Review
Microbiology
Virginie Gazil, Octave Nadile Bandiaky, Emmanuelle Renard, Katia Idiri, Xavier Struillou, Assem Soueidan
Summary: The success rates of dental implants at 5 and 10 years are nearly 90%. The prevalence of peri-implant diseases, such as peri-implantitis and peri-implant mucositis, is significant. Recent studies using new generation sequencing methods have compared the microbiota of healthy and diseased periodontal and peri-implant sites, revealing distinct differences in diversity and composition. Understanding the characteristics of the peri-implant microbiota can optimize therapeutic strategies for peri-implant diseases.
Review
Biotechnology & Applied Microbiology
Magda Aline Nagasawa, Marcio de Carvalho Formiga, Vittorio Moraschini, Martinna Bertolini, Joao Gabriel Silva Souza, Magda Feres, Luciene C. Figueiredo, Jamil Awad Shibli
Summary: This systematic review evaluated the features of the progression of experimentally induced gingivitis and peri-implant mucositis in humans. It found that peri-implant mucositis had a more exacerbated clinical response than gingivitis. Additionally, dental implants accumulated less biofilm but had more heterogeneous alterations in the microbiota.
Review
Chemistry, Multidisciplinary
Andrea Butera, Maurizio Pascadopoli, Matteo Pellegrini, Simone Gallo, Paolo Zampetti, Andrea Scribante
Summary: Peri-implant infections are common complications of dental implants, and this review evaluates the changes in oral microbiota associated with peri-implant disease. The study finds similarities and differences between peri-implantitis and periodontitis in microbial composition. The use of probiotics, in combination with mechanical debridement, shows potential for reducing peri-implant pockets. Transcriptomics can provide valuable insights into bacterial virulence factors for the prevention, diagnosis, and treatment of peri-implant pathology.
APPLIED SCIENCES-BASEL
(2022)
Article
Microbiology
Yuchen Zhang, Yinhu Li, Yuguang Yang, Yiqing Wang, Xiao Cao, Yu Jin, Yue Xu, Shuai Cheng Li, Qin Zhou
Summary: This study analyzed plaque samples from patients with periodontitis and peri-implantitis, finding that subgingival communities became less connected and competitive when inflammation arose, while supragingival communities tended to be more connected and competitive. Moreover, periodontitis and peri-implantitis were associated with significantly increased microbial stability in the subgingival microbiome.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Nutrition & Dietetics
Hasinthi Swarnamali, Nidhi Medara, Aditi Chopra, Axel Spahr, Thilini N. Jayasinghe
Summary: This study systematically evaluated the effects of dietary fiber intake on periodontal diseases. The results indicated that dietary fiber intervention can reduce clinical and especially inflammatory markers of periodontal diseases. This provides promising evidence for dietary fiber as an intervention for inflammatory conditions like periodontal diseases.
Review
Medicine, Research & Experimental
Carlos Henrique Alves, Karolayne Larissa Russi, Natalia Conceicao Rocha, Fabio Bastos, Michelle Darrieux, Thais Manzano Parisotto, Raquel Girardello
Summary: In recent decades, there have been significant advances in ortho-aesthetic-functional rehabilitation with the introduction of implantology. However, there is still a percentage of failures in implantology surgeries, mainly due to infections caused by bacterial proliferation, fungi presence, and biofilm formation, leading to peri-implantitis. Various studies have been conducted to explore the interaction between the host-oral microbiome and the development of peri-implantitis. Peri-implantitis is associated with a diversity of bacterial species, with Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia being identified in higher proportions of peri-implantitis samples. In addition, the injury of peri-implant tissue triggers an inflammatory response mediated by the activation of innate immune cells, such as macrophages, dendritic cells, mast cells, and neutrophils. Activation of the host immune system may disrupt the balance of oral microbiota, leading to dysbiosis and the production of various substances that contribute to implant loss.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Giovanni Barbagallo, Maria Santagati, Alaa Guni, Paolo Torrisi, Ambra Spitale, Stefania Stefani, Sebastiano Ferlito, Luigi Nibali
Summary: The microbial profiles of healthy and diseased periodontal and peri-implant sites were found to be distinct, suggesting the potential for identifying biomarkers for periodontal health and disease and developing new strategies for treatment.
CLINICAL ORAL INVESTIGATIONS
(2022)
Article
Endocrinology & Metabolism
A. Scarano, F. Inchingolo, S. Scogna, L. Leo, A. Greco Lucchina, L. Mavriqi
Summary: Cement-retained restorations on implants offer better passive fit and aesthetics, but excess cement can lead to biological complications such as peri-implant tissue inflammation and periimplantitis. Careful cementation methods and materials can help prevent these cement-related peri-implant diseases.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2021)
Review
Dentistry, Oral Surgery & Medicine
Ann M. Decker, Yvonne L. Kapila, Hom-Lay Wang
Summary: Chronic stress is linked to periodontal diseases and may worsen oral tissue conditions. Through further research trials and improved data collection methods, it is discovered that chronic stress and related diseases may have significant impacts on the progression of periodontal/peri-implant diseases and treatment outcomes.
PERIODONTOLOGY 2000
(2021)
Article
Dentistry, Oral Surgery & Medicine
David Herrera, Tord Berglundh, Frank Schwarz, Iain Chapple, Soren Jepsen, Anton Sculean, Moritz Kebschull, Panos N. Papapanou, Maurizio S. Tonetti, Mariano Sanz
Summary: This study aims to develop clinical practice guidelines for the prevention and treatment of peri-implant diseases, emphasizing the need for interdisciplinary approaches and interventions at different stages. The guidelines provide recommendations for maintaining healthy peri-implant tissues and managing peri-implant diseases.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Review
Microbiology
Massimo Amato, Federica Di Spirito, Francesco D'Ambrosio, Giovanni Boccia, Giuseppina Moccia, Francesco De Caro
Summary: Periodontitis and peri-implantitis are diseases that lead to tooth and dental implant loss, and probiotics have been investigated for their potential beneficial effects. However, there is no definitive conclusion on the effectiveness of probiotics in periodontal management. Further studies are needed to validate their use and provide recommended protocols.
Article
Dentistry, Oral Surgery & Medicine
Alejandra Chaparro, Pablo Atria, Ornella Realini, Lara J. Monteiro, Daniel Betancur, Stephanie Acuna-Gallardo, Valeria Ramirez, Maria Jose Bendek, Andres Pascual, Jose Nart, Victor Beltran, Antonio Sanz
Summary: The increased concentration of EVs with downregulated expression of miRNA-21-3p and miRNA-150-5p could be associated with the development of peri-implantitis.
JOURNAL OF PERIODONTOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Laila Kabir, Meike Stiesch, Jasmin Grischke
Summary: The study found that a reduced width of keratinized mucosa is a risk indicator for the severity of peri-implant mucositis in periodontally healthy patients and patients without a history of periodontitis. Additionally, poor oral hygiene, lack of residual teeth, maxillary implants, and the number of implants per patient were also significantly associated with severity scores.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Infectious Diseases
Michele Antonio Lopez, Pier Carmine Passarelli, Emmanuele Godino, Nicolo Lombardo, Francesca Romana Altamura, Alessandro Speranza, Andrea Lopez, Piero Papi, Giorgio Pompa, Antonio D'Addona
Summary: The study demonstrated the efficacy of HYBENX(R) in treating peri-implantitis and suggested that using HYBENX(R) along with open-flap debridement may be an effective technique, although further studies are needed to understand its potential benefits fully.
Article
Health Care Sciences & Services
Mikiko Yamazaki, Kosaku Yamazaki, Yuh Baba, Hiroshi Ito, Bruno G. Loos, Keiso Takahashi
Summary: This study evaluates the factors and impact of implant failure in patients with periodontitis. The results suggest that the stage and grade of the disease, as well as bone augmentation and number of implants, are influential factors in the development of peri-implant disease.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Z. Yonel, T. Kocher, I. L. C. Chapple, T. Dietrich, H. Voelzke, M. Nauck, G. Collins, L. J. Gray, B. Holtfreter
Summary: The study aims to develop and validate a score in dental settings to identify individuals at risk of undiagnosed nondiabetic hyperglycemia or type 2 diabetes. The model includes several variables such as age, sex, body mass index, smoking status, and dental factors. The predictive performance and clinical utility of the model were assessed.
JOURNAL OF DENTAL RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Georgios N. Antonoglou, Mario Romandini, Jukka H. Meurman, Markku Surakka, Sok-Ja Janket, Mariano Sanz
Summary: This study investigated the association between periodontitis and edentulism with cardiovascular disease (CVD) and all-cause mortality. The results demonstrated a strong link between edentulism and CVD and all-cause mortality, while periodontitis showed no significant association.
JOURNAL OF PERIODONTAL RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Carolina Encalada Abad, Ignacio Sanz-Sanchez, Victor Serrano, Javier Sanz Esporrin, Ignacio Sanz-Martin, Mariano Sanz
Summary: This study aimed to evaluate the efficacy of leukocyte and platelet-rich fibrin (L-PRF) for alveolar ridge preservation (ARP) compared with spontaneous healing. The results showed that L-PRF did not minimize bone resorption after tooth extraction in non-molar sites or reduce the need for bone regeneration when placing implants. Furthermore, its use did not improve patient-reported outcome measures (PROM's).
CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Enrique Bravo, Benjamin Serrano, Honorato Ribeiro-Vidal, Leire Virto, Ignacio Sanz Sanchez, David Herrera, Mariano Sanz
Summary: The study aims to evaluate biofilm formation on hybrid titanium implants with moderately rough and turned surface topographies. A dynamic in vitro multispecies biofilm model was used to assess biofilm formation on the tested implant surfaces. The study found that the moderately rough implant surfaces had significantly higher bacterial biomass and total bacterial counts compared to the turned surface area of HS implants. These findings highlight the importance of implant surface topography in influencing in vitro biofilm formation.
CLINICAL ORAL IMPLANTS RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Leire Virto, Veronica Odeh, Enrique Garcia-Quismondo, David Herrera, Jesus Palma, Faleh Tamimi, Mariano Sanz
Summary: The objective of this study was to investigate the effect of electrochemical treatment on biofilms developed on titanium dental implants. The study found that electrochemical treatment had an impact on the structure and bacterial composition of the biofilms. The reduction in bacterial counts, especially for Fusobacterium nucleatum, demonstrated a bactericidal effect of the treatment.
CLINICAL ORAL IMPLANTS RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Margarita Iniesta, Cristina Chamorro, Nagore Ambrosio, Maria Jose Marin, Mariano Sanz, David Herrera
Summary: The aim of this study was to characterize the subgingival microbiome in subjects with different periodontal health statuses. Subgingival samples were collected from Spanish subjects and analyzed using high-throughput sequencing technologies. Significant differences were found in the subgingival microbiome among periodontal health, gingivitis and different stages of periodontitis, suggesting distinct microbial profiles.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
David Herrera, Tord Berglundh, Frank Schwarz, Iain Chapple, Soren Jepsen, Anton Sculean, Moritz Kebschull, Panos N. Papapanou, Maurizio S. Tonetti, Mariano Sanz
Summary: This study aims to develop clinical practice guidelines for the prevention and treatment of peri-implant diseases, emphasizing the need for interdisciplinary approaches and interventions at different stages. The guidelines provide recommendations for maintaining healthy peri-implant tissues and managing peri-implant diseases.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Melissa M. M. Grant, Ann E. E. Scott, John B. B. Matthews, Helen R. R. Griffiths, Iain L. C. Chapple
Summary: Curcumin can decrease inflammatory response induced by oral bacterium and be potentially useful in treating gingivitis. Its mechanism of action involves the modulation of transcription factors and enzymes related to the inflammatory cascade.
JOURNAL OF PERIODONTAL RESEARCH
(2023)
Editorial Material
Dentistry, Oral Surgery & Medicine
Maurizio S. S. Tonetti, Lisa Heitz-Mayfield, Panos N. N. Papapanou, Mariano Sanz
Summary: Consensus on a valid and comprehensive set of outcomes for implant dentistry interventions is necessary for improving clinical guidelines and policy. The Implant Dentistry Core Outcome Set and Measurements (ID-COSM) initiative has identified four core outcome domain areas and several mandatory outcomes for trials. This innovative approach combines input from scientific evidence, patients, and industry representatives.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Beant Singh Thandi, Rosemarie Jane, Vinay Chavda, Iain L. C. Chapple
Summary: This case report describes the successful diagnosis and management of a rare condition called non-ulcerating necrotising sialometaplasia, which was confounded by a simultaneous episode of pericoronitis. The importance of investigating suspicious lesions and listening to patients' complaints is emphasized.
BRITISH DENTAL JOURNAL
(2023)
Article
Dentistry, Oral Surgery & Medicine
Lucas Menezes dos Anjos, Aurelio de Oliveira Rocha, Gabriel Leonardo Magrin, Pedro Vitali Kammer, Cesar Augusto Magalhaes Benfatti, Julio Cesar Matias de Souza, Mariano Sanz, Bruno Alexandre Pacheco de Castro Henriques
Summary: This bibliometric study analyzed the characteristics of the 100 most cited articles on bone grafts in dentistry and found scientific progress on bone grafts in dentistry. The most prominent trend was the use of xenogeneic grafts for horizontal and/or vertical ridge augmentation.
CLINICAL ORAL IMPLANTS RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Yuki Ichioka, Leire Virto, Paula Nuevo, Juan Daniel Gamonal, Jan Derks, Lena Larsson, Mariano Sanz, Tord Berglundh
Summary: The aim of this study was to evaluate the cleaning efficacy of two mechanical and two chemical protocols in the decontamination of implant surfaces. Results showed that air-polishing and rotating titanium brush were more effective in removing biofilm compared to other methods. The use of chemical agents did not provide significant overall benefit, and complete biofilm removal was not achieved with any treatment method.
CLINICAL ORAL IMPLANTS RESEARCH
(2023)
Review
Dentistry, Oral Surgery & Medicine
Erika B. S. Carvalho, Mario Romandini, Sofya Sadilina, Adriana C. P. Sant'Ana, Mariano Sanz
Summary: This study aimed to answer the question: In systemically healthy human subjects, what are the differences in terms of bacterial presence/count between peri-implantitis and peri-implant health/mucositis? The results showed that peri-implantitis is associated with the presence of S. epidermidis and specific periodontopathogens (P. gingivalis, T. forsythia, T. denticola, F. nucleatum, and P. intermedia), while it is not associated with certain other bacteria (A. actinomycetemcomitans, S. aureus, and C. rectus).
CLINICAL ORAL IMPLANTS RESEARCH
(2023)
Article
Infectious Diseases
Sian E. Faustini, Alex Cook, Harriet Hill, Saly Al-Taei, Jennifer Heaney, Elena Efstathiou, Chloe Tanner, Neal Townsend, Zahra Ahmed, Mohammad Dinally, Madeeha Hoque, Margaret Goodall, Zania Stamataki, Timothy Plant, Iain Chapple, Pitch Consortium, Adrian M. Shields, Alex G. Richter
Summary: This study investigated the importance of salivary SARS-CoV-2 antibodies and found that salivary antibody responses differ from serum antibody responses, typically lacking neutralizing activity. While saliva is an attractive non-invasive surveillance tool, it cannot be used as a proxy for serum antibody measurement.
JOURNAL OF INFECTION
(2023)