Article
Engineering, Biomedical
Maria Eduarda Anastacio Borges Correa, Carolini Mendes, Joao Vitor Silvano Bittencourt, Aline Takejima, Isio Carvalho de Souza, Simone Cristina Dizaro de Carvalho, Ingrid Gabriela Orlandini, Thiago Antonio Moretti de Andrade, Luiz Cesar Guarita-Souza, Paulo Cesar Lock Silveira
Summary: This study evaluated the effects of a decellularized amniotic membrane solubilized with hyaluronic acid on the healing process of cutaneous wounds. The results showed that the proposed combined therapy accelerated tissue repair and reduced inflammatory response.
ANNALS OF BIOMEDICAL ENGINEERING
(2022)
Article
Biotechnology & Applied Microbiology
Kunal Sarkar, Kaushik Dutta, Arindam Chatterjee, Jit Sarkar, Dipankar Das, Arbind Prasad, Dipankar Chattopadhyay, Krishnendu Acharya, Madhusudan Das, Suresh K. Verma, Sriparna De
Summary: In this study, folic acid functionalized nanoceria were formulated and their potential efficacy in the wound healing process was explored. The nanoformulation showed remarkable bacteriostatic effect and satisfactory biocompatibility. Moreover, the spray of FA-nanoceria demonstrated excellent wound healing capacity within 14 days in an in vivo mice model.
Article
Pharmacology & Pharmacy
Nabil A. Alhakamy, Giuseppe Caruso, Anna Privitera, Osama A. A. Ahmed, Usama A. Fahmy, Shadab Md, Gamal A. Mohamed, Sabrin R. M. Ibrahim, Basma G. Eid, Ashraf B. Abdel-Naim, Filippo Caraci
Summary: Impaired diabetic wound healing is a global concern for healthcare professionals. This study developed a fluoxetine ecofriendly nanoemulsion (FLX-EFNE) and demonstrated its significant efficacy in promoting wound healing in diabetic rats.
Article
Biochemistry & Molecular Biology
Huda S. AlSalem, Abeer Abdulaziz H. Bukhari
Summary: Three biodegradable wound dressings were successfully prepared using freeze drying technique. The dressings were based on binary Collagen (COL), Hyaluronic acid (HA) crosslinked and loaded with silver nanoparticles (AgNPs), Gentamicin (GENT), or AgNPs/GENT. The dressings showed physically interaction between polymer network and the loaded antibiotic, superior swelling properties, and rapid degradation. They exhibited antibacterial activity against G+, G-, yeast, and fungi. Cytotoxicity and wound healing evaluations showed superior results for all dressings except the one mixed with AgNPs and Gentamicin. The results recommended individually loaded COL/HA with either AgNPs or Gentamicin as antibacterial and wound healing dressings.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Ying Liu, Jiake Mo, Fang Liang, Siwei Jiang, Jing Xiong, Xubiao Meng, Zhaohui Mo
Summary: The Chinese traditional medicine Pien-Tze-Huang (PZH) has been found to be effective in treating diabetic foot ulcers. It promotes wound healing, vasculature, and upregulates the expression of growth factors. PZH also activates the Nrf2/ARE pathway and reduces inflammatory cytokines.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Tangtang He, Pengfei Sun, Bo Liu, Shiwei Wan, Penghua Fang, Jun Chen, Guicheng Huang, Wen Min
Summary: The study found that puffball spores can accelerate diabetic wound healing by activating the Akt/Nrf2 signaling pathway, promoting the expression of antioxidant genes, and enhancing angiogenesis and collagen deposition. This provides a theoretical basis for the treatment of diabetic and refractory wounds.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Emergency Medicine
Weiguo Xie, Xueqing Zhou, Weigang Hu, Zhigang Chu, Qiongfang Ruan, Haimou Zhang, Min Li, Hongyu Zhang, Xiaodong Huang, Paul Yao
Summary: The study found that PTE has a stronger effect than resveratrol in accelerating diabetic wound healing, possibly due to its ability to ameliorate diabetes-induced epigenetic changes in HSCs. Bone marrow transplantation of PTE-treated diabetic HSCs can restore diabetes-induced suppression of estrogen receptor beta and its target genes, protecting against oxidative stress, mitochondrial dysfunction, and elevated pro-inflammatory cytokines in PBMCs and macrophages, ultimately accelerating wound healing.
Article
Medicine, Research & Experimental
Kaan Kaltalioglu
Summary: This study found that sinapic acid, a phytochemical, has the potential to promote wound healing in individuals with diabetes. By using sinapic acid-loaded gels, the researchers observed improved re-epithelialization and angiogenesis, increased collagen content, and decreased oxidative damage in diabetic wounds. These findings suggest that topical application of sinapic acid can be an effective approach for promoting diabetic wound healing, especially at low doses.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Chemistry, Physical
Balzhima Shagdarova, Mariya Konovalova, Yuliya Zhuikova, Alexey Lunkov, Vsevolod Zhuikov, Dolgor Khaydapova, Alla Il'ina, Elena Svirshchevskaya, Valery Varlamov
Summary: A panel of hydrogels based on chitosan, collagen, and silver nanoparticles were produced and studied for their potential application in treating diabetic ulcers. The hydrogels showed good mechanical properties and biological activity, and promoted wound healing in a mouse model.
Article
Biochemistry & Molecular Biology
Lubomir Petrov, Olya Stoilova, Georgi Pramatarov, Hristiyana Kanzova, Elina Tsvetanova, Madlena Andreeva, Almira Georgieva, Dimitrinka Atanasova, Stanislav Philipov, Albena Alexandrova
Summary: The study aimed to investigate the effect of the combined application of chitosan and diosgenin on a mouse skin wound model. The results showed that the combined application significantly reduced wound area and maintained high levels of total glutathione in wound tissues.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
M. C. Linju, M. R. Rekha
Summary: The present study developed a L-proline conjugated chitosan scaffold for wound healing. The scaffold was characterized by various tests and showed no cytotoxicity. In vitro experiments demonstrated that the modified scaffold promoted wound closure and collagen deposition. These findings suggest that the L-proline conjugated scaffold has potential as a wound dressing to improve wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Biochemistry & Molecular Biology
Nur Izzah Md Fadilah, Shou Jin Phang, Nurkhuzaiah Kamaruzaman, Atiqah Salleh, Mazlan Zawani, Arka Sanyal, Manira Maarof, Mh Busra Fauzi
Summary: Natural antioxidant-incorporated biomaterials have shown promise in promoting skin wound healing and tissue regeneration. However, the low bioavailability of these biomaterials limits their therapeutic activity at the injury site. This review summarizes recent literature on the role of antioxidant-incorporated biomaterials and their mechanisms in promoting wound healing, supported by in vitro, in vivo, and clinical studies.
Review
Medicine, Research & Experimental
Qinzhi Yang, Dan Fang, Jinxiang Chen, Shaorun Hu, Ni Chen, Jun Jiang, Min Zeng, Mao Luo
Summary: Diabetes is a chronic disease that causes blood glucose imbalance and organ damage. Diabetic wound formation involves complex mechanisms related to oxidative stress. Recent studies have shown the critical role of long noncoding RNAs (lncRNAs) in regulating diabetic wound healing and oxidative stress.
Article
Biochemistry & Molecular Biology
Maria del Carmen Gallego-Lopez, Maria Luisa Ojeda, Ines Romero-Herrera, Fatima Nogales, Olimpia Carreras
Summary: This study examined the impact of binge drinking (BD) on folic acid (FA) homeostasis and antioxidant properties in the liver of adolescent rats. The findings showed that BD led to decreased FA levels in the liver, along with elevated transaminase levels and imbalanced antioxidant system. However, FA supplementation effectively restored FA levels, reduced liver damage, and improved antioxidant activity.
Review
Biotechnology & Applied Microbiology
Wenqian Zhang, Lang Chen, Yuan Xiong, Adriana C. Panayi, Abudula Abududilibaier, Yiqiang Hu, Chenyan Yu, Wu Zhou, Yun Sun, Mengfei Liu, Hang Xue, Liangcong Hu, Chenchen Yan, Xuedong Xie, Ze Lin, Faqi Cao, Bobin Mi, Guohui Liu
Summary: Ulcers are a common complication of diabetes with high recurrence rates, and oxidative stress is identified as a key factor in impaired wound healing. Various antioxidant therapies have been proposed in the past 5 years to target oxidative stress and improve diabetic wound healing outcomes. These therapies include targeting Nrf2 and NF kappa B pathways, as well as utilizing vitamins, enzymes, hormones, medicinal plants, and biological materials.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Cell Biology
Mei Zhao, Li Yuan, Man-man Yuan, Li-li Huang, Chang Su, Yuan-hua Ghen, Yu-ying Yang, Yan Hu, De-xiang Xu
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2018)
Article
Immunology
Yuan-Hua Chen, Mei Zhao, Xue Chen, Ying Zhang, Hua Wang, Ying-Ying Huang, Zhen Wang, Zhi-Hui Zhang, Cheng Zhang, De-Xiang Xu
JOURNAL OF IMMUNOLOGY
(2012)
Article
Endocrinology & Metabolism
Hua Wang, Ling Li, Mei Zhao, Yuan-Hua Chen, Zhi-Hui Zhang, Cheng Zhang, Yan-Li Ji, Xiu-Hong Meng, De-Xiang Xu
JOURNAL OF PINEAL RESEARCH
(2011)
Article
Multidisciplinary Sciences
Qian Niu, Ruke Zhang, Min Zhao, Sugen Zeng, Xunbei Huang, Hong Jiang, Youfang An, Luwen Zhang
Article
Multidisciplinary Sciences
Mei Zhao, Man Man Yuan, Li Yuan, Li Li Huang, Jian Hong Liao, Xiao Ling Yu, Chang Su, Yuan Hua Chen, Yu Ying Yang, Huan Yu, De Xiang Xu
Article
Toxicology
Mei Zhao, Yuan-Hua Chen, Xue Chen, Xu-Ting Dong, Jun Zhou, Hua Wang, Shu-Xian Wu, Cheng Zhang, De-Xiang Xu
TOXICOLOGY LETTERS
(2014)
Article
Clinical Neurology
Xue-qi Wang, Hong-xia Zhuang, Li-xiang Zhang, Xia Chen, Chao-shi Niu, Mei Zhao
WORLD NEUROSURGERY
(2019)
Article
Multidisciplinary Sciences
Yuan Hua Chen, Li Li, Wei Chen, Zhi Bing Liu, Li Ma, Xing Xing Gao, Jia Liu He, Hua Wang, Mei Zhao, Yuan Yuan Yang, De Xiang Xu
SCIENTIFIC REPORTS
(2019)
Article
Nutrition & Dietetics
Yuying Yang, Hongyan Kan, Xiaoling Yu, Yuanyuan Yang, Li Li, Mei Zhao
JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
(2020)
Article
Biochemical Research Methods
Qiting Qing, Lili Huang, Wanxiao Sun, Jing Chen, Ningning Yu, Yuanhua Chen, Dexiang Xu, Mei Zhao
Summary: This study investigated the effects of maternal lipopolysaccharide (LPS) exposure during pregnancy on metabolic profiling of maternal serum and male fetal liver. The results revealed alterations in glycerophospholipid and fatty acid metabolites in both maternal serum and male fetal livers, with an upregulation of glycerophospholipids containing saturated fatty acids (SFAs) and downregulation of those containing polyunsaturated fatty acids (PUFAs). This concordance between maternal and fetal alterations in metabolites may provide insight into the mechanisms by which maternal LPS exposure induces metabolic disorders in male offspring.
BIOMEDICAL CHROMATOGRAPHY
(2022)
Article
Multidisciplinary Sciences
Jing Chen, Yuying Yang, Ningning Yu, Wanxiao Sun, Yuanyuan Yang, Mei Zhao
Summary: This study explored the relationship between gut microbiome characteristics and the effect of MNT on glycemic control in pregnant women with GDM. The results showed that the abundance of characteristic gut microbiome positively correlated with blood glucose, and an increase in the abundance of characteristic gut microbiome could help control blood glucose in pregnant women with GDM.
Article
Health Care Sciences & Services
Lan Geng, Genyan Jiang, Lingling Yu, Yueming Xu, Wei Huang, Zhiqi Chen, Xiaoyan Qi, Ting Zhang, Mei Zhao
Summary: This study evaluated the quality, behavior change techniques, and content-related features of weight management apps in China. The overall quality was found to be moderate, with common behavior change techniques including goal review, guidance, self-monitoring, goal setting, and performance feedback. The most prevalent features were web access, monitoring and tracking, goal setting, and sending alerts.
JMIR MHEALTH AND UHEALTH
(2023)
Article
Public, Environmental & Occupational Health
Hong-Chun Lu, Li Yuan, Huan Yu, Hai-Shan Tang, Yang-Yang Zhao, Li-li Huang, Chang Su, Yuan-Hua Chen, De-Xiang Xu, Mei Zhao
JOURNAL OF PUBLIC HEALTH-HEIDELBERG
(2019)
Article
Nutrition & Dietetics
Lili Huang, Xiaoling Yu, Li Li, Yuanhua Chen, Yuanyuan Yang, Yuying Yang, Yan Hu, Yangyang Zhao, Haishan Tang, Dexiang Xu, Mei Zhao
ASIA PACIFIC JOURNAL OF CLINICAL NUTRITION
(2019)