Journal
GREEN CHEMISTRY
Volume 17, Issue 3, Pages 1802-1810Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4gc02318h
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Funding
- National Science Foundation [CHE-1352665]
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Copper(II) chloride catalyzes the three-component coupling of cyclohexanone, amines, and alkynes to produce tetrasubstituted propargylamines. As a wide range of substrates react without solvent, excess starting material, or other additives, water is the sole by-product. Studies demonstrate that this reaction is first order in copper, cyclohexanone, amine, and alkyne. These mild conditions allow for the first direct, catalytic synthesis of silyl-protected tetrasubstituted propargylamines.
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