Article
Chemistry, Physical
Sumitha Kanniappan Rajendran, Julfikar Hassan Mondal, Md. Sayem Alam
Summary: The micellization behavior of anionic surfactant in aqueous medium was investigated, along with the effect of anionic hydrotrope. The results showed that the critical micelle concentration of the surfactant decreased with increasing hydrotrope concentration. The interactions between the hydrotrope and surfactant were found to be synergistic. Thermodynamic parameters of micellization were calculated and the non-covalent interactions in the mixed surfactant-hydrotrope systems were revealed using experimental techniques.
CHEMICAL PHYSICS LETTERS
(2022)
Article
Polymer Science
Alexander L. Kwiatkowski, Vyacheslav S. Molchanov, Alexander I. Kuklin, Yuri M. Chesnokov, Olga E. Philippova
Summary: This study investigates the structural transformation of charged hybrid surfactant/polymer micelles induced by salt concentration. The results show that small salt concentration leads to the formation of beads-on-string aggregates on polymer chains, while the addition of KCl transforms these aggregates into rods. The presence of the polymer delays the transition from spheres to rods at higher salt concentrations. The rods formed in the hybrid system are shorter than those in the polymer-free surfactant solution, indicating the stabilization of the semi-spherical endcaps by the embedded polymer. The study also reveals the localization of the polymer within the aggregates.
Article
Chemistry, Physical
Xin-Ning Bao, Wei-Dong Zhang, Hong-Ze Gang, Shi-Zhong Yang, Ying-Cheng Li, Bo-Zhong Mu
Summary: A novel binary system consisting of a cationic surfactant and a counter ion that can form wormlike micelles with high viscosity is proposed. The experimental results show the formation of long elongated wormlike micelles in dilute solution at temperatures exceeding 60 degrees Celsius.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Chemistry, Physical
Wannian Zhang, Kai Wang, Caiping Wang, Shanlin Zhao, Zhiqiang Zhang, Fang Yu, Yu-Peng He
Summary: This paper investigates four virtual descriptors of two anionic surfactants through simulation and analysis, and determines the relationships between these descriptors and the interfacial properties of the surfactants. The descriptors accurately evaluate the performance of the surfactants and reveal the patterns for different surfactants and ion concentration gradients.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Review
Biochemistry & Molecular Biology
Mari Numata, Dennis R. Voelker
Summary: Pulmonary surfactant, a mixture of lipids and proteins, has anti-inflammatory effects and can prevent viral replication by regulating Toll-like receptors and blocking interactions between viruses and host cells. Components like phosphatidylglycerol and phosphatidylinositol show potential as prophylaxis and treatment for respiratory viral infections.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2022)
Review
Immunology
Mari Numata, Pitchaimani Kandasamy, Dennis R. Voelker
Summary: The pulmonary surfactant system is a complex of lipids and proteins that regulates the properties of the alveoli and the immune system in the lung. The main components, phosphatidylglycerol (PG) and phosphatidylinositol (PI), have been found to inhibit inflammatory responses and have antiviral effects against respiratory viruses, including SARS-CoV-2.
IMMUNOLOGICAL REVIEWS
(2023)
Article
Immunology
Nagesh Kishan Panchal, Purushotham Swarnalatha, Sabina Evan Prince
Summary: Ibuprofen, a commonly used nonsteroidal anti-inflammatory drug, can cause serious adverse effects on organs when used for a long duration or overdosed. Trichopus zeylanicus, a medicinal plant, has been found to have beneficial effects and can ameliorate ibuprofen-induced hepatic toxicity and enteropathy in rats.
INFLAMMOPHARMACOLOGY
(2022)
Article
Chemistry, Physical
Natalia Rojas-Valencia, Sara Gomez, Tommaso Giovannini, Chiara Cappel, Albeiro Restrepo, Francisco Nunez-Zarur
Summary: UV-vis spectra of anionic ibuprofen and naproxen in a model lipid bilayer of the cell membrane are investigated using computational techniques in combination with a comparative analysis of drug spectra in purely aqueous environments. The simulations aim at elucidating the intricacies behind the negligible changes in the maximum absorption wavelength in the experimental spectra; Results suggest that the molecular orbitals involved in the electronic transitions are the same, regardless of the chemical environment. A thorough analysis of the contacts between the drug and water molecules reveals that no significant changes in UV-vis spectra are a consequence of ibuprofen and naproxen molecules being permanently microsolvated by water molecules, despite the presence of lipid molecules.
JOURNAL OF PHYSICAL CHEMISTRY B
(2023)
Article
Immunology
Huanyu Jiang, Yubiao Zhang, Geliang Hu, Xiaobin Shang, Jianghua Ming, Ming Deng, Yaming Li, Yonggang Ma, Shiqing Liu, Yan Zhou
Summary: The study reveals the important role of surfactant protein D (SP-D) in regulating inflammation and immune response in osteoarthritis (OA). SP-D exhibits chondroprotective properties by downregulating inflammation-related genes, suppressing cytokine production, and reducing infiltration of inflammatory cells. The binding of SP-D to the TLR4/MD-2 complex further inhibits TLR4-mediated signaling activation. These findings suggest that SP-D has a beneficial effect in attenuating inflammation and preserving cartilage integrity in OA.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Joakim Steiness, Daniel Hagi-Pedersen, Troels Haxholdt Lunn, Martin Lindberg-Larsen, Ben Kristian Graungaard, Lars Hyldborg Lundstrom, Peter Lindholm, Stig Brorson, Manuel Josef Bieder, Torben Beck, Michael Skettrup, Adam Gregers von Cappeln, Kasper Hojgaard Thybo, Kasper Smidt Gasbjerg, Soren Overgaard, Janus Christian Jakobsen, Ole Mathiesen
Summary: This study aims to investigate the benefits and harms of different combinations of paracetamol, ibuprofen, and dexamethasone following total hip arthroplasty. The randomized controlled trial will be conducted at multiple Danish hospitals, with follow-up periods of 90 days and 1 year.
Article
Chemistry, Analytical
Saied Shafiei-Navid, Rahman Hosseinzadeh, Milad Ghani
Summary: A new sorbent ACA-LDH was successfully synthesized for extracting NSAIDs, with parameters optimized using response surface methodology. The method was proven effective for identifying NSAIDs in real samples.
MICROCHEMICAL JOURNAL
(2022)
Article
Chemistry, Physical
Suraya Jabeen, Mohd Sajid Lone, Saima Afzal, Pawandeep Kour, Arjumund Shaheeen, Firdaus Ahmad Ahanger, Ghulam Mohammad Rather, Aijaz Ahmad Dar
Summary: The study investigated the interactions between a water-soluble anionic polymer and a cationic amphiphile under different conditions, revealing significant differences in the ions provided by NaCl and NaSl. The effects were analyzed through tensiometric, conductometric, and rheometric measurements, showing variations in physicochemical properties.
COLLOID AND POLYMER SCIENCE
(2021)
Article
Immunology
Maria R. Xavier, Thiago S. Freitas, Raimundo L. S. Pereira, Emanuelle M. Marinho, Paulo N. Bandeira, Amanda P. de Sousa, Larissa S. Oliveira, Lucas Lima Bezerra, Jose B. A. Neto, Maria M. C. Silva, Beatriz G. Cruz, Janaina E. Rocha, Cristina R. S. Barbosa, Antonio W. da Silva, Jane E. S. A. de Menezes, Henrique D. M. Coutinho, Marcia M. Marinho, Emmanuel S. Marinho, Helcio S. dos Santos, Alexandre M. R. Teixeira
Summary: This study evaluated the anti-inflammatory and antibacterial effects of the ibuprofen derivative MET-IBU. The results showed that MET-IBU had anti-inflammatory properties and enhanced the sensitivity of multidrug-resistant bacteria to antibiotics, effectively inhibiting the growth of several pathogenic bacteria.
MICROBIAL PATHOGENESIS
(2022)
Article
Chemistry, Physical
Abhishek Srivastava, Vinay Kumar Singh, Neetu Srivastava, Bushra Yaseen, Chinky Gangwar, Radhey Mohan Naik
Summary: The kinetic investigation of the Hg(II)-promoted reaction between [Fe(CN)(6)](4-) and N-R-salt in anionic SDS micellar medium has been carried out using UV-visible spectrophotometer. Pseudo-first-order conditions were used to examine the progress of the reaction as a function of various parameters. The results show that [Hg2+], [SDS], pH, and [N-R-salt] are the decisive parameters affecting the reaction rate.
RUSSIAN JOURNAL OF PHYSICAL CHEMISTRY A
(2023)
Article
Surgery
Ray W. Chang, Danielle M. Tompkins, Stephen M. Cohn
Summary: The study found that the risks of short-term NSAID use may be overemphasized when used appropriately for managing acute postoperative pain, highlighting the importance of alternative analgesic options in the context of the opioid epidemic.
Article
Chemistry, Multidisciplinary
Nawal K. Paul, Tyler Mercer, Hussein Al-Mughaid, D. Gerrard Marangoni, Michael J. McAlduff, Kulbir Singh, T. Bruce Grindley
CANADIAN JOURNAL OF CHEMISTRY
(2015)
Article
Chemistry, Multidisciplinary
Vijay Patel, Debes Ray, Kulbir Singh, Ludmila Abezgauz, Gerrard Marangoni, Vinod K. Aswal, P. Bahadur
Article
Chemistry, Multidisciplinary
David J. Greencorn, Victoria M. Sandre, Emily K. Piggott, Michael R. Hillier, A. James Mitchell, Taryn M. Reid, Michael J. McAlduff, Kulbir Singh, D. Gerrard Marangoni
CANADIAN JOURNAL OF CHEMISTRY
(2018)
Article
Chemistry, Physical
Yevgen Karpichev, Nusrat Jahan, Nawal Paul, Christian P. Petropolis, Tyler Mercer, T. Bruce Grindley, D. Gerrard Marangoni
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2014)
Article
Chemistry, Physical
Aleisha McLachlan, Kulbir Singh, Emily Piggott, Michael McAlduff, Shannon MacLennan, Victoria Sandre, Taryn Reid, D. Gerrard Marangoni
JOURNAL OF PHYSICAL CHEMISTRY B
(2019)
Article
Chemistry, Applied
Nicholas P. Petropolis, Harrison M. Petropolis, Nicole E. MacNeil, Taylor M. Doucet, D. Gerrard Marangoni
Summary: Favorable interactions were found between sodium dodecyl sulfate micelles and glyme cosurfactants, while little favorable interactions were observed between dodecyltrimethylammonium bromide micelles and glymes. These results were determined through conductance experiments and C-13 nuclear magnetic resonance chemical shifts analysis.
JOURNAL OF SURFACTANTS AND DETERGENTS
(2021)
Article
Chemistry, Physical
Sanjay Tiwari, Kulbir Singh, D. Gerrard Marangoni, Pratap Bahadur
Summary: This study investigates the solubilization of quercetin, a hydrophobic flavonoid, in a saline solution of an amphiphilic copolymer. The results show that the copolymer solution has superior solubilization compared to linear counterparts and provides a protective environment for quercetin against oxidation.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Chemistry, Multidisciplinary
Olivia M. Singer, Jacob W. Campbell, Jacob G. Hoare, Jason D. Masuda, Gerrard Marangoni, Robert D. Singer
Summary: Gemini surfactants are composed of two hydrocarbon tails with corresponding polar headgroups, linked via a covalent spacer. The improved synthetic approach of these symmetrical gemini surfactants has led to their characterization of crystalline packing for the first time ever using X-ray crystallographic analysis.
Article
Chemistry, Multidisciplinary
Shannon MacLennan, D. Gerrard Marangoni
Summary: This study determined the enthalpies of mixed micelle formation (ΔmicH) for various SDS/glyme systems using isoperibol solution calorimetry, with the concentration of glycol ether and temperature as variables. The glycol ethers investigated were DEGDME, TEGDME, TetraEGDME, and DEGDEE. The CMC values of the SDS/glyme mixed micelles were determined directly based on the data from the calorimeter. The entropies and Gibbs energies of mixed micellization (ΔmicS and ΔmicG) were calculated using the charged pseudo-phase separation model. The results showed that the CMC values and mixed micelle formation enthalpies were dependent on the structure and concentration of the glyme in the mixed solvents, indicating the importance of alkyl chain interactions, hydrophobic effects, and electrostatic contributions in micelle thermodynamics.
JOURNAL OF THE INDIAN CHEMICAL SOCIETY
(2023)
Article
Neurosciences
Daniel A. Kane, Alexander C. Y. Foo, Erin B. Noftall, Karen Brebner, D. Gerrard Marangoni
Summary: Lactate, as the end product of glycolysis, plays various physiological roles by traveling within and between cells. However, its application to physical bioenergetics has been underexplored. This study suggests that lactate shuttling, as an allostatic thermoregulatory strategy, mitigates the consequences of elevated metabolic heat by exchanging extracellular lactate between tissues. The results of experiments on rat cortical brain samples support this hypothesis by showing lower heat and respiratory oxygen consumption rates during lactate-linked respiration compared to pyruvate-linked respiration.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Chemistry, Physical
Brooke A. Morris, Ahmed A. Elgendy, Nicole E. MacNeil, Olivia M. Singer, Jacob G. Hoare, Robert D. Singer, D. Gerrard Marangoni
Summary: The partition constants of primary alcohols in symmetric gemini surfactant aggregates were calculated from diffusion coefficients obtained from NMR-diffusion experiments. The Gibbs energy of transfer for the alcohols from water to the gemini aggregate phase decreased linearly with an increase in the alcohol carbon length. The partition coefficients of the alcohols in the symmetric gemini aggregates showed little dependence on the spacer length of the gemini amphiphiles and were consistent as the length of the main surfactant chain increased.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Chemistry, Physical
S. M. Shortall, D. G. Marangoni, S. D. Wettig
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2020)
Article
Chemistry, Multidisciplinary
Aleisha McLachlan, Kulbir Singh, Michael McAlduff, D. Gerrard Marangoni, Samantha Shortall, Shawn D. Wettig
Article
Chemistry, Physical
S. Chavda, D. Danino, V. K. Aswal, K. Singh, D. G. Marangoni, P. Bahadur
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2017)