Article
Agriculture, Dairy & Animal Science
Esra Tugce Gul, Osman Olgun, Gozde Kilinc, Alponder Yilidz, Ainhoa Sarmiento-Garcia
Summary: The purpose of this study was to evaluate the performance, quality of eggs internally and externally, and antioxidant capacity of yolks in laying quails with the administration of choline and betaine to diets containing reduced methionine levels. The results showed that methionine can be reduced to a level of 0.30% without negative effects on egg production, while the combination of methionine (0.30%) and betaine (0.20%) can improve the antioxidant stability of eggs.
Article
Clinical Neurology
Mengyuan Miao, Jigang Du, Bizhong Che, Yufei Guo, Jintao Zhang, Zhong Ju, Tan Xu, Xiaoyan Zhong, Yonghong Zhang, Chongke Zhong
Summary: This study found that poststroke depression patients had lower levels of choline and betaine compared to those without depression. Adjusted odds ratios for the highest tertile of choline and betaine were significantly lower, and each 1 SD increase in choline or betaine was associated with a decreased risk of PSD. The addition of choline or betaine to the risk factors model improved risk reclassification for PSD.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jie Zhang, Brian Head, Scott W. Leonard, Jaewoo Choi, Robyn L. Tanguay, Maret G. Traber
Summary: The study investigates the molecular mechanism of Vitamin E in embryogenesis, revealing that Vitamin E deficiency leads to complex biochemical pathway changes, with betaine playing a key role in maintaining glutathione homeostasis. Additionally, changes in amino acids and thiols during embryonic development are associated with Vitamin E deficiency.
Article
Nutrition & Dietetics
Heleen Van Puyvelde, Nikos Papadimitriou, Joanna Clasen, David Muller, Carine Biessy, Pietro Ferrari, Jytte Halkjaer, Kim Overvad, Anne Tjonneland, Renee T. Fortner, Verena Katzke, Matthias B. Schulze, Paolo Chiodini, Giovanna Masala, Valeria Pala, Carlotta Sacerdote, Rosario Tumino, Marije F. Bakker, Antonio Agudo, Eva Ardanaz, Maria Dolores Chirlaque Lopez, Maria-Jose Sanchez, Ulrika Ericson, Bjorn Gylling, Therese Karlsson, Jonas Manjer, Julie A. Schmidt, Genevieve Nicolas, Corinne Casagrande, Elisabete Weiderpass, Alicia K. Heath, Lode Godderis, Koen Van Herck, Dirk De Bacquer, Marc J. Gunter, Inge Huybrechts
Summary: The study did not find strong evidence for an association between methyl-group donors involved in one-carbon metabolism and breast cancer risk. However, there was a potential U-shaped trend suggested for dietary folate intake and breast cancer risk. Further research is needed to clarify this association.
Article
Nutrition & Dietetics
Peicong Ge, Yaobo Zhao, Yuanren Zhai, Qian Zhang, Xun Ye, Jia Wang, Rong Wang, Yan Zhang, Dong Zhang, Jizong Zhao
Summary: Circulating choline and betaine are negatively associated with the risk of MMD and its subtypes.
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Xiong-Fei Pan, Jae Jeong Yang, Xiao-Ou Shu, Steven C. Moore, Nicholette D. Palmer, Marta Guasch-Ferre, David M. Herrington, Sei Harada, Heather Eliassen, Thomas J. Wang, Robert E. Gerszten, Demetrius Albanes, Ioanna Tzoulaki, Ibrahim Karaman, Paul Elliott, Huilian Zhu, Lynne E. Wagenknecht, Wei Zheng, Hui Cai, Qiuyin Cai, Charles E. Matthews, Cristina Menni, Katie A. Meyer, Loren P. Lipworth, Jennifer Ose, Myriam Fornage, Cornelia M. Ulrich, Danxia Yu
Summary: The study showed that circulating choline, carnitine, and DMG were associated with unfavorable cardiometabolic risk profiles, while circulating betaine was associated with a favorable cardiometabolic risk profile.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Ecology
Rachel Stirrup, Michaela A. Mausz, Eleonora Silvano, Andrew Murphy, Richard Guillonneau, Mussa Quareshy, Branko Rihtman, Maria Aguilo Ferretjans, Ruo He, Jonathan D. Todd, Feng Chen, David J. Scanlan, Yin Chen
Summary: Lipids play a crucial role in maintaining cell integrity and homeostasis. The cosmopolitan marine roseobacter clade (MRC) and SAR11 clade bacteria produce a variety of amino acid-containing lipids. The study reveals that these lipids are present in both the inner and outer membranes of MRC bacteria. The inability to produce these lipids impacts membrane proteome, nutrient transport, competitiveness, and phage attachment.
Article
Agriculture, Dairy & Animal Science
Aisha Zaki, Shouqun Jiang, Saad Zaghloul, Talaat K. El-Rayes, Ahmed A. Saleh, Mahmoud Mostafa Azzam, Marco Ragni, Mahmoud Alagawany
Summary: This research evaluated the effects of using betaine as a substitute for choline on the productive performance, egg quality parameters, fatty acids profile, and antioxidant status in laying hens. The results showed that replacing choline with betaine did not significantly affect body weight, egg production, and feed intake. However, egg weight and egg mass increased, and yolk color improved in the group supplemented with betaine. The levels of various blood parameters, liver malondialdehyde content, yolk vitamin E, and fatty acid levels were not significantly affected by betaine supplementation. Additionally, hens fed betaine displayed an increased antibody titer for Newcastle disease virus.
Article
Multidisciplinary Sciences
Adam S. Chan, Songhua Wu, Stephen T. Vernon, Owen Tang, Gemma A. Figtree, Tongliang Liu, Jean Y. H. Yang, Ellis Patrick
Summary: Cardiovascular disease remains a leading cause of mortality, affecting an estimated half a billion people in 2019. However, the detection of signals between specific pathophysiology and coronary plaque phenotypes using complex multi-omic discovery datasets is challenging due to individual diversity and risk factors. This study illustrates different methods for identifying subcohorts of individuals with subclinical coronary artery disease (CAD) and distinct metabolomic signatures, showing that utilizing these subcohorts can improve prediction and facilitate the discovery of novel biomarkers.
Article
Multidisciplinary Sciences
Adam S. Chan, Songhua Wu, Stephen T. Vernon, Owen Tang, Gemma A. Figtree, Tongliang Liu, Jean Y. . H. Yang, Ellis Patrick
Summary: Cardiovascular disease remains a leading cause of mortality, affecting an estimated half a billion people in 2019. However, detecting signals between specific pathophysiology and coronary plaque phenotypes using complex multiomic discovery datasets is challenging due to individual diversity and risk factors. Various methods, including knowledge-guided and data-driven approaches, can help identify subcohorts with distinctive metabolomic signatures and subclinical CAD, improving prediction and facilitating the discovery of new biomarkers. Analyzing cohort heterogeneity through these subcohorts can advance our understanding of CVD and provide more effective preventative treatments.
Article
Agriculture, Multidisciplinary
Shan Huang, Si Ying Lim, Sock Hwee Tan, Mark Y. Chan, Wuzhong Ni, Sam Fong Yau Li
Summary: The relationship between TMAO, betaine, and choline with acute myocardial infarction (AMI) is unclear. This study found that high betaine + low TMAO levels are associated with a significant protective effect against AMI. Furthermore, age is positively correlated with TMAO concentration, indicating a potential interplay between age and the risk of AMI associated with metabolite combination.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Oncology
Monireh Sadat Seyyedsalehi, Marta Rossi, Maryam Hadji, Hamideh Rashidian, Maryam Marzban, Maria Parpinel, Federica Fiori, Ahmad Naghibzadeh-Tahami, Yusuf A. Hannun, Chiara Luberto, Kazem Zendehdel, Paolo Boffetta
Summary: This study found that dietary betaine, choline, and choline-containing compounds are associated with the risk of colorectal cancer (CRC). Men who consume phosphocholine and sphingomyelin are more likely to develop CRC, while women who consume betaine have a decreased risk. Therefore, modifying the diet to increase betaine intake and managing the consumption of animal products can help reduce the risk of CRC.
Article
Psychology, Multidisciplinary
Madison S. Dulin, Susan J. Loveall, Laura J. Mattie
Summary: The present study aimed to characterize the home-literacy environments of toddlers with Down syndrome and examine the predictors of child receptive vocabulary. Results indicated that toddlers with Down syndrome experience rich home-literacy environments and interactive shared storybook reading encounters. Child engagement and the home language environment were found to be positively correlated with toddlers' concurrent and later receptive vocabularies. The richness of the home-literacy environment and the quality of shared storybook reading activity emerged as moderate predictors of receptive vocabulary 6 months later.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Psychology, Developmental
Ruoyu (Lexie) Hu, Paul Fletcher, Zhixiang Zhang, Weilan Liang, Virginia Marchm, Twila Tardif
Summary: This study examined the early grammatical marking in Mandarin and found a clear order of acquisition among Mandarin-speaking children. The findings suggest that the acquisition of grammatical markers in Mandarin differs from English or other languages. The study also indicates that perceptually salient and obligatory markers, with clear form-meaning mappings, are acquired earlier than others.
DEVELOPMENTAL PSYCHOLOGY
(2022)
Article
Nutrition & Dietetics
HanByul Jang, Hyunjung Lim, Kyung-Hee Park, SangIck Park, Hye-Ja Lee
Summary: Reduced choline and increased B/C levels during lifestyle intervention were associated with improvements in LDL-cholesterol and triglycerides, low-fat and high-fiber intakes, as well as a decrease in Firmicutes abundance. These changes in circulating choline and B/C levels could predict individuals' metabolic compositions in response to lifestyle intervention.
Article
Pediatrics
Thiviya Selvanathan, Ting Guo, Eddie Kwan, Vann Chau, Rollin Brant, Anne R. Synnes, Ruth E. Grunau, Steven P. Miller
Summary: Small birth head circumference is associated with poorer neurodevelopment outcomes, while small head circumference at discharge is linked to lower scores in motor, cognitive, and language assessments in children with small birth head circumference. Head circumference strongly correlates with total cerebral volume at term-equivalent age, but total cerebral volume is not associated with developmental outcomes.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2022)
Article
Pediatrics
Anne R. Synnes, Julie Petrie, Ruth E. Grunau, Paige Church, Edmond Kelly, Diane Moddemann, Xiang Ye, Shoo K. Lee, Karel O'Brien
Summary: According to this study, FICare did not have a significant impact on cognitive and language delay in very preterm infants, but did show improvements in motor development.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2022)
Article
Obstetrics & Gynecology
Christopher McPherson, Ruth E. Grunau
Summary: Chronic pain and agitation in neonates can affect brain development. Oral sweet-tasting solutions should be used carefully to alleviate behavioral responses to mild pain, with the understanding that long-term effects are unknown. Rapid-acting opioids are recommended for premedication in non-emergent endotracheal intubations. Continuous low-dose morphine or dexmedetomidine can be considered for preterm or term neonates experiencing stress during mechanical ventilation or therapeutic hypothermia. Further research is needed on the pharmacokinetics, pharmacodynamics, safety, and efficacy of pharmacological agents for managing mild, moderate, and chronic pain and stress in neonates.
CLINICS IN PERINATOLOGY
(2022)
Article
Pediatrics
Min Sheng, Ting Guo, Connor Mabbott, Vann Chau, Anne Synnes, Linda S. de Vries, Ruth E. Grunau, Steven P. Miller
Summary: This study evaluated the relationship between ventricular volume and neurodevelopmental outcomes in children born very preterm. The results showed that ventricular size at birth was associated with cognitive and motor outcomes at 4.5 years, suggesting abnormal white matter maturation in the setting of enlarged ventricular size.
JOURNAL OF PEDIATRICS
(2022)
Article
Obstetrics & Gynecology
Emma G. Duerden, Mia A. Mclean, Cecil Chau, Ting Guo, Margot Mackay, Vann Chau, Anne Synnes, Steven P. Miller, Ruth E. Grunau
Summary: This study found that in extremely preterm neonates born between 24-28 weeks' gestational age, more invasive procedures were associated with poorer sensory processing. Additionally, in the overall cohort, fewer sensory processing problems were correlated with greater thalamic growth between birth and term-equivalent age.
EARLY HUMAN DEVELOPMENT
(2022)
Article
Clinical Neurology
Graham S. Donen, Zoe White, Elodie Sauge, Morten Ritso, Marine Theret, John Boyd, Angela M. Devlin, Fabio M. Rossi, Pascal Bernatchez
Summary: This study found that housing mice at thermoneutral temperature and feeding them a Western diet aggravated muscular dystrophy, without affecting non-diseased mice. These findings improve rodent modeling of human muscular dystrophy and provide insights into the role of metabolic abnormalities in muscle wasting.
Article
Multidisciplinary Sciences
Matthias W. Wagner, Delvin So, Ting Guo, Lauren Erdman, Min Sheng, S. Ufkes, Ruth E. Grunau, Anne Synnes, Helen M. Branson, Vann Chau, Manohar M. Shroff, Birgit B. Ertl-Wagner, Steven P. Miller
Summary: This study aims to predict adverse neurodevelopmental outcomes in very preterm neonates. By using brain MRI and extracting radiomic features, it was found that radiomic features outperformed clinical variables in predicting motor outcomes, and combining the two improved predictive performance.
SCIENTIFIC REPORTS
(2022)
Article
Pediatrics
Natalie Hoi-Man Chan, Anne Synnes, Ruth E. Grunau, Lindsay Colby, Julie Petrie, Tracy Elfring, Lindsay Richter, Leonora Hendson, Rudaina Banihani, Thuy Mai Luu
Summary: Preterm infants are at risk for language delay, and exposure to multiple languages is associated with lower language scores. Primary language at home has a weaker impact on language development.
Article
Neurosciences
Jillian Vinall Miller, Vann Chau, Anne Synnes, Steven P. Miller, Ruth E. Grunau
Summary: This study suggests that supportive maternal behavior can buffer the association between early brain dysmaturation and cognitive and language performance, providing an opportunity to promote optimal neurodevelopment in children born very preterm.
BIOLOGICAL PSYCHIATRY
(2022)
Article
Medicine, General & Internal
Mia A. McLean, Olivia C. Scoten, Cecil M. Y. Chau, Anne Synnes, Steven P. Miller, Ruth E. Grunau
Summary: The study investigates the association between neonatal pain-related stress and the development of internalizing behaviors in children born very preterm. It also examines whether supportive parenting behaviors and lower parenting stress can attenuate this association.
Article
Medicine, General & Internal
Noha Gomaa, Chaini Konwar, Nicole Gladish, Stephanie H. Au-Young, Ting Guo, Min Sheng, Sarah M. Merrill, Edmond Kelly, Vann Chau, Helen M. Branson, Linh G. Ly, Emma G. Duerden, Ruth E. Grunau, Michael S. Kobor, Steven P. Miller
Summary: This cohort study of very preterm neonates suggests that biological aging may be associated with impaired brain growth and neurodevelopmental outcomes. The associations between epigenetic aging and adverse neonatal brain health warrant further attention.
Article
Psychiatry
Sarah M. Hutchison, Ursula Brain, Ruth E. Grunau, Boris Kuzeljevic, Mike Irvine, Louise C. Masse, Tim F. Oberlander
Summary: Prenatal exposure to selective serotonin reuptake inhibitor (SSRI) antidepressants is associated with increased internalising and anxious behaviours in young children, but it is unclear whether this association persists into early adolescence. Furthermore, the contribution of in utero SSRI exposure versus underlying maternal mood to these associations is not well established.
Article
Pediatrics
Thiviya Selvanathan, Pearl Zaki, Mia A. McLean, Stephanie H. Au-Young, Cecil M. Y. Chau, Vann Chau, Anne R. Synnes, Linh G. Ly, Edmond Kelly, Ruth E. Grunau, Steven P. Miller
Summary: We assessed variability of analgesic use across three tertiary neonatal intensive care units accounting for early-life pain, and determined whether analgesia exposure modifies associations between early-life pain and neurodevelopment.
PEDIATRIC RESEARCH
(2023)
Review
Physiology
Taylor A. Ricci, Nicha Boonpattrawong, Ismail Laher, Angela M. Devlin
Summary: Maternal nutrition during pregnancy can have long-lasting effects on fetal development and increase the risk of cardiovascular disease in later life. This review examines the impact of maternal diet on offspring vascular function, including the effects of maternal micronutrient intake, high-fat diets, caloric restriction, and low protein intake on endothelial function. The review also discusses study design differences, potential underlying mechanisms, and identifies areas for future research.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2023)
Article
Nutrition & Dietetics
Kelsey M. Cochrane, Rajavel Elango, Angela M. Devlin, Chantal Mayer, Jennifer A. Hutcheon, Crystal D. Karakochuk
Summary: This study investigated the effect of (6S)-5-methyltetrahydrofolic acid ((6S)-5-MTHF) and folic acid on blood folate status during pregnancy. The results showed that supplementation with (6S)-5-MTHF may reduce plasma unmetabolised folic acid (UMFA) by approximately 50% compared to folic acid supplementation, but the biological relevance of this finding remains unclear.
BRITISH JOURNAL OF NUTRITION
(2023)
