgery.
ANNALS OF THORACIC SURGERY
(2021)
Article
Surgery
Lena Shally, Kashif Saeed, Derek Berglund, Mark Dudash, Katie Frank, Vladan N. Obradovic, Anthony T. Petrick, David L. Diehl, Jon D. Gabrielsen, David M. Parker
Summary: This study compares perioperative and long-term outcomes, cost-effectiveness, and reimbursement for per-oral endoscopic myotomy (POEM) and laparoscopic Heller myotomy (LHM). The results show that compared to LHM, POEM has shorter operative time and length of stay, longer myotomy length, and greater resolution of dysphagia symptoms. POEM costs are significantly lower than LHM, but reimbursement is poor.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Ehsan Sediqi, Alexandros Tsoposidis, Ville Wallenius, Hans Axelsson, Jan Persson, Erik Johnsson, Lars Lundell, Srdjan Kostic
Summary: This study found that after more than a decade of follow-up, laparoscopic myotomy was superior to repetitive pneumatic dilatation in the management of newly diagnosed achalasia, providing long-term relief of dysphagia and better control of reflux symptoms.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Gastroenterology & Hepatology
Taher Omari, Charles Cock, Peter Wu, Michal Marcin Szczesniak, Mistyka Schar, Jan Tack, Nathalie Rommel
Summary: This study aimed to establish a methodology for diagnosing oropharyngeal disorders using P-HRM-I. The results showed that UES relaxation pressure was the best indicator for differentiating patients from controls and diagnosing UES disorders. A diagnostic scheme was also devised to identify patients with UES disorder or propulsive disorder. Additionally, the study found that patients with pharyngeal pressurizations and evidence of reduced UES relaxation and/or distensibility had higher aspiration scores.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Gastroenterology & Hepatology
Jan Tack, Borislav Vladimirov, Ivo Horny, Chui Fung Chong, Jessica Eisner, Richard Czerniak, Yohei Takanami
Summary: This study compared the effectiveness and safety of vonoprazan and esomeprazole in preventing heartburn symptoms in patients with GERD who had a partial response to esomeprazole treatment. The results showed no significant difference in efficacy and safety between the two treatments, and vonoprazan was well tolerated.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Review
Gastroenterology & Hepatology
Michelle Bosman, Fabienne Smeets, Sigrid Elsenbruch, Jan Tack, Magnus Simren, Nicholas Talley, Bjorn Winkens, Ad Masclee, Daniel Keszthelyi
Summary: This study conducted a systematic review and meta-analysis to investigate the placebo response in pharmacological trials for functional dyspepsia (FD). The study found that the pooled placebo response rate ranged from 35.5% to 39.6% depending on the responder definition used. Lower baseline symptom scores were significantly associated with higher placebo response rates. The study suggests considering entry criteria based on symptom severity and separate reporting of core FD symptoms in future trials.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Review
Gastroenterology & Hepatology
Maria Rosa Ingrosso, Michael Camilleri, Jan Tack, Gianluca Ianiro, Christopher J. Black, Alexander C. Ford
Summary: This study evaluated the efficacy and safety of drugs for gastroparesis through a network meta-analysis. The results showed that oral dopamine antagonists and tachykinin-1 antagonists were more effective than placebo. For individual symptoms, oral metoclopramide showed good efficacy for nausea, fullness, and bloating. However, the confidence in the evidence for most comparisons was low to moderate, indicating a need for more effective therapies for gastroparesis.
Article
Gastroenterology & Hepatology
Lin Chang, Brooks D. D. Cash, Anthony Lembo, David C. C. Kunkel, Brett A. A. English, Beatriz Lindstrom, Guibao Gu, Sharon Skare, Kye Gilder, Stewart Turner, Fabio Cataldi, Donald Lipkis, Tack Jan
Summary: This study assessed the efficacy and safety of olorinab to treat abdominal pain in patients with irritable bowel syndrome. Although no significant difference was found in pain relief, olorinab significantly improved symptoms in patients with moderate-to-severe pain.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Biochemistry & Molecular Biology
Hideki Mori, Wout Verbeure, Rina Tanemoto, Emily Ruilova Sosoranga, Jan Tack
Summary: Motilin, secreted by the duodenum, regulates the migrating motor complex during fasting and affects various gastrointestinal functions. It stimulates gallbladder contraction, pepsin secretion, and pancreatic juice and insulin secretion. Motilin is also associated with appetite and potential treatments for obesity. Gastric acid and bile are the main regulators of motilin release. Different caloric foods have diverse effects on motilin levels, and non-caloric bitter substances can suppress appetite. Motilin receptor agonists and antagonists have been developed but are not yet clinically utilized.
Review
Gastroenterology & Hepatology
B. W. L. C. M. Broeders, F. Carbone, L. M. Balsiger, J. Schol, K. Raymenants, I. Huang, A. Verheyden, T. Vanuytsel, J. Tack
Summary: This study provides a comprehensive overview of the pathophysiology of functional dyspepsia (FD), focusing on the shift towards duodenal mechanisms. Recent studies have shown that duodenal factors such as acid, bile salt exposure, eosinophil and mast cell activation are associated with symptoms and can be related to gastric sensorimotor dysfunction. Future research should focus on inhibiting duodenal mast cell activation, eosinophilia, and loss of mucosal integrity for the treatment of FD.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Gastroenterology & Hepatology
Jan Tack, Katayoun Derakhchan, Andre Gabriel, William Spalding, Brian Terreri, Ashraf Youssef, Bahij Kreidieh, Peter R. Kowey, Mena Boules
Summary: This review summarizes the cardiovascular safety data of prucalopride, a high-affinity 5-HT4 agonist, in the treatment of chronic idiopathic constipation (CIC), and concludes that prucalopride does not have significant effects on cardiovascular safety.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Review
Pharmacology & Pharmacy
Emidio Scarpellini, Bert Broeders, Jolien Schol, Pierangelo Santori, Mariachiara Addarii, Luigi Boccuto, Florencia Carbone, Ludovico Abenavoli, Jan Tack
Summary: Peppermint oil is a safe herbal medicine therapy with promising scientific perspectives and rapidly expanding use in clinical practice in the field of gastroenterology. It can improve endoscopic performance and treat functional dyspepsia and irritable bowel syndrome.
CURRENT PHARMACEUTICAL DESIGN
(2023)
Article
Gastroenterology & Hepatology
Johann P. Hreinsson, Hans Tornblom, Jan Tack, Douglas A. Drossman, William E. Whitehead, Shrikant I. Bangdiwala, Ami D. Sperber, Olafur S. Palsson, Magnus Simren
Summary: This study evaluated the validity of the Rome IV criteria for gut-brain interaction disorders through factor analysis in global, geographical, gender, and age-group dimensions. The results indicate that the Rome IV criteria are globally valid and represent universal diagnostic entities for these disorders.
Review
Gastroenterology & Hepatology
Gregory O'Grady, Chris Varghese, Gabriel Schamberg, Stefan Calder, Peng Du, William Xu, Jan Tack, Charlotte Daker, Hayat L. Mousa, Thomas P. Abell, Henry Parkman, Vincent Ho, L. Alan Bradshaw, Anthony N. Hobson, Christopher A. Andrews, Armen Gharibans, BSGM Working Grp
Summary: Chronic gastric symptoms are common, but it is difficult to differentiate specific mechanisms. Body surface gastric mapping (BSGM) is a non-invasive method that measures and maps gastric myoelectrical activity. The adoption of BSGM in clinical practice is expanding, and a working group was formed to standardize clinical BSGM methods. The group reviewed the principles, methods, and clinical applications of BSGM, as well as identified knowledge gaps and future research priorities.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Review
Nutrition & Dietetics
Claudia Di Rosa, Annamaria Altomare, Vittoria Terrigno, Florencia Carbone, Jan Tack, Michele Cicala, Michele Pier Luca Guarino
Summary: Irritable bowel syndrome (IBS) is a chronic gastrointestinal disorder characterized by abdominal pain and altered bowel habits. The exact cause of IBS is not fully understood, but it is believed to involve a combination of factors such as abnormal gut motility, inflammation, increased intestinal permeability, and sensitivity. Diet and gut microbiota have also been identified as important contributors to IBS. This review examines the effects of dietary components, functional foods, prebiotics, probiotics, and symbiotics on symptoms and gut microbiota in individuals with IBS-C.
Review
Genetics & Heredity
Luigi Boccuto, Jan Tack, Gianluca Ianiro, Ludovico Abenavoli, Emidio Scarpellini
Summary: The human gut microbiota is a complex ecosystem that includes bacteria, viruses, protozoa, archaea, fungi, and yeasts. The gut microbiome refers to the genome of these microbes actively involved in functions such as digestion, immune system regulation, and metabolism. The interaction between the gut microbiome and human genes plays a crucial role in human health and disease.
Article
Pharmacology & Pharmacy
Tom de Waal, Joachim Brouwers, Philippe Berben, Talia Flanagan, Jan Tack, Wim Vandenberghe, Tim Vanuytsel, Patrick Augustijns
Summary: Parkinson's disease may not only impact the motor system but also the physiology of the gastrointestinal tract. The composition of intestinal fluids in PD patients is generally similar to healthy controls, with only minor differences. These differences may be attributed to slower gastric emptying and altered intestinal bacterial metabolism.
Editorial Material
Gastroenterology & Hepatology
Michael Camilleri, Jan Tack