Review
Pediatrics
Megan A. Sylvester, Gabrielle Mintz, Giovanni Sisti
Summary: The diagnosis of previable preterm pre-labor rupture of membranes (PROM) is associated with poor outcomes for both the mother and the fetus. A meta-analysis was conducted to compare the effects of active management and expectant management on maternal risks. The results showed no significant differences in maternal risks between active management and expectant management for previable preterm PROM at <24 weeks.
Article
Multidisciplinary Sciences
Yuki Takahashi, Masatoshi Saito, Haruo Usuda, Tsukasa Takahashi, Shimpei Watanabe, Takushi Hanita, Shinichi Sato, Yusaku Kumagai, Shota Koshinami, Hideyuki Ikeda, Sean Carter, Erin L. Fee, Lucy Furfaro, Sylvain Chemtob, Jeffrey Keelan, David Olson, Nobuo Yaegashi, John P. Newnham, Alan H. Jobe, Matthew W. Kemp
Summary: This study investigated the anti-inflammatory efficacy of rytvela in a preterm sheep model of chorioamnionitis, showing that rytvela reduced LPS-induced inflammation and partially inhibited the expression of cytokines/chemokines in fetal tissues undergoing an active inflammatory response.
Review
Obstetrics & Gynecology
Ana N. Goncalves, Jorge Correia-Pinto, Cristina Nogueira-Silva
Summary: The study compares different imagiological methods for predicting fetal pulmonary hypoplasia in general diseases, PROM, and CDH. Results show discrepancies in predictive values due to group heterogeneity, with 2D measurements being more affected than 3D. Ultrasonographic methods, especially 2D-US, demonstrate useful predictive value in outcome estimation for PROM and CDH.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
M. N. Liu, Y. K. Zhao, W. B. Chen, D. P. Wang, R. J. Dong, Q. Y. Xu, Y. Z. Jin, Y. Li, S. Q. Lu, Z. A. Jin, J. Y. Wang
Summary: There is an increase in premature births due to premature rupture of the fetal membrane (PROM). Soluble trigger receptor -1 (sTREM-1), mid-regional pro-adrenomedullin (MR-proADM), and IL-6 may be useful markers for detecting early neonatal infection in premature infants with PROM.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2021)
Article
Multidisciplinary Sciences
Ji Eun Lee, Kyo Hoon Park, Hyeon Ji Kim, Yu Mi Kim, Ji-Woong Choi, Sue Shin, Kyong-No Lee
Summary: This study identified potential novel biomarkers (coagulation factor V and S100A9) and protein pathways associated with SPTB in women with PTL without IAI, providing insights into the molecular pathogenesis and therapeutic targets specific to idiopathic SPTB.
Article
Cell Biology
Valeria Garcia-Flores, Roberto Romero, Azam Peyvandipour, Jose Galaz, Errile Pusod, Bogdan Panaitescu, Derek Miller, Yi Xu, Li Tao, Zhenjie Liu, Adi L. Tarca, Roger Pique-Regi, Nardhy Gomez-Lopez
Summary: Preterm birth is a leading cause of perinatal morbidity and mortality worldwide, often resulting from preterm labor syndrome. Intra-amniotic infection has been identified as a primary cause of preterm labor, leading to premature activation of the parturition process in reproductive tissues. Using single-cell RNA sequencing, researchers created a comprehensive atlas of single-cell profiles in the murine uterus, decidua, and cervix during infection-induced preterm labor. The study revealed the impact of preterm labor on specific immune and non-immune cell subsets, identified shared and tissue-specific gene expression signatures, and determined cell-to-cell communication pathways involved in preterm labor. Comparisons with human uterine cell interactions highlighted conserved signaling pathways implicated in labor. This scRNA-seq data provides valuable insights into the cellular landscape and communication in reproductive tissues during preterm labor.
Article
Multidisciplinary Sciences
Jose Galaz, Roberto Romero, Jonathan M. Greenberg, Kevin R. Theis, Marcia Arenas-Hernandez, Yi Xu, Marcelo Farias-Jofre, Derek Miller, Tomi Kanninen, Valeria Garcia-Flores, Nardhy Gomez-Lopez
Summary: This study provides mechanistic insights into the host-microbiome interactions within the cervico-vaginal microenvironment during premature labor and birth. The intra-amniotic delivery of LPS and IL-1 alpha triggers inflammatory responses and changes in the vaginal microbiome, leading to signs of active labor. Conversely, blocking progesterone action with RU-486 triggers local immune responses and signs of active labor without altering the vaginal microbiome. Additionally, preterm labor facilitates the ascension of cervico-vaginal bacteria into the amniotic cavity.
Article
Medicine, Research & Experimental
Kenichiro Motomura, Roberto Romero, Jose Galaz, Li Tao, Valeria Garcia-Flores, Yi Xu, Bogdan Done, Marcia Arenas-Hernandez, Derek Miller, Pedro Gutierrez-Contreras, Marcelo Farias-Jofre, Siddhesh Aras, Lawrence Grossman, Adi L. Tarca, Nardhy Gomez-Lopez
Summary: The study reveals a dual role for the NLRP3 pathway in the syndrome of preterm birth, playing a crucial role in triggering the premature onset of labor cascade. The research findings demonstrate that NLRP3 signaling is necessary in both the fetus and the mother for the premature activation of the labor cascade, potentially preventing adverse perinatal outcomes.
Article
Immunology
Chunmei Yan, Fanzhen Hong, Gang Xin, Shuhong Duan, Xiaohui Deng, Yongping Xu
Summary: This study compared the vaginal microbiota between pregnant women with PPROM and controls, revealing significant differences in microbial composition and diversity. The dysbiotic vaginal microbiota in patients with PPROM may serve as biomarkers for screening and early diagnosis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Daichi Urushiyama, Eriko Ohnishi, Wataru Suda, Masamitsu Kurakazu, Chihiro Kiyoshima, Toyofumi Hirakawa, Kohei Miyata, Fusanori Yotsumoto, Kazuki Nabeshima, Takashi Setoue, Shinichiro Nagamitsu, Masahira Hattori, Kenichiro Hata, Shingo Miyamoto
Summary: Analyzing vaginal microbiota can help evaluate the risk of chorioamnionitis in preterm labor, with appropriate interventions potentially improving perinatal prognosis.
SCIENTIFIC REPORTS
(2021)
Article
Obstetrics & Gynecology
Eric B. Jelin, Jody E. Hooper, Eleonora Duregon, Alex K. Williamson, Sarah Olson, Kristin Voegtline, Angie C. Jelin
Summary: This study retrospectively reviewed autopsy data of fetuses and neonates diagnosed with EPRA between 1987 and 2018. It found that the degree of pulmonary hypoplasia in EPRA increases with the length of anhydramnios, highlighting the potential benefits of early initiation of amnioinfusions.
JOURNAL OF PERINATOLOGY
(2021)
Article
Obstetrics & Gynecology
Samantha C. Do, Hayley Miller, Stephanie A. Leonard, Imee A. Datoc, Anna Girsen, Shanthi Kappagoda, Ronald S. Gibbs, Natali Aziz
Summary: In this study, lactate levels did not significantly differ between pregnant women with intraamniotic infection and those without, while procalcitonin levels were higher in women with infection, indicating its potential as a marker for peripartum infection. Additional research is warranted to further investigate the utility of procalcitonin as an infection marker during labor.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2021)
Article
Obstetrics & Gynecology
Romana Brun, Julia Girsberger, Martina Rothenbuhler, Catrin Argyle, Juliane Hutmacher, Christian Haslinger, Brigitte Leeners
Summary: This study evaluated the use of wearable sensors for predicting intraamniotic infection in pregnant women with premature rupture of membranes (PPROM). The results showed that the wearable device was able to measure physiological parameters and detect early signs of intraamniotic infection. However, further larger studies are needed to confirm the findings before implementing this technique in standard clinical management.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Multidisciplinary Sciences
Maria Orsaria, Stefania Liviero, Emma Rossetti, Carla Pittini, Lorenza Driul, Ambrogio P. Londero, Laura Mariuzzi
Summary: The study found that acute placental inflammation can either be due to infection or sterile inflammation. The prevalence of acute placental inflammation was 6.06%, with about half of the cases being sterile. Acute placental inflammation was associated with adverse fetal and neonatal outcomes, particularly chorionic vasculitis was a risk factor for postnatal death.
SCIENTIFIC REPORTS
(2021)
Article
Obstetrics & Gynecology
Tracy Caroline Bank, Emily Nuss, Keshab Subedi, Matthew K. Hoffman, Anthony Sciscione
Summary: This study aimed to compare the outcomes of women with isolated maternal fevers treated with antibiotics and expectant management. The results showed a lower rate of postpartum fever in women who received antibiotics, but a higher rate of neonatal intensive care unit admissions and 5-minute Apgar score of <7.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Psychology, Clinical
Claudia Lazarides, Nora K. Moog, Glenn Verner, Manuel C. Voelkle, Wolfgang Henrich, Christine M. Heim, Thorsten Braun, Pathik D. Wadhwa, Claudia Buss, Sonja Entringer
Summary: This study found that a history of prenatal loss is associated with higher stress and impaired mood levels during subsequent pregnancies. These findings are important for designing interventions to reduce stress during pregnancy in this high-risk group.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Linda Dieckmann, Cristiana Cruceanu, Marius Lahti-Pulkkinen, Jari Lahti, Tuomas Kvist, Hannele Laivuori, Sara Sammallahti, Pia M. Villa, Sanna Suomalainen-Koenig, Rebecca C. Rancourt, Andreas Plagemann, Wolfgang Henrich, Johan G. Eriksson, Eero Kajantie, Sonja Entringer, Thorsten Braun, Katri Raikkonen, Elisabeth B. Binder, Darina Czamara
Summary: The placenta plays a central role in early development and has implications for disease risk. DNA methylation studies of the human placenta can provide insights into its function. This study compares different methods of estimating cell types in placental DNA samples and finds that using a reference-based approach gives more accurate results than a reference-free approach.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Obstetrics & Gynecology
Larry Hinkson, Madeleine Schauer, Elisabetta Latartara, Maria Alonso-Espias, Emma Rossetti, Pimrapat Gebert, Susan Hinkson, Wolfgang Henrich
Summary: This study aimed to assess the feasibility of performing external cephalic version (ECV) on the leading twin in breech presentation of dichorionic and diamniotic twin pregnancies without the use of anesthesia and tocolysis. The results showed a success rate of 56% for ECV without anesthesia or tocolysis, leading to an increase in the rate of spontaneous vaginal delivery and a reduction in blood loss.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2022)
Article
Endocrinology & Metabolism
Gulen Yerlikaya-Schatten, Theresa Schonleitner, Michael Feichtinger, Grammata Kotzaeridi, Daniel Eppel, Karen Weisshaupt, Wolfgang Henrich, Christian S. Goebl
Summary: This study examined the fetal biometry and abdominal fat thickness of twin pregnancies conceived after gastric bypass surgery. The results showed that the growth rate of fetal subcutaneous adipose tissue thickness was slower in the offspring of women with a history of gastric bypass, leading to decreased fetal subcutaneous adipose tissue thickness and abdominal circumference. Additionally, infants born to mothers with gastric bypass had lower birth weight percentiles compared to those born to obese mothers. The study concludes that intrauterine growth delay in twin pregnancies after gastric bypass is likely a multifactorial event with altered metabolism as the most important factor.
Review
Obstetrics & Gynecology
Rick Enste, Patrick Cricchio, Pierre-Yves Dewandre, Thorsten Braun, Christopher O. Leonards, Phil Niggemann, Claudia Spies, Wolfgang Henrich, Lutz Kaufner
Summary: Placenta accreta spectrum (PAS) is a condition where the placenta abnormally adheres to the uterine wall, leading to postpartum hemorrhage and maternal complications. Effective management strategies, such as specialized centers, multidisciplinary teams, novel diagnostics/pharmaceuticals, and innovative surgical/interventional approaches, are crucial.
JOURNAL OF PERINATAL MEDICINE
(2023)
Review
Obstetrics & Gynecology
Rick Enste, Patrick Cricchio, Pierre-Yves Dewandre, Thorsten Braun, Christopher O. Leonards, Phil Niggemann, Claudia Spies, Wolfgang Henrich, Lutz Kaufner
Summary: This two-part review summarizes challenging aspects in the management of placenta accreta spectrum (PAS) and provides evidence-based recommendations to improve management strategies and outcomes.
JOURNAL OF PERINATAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Alexander Paping, Clara Basler, Kerstin Melchior, Loreen Ehrlich, Mario Thiele, Georg N. Duda, Wolfgang Henrich, Thorsten Braun
Summary: The study aimed to evaluate the reliability of intraoperative ultrasound in identifying histologically confirmed uterine scar tissue. The results showed that intraoperative ultrasound was more accurate in identifying scar tissue compared to preoperative ultrasound. This is important for studying uterine wound healing and preventing uterine wall rupture.
JOURNAL OF PERINATAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Gina Barzen, Karl Stangl, Jens-Uwe Blohmer, Wolfgang Henrich, Thomas Doerner, Alexander Lembcke, Verena Stangl
Summary: This article discusses the importance of monitoring and treating Kawasaki Disease (KD) patients with coronary artery involvement during pregnancy. The case report focuses on a 30-year-old woman with KD who successfully underwent pregnancy despite having thrombotically occluded calcified giant coronary aneurysms. The patient was diagnosed with breast cancer during her pregnancy, and the article highlights the need for interdisciplinary cooperation when managing complex clinical conditions.
EUROPEAN HEART JOURNAL-CASE REPORTS
(2022)
Article
Obstetrics & Gynecology
Dorota Sroka, Lisa-Antonia Lorenz-Meyer, Valerie Scherfeld, Julie Thoma, Andreas Busjahn, Wolfgang Henrich, Stefan Verlohren
Summary: A retrospective study found that integrating the soluble fms-like tyrosine kinase 1 (sFlt-1)/placental growth factor (PlGF) ratio with other markers in a multi-marker regression model had better predictive performance for adverse maternal and fetal outcomes related to preeclampsia in women beyond 34 weeks of gestation.
FETAL DIAGNOSIS AND THERAPY
(2023)
Article
Medicine, General & Internal
Selina Balke, Petra Weid, Laura Fangmann, Paul Rostin, Wolfgang Henrich, Josefine Theresia Koenigbauer
Summary: This study analyzed data from 1664 patients with gestational diabetes (GDM) and found a strong correlation between glucose levels in the 75 g oGTT and adverse perinatal fetomaternal outcomes. Three subtypes of GDM were identified based on glucose levels, and significant differences were observed in baseline characteristics, insulin therapy, mode of delivery, and fetal growth among the subgroups. The findings suggest the need for individualized prenatal care after a GDM diagnosis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Larry Hinkson, Vanessa Ande Ruan, Madeleine Schauer, Pimrapat Gebert, Boris Tutschek, Wolfgang Henrich
Summary: The study aimed to assess the prevalence of uterine anomalies in breech presentation and its impact on external cephalic version, delivery options, and perinatal outcomes. The results showed a higher rate of newly diagnosed uterine anomalies in the third trimester with breech compared to the diagnosis prior to pregnancy. Vaginal breech delivery had a success rate of 55.5% while external cephalic version was unsuccessful.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2023)
Article
Obstetrics & Gynecology
Florence Vibert, Guel Schmidt, Kerstin Loeffler, Adam Gasiorek-Wiens, Wolfgang Henrich, Stefan Verlohren
Summary: The purpose of this study was to determine the accuracy of prenatal ultrasound in classifying facial clefts. The study found that prenatal ultrasound had a high accuracy of 88.9% in diagnosing facial clefts, which can help guide parents in postnatal care and surgical treatment.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Pediatrics
Joachim Carsten Will, Nina Siedentopf, Oliver Schmid, Teresa Mira Gruber, Wolfgang Henrich, Christoph Hertzberg, Bernhard Weschke
Summary: Cardiac rhabdomyomas can potentially indicate the presence of Tuberous Sclerosis Complex (TSC). Though they usually regress without intervention, they can grow and disrupt heart function, posing a threat to the child's life. Administering rapalogs, like sirolimus, to a pregnant mother with TSC can effectively stop the growth of cardiac tumors and cause them to shrink. This article presents a successful case of treating a fetal cardiac rhabdomyoma in a TSC patient using sirolimus.
Article
Obstetrics & Gynecology
Charlotte K. Metz, Anna S. Skof, Jalid Sehouli, Jan-Peter Siedentopf, Pimrapat Gebert, Fabian Weiss, Irene Alba Alejandre, Michaela Heinrich-Rohr, Katharina Weizsaecker, Wolfgang Henrich, Andreas M. Kaufmann, Irena Rohr
Summary: The purpose of this study was to investigate the influence of HIV infection and pregnancy on HR-HPV infection and progression. The study found that a high HIV viral load and a low CD4 T cell count were associated with a higher prevalence of HR-HPV infections and multiple infections. It is recommended to perform more attentive and comprehensive HPV screening and cytological examination for pregnant women with HIV infection.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Obstetrics & Gynecology
Madeleine Schauer, Elisabetta Latartara, Maria Alonso-Espias, Emma Rossetti, Pimrapat Gebert, Wolfgang Henrich, Larry Hinkson
Summary: This study found that women with breech presentation do not have higher levels of psychological distress compared to women with cephalic presentation. However, they still experience symptoms of potential mental disorders. Younger women and multiparous women may need additional support and should be assessed using a standardized screening tool for perinatal psychological distress.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)