Journal
JOURNAL OF PHARMACEUTICAL SCIENCES
Volume 107, Issue 9, Pages 2465-2471Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.xphs.2018.05.003
Keywords
nanoparticles; mixing; protein delivery; peptide delivery; formulation; particle size; polymeric drug carrier
Funding
- Optimeos Life Sciences
- Princeton Old Guard Fund
- NSF [1605816]
- Bill and Melinda Gates Foundation (BMGF) [OPP1150755]
- Bill and Melinda Gates Foundation [OPP1150755] Funding Source: Bill and Melinda Gates Foundation
- Directorate For Engineering
- Div Of Chem, Bioeng, Env, & Transp Sys [1605816] Funding Source: National Science Foundation
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Flash NanoPrecipitation is a scalable approach to generate polymeric nanoparticles using rapid micromixing in specially designed geometries such as a confined impinging jets mixer or a Multi-Inlet Vortex Mixer (MIVM). A major limitation of formulation screening using the MIVM is that a single run requires tens of milligrams of the therapeutic. To overcome this, we have developed a scaled-down version of the MIVM, requiring as little as 0.2 mg of therapeutic, for formulation screening. The redesigned mixer can then be attached to pumps for scale-up of the identified formulation. It was shown that Reynolds number allowed accurate scaling between the 2 MIVM designs. The utility of the small-scale MIVM for formulation development was demonstrated through the encapsulation of a number of hydrophilic macromolecules using inverse Flash NanoPrecipitation with target loadings as high as 50% by mass. (c) 2018 The Authors. Published by Elsevier Inc. on behalf of the American Pharmacists Association (R).
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