Kinase analysis in alcoholic hepatitis identifies p90RSK as a potential mediator of liver fibrogenesis

A Histologic Scoring System for Prognosis of Patients With Alcoholic Hepatitis

(2014) José Altamirano et al.   GASTROENTEROLOGY

CCL20 mediates lipopolysaccharide induced liver injury and is a potential driver of inflammation and fibrosis in alcoholic hepatitis

(2014) Silvia Affò et al.   GUT

Alcohol Activates the Hedgehog Pathway and Induces Related Procarcinogenic Processes in the Alcohol-Preferring Rat Model of Hepatocarcinogenesis

(2013) Isaac S. Chan et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

The unusual mechanism of inhibition of the p90 ribosomal S6 kinase (RSK) by flavonol rhamnosides

(2013) Darkhan Utepbergenov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Human and experimental evidence supporting a role for osteopontin in alcoholic hepatitis

(2013) Oriol Morales-Ibanez et al.   HEPATOLOGY

Cell-specific PPARγ deficiency establishes anti-inflammatory and anti-fibrogenic properties for this nuclear receptor in non-parenchymal liver cells

(2013) Eva Morán-Salvador et al.   JOURNAL OF HEPATOLOGY

Insights into the Inhibition of the p90 Ribosomal S6 Kinase (RSK) by the Flavonol Glycoside SL0101 from the 1.5 Å Crystal Structure of the N-Terminal Domain of RSK2 with Bound Inhibitor

(2012) Darkhan Utepbergenov et al.   BIOCHEMISTRY

Dynamic Reprogramming of the Kinome in Response to Targeted MEK Inhibition in Triple-Negative Breast Cancer

(2012) James S. Duncan et al.   CELL

A Crucial Role for p90RSK-Mediated Reduction of ERK5 Transcriptional Activity in Endothelial Dysfunction and Atherosclerosis

(2012) Nhat-Tu Le et al.   CIRCULATION

p90RSK Targets the ERK5-CHIP Ubiquitin E3 Ligase Activity in Diabetic Hearts and Promotes Cardiac Apoptosis and Dysfunction

(2012) Nhat-Tu Le et al.   CIRCULATION RESEARCH

Transcriptome analysis identifies TNF superfamily receptors as potential therapeutic targets in alcoholic hepatitis

(2012) Silvia Affò et al.   GUT

Liver progenitor cell markers correlate with liver damage and predict short-term mortality in patients with alcoholic hepatitis

(2012) Pau Sancho-Bru et al.   HEPATOLOGY

Macrophage migration inhibitory factor contributes to ethanol-induced liver injury by mediating cell injury, steatohepatitis, and steatosis

(2012) Mark A. Barnes et al.   HEPATOLOGY

IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice

(2012) Jan Petrasek et al.   JOURNAL OF CLINICAL INVESTIGATION

Kaempferol acts through mitogen-activated protein kinases and protein kinase B/AKT to elicit protection in a model of neuroinflammation in BV2 microglial cells

(2011) SE Park et al.   BRITISH JOURNAL OF PHARMACOLOGY

Alcoholic Liver Disease: Pathogenesis and New Therapeutic Targets

(2011) Bin Gao et al.   GASTROENTEROLOGY

Alcoholic liver disease: pathogenesis and new targets for therapy

(2011) José Altamirano et al.   Nature Reviews Gastroenterology & Hepatology

Kaempferol protects against doxorubicin-induced cardiotoxicity in vivo and in vitro

(2011) Jing Xiao et al.   TOXICOLOGY

RSK2 mediates NF-κB activity through the phosphorylation of IκBα in the TNF-R1 pathway

(2010) Cong Peng et al.   FASEB JOURNAL

Proteinase-activated receptors induce interleukin-8 expression by intestinal epithelial cells through ERK/RSK90 activation and histone acetylation

(2010) Hongying Wang et al.   FASEB JOURNAL

Interleukin-22 treatment ameliorates alcoholic liver injury in a murine model of chronic-binge ethanol feeding: Role of signal transducer and activator of transcription 3

(2010) Sung Hwan Ki et al.   HEPATOLOGY

Hepatic Expression of CXC Chemokines Predicts Portal Hypertension and Survival in Patients With Alcoholic Hepatitis

(2009) Marlene Dominguez et al.   GASTROENTEROLOGY

Ghrelin attenuates hepatocellular injury and liver fibrogenesis in rodents and influences fibrosis progression in humans

(2009) Montserrat Moreno et al.   HEPATOLOGY

Signalling pathways in alcohol-induced liver inflammation

(2009) Pranoti Mandrekar et al.   JOURNAL OF HEPATOLOGY

Novel functional profiling approach combining reverse phase protein microarrays and human 3-Dex vivotissue cultures: Expression of apoptosis-related proteins in human colon cancer

(2009) Farzaneh Pirnia et al.   PROTEOMICS

Involvement of 90-kuD ribosomal S6 kinase in collagen type I expression in rat hepatic fibrosis

(2009) Miao-Fang Yang et al.   WORLD JOURNAL OF GASTROENTEROLOGY

A New Scoring System for Prognostic Stratification of Patients With Alcoholic Hepatitis

(2008) Marlene Dominguez et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Cytokines and Renin-Angiotensin System Signaling in Hepatic Fibrosis

(2008) Montserrat Moreno et al.   Clinics in Liver Disease

The RSK family of kinases: emerging roles in cellular signalling

(2008) Rana Anjum et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY