Editorial Material
Medicine, General & Internal
John M. M. Carethers
Summary: A 56-year-old man with no significant medical history declined screening colonoscopy in the past but now wants a less invasive test due to his father's death from colorectal cancer. What is the next course of action?
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Biology
Jikun Zhao, Dadong Kuang, Xianshuo Cheng, Jiwei Geng, Yong Huang, Haojie Zhao, Zhibin Yang
Summary: Genomics and bioinformatics methods were used to identify genes and molecular markers associated with colorectal cancer. The study revealed 16 key genes that are significantly associated with the prognosis of colon cancer, providing valuable insights for potential diagnostic markers and targeted therapies.
OPEN LIFE SCIENCES
(2023)
Review
Oncology
Gemma Ibanez-Sanz, Rebeca Sanz-Pamplona, Montse Garcia
Summary: Interval colorectal cancer serves as a measure of screening programme effectiveness, with further study into its epidemiological, clinical, and molecular characteristics providing insights for disease prevention.
Article
Medicine, General & Internal
Erica K. Barnell, Elizabeth M. Wurtzler, Julie La Rocca, Thomas Fitzgerald, Jessica Petrone, Yansheng Hao, Yiming Kang, Faith L. Holmes, David A. Lieberman
Summary: This study evaluated the sensitivity and specificity of a noninvasive multitarget stool RNA test for colorectal cancer and precancerous lesions. The results showed that the test had a sensitivity of 94% for detecting colorectal cancer and 46% for detecting advanced adenomas, with a specificity of 88%.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Review
Gastroenterology & Hepatology
Marina Hanna, Neelendu Dey, William M. Grady
Summary: Colorectal cancer is a common cancer globally and is a leading cause of cancer-related deaths. Current screening methods for colorectal cancer have limitations and many people are not compliant with screening recommendations. Novel screening tests based on advances in molecular biology, genetics, and epigenetics, as well as sequencing technologies and computational analytic methods, have been developed to improve early detection of colorectal cancer.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Medicine, General & Internal
Francis Yew Fu Tieng, Nadiah Abu, Siti Nurmi Nasir, Learn-Han Lee, Nurul-Syakima Ab Mutalib
Summary: Early detection of colorectal cancer is crucial for reducing mortality rates, and the introduction of circulating tumor cells (CTCs) has provided a less invasive method for detection. The current gold standard is the CellSearch system, but there are still challenges to be addressed.
Review
Medical Laboratory Technology
Fenqi Du, Yanlong Liu
Summary: Colorectal cancer is a common malignant tumor and the use of immune checkpoint inhibitors (ICIs) in its treatment is actively being explored. Predictive molecular markers play a crucial role in identifying patient populations that can benefit from ICIs.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Multidisciplinary Sciences
Selda Tekiner, Gulsen Ceyhun Peker, Mine Ceylan Dogan
Summary: This study evaluated the health beliefs of relatively young individuals in Turkey regarding colorectal cancer screening before the screening age, finding that attitudes towards preventive health measures are mainly associated with age, gender, education level, and marital status.
Review
Oncology
Iris Lansdorp-Vogelaar, Reinier Meester, Lucie de Jonge, Andrea Buron, Ulrike Haug, Carlo Senore
Summary: Risk-based colorectal cancer screening can optimize resource allocation and improve the benefit-harm ratio. Reliable risk prediction models and participation are essential for successful implementation. While recognizing the limitations of current approaches, introducing tailored strategies within screening programmes is feasible and may lead to substantial improvements.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Oncology
Fanny Boyaval, Hans Dalebout, Rene Van Zeijl, Wenjun Wang, Arantza Farina-Sarasqueta, Guinevere S. M. Lageveen-Kammeijer, Jurjen J. Boonstra, Liam A. McDonnell, Manfred Wuhrer, Hans Morreau, Bram Heijs
Summary: This study investigates the changes in sugar molecules during the progression of colorectal cancer (CRC) and finds that these sugar signatures can clearly differentiate different stages of CRC progression, especially between pre-cancerous and cancerous tissue. The study also observes the spreading of glycosylation signatures into the tumor microenvironment.
Article
Biochemistry & Molecular Biology
Jacopo Troisi, Maria Tafuro, Martina Lombardi, Giovanni Scala, Sean M. Richards, Steven J. K. Symes, Paolo Antonio Ascierto, Paolo Delrio, Fabiana Tatangelo, Carlo Buonerba, Biancamaria Pierri, Pellegrino Cerino
Summary: The objective of this study was to develop a novel screening approach for colorectal cancer using serum metabolomic profiles, and to evaluate the metabolic alterations associated with the disease. The results showed that the metabolomic signature can be used as a non-invasive screening tool for colorectal cancer, and identified differences primarily associated with cell glucose metabolism.
Review
Oncology
Enea Ferlizza, Rossella Solmi, Michela Sgarzi, Luigi Ricciardiello, Mattia Lauriola
Summary: Colorectal cancer (CRC) ranks as the third most common cancer worldwide, emphasizing the significance of early detection. Screening through fecal occult blood tests has shown to reduce CRC incidence and mortality, however, low participation rates and false positives are key challenges. Recent research has focused on new fecal tests, biomarkers, and liquid biopsy methods to enhance accuracy and participation in CRC screening.
Review
Biochemistry & Molecular Biology
Carolin Czauderna, Kim Luley, Nikolas von Bubnoff, Jens U. Marquardt
Summary: Liver metastases are the most common site of metastasis in colorectal cancer. Current treatment approaches involve systemic therapies and surgical/interventional strategies, with the use of predictive and prognostic biomarkers leading to improved survival rates. Treatment selection based on patient status, tumor characteristics, and molecular/genetic status is recommended for better outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Public, Environmental & Occupational Health
Krishna P. Sharma, Amy DeGroff, Annette E. Maxwell, Allison M. Cole, Ngoc Cam Escoffery, Peggy A. Hannon
Summary: Client reminders, provider assessment and feedback, and colorectal cancer screening champions were found to be associated with increased clinic-level colorectal cancer screening rates according to this study. The universal implementation of these strategies can substantially increase colorectal cancer screening rates in the U.S.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2021)
Article
Oncology
Reid M. Ness
Summary: In the past 2 years, significant changes have been made to the NCCN Guidelines for Colorectal Cancer (CRC) Screening, including lowering the age for initiation of screening, changing surveillance intervals, and adjusting the timing of the first surveillance examination for certain patients.
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2022)