Article
Chemistry, Applied
Yi-Jun Jo, Muhammad Gulfam, Sung-Han Jo, Yeong-Soon Gal, Chul-Woong Oh, Sang-Hyug Park, Kwon Taek Lim
Summary: Researchers developed stimuli-responsive hydrogels based on hyaluronic acid and diselenide cross-linker for controlled drug release. These hydrogels exhibited rapid drug release under acidic, reducing, oxidizing, and NIR irradiation conditions, and showed good cytocompatibility and anti-tumor effect.
CARBOHYDRATE POLYMERS
(2022)
Review
Materials Science, Biomaterials
Ruosen Xie, Yuyuan Wang, Shaoqin Gong
Summary: This review summarizes the latest non-viral vectors that utilize external stimuli for spatially and temporally controlled genome editing, and their applications in vitro and in vivo.
BIOMATERIALS SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Sophia Bailey, Erik Hopkins, Naomi Baxter, Isobel Whitehead, Javier Read de Alaniz, Maxwell Wilson
Summary: This study demonstrates a light-guided patterning platform using natural extracellular matrix (ECM) proteins as a substrate to program cellular behaviors. The platform enables the patterning of common ECM proteins with commercially available functional small molecules and growth factors. It also highlights the ability to spatially control cell behavior through patterned chemical modification of natural ECM.
ADVANCED MATERIALS
(2023)
Article
Polymer Science
Ly Mai Thi Nguyen, Nguyen Khai Hoang Nguyen, Huan Hoang Dang, Anh Duc Song Nguyen, Thuy Thu Truong, Ha Tran Nguyen, Thiet Quoc Nguyen, Son Thanh Cu, Ngan Nguyen Le, Tin Chanh Duc Doan, Le-Thu T. Nguyen
Summary: A thermally reversible and high-performance polydimethylsiloxane (PDMS)-based network can be easily achieved using a novel single-molecule silicone-based Diels-Alder crosslinker that combines thiol-acrylate Michael addition and Diels-Alder click chemistries in a one-pot fashion. The high flexibility of the silicone-derived crosslinker enables good healing of complete cuts without the need for a pre-healing step to dissociate the dynamic DA bonds. The cut healing process is possible with a single heating step at 70 degrees Celsius, resulting in a relatively good healing efficiency with a tensile strength recovery of above 80%.
Article
Materials Science, Multidisciplinary
Sungmin Jung, Yoon Sang Kim, Han Gyeol Jang, Jong Hyuk Park, Min Park, Yong-Seok Choi, Jaewoo Kim
Summary: This article presents a microbead-type latent curing agent based on benzyl 2-methylimidazole (BMI) incorporated with thermally responsive Diels-Alder (DA) linkages, which can trigger an immediate curing reaction above a certain temperature. The latent curing agent has a long storage stability and provides better curing performance.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Polymer Science
Alexis Morinval, Luc Averous
Summary: This study developed a thermally responsive network based on reversible Diels-Alder reaction, by chemically modifying AMS and PBAT. It successfully addressed the incompatibility between the two materials, offering potential for developing high-performance materials in the circular bioeconomy.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Chemistry, Organic
Pratiksha Bhorali, Jyotshna Phukon, Sanjib Gogoi
Summary: An unprecedented (5 + 2)-cycloaddition reaction between ortho-hydroxyethyl phenol and internal alkyne was developed using rhodium(iii) catalysis. This reaction provided benzoxepine derivatives with high biological significance. A wide range of ortho-hydroxyethyl phenols and internal alkynes were effectively used to obtain high yields of benzoxepines.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Review
Materials Science, Biomaterials
Jiacheng Liu, Chengcheng Du, Wei Huang, Yiting Lei
Summary: Injectable smart stimuli-responsive hydrogels have gained attention for their minimally invasive nature and adaptive behavior. By responding to various stimuli, these advanced hydrogels have revolutionary applications in tissue engineering, drug delivery, and disease treatment. The integration of natural and synthetic materials is a rational strategy for developing ideal injectable smart stimuli-responsive hydrogels.
BIOMATERIALS SCIENCE
(2023)
Article
Materials Science, Multidisciplinary
Potao Sun, Zeyan Shi, Wenxia Sima, Xinyu Tang, Tao Yuan, Ming Yang, Hang Xu, Zhaoping Li
Summary: This study presents an intrinsic self-healing epoxy resin based on reversible anthracene photodimerization (ISEP-RAP) that remains mechanically robust while efficiently repairing cracks and electrical damage. The damaged area is decrosslinked and repaired through UV and thermal excitation, and then recrosslinked to restore mechanical and electrical properties. ISEP-RAP exhibits excellent tensile and dielectric strength, along with dimensional stability.
JOURNAL OF MATERIALS CHEMISTRY C
(2023)
Article
Materials Science, Multidisciplinary
Potao Sun, Zeyan Shi, Wenxia Sima, Xinyu Tang, Tao Yuan, Ming Yang, Hang Xu, Zhaoping Li
Summary: This study presents an intrinsic self-healing epoxy resin based on reversible anthracene photodimerization, which achieves efficient self-healing of scratches and electrical trees while maintaining high mechanical strength. The material undergoes a reversible crosslinking and decrosslinking process to fill and repair the damaged channels. The self-healing process is repeatable and non-contact, providing a new method for mechanical robust insulation materials.
JOURNAL OF MATERIALS CHEMISTRY C
(2023)
Article
Materials Science, Biomaterials
Buyun Guo, Rong Fan, Shuwei Shen, Yue Xue, Zhiqiang Zhu, Ronald X. Xu
Summary: The study proposes a tailored drug delivery strategy utilizing a photo-responsive material combined with tumor margin imaging for automated drug release. Concept verification demonstrates the therapeutic effect and technical potential of this strategy in vitro.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Materials Science, Composites
Chongchong Yang, Dandan Zhu, Chengyuan Sun, Buyun Chen, Yinghao Li, Indra Neel Pulidindi, Zhen Zheng, Xinling Wang
Summary: A more facile and efficient self-healing strategy for carbon fiber/thermoset resin interphase was developed based on the electrothermal effect of carbon fiber driving reversible transformation of covalent bonds. The introduction of DielsAlder cycloaddition adduct into the interphase region endowed the interface with thermoreversible covalent bonds, improving repair efficiency. Characterization of the modified carbon fiber was done through SEM, AFM, XPS, and TGA analysis, while adjusting the temperature range in CFRPs was achieved by controlling electric current applied to CFs. The self-healing behavior of the damaged interphase was verified through interfacial shear strength measurement, demonstrating the effectiveness of the electrothermal effect in promoting reversible transformation and improving interfacial adhesion.
COMPOSITES SCIENCE AND TECHNOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Jose Munoz
Summary: The ability of electronic devices to act as switches makes digital information processing possible. Succeeding graphene, emerging inorganic 2D materials have been identified as alternative materials to harbor a variety of active molecular components to move the current silicon-based semiconductor technology forward to a post-Moore era focused on molecule-based information processing components.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Organic
Li Pang, Shu-Jun Fang, Pei-Sen Zou, Wang Wang, Jun-Cheng Su, Xiao-Qing Liu, Cheng-Xue Pan, Dong-Liang Mo, Gui-Fa Su
Summary: We report a transition-metal free [4 + 4] cycloaddition reaction between 2-alkynyl quinazolines and aza-ortho-quinone methides (ao-QMs) generated from 2-(bromomethyl)anilines, leading to the synthesis of various [1,5]diazocino[2,1-b]quinazolinones in good to excellent yields under mild reaction conditions and short reaction time. Furthermore, a [1,5]diazocino[2,1-b]quinazolinone derived from estrone was easily prepared in 30% total yield over five steps, and showed significant inhibition of nitric oxide generation in LPS-stimulated RAW264.7 cells. This method offers advantages such as broad substrate scope, gram-scale preparation, and simple purification operation without flash column chromatography.
ORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Engineering, Manufacturing
Wei Cai, Zhaoxin Li, Jiajia Liu, Shuilai Qiu, Ying Pan, Zhoumei Xu, Chao Ma, Yuan Hu
Summary: By utilizing reversible Diels-Alder reaction, precise control over the formation and elimination of surface functionalization composed of triallyl isocyanurate on black phosphorous (BP) nanosheets has been achieved. This surface functionalization not only enhances the interfacial interaction between BP nanosheets and polymer matrix, but also converts them into phosphorus pentoxide and phosphoric acid with dehydration carbonization effect. Incorporating functionalized BP nanosheets significantly reduces the peak heat release rate (PHRR) and total heat release (THR) of thermoplastic polyurethane (TPU) in cone calorimetric tests.
COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING
(2021)
Article
Chemistry, Medicinal
Enrique-J Montagut, Gerardo Acosta, Fernando Albericio, Miriam Royo, Gerard Godoy-Tena, Alicia Lacoma, Cristina Prat, Juan-Pablo Salvador, Maria-Pilar Marco
Summary: An immunochemical strategy for detecting and quantifying AIP-IV, a quorum sensing signaling molecule produced by Staphylococcus aureus agr type IV, is reported. The use of theoretical calculations and molecular modeling studies assisted in designing a suitable peptide hapten and obtaining specific antibodies. The developed ELISA achieved high sensitivity and specificity, and its potential for biomedical investigations related to QS in pathogenesis and clinical outcomes was demonstrated.
ACS INFECTIOUS DISEASES
(2022)
Article
Chemistry, Multidisciplinary
Fernando Fernandez, Alberto G. Fernandez, Rosalino Balo, Victor M. Sanchez-Pedregal, Miriam Royo, Raquel G. Soengas, Ramon J. Estevez, Juan C. Estevez
Summary: A stereoselective synthesis of polyhydroxylated cyclopentane beta-amino acids from hexoses is reported, involving ring-closing metathesis and stereoselective aza-Michael functionalization. Examples of synthesis of polysubstituted 2-amino-cyclopentanecarboxylic acid derivatives starting from protected D-mannose and D-galactose are provided, along with a general protocol for incorporating these highly functionalized alicyclic beta-amino acids into peptides.
Article
Nanoscience & Nanotechnology
J. Alejandro De Sousa, Raphael Pfattner, Diego Gutierrez, Kilian Jutglar, T. Bromley Stefan, Jaume Veciana, Concepcio Rovira, Marta Mas-Torrent, Bruno Fabre, Nuria Crivillers
Summary: The preparation of monolayers based on an organic radical and its diamagnetic counterpart has been investigated on hydrogen-terminated silicon surfaces. The monolayers exhibit a characteristic diode behavior in solid-state metal/monolayer/semiconductor junctions, which is influenced by the electronic characteristics of the organic molecule. The presence of the radical significantly enhances the rectification ratio and photosensitivity of the junction.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Davide Blasi, Nerea Gonzalez-Pato, Xavier Rodriguez Rodriguez, Inigo Diez-Zabala, Sumithra Yasaswini Srinivasan, Nuria Camarero, Oriol Esquivias, Monica Roldan, Judith Guasch, Anna Laromaine, Pau Gorostiza, Jaume Veciana, Imma Ratera
Summary: Ratiometric fluorescent nanothermometers with near-infrared emission are designed and studied, based on the dual emission of monomer and excimer species, for in vivo sensing with high spatial resolution and sensitivity. The temperature-dependent fluorescence of the organic nanoparticles allows them to act as internal reference probes. The nanoparticles show great temperature sensitivity and response, excellent reversibility and stability, and are able to monitor temperature changes at the nano-microscale.
Article
Pharmacology & Pharmacy
Adria Lopez-Cano, Neus Ferrer-Miralles, Julieta Sanchez, Jose Vicente Carratala, Xavier Rodriguez Rodriguez, Imma Ratera, Judith Guasch, Oscar Q. Q. Pich, Paula Bierge, Cristina Garcia-de-la-Maria, Jose M. M. Miro, Elena Garcia-Fruitos, Anna Aris
Summary: Antibiotic resistance has significantly increased, calling for the development of new antimicrobial drugs. Host Defense Peptides (HDPs) have the potential to be used as antimicrobial agents and immune regulators. The present study aims to design recombinant multidomain proteins based on HDPs to create a new generation of tailored antimicrobials. Three new antimicrobials were designed and tested, with D5L37D5L37 showing the highest efficacy against various healthcare-associated pathogens. This study highlights the potential of using HDP combinations for the development of new antimicrobial drugs.
Article
Endocrinology & Metabolism
Alba Sanz-Gonzalez, Irene Cozar-Castellano, Christophe Broca, Julia Sabatier, Gerardo A. Acosta, Miriam Royo, Carla Hernando-Munoz, Tomas Torroba, German Perdomo, Beatriz Merino
Summary: This study investigated the use of synthetic preimplantation factor (sPIF) as a potential therapeutic tool for improving glucose-stimulated insulin secretion, glucose tolerance, and insulin sensitivity in diabetes. The results showed that sPIF significantly increased insulin secretion in human islets. Furthermore, continuous administration of sPIF improved circulating insulin levels and glucose tolerance in a preclinical murine model of type 2 diabetes.
DIABETES OBESITY & METABOLISM
(2023)
Review
Materials Science, Biomaterials
Miquel Castellote-Borrell, Francesca Merlina, Adrian R. Rodriguez, Judith Guasch
Summary: Tumoroids are 3D in vitro models that mimic the architecture of in vivo tumors and preserve patient-specific characteristics. Currently, they are mostly established using basement membrane extracts (BME) or synthetic polymers. However, BME lack defined composition and reproducibility, while synthetic polymers lack complexity. Biohybrid hydrogels, which combine natural and synthetic components, offer a solution by providing superior 3D culture systems. This review summarizes the efforts to produce tumoroids using different types of biohybrid hydrogels, classified by their crosslinking mechanism.
Article
Materials Science, Multidisciplinary
Adriana R. Kyvik, Ramon Roca-Pinilla, Karla Mayolo-Deloisa, Xavier Rodriguez Rodriguez, Marc Martinez-Miguel, Marta Martos, Mariana Kober, Nora Ventosa, Jaume Veciana, Judith Guasch, Elena Garcia-Fruitos, Anna Aris, Imma Ratera
Summary: In this study, novel biofunctionalized gold surfaces with the antimicrobial multidomain recombinant protein JAMF1 were developed. The immobilized JAMF1 protein successfully reduced biofilm formation of both Escherichia coli and carbapenem-resistant Klebsiella pneumoniae. This strategy provides new possibilities for biomolecule immobilization in fundamental biological studies and biotechnological applications.
MATERIALS ADVANCES
(2023)
Article
Materials Science, Multidisciplinary
Nerea Gonzalez-Pato, Xavier Rodriguez Rodriguez, Nicola Pellizzi, Claudia Fasolato, Judith Guasch, Paolo Postorino, Jaume Veciana, Alejandro R. R. Goni, Imma Ratera
Summary: We developed an easy and low-cost method to prepare highly homogeneous electroactive substrates for simultaneous surface-enhanced Raman spectroscopy (SERS) and electrochemical measurements. The substrates were made by depositing a quasi-hexagonal pattern of uniformly distributed gold nanoparticles (AuNPs) on conductive indium tin oxide (ITO) using block-copolymer micellar lithography, followed by electrodeposition of additional gold onto the pre-patterned ITO. The resulting substrates exhibited strong and homogeneous Raman signals and demonstrated good electrochemical performance.
MATERIALS ADVANCES
(2023)
Article
Chemistry, Physical
Nerea Gonzalez-Pato, Davide Blasi, Domna M. Nikolaidou, Francesco Bertocchi, Jesus Cerda, Francesca Terenziani, Nora Ventosa, Juan Arago, Andrea Lapini, Jaume Veciana, Imma Ratera
Summary: This article reports the preparation and characterization of organic nanoparticles doped with polychlorinated trityl radicals as nanothermometers for temperature sensing. The nanoparticles show excellent thermal sensitivity and have the potential to be used as nanothermometers in bio applications.
Article
Engineering, Electrical & Electronic
Raphael Pfattner, Elena Laukhina, Jinghai Li, Rossella L. Zaffino, Nuria Aliaga-Alcalde, Marta Mas-Torrent, Vladimir Laukhin, Jaume Veciana
Summary: Composites with different components exhibit unique synergistic properties, and the energy bandgap in their electronic structure can be tuned to design tailor-made systems. A study found an emergent insulator-metal transition in bilayered thin-films at room temperature, and the electrical/optical bandgaps could be adjusted. This makes these materials ideal candidates for flexible and soft sensors for various applications.
ACS APPLIED ELECTRONIC MATERIALS
(2022)
