Article
Critical Care Medicine
Steven L. Shein, Aline B. Maddux, Margaret J. Klein, Anoopindar Bhalla, George Briassoulis, Mary K. Dahmer, Guillaume Emeriaud, Heidi R. Flori, Rainer Gedeit, Stavroula Ilia, Martin C. J. Kneyber, Natalie Napolitano, Shinichiro Ohshimo, Marti Pons-Odena, Sarah Rubin, Benjamin R. White, Nadir Yehya, Robinder Khemani, Lincoln Smith
Summary: This study aimed to characterize the frequency and outcomes of children meeting at risk for pediatric acute respiratory distress syndrome criteria. The results showed that the criteria identified high-risk critically ill children and were associated with increased mortality and longer treatment durations.
CRITICAL CARE MEDICINE
(2022)
Article
Critical Care Medicine
Nadir Yehya, Hossein Fazelinia, Gladys G. Lawrence, Lynn A. Spruce, Mark Mai, G. Scott Worthen, Jason D. Christie
Summary: This study found that plasma nucleosomes are associated with the severity of acute respiratory distress syndrome (ARDS) in children, as well as with nonpulmonary organ failures. Nucleosomes were also linked to higher mortality rates and fewer ventilator-free days in the pediatric ARDS patients. Proteomic analysis further showed elevated levels of core nucleosome histones in septic children with ARDS.
CRITICAL CARE MEDICINE
(2021)
Article
Critical Care Medicine
Anoopindar K. Bhalla, Margaret J. Klein, Guillaume Emeriaud, Yolanda M. Lopez-Fernandez, Natalie Napolitano, Analia Fernandez, Awni M. Al-Subu, Rainer Gedeit, Steven L. Shein, Ryan Nofziger, Deyin Doreen Hsing, George Briassoulis, Stavroula Ilia, Florent Baudin, Byron Enrique Pineres-Olave, Ledys Maria Izquierdo, John C. Lin, Ira M. Cheifetz, Martin C. J. Kneyber, Lincoln Smith, Robinder G. Khemani, Christopher J. L. Newth
Summary: The study described mechanical ventilation management in pediatric acute respiratory distress syndrome and found that nonadherence to lung-protective ventilation principles is common, potentially impacting outcomes. Modifiable factors exist that may improve adherence.
CRITICAL CARE MEDICINE
(2021)
Article
Multidisciplinary Sciences
Alexander C. Reisinger, Tobias Niedrist, Florian Posch, Stefan Hatzl, Gerald Hackl, Juergen Prattes, Gernot Schilcher, Anna-Maria Meissl, Reinhard B. Raggam, Markus Herrmann, Philipp Eller
Summary: Soluble urokinase plasminogen activator receptor (suPAR) levels at ICU admission are associated with ICU and 28-day mortality, as well as SOFA score, coagulation and inflammation markers, and AKI-3 occurrence. suPAR may offer additional value for risk stratification, especially in ICU patients with moderate organ dysfunction.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Long Chen, Jie Li, Yuan Shi
Summary: This multicenter prospective cross-sectional study in China aimed to investigate the etiological factors, clinical characteristics, and outcomes of perinatal neonatal acute respiratory distress syndrome (NARDS). The incidence of NARDS was 1.44%, with pneumonia, asphyxia, and early-onset sepsis as the main triggers. The use of multiple doses of surfactant was associated with increased mortality.
Article
Critical Care Medicine
Jerome Rambaud, Ryan P. Barbaro, Duncan J. Macrae, Heidi Dalton
Summary: This article aims to systematically review and synthesize literature on children receiving extracorporeal membrane oxygenation (ECMO) support in pediatric acute respiratory distress syndrome (PARDS), with the goal of updating the recommendations from the Pediatric Acute Lung Injury Consensus Conference. Based on the analysis of 18 studies, six clinical recommendations, three good practice statements, two policy statements, and one research statement were generated.
PEDIATRIC CRITICAL CARE MEDICINE
(2023)
Article
Multidisciplinary Sciences
Xiaoting Yang, Jing Wang, Wei Liu
Summary: In this study, molecular markers associated with type II alveolar epithelial cell injury in acute lung injury (ALI) were identified using bioinformatics methods. The results provide new insights for the diagnosis and treatment of ALI/ARDS.
SCIENTIFIC REPORTS
(2023)
Review
Biology
Jane E. Whitney, In-Hee Lee, Ji-Won Lee, Sek Won Kong
Summary: Pediatric acute respiratory distress syndrome (PARDS) is a common and deadly disease in critically ill children, but lacks targeted therapies. This article summarizes the existing literature on the molecular mechanisms of PARDS and proposes the use of novel profiling methods such as single-cell RNA sequencing to investigate the pathophysiological mechanisms and identify targeted therapies.
Review
Anesthesiology
Spencer P. Walsh, David Shaz, David Amar
Summary: Recent evidence indicates that there is no significant difference in outcomes between thoracic surgery patients who are ventilated with low or higher tidal volume. The effects of low versus higher positive end-expiratory pressure are also unclear.
Article
Critical Care Medicine
Christopher L. Carroll, Natalie Napolitano, Marti Pons-Odena, Narayan Prabhu Iyer, Steven Kwasi Korang, Sandrine Essouri
Summary: This study developed evidence-based recommendations for the effectiveness of noninvasive respiratory support for pediatric acute respiratory distress syndrome (PARDS), including considerations of timing, duration, disease severity, and treatment delivery. The study found that noninvasive ventilation (NIV) is widely used for respiratory failure in children and may be beneficial for some patients with PARDS, but close monitoring is required for worsening disease and NIV failure.
PEDIATRIC CRITICAL CARE MEDICINE
(2023)
Article
Multidisciplinary Sciences
Luis F. Reyes, Alirio Bastidas, Paula O. Narvaez, Daniela Parra-Tanoux, Yuli Fuentes, Cristian C. Serrano-Mayorga, Valentina Ortiz, Eder L. Caceres, Gustavo Ospina-Tascon, Ana M. Diaz, Manuel Jibaja, Magdalena Vera, Edwin Silva, Luis Antonio Gorordo-Delsol, Francesca Maraschin, Fabio Varon-Vega, Ricardo Buitrago, Marcela Poveda, Lina M. Saucedo, Elisa Estenssoro, Guillermo Ortiz, Nicolas Nin, Luis E. Calderon, Gina S. Montano, Aldair J. Chaar, Fernanda Garcia, Vanessa Ramirez, Fabricio Picoita, Cristian Pelaez, Luis Unigarro, Gilberto Friedman, Laura Cucunubo, Alejandro Bruhn, Glenn Hernandez, Ignacio Martin-Loeches
Summary: This study aims to investigate the clinical characteristics, in-hospital outcomes, and factors associated with ICU admission due to COVID-19 in Latin American countries. The results show a lower mortality rate for COVID-19 patients in Latin America compared to previous reports, but a higher mortality rate for ICU patients. Additionally, patients discharged from the ICU had worse self-care ability.
Article
Critical Care Medicine
Ivor S. Douglas, Chester A. Rosenthal, Diandra D. Swanson, Terra Hiller, Judy Oakes, Jamie Bach, Christopher Whelchel, Jennifer Pickering, Tobias George, Mark Kearns, Michael Hanley, Kara Mould, Sarah Roark, Jason Mansoori, Anuj Mehta, Eric P. Schmidt, Anna Neumeier
Summary: This study demonstrates that prolonged prone position ventilation for patients with coronavirus disease 2019 acute respiratory distress syndrome is feasible and relatively safe, with implications for wider adoption in treating critically ill coronavirus disease 2019 patients and acute respiratory distress syndrome of other etiologies.
CRITICAL CARE MEDICINE
(2021)
Article
Multidisciplinary Sciences
Qiuyue Li, Hongyu Zheng, Bing Chen
Summary: This study aimed to screen macrophage-related biomarkers for the diagnosis and treatment of sepsis-induced ARDS using bioinformatics and machine learning algorithms. Three key genes, SGK1, DYSF, and MSRB1, were identified as potential targets for the early diagnosis of sepsis-induced ARDS.
SCIENTIFIC REPORTS
(2023)
Article
Critical Care Medicine
Elisa Estenssoro, Cecilia Loudet, Fernando G. Rios, Vanina S. Kanoore Edul, Gustavo Plotnikow, Macarena Andrian, Ignacio Romero, Marco Bezzi, Carla Groer, Cristina Orlandi, Paolo N. Rubatto Birri, Maria F. Valenti, Eleonora Cunto, Maria G. Saenz, Norberto Tiribelli, Vanina Aphalo, Rosa Reina
Summary: The study investigated invasively ventilated COVID-19 patients in Argentina, where lung-protective ventilation was widely used but mortality remained high. Predictors of mortality in this study were largely consistent with findings from high-income countries.
LANCET RESPIRATORY MEDICINE
(2021)
Article
Multidisciplinary Sciences
Ser Hon Puah, Barnaby Edward Young, Po Ying Chia, Vui Kian Ho, Jiashen Loh, Roshni Sadashiv Gokhale, Seow Yen Tan, Duu Wen Sewa, Shirin Kalimuddin, Chee Keat Tan, Surinder K. M. S. Pada, Matthew Edward Cove, Louis Yi Ann Chai, Purnima Parthasarathy, Benjamin Choon Heng Ho, Jensen Jiansheng Ng, Li Min Ling, John A. Abisheganaden, Vernon J. M. Lee, Cher Heng Tan, Raymond T. P. Lin, Yee Sin Leo, David C. Lye, Tsin Wen Yeo
Summary: This study aimed to describe a case series of critically and non-critically ill COVID-19 patients in Singapore. The results showed that ventilated patients were older, had more dyspnea, and higher levels of inflammatory markers, but there were no fatalities among COVID-19 patients who required mechanical ventilation in Singapore.
SCIENTIFIC REPORTS
(2021)
Article
Pediatrics
Shin Miyata, Jayun Cho, Kazuhide Matsushima, Olga Lebedevskiy, Hanna Park, Courtney A. Fortner, David W. Bliss
JOURNAL OF PEDIATRIC SURGERY
(2017)
Article
Pediatrics
Shin Miyata, Jayun Cho, Hanna Park, Kazuhide Matsushima, David W. Bliss
JOURNAL OF PEDIATRIC SURGERY
(2017)
Article
Pediatrics
Shin Miyata, Jamie Golden, Olga Lebedevskiy, David W. Bliss
JOURNAL OF PEDIATRIC SURGERY
(2018)
Article
Surgery
Shin Miyata, Jayun Cho, Olga Lebedevskiy, Kazuhide Matsushima, Esther Bae, David W. Bliss
JOURNAL OF SURGICAL RESEARCH
(2017)
Review
Immunology
Noppadol Wacharachaisurapol, Jeffrey M. Bender, Larry Wang, David Bliss, Skorn Ponrartana, Pia S. Pannaraj
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2017)
Article
Pediatrics
Shin Miyata, Jamie Golden, Olga Lebedevskiy, James E. Stein, David W. Bliss
PEDIATRIC SURGERY INTERNATIONAL
(2017)
Article
Pediatrics
Jamie Golden, Wesley E. Barry, Gene Jang, Nam Nguyen, David Bliss
PEDIATRIC SURGERY INTERNATIONAL
(2017)
Article
Pediatrics
Loren Berman, Shawn Rangel, Adam Goldin, David Skarda, Madelene Ottosen, David Bliss, Patricia Valusek, Mary Fallat, KuoJen Tsao
JOURNAL OF PEDIATRIC SURGERY
(2018)
Article
Critical Care Medicine
Cory McLaughlin, David Darcy, Caron Park, Christianne J. Lane, Wendy J. Mack, David W. Bliss, Anoopindar Bhalla, Jeffrey S. Upperman, Avery B. Nathens, Randall S. Burd, Aaron R. Jensen
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
(2019)
Article
Pediatrics
Wesley E. Barry, Shannon L. Castle, Jamie Golden, David M. Rosenberg, Aaron R. Jensen, David Bliss
JOURNAL OF PEDIATRIC SURGERY
(2019)
Article
Pediatrics
Cory McLaughlin, Caron Park, Christianne J. Lane, Wendy J. Mack, David Bliss, Jeffrey S. Upperman, Aaron R. Jensen
JOURNAL OF PEDIATRIC SURGERY
(2020)
Article
Surgery
Cory M. McLaughlin, Erica N. Barin, Michael Fenlon, Colleen Azen, Timothy W. Deakers, James E. Stein, David W. Bliss, Jeffrey S. Upperman, Aaron R. Jensen
Article
Critical Care Medicine
Michael J. LaQuaglia, Melissa Anderson, Catherine J. Goodhue, Maria Bautista-Durand, Ryan Spurrier, Shadassa Ourshalimian, Lillian Lai, Philip Stanley, Pradip P. Chaudhari, David Bliss
Summary: This study retrospectively reviewed the charts of patients under 18 who underwent head CT at a level 1 pediatric trauma center and adult general hospitals in 2019. It was found that children receiving head CT at the PTC had significantly lower radiation doses.
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
(2021)
Article
Pediatrics
Katie W. Russell, Shannon N. Acker, Romeo C. Ignacio, Katrine M. Lofberg, Erin M. Garvey, Stephanie D. Chao, David W. Bliss, Caitlin A. Smith, Deepika Nehra, Melissa L. Anderson, Brittney L. Bunnell, Niti Shahi, John M. Perry, Lauren L. Evans, Jacky Z. Kwong, Joseph Tobias, Autumn Rohan, Kaci L. Pickett, Jill L. Kaar, Zachary J. Kastenberg, Antoinette L. Laskey, Eric R. Scaife, Aaron R. Jensen
Summary: This retrospective study conducted on nine centers of the Western Pediatric Surgery Research Consortium found no significant increase in the rates of child physical abuse and severity of injury during the early months of the COVID-19 pandemic compared to the prior benchmark period.
JOURNAL OF PEDIATRIC SURGERY
(2022)