Article
Oncology
Carolyn S. Harris, Kord M. Kober, Bruce Cooper, Yvette P. Conley, Anand A. Dhruva, Marilyn J. Hammer, Steven Paul, Jon D. Levine, Christine A. Miaskowski
Summary: This study aimed to investigate symptom clusters in oncology patients undergoing chemotherapy and found that psychological, gastrointestinal, weight gain, hormonal, and respiratory clusters were common, while respiratory and hormonal clusters were distinct.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Oncology
Kirsten A. Nyrop, Allison M. Deal, Yi Tang Chen, Bryce B. Reeve, Ethan M. Basch, William A. Wood, Shlomit S. Shachar, Lisa A. Carey, Katherine E. Reeder-Hayes, E. Claire Dees, Trevor A. Jolly, Gretchen G. Kimmick, Meghan S. Karuturi, Raquel E. Reinbolt, JoEllen C. Speca, Jordan T. Lee, Addison Brenizer, Hyman B. Muss
Summary: Younger and older women with early breast cancer who received identical chemotherapy regimens generally experienced similar levels of symptom severity, symptom-related interference with daily activities, and adverse events.
Article
Oncology
Kai-nan Zhou, Yan Wang, Yi Xie, Shu-han Yang, Su-ying Liu, Yu-hang Fang, Ying Zhang
Summary: The purpose of this study is to determine the incidence and severity of symptoms in patients with cervical cancer within 6 months after radiotherapy and chemotherapy. The study identified nine symptom clusters and highlighted the three most serious symptom clusters. This research provides important insights for improving symptom management in cervical cancer patients after radiotherapy and chemotherapy.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Oncology
Susan Storey, Xiao Luo, Susan Ofner, Susan M. Perkins, Diane Von Ah
Summary: Colorectal cancer survivors with diabetes and hyperglycemia experience more symptoms and exhibit two distinct symptom clusters compared to those without hyperglycemia.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Geriatrics & Gerontology
Marlen Sunde Johannessen, Christine Miaskowski, Anne Grethe Kleven, Christine Seel Ritchie, Steven M. Paul, Ellen Karine Grov, Martine Hareide, Henrik Gaudernack, Inger Utne
Summary: Differences in occurrence, severity, and distress ratings for 32 symptoms between younger older adults (YOA) and older adults (OA) at initiation of chemotherapy were evaluated. Older patients reported a moderate symptom burden, and the symptoms with the highest occurrence rates were not always the most severe or the most distressing. Evaluation of different dimensions of the symptom experience (occurrence, severity, and distress) is necessary for older oncology patients.
Article
Oncology
Anders Winther Molby Nielsen, Marie Lundorff, Hanne Melgaard Nielsen, Jan Alsner, Birgitte Vrou Offersen, Morten Horsholt Kristensen, Robert Zachariae
Summary: The study found that breast cancer survivors exhibit different symptom trajectories, with a substantial minority continuing to experience high symptom burden for several years post-treatment. Those in the high-burden symptom trajectory not only showed a high probability of burden across multiple symptoms, but also reported poorer physical and social functioning over time.
Review
Oncology
Winnie K. W. So, Bernard M. H. Law, Marques S. N. Ng, Xiaole He, Dorothy N. S. Chan, Carmen W. H. Chan, Alexandra L. McCarthy
Summary: Breast cancer patients commonly experience fatigue-sleep disturbance and psychological symptom clusters. The composition of symptom clusters tends to vary across different stages of cancer treatment. Future studies should focus on examining symptom clusters in patients undergoing different treatment types and use standardized instruments to assess symptoms.
Article
Oncology
Rachel A. Pozzar, Marilyn J. Hammer, Bruce A. Cooper, Kord M. Kober, Lee-May Chen, Steven M. Paul, Yvette P. Conley, Frances Cartwright, Fay Wright, Jon D. Levine, Christine Miaskowski
Summary: The study found that hormone, respiratory, weight change, and psychological symptom clusters are relatively stable across a chemotherapy cycle, highlighting the importance of clinicians initiating multimodal interventions for patients with gynecologic cancer.
Article
Nursing
Yuan Li, Na Ni, Zijun Zhou, Jianyu Dong, Ying Fu, Jiaxin Li, Ze Luan, Xin Peng
Summary: The study aimed to explore the level of hope and symptom burden among breast cancer women undergoing chemotherapy. Factors such as age, religious beliefs, and symptom burden were found to be predictive of hope levels. Efforts to improve hope levels and decrease symptom burden can have a positive impact on patients' well-being.
JOURNAL OF CLINICAL NURSING
(2021)
Article
Oncology
Ruzhen Luo, Hongbo Chen, Yanhui Liu, Hongyu Sun, Siyuan Tang, Yuhong Chen
Summary: The purpose of this study was to identify symptom clusters in breast cancer patients undergoing adjuvant chemotherapy. A sample of 620 breast cancer patients receiving adjuvant chemotherapy was recruited, and data were collected eight times during the chemotherapy cycles. The results showed that different symptom clusters emerged in different chemotherapy cycles, including gastrointestinal, emotional and psychological, neurological, menopausal, and self-image disorder symptom clusters. It is important for healthcare providers to understand and care for breast cancer patients and help them manage concurrent symptoms to improve their quality of life.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Health Care Sciences & Services
Kurt Kroenke, Veronica Lam, Kathryn J. Ruddy, Deirdre R. Pachman, Jeph Herrin, Parvez A. Rahman, Joan M. Griffin, Andrea L. Cheville
Summary: This study aims to investigate the prevalence, severity, and co-occurrence of SPPADE symptoms, as well as their association with cancer type and patient characteristics. The findings suggest that SPPADE symptoms are prevalent, severe, and commonly co-occur in oncology and other clinical populations. The study highlights the importance of optimizing detection and management of SPPADE symptoms in all types of cancer patients.
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2023)
Article
Health Care Sciences & Services
Natalie L. Wilson, Thomas J. Hoffman, Sonya L. Heath, Michael S. Saag, Christine Miaskowski
Summary: This study found that the number and types of symptom clusters were relatively similar regardless of whether symptom occurrence rates or distress ratings were used to create the clusters. These symptom clusters may provide insights into the development of targeted interventions for multiple co-occurring symptoms.
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2022)
Article
Health Care Sciences & Services
Liang Fu, Xiuqin Feng, Yongyan Jin, Zhenqi Lu, Rufang Li, Wenxia Xu, Victor T. Chang, Yan Hu, Xianghong Ye
Summary: This study aimed to explore symptom clusters and their impact on quality of life (QoL) in gastric cancer patients receiving chemotherapy. The study identified five symptom clusters and found that these clusters had significantly negative effects on all aspects of QoL except social well-being. Further research is needed to investigate interventions for symptom clusters and their effects on improving QoL.
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2022)
Editorial Material
Medicine, General & Internal
Xavier Pivot
Summary: The study confirms the efficacy of pembrolizumab combined with chemotherapy in prolonging overall survival of patients with advanced triple-negative breast cancer, providing a breakthrough therapeutic treatment for this patient population.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Nursing
Mohammad Al Qadire, Ma'en Aljezawi, Omar Al Omari, Aiah Monther Alatoum, Atika Khalaf
Summary: This study examined symptom clusters in cancer patients undergoing chemotherapy, finding that chemotherapy-related symptoms, psychological symptoms, fatigue and pain symptoms, and gastrointestinal symptoms were the most prevalent. The findings highlight the importance of early comprehensive assessment and treatment of symptoms for patients receiving chemotherapy.
CLINICAL NURSING RESEARCH
(2023)
Article
Critical Care Medicine
Lacey W. Heinsberg, Annie I. Arockiaraj, Elizabeth A. Crago, Dianxu Ren, John R. Shaffer, Paula R. Sherwood, Susan M. Sereika, Daniel E. Weeks, Yvette P. Conley
NEUROCRITICAL CARE
(2020)
Article
Nursing
Hongjin Li, Anna L. Marsland, Yvette P. Conley, Susan M. Sereika, Catherine M. Bender
BIOLOGICAL RESEARCH FOR NURSING
(2020)
Article
Nursing
Yehui Zhu, Theresa A. Koleck, Catherine M. Bender, Yvette P. Conley
BIOLOGICAL RESEARCH FOR NURSING
(2020)
Article
Oncology
Raymond Javan Chan, Bruce Cooper, Bogda Koczwara, Alexandre Chan, Chia Jie Tan, Steven M. Paul, Laura B. Dunn, Yvette P. Conley, Kord M. Kober, Jon D. Levine, Christine Miaskowski
SUPPORTIVE CARE IN CANCER
(2020)
Article
Oncology
Fay Wright, Kord M. Kober, Bruce A. Cooper, Steven M. Paul, Yvette P. Conley, Marilyn Hammer, Jon D. Levine, Christine Miaskowski
SUPPORTIVE CARE IN CANCER
(2020)
Article
Statistics & Probability
Yingda Jiang, Chi-Yang Chiu, Qi Yan, Wei Chen, Michael B. Gorin, Yvette P. Conley, M'hamed Lajmi Lakhal-Chaieb, Richard J. Cook, Christopher Amos, Alexander F. Wilson, Joan E. Bailey-Wilson, Francis J. McMahon, Ana Vazquez, Ao Yuan, Xiaogang Zhong, Momiao Xiong, Daniel E. Weeks, Ruzong Fan
Summary: Genetics plays a significant role in age-related macular degeneration (AMD) and the study utilized a new generalized functional linear mixed model (GFLMM) to test for gene-based association in AMD families. Significant associations were found with known AMD genes CFH and ARMS2, while suggestive signals were observed in genes like ASAH1, CLEC6A, TMEM63C, and SGSM1. The GFLMM-based statistics provided a new tool for conducting family-based genetic studies of complex diseases.
JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION
(2021)
Article
Nursing
Komal Singh, Huangshen Cao, Christine Miaskowski, Yvette P. Conley, Marilyn Hammer, Fay Wright, Jon D. Levine, Kord M. Kober
Summary: This study aimed to evaluate perturbed biological pathways associated with endocytosis and apoptosis in oncology patients, and found that inflammation of the GI mucosa induced by chemotherapy may lead to initiation of endocytotic and apoptotic processes in the gut, which are associated with the occurrence of chemotherapy-induced nausea.
BIOLOGICAL RESEARCH FOR NURSING
(2021)
Article
Multidisciplinary Sciences
Amin M. Cheikhi, Zariel Johnson, Dana R. Julian, Sarah Wheeler, Carol Feghali-Bostwick, Yvette P. Conley, James Lyons-Weiler, Cecelia C. Yates
Article
Oncology
Rafael Diaz, Kord M. Kober, Carol Viele, Bruce A. Cooper, Steven M. Paul, Marilyn Hammer, Fay Wright, Yvette P. Conley, Jon D. Levine, Christine Miaskowski
Summary: Chemotherapy-induced diarrhea (CID) is a common symptom that occurs in 50 to 80% of patients. This study identified four distinct diarrhea profiles among 1133 patients: none (58.3%), decreasing (22.0%), increasing (5.2%), and high (14.5%). Patients in the high class had lower functional status, worse comorbidity profile, were more likely to have gastrointestinal cancer, and receive chemotherapy on a 14-day cycle compared to the none class.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Nursing
Monica A. Wagner, Susan W. Wesmiller, Meaghan Maydick, Lisa M. Gawron, Frances M. Peterson-Burch, Yvette P. Conley
Summary: Integrating omics into non-pharmacological intervention research helps understand response variability and discover genes associated with intervention effectiveness. This study found nine genes related to response, indicating potential targets for future investigations using omic approaches in non-pharmacological interventions.
BIOLOGICAL RESEARCH FOR NURSING
(2021)
Article
Oncology
Mei R. Fu, Bradley E. Aouizerat, Gary Yu, Yvette Conley, Deborah Axelrod, Amber A. Guth, Jean-Pierre Gagner, Jeanna M. Qiu, David Zagzag
Summary: The study aimed to identify lymphedema symptom patterns and their association with phenotypic characteristics and biomarkers using latent class analysis (LCA). Three distinct lymphedema symptom classes were identified at 8 weeks and 12 months post-surgery, with participants more likely to be in the severe symptom classes at 12 months post-surgery if they had specific phenotypic characteristics and biomarker levels. Pre-surgery levels of IL1-a, IL-6, IL-8, and VEGF were associated with the severe symptom class at 8 weeks post-surgery, suggesting predictive value for lymphedema symptoms.
CURRENT BREAST CANCER REPORTS
(2021)
Article
Oncology
Anna Wilcoxon, Kord M. Kober, Carol Viele, Kimberly Topp, Betty Smoot, Gary Abrams, Margaret Chesney, Steven M. Paul, Yvette P. Conley, Jon D. Levine, Christine Miaskowski
ONCOLOGY NURSING FORUM
(2020)
Article
Genetics & Heredity
Allison H. Rietze, Yvette P. Conley, Dianxu Ren, Cindy M. Anderson, James M. Roberts, Arun Jeyabalan, Carl A. Hubel, Mandy J. Schmella
EPIGENETICS INSIGHTS
(2020)
Article
Oncology
Kate R. Oppegaard, Laura B. Dunn, Kord M. Kober, Lynda Mackin, Marilyn J. Hammer, Yvette P. Conley, Jon David Levine, Christine Miaskowski
ONCOLOGY NURSING FORUM
(2020)
Article
Neurosciences
Kord M. Kober, Man-Cheung Lee, Adam Olshen, Yvette P. Conley, Marina Sirota, Michael Keiser, Marilyn J. Hammer, Gary Abrams, Mark Schumacher, Jon D. Levine, Christine Miaskowski