Mechanistic Physiologically Based Pharmacokinetic Modeling of the Dissolution and Food Effect of a Biopharmaceutics Classification System IV Compound—The Venetoclax Story

Title
Mechanistic Physiologically Based Pharmacokinetic Modeling of the Dissolution and Food Effect of a Biopharmaceutics Classification System IV Compound—The Venetoclax Story
Authors
Keywords
amorphous, absorption, distribution, metabolism, and excretion (ADME), bioavailability, food effect, physiologically based pharmacokinetic modeling, clinical pharmacokinetics, intestinal absorption, passive diffusion/transport, drug interaction
Journal
JOURNAL OF PHARMACEUTICAL SCIENCES
Volume 107, Issue 1, Pages 495-502
Publisher
Elsevier BV
Online
2017-10-12
DOI
10.1016/j.xphs.2017.09.027

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